Abstract: The present invention provides polymer micelles with cross-linked ionic cores as delivery vehicles for therapeutics, diagnostics, nucleic acids, proteins, small molecules and the like. The present invention provides additionally methods of synthesis and uses for such micelles.

Abstract: The present invention provides polymer conjugates and methods of use thereof.

Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.

Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.

Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.

Abstract: The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates.

Abstract: Compositions and methods for the delivery of a protein of interest are provided.

Abstract: The present invention provides polymer aggregates as delivery vehicles for therapeutics and diagnostics. The present invention additionally provides methods of synthesis and uses for such aggregates.

Abstract: Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided.

Abstract: In one aspect, this invention relates to a substantially water-insoluble pesticidal aggregate produced from a mixture comprising: (a) a polymer having at least three similarly charged electrostatic moieties; (b) an amphiphilic surfactant having at least one electrostatically charged moiety of opposite charge to the polymer; and (c) a pesticide. In other aspects, this invention relates pesticidal compositions comprising such a pesticidal aggregate and an agriculturally acceptable carrier, as well as to a method of controlling pests using such pesticidal compositions.

Abstract: An improved pesticide delivery system is disclosed. The system is based on a microblend comprising (a) an amphophilic compound containing at least one hydrophilic group and at least one hydrophobic group and (b) a second compound. Compositions based on the microblend and methods of using the compositions to control pests are also disclosed.

Abstract: Compositions and methods for increasing protein production are provided.

Abstract: An improved pesticide delivery system is disclosed. The system is based on a microblend comprising (a) an amphiphilic compound containing at least one hydrophilic group and at least one hydrophobic group and (b) a pesticide. Compositions based on the microblend and methods of using the compositions to control pests are also disclosed.

Abstract: Compositions and methods for increasing protein production are provided.

Abstract: The present invention provides polymer micelles with cross-linked ionic cores as delivery vehicles for therapeutics, diagnostics, nucleic acids, proteins, small molecules and the like. The present invention provides additionally methods of synthesis and uses for such micelles.

Abstract: The present invention provides polymer micelles with cross-linked ionic cores as delivery vehicles for therapeutics, diagnostics, nucleic acids, proteins, small molecules and the like. The present invention provides additionally methods of synthesis and uses for such micelles.

Abstract: Compositions induce the activation of dendritic cells comprising a polynucleotide, such as viruses, RNA, DNA, plasmid DNA, or derivatives thereof and at least one block copolymer of alkylethers. The present invention further relates to compositions for inducing the activation of dendritic cells wherein the block copolymers are PLURONIC F127 and L61. More particular, the compositions comprise block copolymers PLURONIC F127/PLURONIC L61. The invention also relates to methods of inducing the activation of dendritic cells in animals comprising administering the compositions of the invention. Additionally, the present invention relates to methods of increasing the immune response of animals comprising administering the compositions of the present invention.

Abstract: A composition for facilitating delivery of biological agents, comprising a therapeutic or diagnostic agent and a supramolecular complex, the latter comprising (i) a block copolymer, having at least one nonionic, water soluble segment and at least one polyionic segment, and (ii) at least one charged surfactant having hydrophobic groups. The charge of the surfactant is opposite to the charge of the polyionic segment of the block copolymer. The constituents of the supramolecular complex are bound by interaction between the opposite charges thereof and between surfactant hydrophobic groups. The therapeutic or diagnostic agent may be an ionic substance, in which case the ionic substance has a net charge opposite to that of the block copolymer, the net charge being no more than 10.

Abstract: A composition for facilitating delivery of biological agents, comprising a supramolecular complex including as constituents a block copolymer, having at least one nonionic, water soluble segment and at least one polyionic segment, and at least one charged surfactant having hydrophobic groups, the charge of the surfactant being opposite to that of the polyionic segment of the block copolymer. The constituents of the complex are bound by interaction between the opposite charges thereof and between surfactant hydrophobic groups. The complex may include an anionic surfactant having a biological activity, in which case the net charge of such anionic surfactant is no more than about 10.

Abstract: The present invention provides polymer micelles with cross-linked ionic cores as delivery vehicles for therapeutics, diagnostics, nucleic acids, proteins, small molecules and the like. The present invention provides additionally methods of synthesis and uses for such micelles.