Patents by Inventor Allan S. Hoffman

Allan S. Hoffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9006193
    Abstract: Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: April 14, 2015
    Assignees: University of Washington, PhaseRx, Inc.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Craig L. Duvall, Danielle Benoit, Robert W. Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
  • Patent number: 8846106
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: September 30, 2014
    Assignees: University of Washington, University of Massachusetts
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Patent number: 8822213
    Abstract: A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: September 2, 2014
    Assignees: University of Washington, PhaseRx, Inc.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Craig L. Duvall, Robert W. Overell, Paul H. Johnson
  • Publication number: 20140228516
    Abstract: A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
    Type: Application
    Filed: February 5, 2014
    Publication date: August 14, 2014
    Applicants: PHASERX, INC., UNIVERSITY OF WASHINGTON
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Robert Overell, Paul Johnson
  • Publication number: 20140219950
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 7, 2014
    Applicants: UNIVERSITY OF MASSACHUSETTS, UNIVERSITY OF WASHINGTON
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Patent number: 8507283
    Abstract: Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: August 13, 2013
    Assignee: University of Washington
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Jr-iuan Lai, John Hoffman, Mitsuhiro Ebara
  • Publication number: 20130017167
    Abstract: Provided herein are polymers having a therapeutic agent covalently coupled to a hydrophobic block thereof, as well as micelles and therapeutic compositions thereof.
    Type: Application
    Filed: November 12, 2010
    Publication date: January 17, 2013
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Sean D. Monahan, Paul H. Johnson, Charbel Diab, Priyadarsi De, Patrick S. Stayton, Allan S. Hoffman
  • Publication number: 20130011362
    Abstract: Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof.
    Type: Application
    Filed: November 17, 2010
    Publication date: January 10, 2013
    Applicants: PhaseRx, Inc., University of Washington through its Center for Commercialization
    Inventors: Sean D. Monahan, Paul H. Johnson, Michael S. DeClue, Priyadarsi De, Anna S. Gall, Patrick S. Stayton, Allan S. Hoffman, Charbel Diab
  • Patent number: 8318816
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: November 27, 2012
    Assignee: University of Washington
    Inventors: Allan S. Hoffman, Patrick S. Stayton, Niren Murthy
  • Publication number: 20120021514
    Abstract: Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.
    Type: Application
    Filed: May 13, 2009
    Publication date: January 26, 2012
    Applicants: PHASERX, INC., UNIVERSITY OF WASHINGTON
    Inventors: Paul Johnson, Patrick S. Stayton, Allan S. Hoffman, Robert Overell, Anna Gall, Mary Prieve, Amber Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20110305660
    Abstract: Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective co-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.
    Type: Application
    Filed: December 8, 2009
    Publication date: December 15, 2011
    Applicants: PhaseRx, Inc., University of Washington
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Scott M. Henry, Robert W. Overell, Paul H. Johnson
  • Publication number: 20110288238
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: July 14, 2011
    Publication date: November 24, 2011
    Applicants: UNIVERSITY OF MASSACHUSETTS, UNIVERSITY OF WASHINGTON
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Publication number: 20110286957
    Abstract: Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.
    Type: Application
    Filed: November 6, 2009
    Publication date: November 24, 2011
    Applicants: PHASERX, INC., UNIVERSITY OF WASHINGTON
    Inventors: Mary G. Prieve, Paul H. Johnson, Patrick S. Stayton, Allan S. Hoffman, Robert W. Overell, Anna S. Gall, Amber E.E. Paschal, Charbel Diab, Priyadarsi De, Michael S. DeClue, Sean D. Monahan
  • Publication number: 20110281934
    Abstract: Provided herein are micelles comprising a plurality of copolymers. In certain instances, micelles provided herein are pH sensitive particles.
    Type: Application
    Filed: May 13, 2009
    Publication date: November 17, 2011
    Applicants: PHASERX, INC., UNIVERSITY OF WASHINGTON
    Inventors: Paul Johnson, Patrick S. Stayton, Allan S. Hoffman, Robert Overell, Anna Gall, Mary Prieve, Amber Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20110281354
    Abstract: A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.
    Type: Application
    Filed: May 13, 2009
    Publication date: November 17, 2011
    Applicants: PHASERX, INC., UNIVERSITY OF WASHINGTON
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Craig L. Duvall, Robert W. Overell, Paul H. Johnson
  • Publication number: 20110266492
    Abstract: Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles.
    Type: Application
    Filed: June 15, 2011
    Publication date: November 3, 2011
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Jr-iuan Lai, John Hoffman, Mitsuhiro Ebara
  • Patent number: 8003129
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: August 23, 2011
    Assignees: University of Washington, Univeristy of Massachusetts
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Patent number: 7981688
    Abstract: Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles.
    Type: Grant
    Filed: March 8, 2007
    Date of Patent: July 19, 2011
    Assignee: University of Washington
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Jr-iuan Lai, John Hoffman, Mitsuhiro Ebara
  • Publication number: 20110142951
    Abstract: Composition comprising a polymeric micelle and an associated polynucleotide.
    Type: Application
    Filed: May 13, 2009
    Publication date: June 16, 2011
    Applicants: UNIVERSITY OF WASHINGTON, PHASERX, INC.
    Inventors: Paul H. Johnson, Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Robert W. Overell, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20110143434
    Abstract: Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.
    Type: Application
    Filed: May 13, 2009
    Publication date: June 16, 2011
    Applicants: UNIVERSITY OF WASHINGTON, PHASERX, INC.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Danielle Benoit, Craig L. Duvall, Paul H. Johnson, Anna S. Gall