Patents by Inventor Alexandra C. McPherron

Alexandra C. McPherron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Growth differentiation factor-8
    Patent number: 6468535
    Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals with antibodies or antisense directed to GDF-8. The animals so treated are characterized by increased muscle tissue.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: October 22, 2002
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • USE OF ANTIBODIES SPECIFIC FOR GROWTH DIFFERENTIATION FACTOR-11
    Publication number: 20020150577
    Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue.
    Type: Application
    Filed: May 16, 2001
    Publication date: October 17, 2002
    Applicant: Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species
    Patent number: 6465239
    Abstract: A transgenic non-human aquatic organisms, such as piscine, crustacea, mollusks, and the like, having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such organisms and nucleic acid sequences encoding GDF-8 polypeptides from such aquatic organisms.
    Type: Grant
    Filed: August 19, 1999
    Date of Patent: October 15, 2002
    Assignee: The John Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Methods of detecting growth differentiation factor-3
    Patent number: 6391565
    Abstract: Growth differentiation factor-3 (GDF-3) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-3 polypeptide and polynucleotide sequences.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: May 21, 2002
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • GROWTH DIFFERENTIATION FACTOR-11
    Publication number: 20010053358
    Abstract: A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-11 (GDF-11) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals with antibodies or antisense directed to GDF-11. The animals so treated are characterized by increased muscle tissue.
    Type: Application
    Filed: December 6, 1999
    Publication date: December 20, 2001
    Applicant: THE JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: SE-JIN LEE, ALEXANDRA C. MCPHERRON
  • GROWTH DIFFERENIATION FACTOR-3
    Publication number: 20010018509
    Abstract: Growth differentiation factor-3 (GDF-3) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-3 polypeptide and polynucleotide sequences.
    Type: Application
    Filed: September 3, 1999
    Publication date: August 30, 2001
    Applicant: THE JOHN HOPKINS UNIVERSITY SCHOOL OF MEDICINE
    Inventors: SE-JIN LEE, ALEXANDRA C. MCPHERRON
  • Antibodies specific for growth differentiation factor-8 and methods of using same
    Patent number: 6096506
    Abstract: Growth differentiation factor-8 (GDF-8) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-8 polypeptide and polynucleotide sequences.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: August 1, 2000
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Growth differentiation factor-3
    Patent number: 6025475
    Abstract: Growth differentiation factor-3 (GDF-3) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-3 polypeptide and polynucleotide sequences.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: February 15, 2000
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Growth differentiation factor-11 transgenic mice
    Patent number: 6008434
    Abstract: A transgenic mouse whose genome comprises a disruption of the endogenous growth differentiation factor-11 (GDF-11) gene is disclosed. Also disclosed are methods for making such mice. The mice exhibit a phenotype of increased muscle tissue.
    Type: Grant
    Filed: February 6, 1997
    Date of Patent: December 28, 1999
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Growth differentiation factor-8 transgenic mice
    Patent number: 5994618
    Abstract: A transgenic mouse whose genome comprises a disruption of the endogenous growth differentiation factor-8 (GDF-8) gene is disclosed. Also disclosed are methods for making such mice. The transgenic mice exhibit a phenotype of increased muscle tissue.
    Type: Grant
    Filed: February 5, 1997
    Date of Patent: November 30, 1999
    Assignee: Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Methods of detecting growth differentiation factor-11
    Patent number: 5914234
    Abstract: Growth differentiation factor-11 (GDF-11) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-11 polypeptide and polynucleotide sequences.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: June 22, 1999
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Growth differentiation factor-8 (GDF-8) and polynucleotides encoding same
    Patent number: 5827733
    Abstract: Growth differentiation factor-8 (GDF-8) polypeptides, polynucleotides encoding GDF-8 polypeptides, and vectors and host cells containing GDF-8 encoding polynucleotides are provided.
    Type: Grant
    Filed: October 29, 1995
    Date of Patent: October 27, 1998
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron
  • Growth differentiation factor-3
    Patent number: 5808007
    Abstract: Growth Differentiation factor-3 (GDF-3) is disclosed along with its polynucleotide sequence and amino acid sequence. Also disclosed are diagnostic and therapeutic methods of using the GDF-3 polypeptide and polynucleotide sequences.
    Type: Grant
    Filed: August 28, 1995
    Date of Patent: September 15, 1998
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Se-Jin Lee, Alexandra C. McPherron