Patents by Inventor Alexandru S. Biris

Alexandru S. Biris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150335789
    Abstract: One aspect of the present invention relates to a multicomponent and biocompatible nanocomposite material, including a graphene structure formed with a plurality of graphene layers; and gold/hydroxyapatite (Au/HA) nanoparticles distributed within the graphene structure; where the nanocomposite material is formed by heating an Au/HA catalyst thin film with a carbon source gas to perform radio frequency chemical vapor deposition (RF-CVD).
    Type: Application
    Filed: July 31, 2015
    Publication date: November 26, 2015
    Inventors: Alexandru S. Biris, Alexandru R. Biris
  • Publication number: 20150296793
    Abstract: A method of increasing the probability and rate of seed germination, increasing vegetative biomass, and increasing water uptake in seeds, in which a seed is introduced to an effective concentration of carbon nanomaterial. The effective concentration of carbon nanomaterial is 10-200 ?g/mL.
    Type: Application
    Filed: May 19, 2015
    Publication date: October 22, 2015
    Inventors: Mariya V. Khodakovskaya, Alexandru S. Biris
  • Publication number: 20150296794
    Abstract: A method of increasing the probability and rate of seed germination, increasing vegetative biomass, and increasing water uptake in seeds, in which a seed is introduced to an effective concentration of carbon nanomaterial. The effective concentration of carbon nanomaterial is 10-200 ?g/mL.
    Type: Application
    Filed: May 19, 2015
    Publication date: October 22, 2015
    Inventors: Mariya V. Khodakovskaya, Alexandru S. Biris
  • Patent number: 9114134
    Abstract: One aspect of the present invention relates to a method of synthesizing a multicomponent and biocompatible nanocomposite material, which includes: synthesizing a gold/hydroxyapatite (Au/HA) catalyst; distributing the Au/HA catalyst into a thin film; and heating the thin film in a reactor with a carbon source gas to perform radio frequency chemical vapor deposition (RF-CVD) to form the nanocomposite material, where the nanocomposite material includes a graphene structure and Au/HA nanoparticles formed by the Au/HA catalyst and distributed within the graphene structure. In another aspect, a multicomponent and biocompatible nanocomposite material includes: a graphene structure formed with a plurality of graphene layers and Au/HA nanoparticles distributed within the graphene structure. The nanocomposite material is formed by heating an Au/HA catalyst thin film with a carbon source gas to perform radio frequency chemical vapor deposition (RF-CVD).
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: August 25, 2015
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Alexandru S. Biris, Alexandru R. Biris
  • Publication number: 20150208663
    Abstract: A method for regulating properties of a plant, includes: providing a nanoagent having at least one nanocomposite; and delivering the nanoagent to the plant. The nanocomposite has at least one gold nanorod, a silver layer coated on an outer surface of the gold nanorod, a pegylated layer coated on the silver layer, and an active layer conjugated to the pegylated layer. The silver layer includes silver nanoparticles. The pegylated layer includes at least one of thiolated polyethylene glycol (HS-PEG), thiolated polyethylene glycol acid (HS-PEG-COOH) and HS-PEG-NHx. The active layer includes at least one bio-active agent configured to interact with the plant. The bio-active agent can be 2,4-dichlorophenoxyacetic acid (2,4-D).
    Type: Application
    Filed: April 10, 2015
    Publication date: July 30, 2015
    Inventors: Mariya Khodakovskaya, Mohamed Hassen Lahiani, Alexandru S. Biris
  • Patent number: 9074187
    Abstract: A method of inducing mineralization in a bone cell is described. The method comprises contacting a bone cell with a composition comprising nanoparticles. The nanoparticles can be single-walled carbon nanotubes, hydroxyapatite nanoparticles, TiO2 nanoparticles or silver nanoparticles. The bone cell can be an osteoblast cell. A method for increasing bone mass, bone healing or bone formation is also described which comprises administering to a subject in need thereof an effective amount of a composition comprising nanoparticles. The subject can suffer from a bone disease such as osteoporosis. The subject can suffer from a bone fracture and the method can comprise contacting bone cells near the bone fracture site with the composition. The composition can further comprise a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: July 7, 2015
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Alexandru S. Biris, Daniel Casciano, Meena Waleed Mahmood
  • Patent number: 9068283
    Abstract: In one aspect, the present invention relates to a layered structure usable in a strain sensor. In one embodiment, the layered structure has a substrate with a first surface and an opposite, second surface defining a body portion therebetween; and a film of carbon nanotubes deposited on the first surface of the substrate, wherein the film of carbon nanotubes is conductive and characterized with an electrical resistance. In one embodiment, the carbon nanotubes are aligned in a preferential direction. In one embodiment, the carbon nanotubes are formed in a yarn such that any mechanical stress increases their electrical response. In one embodiment, the carbon nanotubes are incorporated into a polymeric scaffold that is attached to the surface of the substrate. In one embodiment, the surfaces of the carbon nanotubes are functionalized such that its electrical conductivity is increased.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: June 30, 2015
    Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Alexandru S. Biris, Steven Trigwell, Walter Hatfield
  • Publication number: 20150129123
    Abstract: A method for producing a biocompatible structure includes: obtaining a load graph and a stress graph representing a relationship between a weight percentage of tissue forming nanoparticles and a maximum load or maximum stress of a polymer film, respectively; determining a first and second weight percentage corresponding to a peak of the load graph and the stress graph respectively; determining an optimal weight percentage based on the first and second weight percentages; preparing a polymer film having the optimal weight percentage of the first tissue forming nanoparticles to the polymer; dividing the polymer film to multiple strips; constructing a scaffold by stacking the strips to form polymer layers and adding bone or composite particles between the polymer layers; applying a solution to the scaffold to form a coated scaffold; and adding second tissue forming particles to the coated scaffold to form the biocompatible structure.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 14, 2015
    Inventor: Alexandru S. Biris
  • Publication number: 20150125380
    Abstract: In one aspect of the invention, a method for growth of carbon nanotubes includes providing a graphitic composite, decorating the graphitic composite with metal nanostructures to form graphene-contained powders, and heating the graphene-contained powders at a target temperature to form the carbon nanotubes in an argon/hydrogen environment that is devoid of a hydrocarbon source. In one embodiment, the target temperature can be as low as about 150° C. (±5° C.).
    Type: Application
    Filed: November 3, 2014
    Publication date: May 7, 2015
    Inventors: Alexandru S. Biris, Enkeleda Dervishi
  • Publication number: 20150039097
    Abstract: A biocompatible structure includes one or more base structures for regeneration of different tissues. Each base structure includes alternately stacked polymer layers and spacer layers. The polymer layer includes a polymer and tissue forming nanoparticles. The polymer includes polyurethane. The tissue forming nanoparticles includes hydroxypatites (HAP) nanoparticles, polymeric nanoparticles, or nanofibers. The spacer layer includes bone particles, polymeric nanoparticles, or nanofibers. The weight percentage of tissue forming nanoparticles to the polymer in the polymer layer in one base structure is different from that in the other base structures. A method of producing the biocompatible structure includes forming multiple base structures stacked together, coating the stacked multiple base structures, and plasma treating the coated structure.
    Type: Application
    Filed: October 8, 2014
    Publication date: February 5, 2015
    Inventor: Alexandru S. Biris
  • Publication number: 20150030660
    Abstract: A structure of, and a method of producing, a biocompatible structure for bone and tissue regeneration are disclosed. The method includes dissolving a polyurethane polymer in methanol, adding hydroxyapatite (HAP) nanoparticles to form a uniformly distributed mixture, applying the mixture to a polytetrafluoroethylene (PTFE) surface to form a polymer film, cutting the polymer film into strips, stacking the strips with layers of bone particles disposed therebetween, coating the stacked strips and layers by the mixture and allowing it to dry, adding bone particles to the coating, and plasma treating the structure to form the biocompatible structure. A weight percentage of the HAP nanoparticles to the polymer is about 5-50% such that a resorption rate of the biocompatible structure substantially matches a rate of tissue generation in the biocompatible structure.
    Type: Application
    Filed: October 3, 2014
    Publication date: January 29, 2015
    Inventor: Alexandru S. Biris
  • Patent number: 8936805
    Abstract: A structure of, and a method of producing, a biocompatible structure for bone and tissue regeneration are disclosed. The method includes dissolving a polyurethane polymer in methanol, adding hydroxyapatite (HAP) nanoparticles to form a uniformly distributed mixture, applying the mixture to a polytetrafluoroethylene (PTFE) surface to form a polymer film, cutting the polymer film into strips, stacking the strips with layers of bone particles disposed therebetween, coating the stacked strips and layers by the mixture and allowing it to dry, adding bone particles to the coating, and plasma treating the structure to form the biocompatible structure. A weight percentage of the HAP nanoparticles to the polymer is about 5-50% such that a resorption rate of the biocompatible structure substantially matches a rate of tissue generation in the biocompatible structure.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: January 20, 2015
    Assignee: Board of Trustees of the University of Arkansas
    Inventor: Alexandru S. Biris
  • Patent number: 8883218
    Abstract: The present invention encompasses a composition capable of delivering and expressing a nucleic acid encoding UDP-Glucuronosyltransferases, p53 or a combination thereof into a cell, and methods for treating tumors.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: November 11, 2014
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Anna Radominska-Pandya, Alexandru S. Biris
  • Publication number: 20140328927
    Abstract: The present invention encompasses a composition capable of delivering and expressing a nucleic acid encoding UDP-Glucuronosyltransferases, p53 or a combination thereof into a cell, and methods for treating tumors.
    Type: Application
    Filed: July 21, 2014
    Publication date: November 6, 2014
    Inventors: Anna Radominska-Pandya, Alexandru S. Biris
  • Publication number: 20140287508
    Abstract: One aspect of the disclosure is directed to a method for activation/enhancement of cell growth of a plant. The method includes providing a nano-sized material contained agent, and treating the plant with the nano-sized material contained agent to allow sufficient interaction of cells of the plant with the nano-sized material so as to activate/enhance the cell growth of the plant.
    Type: Application
    Filed: February 20, 2014
    Publication date: September 25, 2014
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Mariya Khodakovskaya, Alexandru S. Biris
  • Publication number: 20140262006
    Abstract: A method for producing a polymer film includes: obtaining a load graph representing a functional relationship between a weight percentage of tissue forming nanoparticles in a polymer film and a maximum load of that polymer film; obtaining a stress graph representing a functional relationship between the weight percentage of tissue forming nanoparticles in a polymer film and maximum stress of that polymer film; determining a first weight percentage corresponding to a peak of the load graph and determining a second weight percentage corresponding to a peak of the stress graph; determining an optimal weight percentage based on the first and second weight percentage values; and producing a polymer film having tissue forming nanoparticles at the optimal weight percentage.
    Type: Application
    Filed: July 22, 2013
    Publication date: September 18, 2014
    Applicant: Board of Trustees of the University of Arkansas
    Inventor: Alexandru S. Biris
  • Publication number: 20140248319
    Abstract: One aspect of the present invention relates to a method of synthesizing a multicomponent and biocompatible nanocomposite material, which includes: synthesizing a gold/hydroxyapatite (Au/HA) catalyst; distributing the Au/HA catalyst into a thin film; and heating the thin film in a reactor with a carbon source gas to perform radio frequency chemical vapor deposition (RF-CVD) to form the nanocomposite material, where the nanocomposite material includes a graphene structure and Au/HA nanoparticles formed by the Au/HA catalyst and distributed within the graphene structure. In another aspect, a multicomponent and biocompatible nanocomposite material includes: a graphene structure formed with a plurality of graphene layers and Au/HA nanoparticles distributed within the graphene structure. The nanocomposite material is formed by heating an Au/HA catalyst thin film with a carbon source gas to perform radio frequency chemical vapor deposition (RF-CVD).
    Type: Application
    Filed: April 22, 2014
    Publication date: September 4, 2014
    Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Alexandru S. Biris, Alexandru R. Biris
  • Publication number: 20140161890
    Abstract: A magnetic oxide-quantum dot nanocomposite has at least one magnetic oxide nanoparticle coated with a silica (SiO2) shell and terminated with at least one thiol group (—SH) and at least one CdSe/ZnS quantum dot linked with the at least one SiO2-coated magnetic oxide nanoparticle via the at least one thiol group. The at least one magnetic oxide nanoparticle can be an iron oxide (Fe3O4) nanoparticle. A method of cancer treatment using the magnetic oxide-quantum dot nanocomposites, includes the steps of delivering a plurality of nmagnetic oxide-quantum dot nanocomposites to a cancer cell, and subjecting the cancer cell with the plurality of magnetic oxide-quantum dot nanocomposites to a radio frequency induction for a period of time effective to cause the cancer cell to die.
    Type: Application
    Filed: February 17, 2014
    Publication date: June 12, 2014
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Alexandru S. Biris, Yang Xu, Daoyuan Wang
  • Patent number: 8741318
    Abstract: One aspect of the present invention relates to a method of synthesizing a multicomponent and biocompatible nanocomposite material, which includes: synthesizing a gold/hydroxyapatite (Au/HA) catalyst; distributing the Au/HA catalyst into a thin film; and heating the thin film in a reactor with a carbon source gas to perform radio frequency chemical vapor deposition (RF-CVD) to form the nanocomposite material, where the nanocomposite material includes a graphene structure and Au/HA nanoparticles formed by the Au/HA catalyst and distributed within the graphene structure. In another aspect, a multicomponent and biocompatible nanocomposite material includes: a graphene structure formed with a plurality of graphene layers and Au/HA nanoparticles distributed within the graphene structure. The nanocomposite material is formed by heating an Au/HA catalyst thin film with a carbon source gas to perform radio frequency chemical vapor deposition (RF-CVD).
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: June 3, 2014
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Alexandru S. Biris, Alexandru R. Biris
  • Patent number: 8697181
    Abstract: A magnetic oxide-quantum dot nanocomposite and methods of synthesizing it. In one embodiment, the magnetic oxide-quantum dot nanocomposite has at least one magnetic oxide nanoparticle coated with a silica (SiO2) shell and terminated with at least one thiol group (—SH), and at least one CdSe/ZnS quantum dot linked with the at least one SiO2-coated magnetic oxide nanoparticle via the at least one thiol group. In one embodiment, the at least one magnetic oxide nanoparticle comprises at least one iron oxide (Fe3O4) nanoparticle.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: April 15, 2014
    Assignee: Board of Trustees of The University of Arkansas
    Inventors: Alexandru S. Biris, Yang Xu, Daoyuan Wang