Patents by Inventor Alexandra C. McPherron
Alexandra C. McPherron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7384753Abstract: Growth differentiation factor-11 (GDF-11) is disclosed along with its polynucleotide sequence and amino acid sequence. The invention provides a method for identifying a compound that affects GDF-11 activity or gene expression.Type: GrantFiled: June 10, 2003Date of Patent: June 10, 2008Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 7381528Abstract: Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a predisposition for increased muscle mass as compared to subjects having wild-type myostatin. Increased muscle mass is particularly desirable for identification of animals used to produce food products, including bovine, porcine, ovine, avian and piscine species.Type: GrantFiled: September 11, 2003Date of Patent: June 3, 2008Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 7332575Abstract: Purified GDF-8 polypeptides of aquatic organisms.Type: GrantFiled: November 15, 2004Date of Patent: February 19, 2008Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 7179884Abstract: Growth differentiation factor-8 (GDF-8) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-8 polypeptide and polynucleotide sequences.Type: GrantFiled: December 31, 2002Date of Patent: February 20, 2007Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 6891082Abstract: The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of modulating an effect of myostatin on a cell by contacting the cell with an agent that affects myostatin signal transduction in the cell. In addition, the invention provides a method of ameliorating the severity of a pathologic condition, which is characterized, at least in part, by an abnormal amount, development or metabolic activity of muscle or adipose tissue in a subject, by modulating myostatin signal transduction in a muscle cell or an adipose tissue cell in the subject.Type: GrantFiled: April 24, 2001Date of Patent: May 10, 2005Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 6858208Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals with antibodies or antisense directed to GDF-8. The animals so treated are characterized by increased muscle tissue.Type: GrantFiled: October 22, 2002Date of Patent: February 22, 2005Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Publication number: 20040088747Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is provided. Also provided are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue and bone tissue.Type: ApplicationFiled: June 10, 2003Publication date: May 6, 2004Applicant: THE JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINEInventors: Se-Jin Lee, Alexandra C. McPherron
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Publication number: 20040055027Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is provided. Also provided are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-8. The animals so treated are characterized by increased muscle tissue and bone content.Type: ApplicationFiled: June 17, 2003Publication date: March 18, 2004Applicant: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Publication number: 20040048307Abstract: Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a predisposition for increased muscle mass as compared to subjects having wild-type myostatin. Increased muscle mass is particularly desirable for identification of animals used to produce food products, including bovine, porcine, ovine, avian and piscine species.Type: ApplicationFiled: September 11, 2003Publication date: March 11, 2004Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINEInventors: Se-Jin Lee, Alexandra C. McPherron
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Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
Patent number: 6656475Abstract: The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of modulating an effect of myostatin on a cell by contacting the cell with an agent that affects myostatin signal transduction in the cell. In addition, the invention provides a method of ameliorating the severity of a pathologic condition, which is characterized, at least in part, by an abnormal amount, development or metabolic activity of muscle or adipose tissue in a subject, by modulating myostatin signal transduction in a muscle cell or an adipose tissue cell in the subject.Type: GrantFiled: July 27, 2000Date of Patent: December 2, 2003Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron -
Publication number: 20030167492Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue and bone tissue.Type: ApplicationFiled: May 31, 2001Publication date: September 4, 2003Applicant: Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 6607884Abstract: The present invention relates to a method for detecting a polynucleotide encoding GDF-8 in a sample by contacting the sample with an oligonucleotide probe that hybridizes specifically with a polynucleotide encoding GDF-8; and detecting specific hybridization of the oligonucleotide probe to a polynucleotide in the sample, thereby detecting a polynucleotide encoding GDF-8 in the sample. The sample can be a tissue sample or a cell sample, for example, a muscle cell sample, which can be obtained, for example, from a mammal such as a bovine, ovine or porcine mammal, or a human.Type: GrantFiled: October 10, 2000Date of Patent: August 19, 2003Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Publication number: 20030120058Abstract: Growth differentiation factor-8 (GDF-8) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-8 polypeptide and polynucleotide sequences.Type: ApplicationFiled: December 31, 2002Publication date: June 26, 2003Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINEInventors: Se-Jin Lee, Alexandra C. McPherron
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Publication number: 20030109684Abstract: Growth Differentiation factor-3 (GDF-3) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-3 polypeptide and polynucleotide sequences.Type: ApplicationFiled: May 21, 2002Publication date: June 12, 2003Inventors: Se-Jin Lee, Alexandra C. McPherron
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Publication number: 20030082181Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-B (GDF-8) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals with antibodies or antisense directed to GDF-8. The animals so treated are characterized by increased muscle tissue.Type: ApplicationFiled: October 22, 2002Publication date: May 1, 2003Applicant: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Publication number: 20030074680Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-8. The animals so treated are characterized by increased muscle tissue and bone content.Type: ApplicationFiled: June 1, 2001Publication date: April 17, 2003Applicant: Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 6517835Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue.Type: GrantFiled: December 6, 1999Date of Patent: February 11, 2003Assignee: The Johns Hopkins UniversityInventors: Se-Jin Lee, Alexandra C. McPherron
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Patent number: 6500664Abstract: Growth differentiation factor-8 (GDF-8) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-8 polypeptide and polynucleotide sequences.Type: GrantFiled: August 1, 2000Date of Patent: December 31, 2002Assignee: The Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron
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Publication number: 20020157126Abstract: The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of modulating an effect of myostatin on a cell by contacting the cell with an agent that affects myostatin signal transduction in the cell. In addition, the invention provides a method of ameliorating the severity of a pathologic condition, which is characterized, at least in part, by an abnormal amount, development or metabolic activity of muscle or adipose tissue in a subject, by modulating myostatin signal transduction in a muscle cell or an adipose tissue cell in the subject.Type: ApplicationFiled: April 24, 2001Publication date: October 24, 2002Inventors: Se-Jin Lee, Alexandra C. McPherron
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Publication number: 20020157125Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-8. The animals so treated are characterized by increased muscle tissue.Type: ApplicationFiled: May 15, 2001Publication date: October 24, 2002Applicant: Johns Hopkins University School of MedicineInventors: Se-Jin Lee, Alexandra C. McPherron