Patents by Inventor Alexis Brice

Alexis Brice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis of hereditary spastic paraplegias (HSP) by detection of a mutation in the KIAA1840 gene or protein
    Patent number: 10519503
    Abstract: An ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP) in a subject is provided which comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein that mutation is indicative of an hereditary spastic paraplegias (HSP).
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: December 31, 2019
    Assignee: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Hamid Azzedine, Alexis Brice, Giovanni Stevanin, Filippo Santorelli, Paola Denora
  • MUTATIONS OF THE PARKIN GENE, COMPOSITIONS, METHODS AND USES
    Publication number: 20170183736
    Abstract: The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.
    Type: Application
    Filed: November 4, 2016
    Publication date: June 29, 2017
    Inventors: Alexis Brice, Christophe Lucking, Patrice Denefle, Sylvain Ricard, Nacer Eddine Abbas, Sandrine Bouley
  • DIAGNOSIS OF HEREDITARY SPASTIC PARAPLEGIAS (HSP) BY DETECTION OF A MUTATION IN THE KIAA1840 GENE OR PROTEIN
    Publication number: 20170175196
    Abstract: An ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP) in a subject is provided which comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein that mutation is indicative of an hereditary spastic paraplegias (HSP).
    Type: Application
    Filed: December 21, 2016
    Publication date: June 22, 2017
    Inventors: Hamid AZZEDINE, Alexis BRICE, Giovanni STEVANIN, Filippo SANTORELLI, Paola DENORA
  • Diagnosis of Hereditary Spastic Paraplegias (HSP) by Identification of a Mutation in the ZFYVE26 Gene or Protein
    Publication number: 20170152562
    Abstract: The Invention relates to an ex vivo method of diagnosing or predicting a hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the ZFYVE26 gene or protein (spastizin), wherein said mutation is indicative of a hereditary spastic paraplegias (HSP).
    Type: Application
    Filed: November 11, 2016
    Publication date: June 1, 2017
    Inventors: Giovanni Stevanin, Sylvain Hanein, Amir Boukhris, Cyril Goizet, Elodie Martin, Alexis Brice
  • Diagnosis of hereditary spastic paraplegias (HSP) by detection of a mutation in the KIAA1840 gene or protein
    Patent number: 9546402
    Abstract: An ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP) in a subject is provided which comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein that mutation is indicative of an hereditary spastic paraplegias (HSP).
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: January 17, 2017
    Assignee: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Hamid Azzedine, Alexis Brice, Giovanni Stevanin, Filippo Santorelli, Paola Denora
  • Mutations of the parkin gene, compositions, methods and uses
    Patent number: 9540693
    Abstract: The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: January 10, 2017
    Assignees: Aventis Pharma S.A., Institut National de la Santé et de la Recherche Médicale
    Inventors: Alexis Brice, Christophe Lucking, Patrice Denefle, Sylvain Ricard, Nacer Eddine Abbas, Sandrine Bouley
  • Diagnosis of hereditary spastic paraplegias (HSP) by identification of a mutation in the ZFYVE26 gene or protein
    Patent number: 9522933
    Abstract: The Invention relates to an ex vivo method of diagnosing or predicting a hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the ZFYVE26 gene or protein (spastizin), wherein said mutation is indicative of a hereditary spastic paraplegias (HSP).
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: December 20, 2016
    Assignee: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM)
    Inventors: Giovanni Stevanin, Sylvain Hanein, Amir Boukhris, Cyril Goizet, Elodie Martin, Alexis Brice
  • DIAGNOSIS OF HEREDITARY SPASTIC PARAPLEGIAS (HSP) BY DETECTION OF A MUTATION IN THE KIAA1840 GENE OR PROTEIN
    Publication number: 20160348172
    Abstract: An ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP) in a subject is provided which comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein that mutation is indicative of an hereditary spastic paraplegias (HSP).
    Type: Application
    Filed: March 12, 2014
    Publication date: December 1, 2016
    Applicant: Institut National De La Sante Et De La Recherche Medicale (INSERM)
    Inventors: Hamid AZZEDINE, Alexis BRICE, Giovanni STEVANIN, Filippo SANTORELLI, Paola DENORA
  • MUTATIONS OF THE PARKIN GENE, COMPOSITIONS, METHODS AND USES
    Publication number: 20150074836
    Abstract: The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.
    Type: Application
    Filed: August 7, 2014
    Publication date: March 12, 2015
    Applicants: Aventis Pharma S.A., Institut National de la Santé et de la Recherche Médicale
    Inventors: Alexis Brice, Christophe Lucking, Patrice Denefle
  • DIAGNOSIS OF HEREDITARY SPASTIC PARAPLEGIAS (HSP) BY DETECTION OF A MUTATION IN THE KIAA1840 GENE OR PROTEIN
    Publication number: 20140308665
    Abstract: An ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP) in a subject is provided which comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein that mutation is indicative of an hereditary spastic paraplegias (HSP).
    Type: Application
    Filed: March 12, 2014
    Publication date: October 16, 2014
    Applicant: Institut National De La Sante Et De La Recherche Medicale (INSERM)
    Inventors: Hamid AZZEDINE, Alexis BRICE, Giovanni STEVANIN, Filippo SANTORELLI, Paola DENORA
  • Mutations of the parkin gene
    Patent number: 8835618
    Abstract: The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: September 16, 2014
    Assignees: Aventis Pharma S.A., Institut National de la Santé et de la Recherche Médicale
    Inventors: Alexis Brice, Christophe Lucking, Patrice Denefle, Sylvain Ricard, Nacer Eddine Abbas, Sandrine Bouley
  • Diagnosis of hereditary spastic paraplegias (HSP) by detection of a mutation in the KIAA1840 gene or protein
    Patent number: 8728727
    Abstract: The invention relates to an ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein said mutation is indicative of an hereditary spastic paraplegias (HSP).
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: May 20, 2014
    Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Hamid Azzedine, Alexis Brice, Giovanni Stevanin, Filippo Santorelli, Paola Denora
  • DIAGNOSIS OF HEREDITARY SPASTIC PARAPLEGIAS (HSP) BY DETECTION OF A MUTATION IN THE KIAA1840 GENE OR PROTEIN
    Publication number: 20130034849
    Abstract: The invention relates to an ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein said mutation is indicative of an hereditary spastic paraplegias (HSP).
    Type: Application
    Filed: August 6, 2012
    Publication date: February 7, 2013
    Inventors: Hamid AZZEDINE, Alexis Brice, Giovanni Stevanin, Filippo Santorelli, Paola Denora
  • Nucleic acids encoding a human PAP1 polypeptide
    Patent number: 8273548
    Abstract: The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.
    Type: Grant
    Filed: March 28, 2006
    Date of Patent: September 25, 2012
    Assignee: Aventis Pharma S.A.
    Inventors: Han Koutnikova, Alexis Brice, Alain Fournier, Laurent Pradier, Catherine Prades, Isabelle Arnould-Reguigne, Marie-Françoise Rosier-Montus, Olga Corti
  • Mutation of the parkin gene, compositions, methods and uses
    Publication number: 20120064598
    Abstract: The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.
    Type: Application
    Filed: August 15, 2011
    Publication date: March 15, 2012
    Applicants: INSTITUT NATIONAL SANTE ET RECHERCHE MEDICALE, AVENTIS PHARMA S.A.
    Inventors: Alexis Brice, Christophe Lucking, Patrice Denefle, Sylvain Ricard, Nacer Eddine Abbas, Sandrine Bouley
  • Mutations of the parkin gene, compositions, methods and uses
    Patent number: 7998667
    Abstract: The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: August 16, 2011
    Assignees: Aventis Pharma S.A., Institut National Sante et Recherche Medicale
    Inventors: Alexis Brice, Christophe Lucking, Patrice Denefle, Sylvain Ricard, Nacer Eddine Abbas, Sandrine Bouley
  • DIAGNOSIS OF HEREDITARY SPASTIC PARAPLEGIAS (HSP) BY INDENTIFICATION OF A MUTATION IN THE KIAA1840 GENE OR PROTEIN
    Publication number: 20110129819
    Abstract: The invention relates to an ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein said mutation is indicative of. an hereditary spastic paraplegias (HSP).
    Type: Application
    Filed: September 11, 2007
    Publication date: June 2, 2011
    Inventors: Hamid Azzedine, Alexis Brice, Giovanni Stevanin, Filippo Santorelli, Paola Denora
  • DIAGNOSIS OF HEREDITARY SPASTIC PARAPLEGIAS (HSP) BY IDENTIFICATION OF A MUTATION IN THE ZFYVE26 GENE OR PROTEIN
    Publication number: 20110117558
    Abstract: The Invention relates to an ex vivo method of diagnosing or predicting a hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the ZFYVE26 gene or protein (spastizin), wherein said mutation is indicative of a hereditary spastic paraplegias (HSP).
    Type: Application
    Filed: March 31, 2009
    Publication date: May 19, 2011
    Inventors: Giovanni Stevanin, Sylvain Hanein, Amir Boukhris, Cyril Goizet, Elodie Martin, Alexis Brice
  • Compositions which can be used for regulating the activity of parkin
    Publication number: 20060287230
    Abstract: The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.
    Type: Application
    Filed: March 28, 2006
    Publication date: December 21, 2006
    Inventors: Hana Koutnikova, Alexis Brice, Alain Fournier, Laurent Pradier, Catherine Prades, Isabelle Arnould-Reguigne, Marie-Francoise Rosier-Montus, Olga Corti
  • Compositions which can be used for regulating the activity of parkin
    Patent number: 7132396
    Abstract: The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: November 7, 2006
    Assignee: Aventis Pharma S.A.
    Inventors: Hana Koutnikova, Alexis Brice, Alain Fournier, Laurent Pradier, Catherine Prades, Isabelle Arnould-Reguigne, Marie-Françoise Rosier-Montus, Olga Corti