Abstract: A medicament delivery device includes a needle disposed at a distal end of the medicament delivery device. The medicament delivery device includes a body for a syringe and a needle cover axially movable relative to the body between an extended position in which the needle cover covers the needle and a retracted position in which the needle protrudes from the distal end of the needle cover. The medicament delivery device includes a plunger axially movable relative to the body to dispense medicament from the medicament delivery device. The medicament delivery device includes a needle cover biasing mechanism configured to bias the needle cover distally from the retracted position to the extended position. The medicament delivery device includes a locking mechanism configured to be moved by the plunger from an initial configuration to an engaged configuration to prevent a distal movement of the needle cover biasing mechanism.

Abstract: An injection device includes a housing, a needle shroud movable within the housing between an extended position and a retracted position, and a needle shroud latch configured to hold the needle shroud in its retracted position. The needle shroud latch includes a button arranged at the housing such that a user can actuate the button by applying an actuation force to the button to hold the needle shroud in its retracted position.

Abstract: An injection device comprising: an injection device body; a plunger comprising one or more plunger recesses; biasing means for applying a biasing force to bias the plunger in a distal direction of the injection device; a casing at least partially enclosing the plunger, the casing comprising one or more toothed beams each comprising a tooth engageable with a corresponding plunger recess of the one or more plunger recesses; and a rotatable collar at least partially enclosing the casing and comprising one or more collar recesses on an inner surface of the rotatable collar.

Abstract: This application relates to an injector device for delivery of a medicament, particularly to an auto-injector device.

Abstract: Some injection devices include an injection device body, a needle shroud retractable into the injection device body, a control spring coupled to the needle shroud and biased to cause the needle shroud to be at least partially extended from the injection device body in an initial position, and a hold detent mechanism coupled to at least the needle shroud. The hold detent mechanism is configured to (i) activate, when the needle shroud is retracted from the initial position into the injection device body to a hold position, to create a hold detent force, and (ii) deactivate, when the needle shroud is extracted from the hold position subsequent to the retraction, to release the hold detent force and enable the needle shroud to extend from the injection device body to substantially the initial position.

Abstract: A medicament delivery device for reducing a force required to activate the device includes a needle disposed at a distal end of the device, a needle cover, and a body. The needle cover is axially movable relative to the body between an initial position in which the needle cover covers the needle and an activated position for dispensing a medicament. The needle protrudes from a distal end of the needle cover when the needle cover is in the activated position. The medicament delivery device includes a carrier configured to support a syringe. The carrier is disposed within the needle cover and includes a deformable element configured to change from a first configuration in which the deformable element is engaged with the needle cover to a second configuration in which the deformable element is not engaged with the needle cover.

Abstract: A computer system is provided. The computer system may be programmed to: (a) receive appliance data relating to a first appliance; (b) compute, using an artificial intelligence model, a predicted remaining lifetime of the first appliance based upon the received appliance data of the first appliance, wherein the artificial intelligence model is trained based upon historical appliance data including data associated with historical lifetimes of similar appliances; (c) determine whether the predicted remaining lifetime exceeds a first threshold; (d) if the determination is that the predicted remaining lifetime exceeds the first threshold, determine one or more replacements for the first appliance; and/or (e) transmit content data to a user device that, when received by the user device, causes the user device to generate a user interface including at least the predicted remaining lifetime of the first appliance and the determined one or more replacements for the first appliance.

Abstract: A medicament delivery device reduces a force required for activation, and the medicament delivery device comprises: a needle at a distal end of the device; a needle cover and a body, wherein the needle cover is axially movable relative to the body between an initial position, in which the needle cover covers the needle, and an activated position for dispensing a medicament from the device; and a carrier configured to support a pre-filled syringe, wherein the carrier is disposed within the needle cover and comprises one or more resilient members, wherein the needle cover comprises one or more first slots and one or more second slots and the one or more resilient members are each configured to engage with a respective one of the one or more first slots when the needle cover is in the initial position, and to enter a respective one of the one or more second slots after a proximal movement of the needle cover from the initial position to an intermediate position.

Abstract: A capacitive system includes a module circuit card assembly including a first modular keying and alignment mechanism and a second modular keying and alignment mechanism. The first and second modular keying and alignment mechanisms are configured for mechanical alignment and electrical connection with a backplane circuit card assembly (CCA). A capacitor is mounted to the module circuit card assembly and is electrically connected to each of the first and second modular keying and alignment mechanisms through a charge/discharge circuit. The circuit is configured to: charge the capacitor with the module circuit card assembly connected to the backplane CCA, discharge the capacitor with the module circuit card assembly connected to the backplane CCA for providing backup power, and discharge the capacitor through a bleed resistor of the circuit upon disconnection of the module circuit card assembly from the backplane CCA.

Abstract: The disclosed technology relates to a ceramic composition and an article formed therefrom. A ceramic article for radio frequency applications is formed of a ceramic material having a chemical formula represented by: Bi1.0+aY2.0?a?x?2yCax+2yFe5?x?yMIVxVyO12 or Bi1.0+aY2.0?a?2yCa2yFe5?y?zVyInzO12. The ceramic material has a composition such that a normalized change in saturation magnetization (?4?Ms), defined as ?4?Ms=[(4?Ms at 20° C.)?(4?Ms at 120° C.)]/(4?Ms at 20° C.), is less than about 0.35.

Abstract: Techniques for collecting, synchronizing, and displaying various types of data relating to a road segment enable, via one or more local or remote processors, servers, transceivers, and/or sensors, (i) enhanced and contextualized analysis of vehicle events by way of synchronizing different data types, relating to a monitored road segment, collected via various different types of data sources; (ii) enhanced and contextualized analysis of filed insurance claims pertaining to a vehicle incident at a road segment; (iii) advantageous machine learning techniques for predicting a level of risk assumed for a given vehicle event or a given road segment; (iv) techniques for accounting for region-specific driver profiles when controlling autonomous vehicles; and/or (v) improved techniques for providing a GUI to display collected data in a meaningful and contextualized manner.

Abstract: There are provided apparatuses for controlling insertion of a membrane channel into a membrane, comprising: a first bath for holding a first liquid in contact with a first surface of the membrane; a second bath for holding a second liquid in contact with a second surface of the membrane, wherein the membrane separates the first and second liquids; a first electrode configured to contact the first liquid; a second electrode configured to contact the second liquid; and a driving circuit configured to apply a potential difference across the membrane via the first and second electrodes to promote insertion of a membrane channel into the membrane from the first liquid or the second liquid. Various configurations of the driving circuit are described that allow effective promotion of membrane channel insertion while reducing the risk of damage to the membrane. Corresponding methods are also described.

Abstract: A computer system is provided. The computer system may be programmed to: (a) receive appliance data relating to a first appliance; (b) compute, using an artificial intelligence model, a predicted remaining lifetime of the first appliance based upon the received appliance data, wherein the artificial intelligence model is trained based upon historical appliance data including historical lifetimes of appliances; and/or (c) transmit content data to a user device that, when received by the user device, causes the user device to generate a user interface including at least the predicted remaining lifetime.

Abstract: An astragal housing includes a housing frame and an interior cover. The housing frame includes a vertically extending mounting wall defining a mounting surface configured for external attachment along a non-hinged vertical edge of a passive door panel, inner and outer vertically extending latch channel walls extending from the mounting wall in a first direction to define a vertically extending latch channel opposite the mounting surface, and inner and outer vertically extending door channel walls extending from the mounting wall in a second direction opposite the first direction to define a vertically extending door channel including the mounting surface. The interior cover has a first hook portion extending over a distal edge of the inner latch channel wall and a second hook portion extending over a distal edge of the inner door channel wall, the interior cover defining an inner lateral surface of the astragal housing.

Abstract: A method comprising: receiving, at a vector processor, a request to store data; performing, by the vector processor, one or more transforms on the data; and directly instructing, by the vector processor, one or more storage device to store the data; wherein performing one or more transforms on the data comprises: erasure encoding the data to generate n data fragments configured such that any k of the data fragments are usable to regenerate the data, where k is less than n; and wherein directly instructing one or more storage device to store the data comprises: directly instructing the one or more storage devices to store the plurality of data fragments.

Abstract: A system to estimate consequences of an explosion includes a scenario generator to generate a scenario based on user input and scenario parameters; an explosive device model generator to generate an explosive device model based on the user input and explosive device parameters; a propagation of hazards modeler to model propagation of hazards into the scenario based on the user input and hazard parameters; an injury modeler to model injuries corresponding to modeling propagation of hazards into the scenario based on injury parameters; and an iteration and output generator to iterate by using additional iterative subsets of the parameters to generate the scenario, generate the explosive device model, model propagation of hazards, and model injuries, until parameter spaces of the parameters are covered. The iteration and output generator generates an injury record based injury outcomes from the modeling of injuries corresponding to the iterating.

Abstract: The present invention relates to the use of a specific binding molecules which binds human ANXA1 in combination with a second active agent for use in the treatment of cancer. Second active agents include thy midylate synthetase inhibitors, nucleobase analogues, checkpoint inhibitors, proteasome inhibitors, taxanes, platinum-based chemotherapy agents and nucleoside analogues. Preferred cancers for treatment are pancreatic cancer, colorectal cancer, breast cancer, lung cancer, myeloma and mantle cell lymphoma. Related kits, products and uses are also provided.

Abstract: Various systems and methods are provided that display various geographic maps and depth graphs in an interactive user interface in substantially real-time in response to input from a user in order to determine information related to measured data points, depth levels, and geological layers and provide the determined information to the user in the interactive user interface. For example, a computing device may be configured to retrieve data from one or more databases and generate one or more interactive user interfaces. The one or more interactive user interfaces may display the retrieved data in a geographic map, a heat map, a cross-plot graph, or one or more depth graphs. The user interface may be interactive in that a user may manipulate any of the graphs to identify trends or current or future issues.

Abstract: The present invention is a method for the synchronized, real-time transmission of content data between two geographically separated computing devices. It involves synchronization of timing between devices, receipt of content data at the first device, and real-time transmission to the second device. The second device sends a cue indicating which content data should be included in a broadcast feed and when. Based on this cue, the first device selects the specified content for inclusion at the designated time, and then transmits the broadcast feed to one or more consumers. This method enhances efficiency and synchronization of content transmission between remote devices, allowing real-time adjustments to the broadcast feed.

Abstract: A modular building assembly of a building includes a modular building unit that forms a portion of the building. The modular building unit includes a structural frame having an exterior side arranged adjacent to an exterior of the building. A façade is mounted on the structural frame. A joining frame is mounted on the structural frame of the modular building unit independently of the façade. The joining frame includes a weather-proofing interface extending along an outer perimeter of the joining frame. The weather-proofing interface engages a joining frame of at least one other modular building assembly to form a seal with the at least one other modular building assembly when the modular building assembly and at least one other modular building assembly are arranged next to one another in the building.