Patents by Inventor Alexandra E. Gould

Alexandra E. Gould has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Certain pyrazoline derivatives with kinase inhibitory activity
    Patent number: 7795249
    Abstract: The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of various diseases.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: September 14, 2010
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Ruth S. Adams, Matthew Duffey, Alexandra E. Gould, Paul D. Greenspan, Bheemashankar A. Kulkarni, Tricia J. Vos
  • PREPARATION OF AMINOTETRALIN COMPOUNDS
    Publication number: 20100197924
    Abstract: The present invention relates to synthetic processes for preparation of aminotetralin compounds with kinase inhibitory activity. The invention also provides synthetic intermediates useful in the processes of the invention.
    Type: Application
    Filed: December 16, 2009
    Publication date: August 5, 2010
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Alexandra E. Gould, Sean J. Harrison, Hirotake Mizutani, Ming Shen, Thomas E. Smyser, Stephen G. Stroud
  • Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity
    Patent number: 7652041
    Abstract: The present invention provides novel cinnamide compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: January 26, 2010
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Ruth S. Adams, Emily F. Calderwood, Alexandra E. Gould, Paul D. Greenspan, Matthew J LaMarche, Yuan Tian, Tricia J. Vos
  • Certain pyrazoline derivatives with kinase inhibitory activity
    Publication number: 20080171754
    Abstract: The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of various diseases.
    Type: Application
    Filed: December 19, 2007
    Publication date: July 17, 2008
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Ruth S. Adams, Matthew Duffey, Alexandra E. Gould, Paul D. Greenspan, Bheemashankar A. Kulkarni, Tricia J. Vos
  • ACE-2 modulating compounds and methods of use thereof
    Patent number: 7045532
    Abstract: ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I): Z-???(I) Wherein Z is a zinc coordinating moiety and ? is an amino-acid mimicking moiety, and pharmaceutically acceptabale salts thereof. Methods of using the inhibitors and pharmaceutical compositions containing the inhibitors to treat a body weight disorder, to decrease appetite, to increase muscle mass, to decrease body fat, to treat diabetes and to treat a state associated with altered lipid metabolism, are also described.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: May 16, 2006
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Susan L. Acton, Timothy D. Ocain, Alexandra E. Gould, Natalie A. Dales, Bing Guan, James A. Brown, Michael Patane, Vivek J. Kadambi, Michael Solomon, Alain Stricker-Krongrad
  • ACE-2 modulating compounds and methods of use thereof
    Publication number: 20040082496
    Abstract: ACE-2 modulating compounds for the treatment of body weight disorders are disclosed. Methods of using the compounds and pharmaceutical compositions containing the compounds are also claimed.
    Type: Application
    Filed: October 31, 2001
    Publication date: April 29, 2004
    Inventors: Susan L. Acton, Timothy D. Ocain, Alexandra E. Gould, Natalie A. Dales, Bing Guan, James A. Brown, Michael Patane, Vivek J. Kadambi, Michael Solomon, Alain Stricker-Krongrad
  • ACE-2 inhibiting compounds and methods of use thereof
    Patent number: 6632830
    Abstract: ACE-2 inhibiting compounds are disclosed. These compounds include compounds of formula (IV): wherein the variables are as described in the specification. Pharmaceutical compositions containing the compounds are also discussed. The pharmaceutical compositions may contain an effective amount of a compound of the invention to treat ACE-2 associated disorders such as a blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: October 14, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Susan L. Acton, Timothy D. Ocain, Alexandra E. Gould, Natalie A. Dales, Bing Guan, James A. Brown