Patents by Inventor Alexandra E. Gould

Alexandra E. Gould has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210015915
    Abstract: The present disclosure provides novel compounds of Formula (I) below. Compounds of the disclosure act as STING modulators/agonists. The present disclosure further relates to methods of synthesis of compounds of Formula (I) and methods of using of compounds of Formula (I) for the prophylaxis or treatment of cancer and other STING-related diseases. The compounds have the structure represented by Formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 21, 2021
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Jeffrey CIAVARRI, Dylan Bradley ENGLAND, Kenneth M. GIGSTAD, Alexandra E. GOULD, Paul GREENSPAN, Yongbo HU, Shi-Chung HUANG, Steven Paul LANGSTON, Hirotake MIZUTANI, Zhan SHI, Stepan VYSKOCIL, He XU
  • Publication number: 20200406852
    Abstract: A restraint system (10) for helping to protect an occupant (60) of a vehicle (20) having a seat (50) for the occupant (60) includes a primary airbag (70) having a stored condition within a roof (32) and being inflatable to a deployed condition aligned with the seat (50). A support airbag (76) has a stored condition within the roof (32) and is inflatable to a deployed condition engaging the primary airbag (70).
    Type: Application
    Filed: December 4, 2018
    Publication date: December 31, 2020
    Inventors: Kurt F. Fischer, Alexandra E. Schroeder, Werner Freisler, Douglas M. Gould, Tobias Klenk, Hylus Ranjit Raj Jayakar
  • Patent number: 10865208
    Abstract: Disclosed are chemical entities which are compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: December 15, 2020
    Assignee: MILLENNIUM PHARMACEUTICALS, INC.
    Inventors: Sharmila Adhikari, Emily Frances Calderwood, Dylan Bradley England, Alexandra E. Gould, Sean J. Harrison, Shih-Chung Huang, Liting Ma
  • Patent number: 10710543
    Abstract: A vehicle occupant safety system helps protect front seat occupants of a vehicle in the event of a collision that results in oblique forward occupant movement. The safety system includes a frontal air bag inflatable between on instrument panel end the front seat vehicle occupant, and a central air bag inflatable adjacent and inboard of the frontal air bag. The frontal air bag can be configured and positioned to receive and cushion the vehicle occupant moving in an oblique direction in the vehicle as the result of a vehicle collision. The central air bag can be configured and positioned to support an inboard portion of the frontal airbag against flattening out in response to receiving the obliquely moving occupant, and to engage the obliquely moving occupant's head and resist rotation of the vehicle occupant's head resulting from moving obliquely into engagement with the frontal air bag.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: July 14, 2020
    Assignee: TRW VEHICLE SAFETY SYSTEMS INC.
    Inventors: Kurt F. Fischer, Douglas M. Gould, Alexandra E. Schroeder
  • Publication number: 20190382406
    Abstract: Disclosed are chemical entities which are compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, and Ra have the values described herein. Chemical entities according to the disclosure can be useful as inhibitors of ATG7. Further provided are pharmaceutical compositions comprising a chemical entity of the disclosure and methods of using the compositions in the treatment of cancer.
    Type: Application
    Filed: November 10, 2017
    Publication date: December 19, 2019
    Inventors: Sharmila ADHIKARI, Emily Frances CALDERWOOD, Dylan Bradley ENGLAND, Alexandra E. GOULD, Sean J. HARRISON, Shih-Chung HUANG, Liting MA
  • Patent number: 9593121
    Abstract: Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R*1 is —H or —CH3; and Y is Formula (II) or Formula (III), wherein R2 is —H, —CH3 or C1-4 alkyloxycarbonyl; and RS7.1, RS7.2 and RS8.1 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: March 14, 2017
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Benjamin Stone Amidon, David P. Cardin, Alexandra E. Gould, Paul D. Greenspan, Sean J. Harrison
  • Publication number: 20150210700
    Abstract: Disclosed are chemical entities that inhibit Uba6, each of which is a compound of Formula /: Formula (I) or a pharmaceutically acceptable salt thereof, wherein R*1 is —H or —CH3; and Y is Formula (II) or Formula (III), wherein R2 is —H, —CH3 or C1-4 alkyloxycarbonyl; and RS7.1, RS7.2 and RS8.1 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.
    Type: Application
    Filed: August 2, 2013
    Publication date: July 30, 2015
    Inventors: Benjamin Stone Amidon, David P. Cardin, Alexandra E. Gould, Paul D. Greenspan, Sean J. Harrison
  • Publication number: 20150112071
    Abstract: The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention.
    Type: Application
    Filed: May 29, 2014
    Publication date: April 23, 2015
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Alexandra E. Gould, Sean J. Harrison, Hirotake Mizutani, Ming Shen, Thomas E. Smyser, Stephen G. Stroud
  • Publication number: 20140256947
    Abstract: The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention.
    Type: Application
    Filed: October 10, 2013
    Publication date: September 11, 2014
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Alexandra E. Gould, Sean J. Harrison, Hirotake Mizutani, Ming Shen, Thomas E. Smyser, Stephen G. Stroud
  • Publication number: 20140243334
    Abstract: This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R2a, R2b, R2c, and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Emily F. Calderwood, Dylan B. England, Alexandra E. Gould, Sean J. Harrison, Liting Ma
  • Publication number: 20140243335
    Abstract: This invention provides compounds of formula (I): wherein R1, R1b, R2a, R2b, R2c, and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Christopher Blackburn, Emily F. Calderwood, Kenneth M. Gigstad, Alexandra E. Gould, Sean J. Harrison, He Xu
  • Patent number: 8778931
    Abstract: This invention provides compounds of formula (I) wherein R1, R2, X, p, q, m, n, and Ring C have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: July 15, 2014
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Alexandra E. Gould
  • Patent number: 8765773
    Abstract: This invention provides compounds of formula (I): wherein R1a, R1b, Ra, R2a, R2b, R1, and X have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: July 1, 2014
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Dylan B. England, Kenneth M. Gigstad, Alexandra E. Gould, Liting Ma, He Xu
  • Patent number: 8513421
    Abstract: This invention provides compounds of formula (I): wherein R1a, R1, R2a, and R2b have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: August 20, 2013
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Alexandra E. Gould, Sean J. Harrison
  • Publication number: 20120165316
    Abstract: This invention provides compounds of formula (I): wherein R1, R2, X, p, q, m, n, and Ring C have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 28, 2012
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventor: Alexandra E. Gould
  • Publication number: 20120094997
    Abstract: This invention provides compounds of formula (I): wherein R1a, R1b, Ra, R2a, R2b, R1, and X have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
    Type: Application
    Filed: October 14, 2011
    Publication date: April 19, 2012
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Dylan B. England, Kenneth M. Gigstad, Alexandra E. Gould, Liting Ma, He Xu
  • Patent number: 8110687
    Abstract: The present invention provides novel bicyclic compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: February 7, 2012
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Emily F. Calderwood, Alexandra E. Gould, Paul D. Greenspan, Robyn Scott Rowland, Tricia J. Vos, Matthew J. LaMarche
  • Publication number: 20120015943
    Abstract: This invention provides compounds of formula (I): wherein R1, R1b, R2a, R2b, R2c, and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
    Type: Application
    Filed: July 18, 2011
    Publication date: January 19, 2012
    Applicant: Millennium Pharmacuticals, Inc.
    Inventors: Christopher Blackburn, Emily F. Calderwood, Kenneth M. Gigstad, Alexandra E. Gould, Sean J. Harrison, He Xu
  • Publication number: 20120015942
    Abstract: This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R2a, R2b, R2c, and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
    Type: Application
    Filed: July 18, 2011
    Publication date: January 19, 2012
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Emily F. Calderwood, Dylan B. England, Alexandra E. Gould, Sean J. Harrison, Liting Ma
  • Publication number: 20110288117
    Abstract: This invention provides compounds of formula (I): wherein R1a, R1, R2a, and R2b have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.
    Type: Application
    Filed: May 18, 2011
    Publication date: November 24, 2011
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Alexandra E. Gould, Sean J. Harrison