Abstract: A method, device, and a vehicle information system are provided for persisting application context from the mobile device to the vehicle information system. An operating context is determined for at least one application executing on the mobile device. A user interface view for display by the vehicle information system is generated and provided to the vehicle information system. The user interface view comprises at least one application user interface element associated with the at least one application, and the application user interface element comprises an application entry point defined by the operating context for the at least one application.

Abstract: Machine-learning methods and apparatus are disclosed to determine frictional state or other parameters in an earthquake zone or other failing medium, using acoustic emission, seismic waves, or other detectable indicators of microscopic processes. Predictions of future failures are demonstrated in different regimes. A classifier is trained using time series of acoustic emission data along with historic data of frictional state or failure events. In disclosed examples, random forests and gradient boost trees are used, and grid-search or EGO procedures are used for hyperparameter tuning. Once trained, the classifier can be applied to testing or live data in order to assess a frictional state, assess seismic hazard, or make predictions regarding a future failure event. The technology has been developed in a double direct shear apparatus, but can be widely applied to seismic faults, other terrestrial failures, or failures in man-made structures. Variations are disclosed.

Abstract: Apparatus and methods for measurement of pore pressure in rock formations through an open, or cemented and/or cased, borehole are described. Such measurements are achieved using the Dynamic Acoustic Elasticity (DAE) method for characterizing nonlinear parameters by perturbing a selected rock formation volume with a High Amplitude, Low Frequency (HALF) acoustic strain wave, and probing this volume using a Low Amplitude, High Frequency (LAHF) acoustic wave. Time reversal techniques may be employed for focusing acoustic energy Into the formation in the vicinity of the pipe or open hole.

Abstract: The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: The present invention is directed to new pyridinone or pyrimidinone hydroxamic acid phosphates of Formula (1) and boronates of Formula (2), stereoisomers thereof; wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation; X is CH or N; and Z is as defined herein; and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: A method, device, and a vehicle information system are provided for persisting application context from the mobile device to the vehicle information system. An operating context is determined for at least one application executing on the mobile device. A user interface view for display by the vehicle information system is generated and provided to the vehicle information system. The user interface view comprises at least one application user interface element associated with the at least one application, and the application user interface element comprises an application entry point defined by the operating context for the at least one application.

Abstract: A method, device, and vehicle information system are provided for persisting application context from the vehicle information system to the mobile device. The mobile device provides access to at least one application executing on the mobile device to the vehicle information system. On termination of that access, an operating context is determined for each of the mobile device applications where possible. In some cases, where application context is persisted from one system or device to the other, the current data is presented in accordance with a transport modality associated with the other device or system.

Abstract: A method, device, and a vehicle information system are provided for persisting application context from the mobile device to the vehicle information system. An operating context is determined for at least one application executing on the mobile device. A user interface view for display by the vehicle information system is generated and provided to the vehicle information system. The user interface view comprises at least one application user interface element associated with the at least one application, and the application user interface element comprises an application entry point defined by the operating context for the at least one application.

Abstract: Conditional activation and deactivation of a microprocessor. A hardware portion of an apparatus performs packet processing on received data, where the hardware portion selectively decodes the received data. A microprocessor performs data processing on decoded data, where the microprocessor is conditionally activated for performing the data processing and is conditionally deactivated when not performing the data processing. An output portion receives processed data and audibly renders the processed data without requiring the microprocessor.

Abstract: A method, device, and vehicle information system are provided for persisting application context from the vehicle information system to the mobile device. The mobile device provides access to at least one application executing on the mobile device to the vehicle information system. On termination of that access, an operating context is determined for each of the mobile device applications where possible. In some cases, where application context is persisted from one system or device to the other, the current data is presented in accordance with a transport modality associated with the other device or system.

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract: A method, device, and vehicle information system are provided for persisting application context from the vehicle information system to the mobile device. The mobile device provides access to at least one application executing on the mobile device to the vehicle information system. On termination of that access, an operating context is determined for each of the mobile device applications where possible. In some cases, where application context is persisted from one system or device to the other, the current data is presented in accordance with a transport modality associated with the other device or system.

Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.

Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.

Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical compositions containing these novel compounds, and methods for the preparation of these compounds.

Abstract: A method, device, and vehicle information system are provided for persisting application context from the vehicle information system to the mobile device. The mobile device provides access to at least one application executing on the mobile device to the vehicle information system. On termination of that access, an operating context is determined for each of the mobile device applications where possible. In some cases, where application context is persisted from one system or device to the other, the current data is presented in accordance with a transport modality associated with the other device or system.

Abstract: A gigahertz sensor array packaging solution for harsh operating environments is disclosed. The sensor array packaging system includes a structural core body comprising sensor mounting features on a surface thereof and an alignment through hole extending from the surface to a backside thereof which incorporates finned features providing cooling and stiffness. The sensor array packaging system further includes one or more electro-optical components mounted to the backside of the structural core body. The sensor array packaging system further includes a wiring board comprising a plurality of sensor array elements contacting walls of the spiral ribbon configuration, each having a cable extending through the through hole to at least one of the one or more electro-optical components.

Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.

Abstract: A gigahertz sensor array packaging solution for harsh operating environments is disclosed. The sensor array packaging system includes a structural core body comprising sensor mounting features on a surface thereof and an alignment through hole extending from the surface to a backside thereof which incorporates finned features providing cooling and stiffness. The sensor array packaging system further includes one or more electro-optical components mounted to the backside of the structural core body. The sensor array packaging system further includes a wiring board comprising a plurality of sensor array elements contacting walls of the spiral ribbon configuration, each having a cable extending through the through hole to at least one of the one or more electro-optical components.

Abstract: The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II): and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B, L1-L4, A, B, R1-R4, and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.