Patents by Inventor Allan S. Hoffman
Allan S. Hoffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110142951Abstract: Composition comprising a polymeric micelle and an associated polynucleotide.Type: ApplicationFiled: May 13, 2009Publication date: June 16, 2011Applicants: UNIVERSITY OF WASHINGTON, PHASERX, INC.Inventors: Paul H. Johnson, Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Robert W. Overell, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
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Publication number: 20110143434Abstract: Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.Type: ApplicationFiled: May 13, 2009Publication date: June 16, 2011Applicants: UNIVERSITY OF WASHINGTON, PHASERX, INC.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Danielle Benoit, Craig L. Duvall, Paul H. Johnson, Anna S. Gall
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Publication number: 20110129921Abstract: Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer.Type: ApplicationFiled: May 13, 2009Publication date: June 2, 2011Applicants: UNIVERSITY OF WASHINGTON, PHASERX, INC.Inventors: Paul H. Johnson, Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Craig L. Duvall, Danielle Benoit, Chen-Chang Lee, Robert W. Overell, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
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Publication number: 20110123636Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.Type: ApplicationFiled: May 13, 2009Publication date: May 26, 2011Applicants: UNIVERSITY OF WASHINGTON, PHASERX, INC.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert W. Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
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Publication number: 20100215749Abstract: Temperature- and pH-responsive copolymer compositions, and drug delivery devices, conjugates, nanoparticles, and micelles that include the compositions.Type: ApplicationFiled: April 8, 2010Publication date: August 26, 2010Applicant: WASHINGTON, UNIVERSITY OFInventors: Patrick S. Stayton, Allan S. Hoffman, Xiangchun Yin, Lakeshia J. Taite, Jessica Garbern
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Publication number: 20100210504Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.Type: ApplicationFiled: April 30, 2010Publication date: August 19, 2010Applicant: University of WashingtonInventors: Allan S. Hoffman, Patrick S. Stayton, Niren Murthy
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Publication number: 20100160216Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.Type: ApplicationFiled: January 5, 2001Publication date: June 24, 2010Inventors: Allan S. Hoffman, Patrick S. Stayton, Niren Murthy
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Publication number: 20100150952Abstract: pH-Responsive polymer-based protein delivery carriers and compositions, methods for making the carriers and compositions, and methods for using the carriers and compositions for intracellular protein antigen delivery, inducing a cytotoxic T-lymphocyte response, introducing a tumor-specific protein antigen to an antigen presenting cell to induce an immune response, and providing tumor protection to a subject.Type: ApplicationFiled: November 9, 2009Publication date: June 17, 2010Applicant: UNIVERSITY OF WASHINGTONInventors: Patrick S. Stayton, Suzanne Foster, Allan S. Hoffman
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Patent number: 7737108Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.Type: GrantFiled: January 5, 2001Date of Patent: June 15, 2010Assignee: University of WashingtonInventors: Allan S. Hoffman, Patrick S. Stayton, Niren Murthy
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Patent number: 7718193Abstract: Temperature- and pH-responsive copolymer compositions, and drug delivery devices, conjugates, nanoparticles, and micelles that include the compositions.Type: GrantFiled: March 16, 2007Date of Patent: May 18, 2010Assignee: University of WashingtonInventors: Patrick S. Stayton, Allan S. Hoffman, Xiangchun Yin, Lakeshia J. Taite, Jessica Garbern
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Patent number: 7625764Abstract: Conjugates that include polymers that are reversibly self-associative in response to a stimulus and methods for using the conjugates.Type: GrantFiled: August 3, 2005Date of Patent: December 1, 2009Assignee: University of WashingtonInventors: Patrick S. Stayton, Allan S. Hoffman, Noah Malmstadt, Tsuyoshi Shimoboji, Samarth Kulkarni
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Publication number: 20080220531Abstract: Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles.Type: ApplicationFiled: March 8, 2007Publication date: September 11, 2008Applicant: Washington, University ofInventors: Patrick S. Stayton, Allan S. Hoffman, Jr-iuan Lai, John Hoffman, Mitsuhiro Ebara
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Publication number: 20080199957Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.Type: ApplicationFiled: April 18, 2008Publication date: August 21, 2008Applicant: WASHINGTON, UNIVERSITY OFInventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
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Patent number: 7374778Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.Type: GrantFiled: May 28, 2004Date of Patent: May 20, 2008Assignees: University of Washington, University of MassachusettsInventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
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Patent number: 6835393Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.Type: GrantFiled: January 5, 1999Date of Patent: December 28, 2004Assignees: University of Washington, University of MassachusettsInventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, David Tirrell, Niren Murthy, Chantal Lackey, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter
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Patent number: 6486213Abstract: There is disclosed block and graft copolymers, and hydrogels thereof, which, in one embodiment, contain both a temperature-sensitive polymer component and a pH-sensitive polymer component, and the use of such copolymers for topical drug delivery to a treatment area. The block and graft copolymers may be physically mixed with one or more drugs (or with other polymers) to form a copolymer-drug mixture. These mixtures may be applied as solid particles suspended in a pharmaceutically acceptable carrier, or as a liquid which gels upon contact with the treatment area. Upon contact with the treatment area, the pH-sensitive polymer component hydrates and swells, thereby causing release of the drug from the mixture. In addition, such hydration and swelling causes the pH-sensitive polymer component to adhere to the tissue of the treatment area, thus prolonging contact time.Type: GrantFiled: June 7, 1995Date of Patent: November 26, 2002Assignee: University of WashingtonInventors: Guohua Chen, Allan S. Hoffman
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Publication number: 20010007666Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.Type: ApplicationFiled: January 5, 1999Publication date: July 12, 2001Inventors: ALLAN S. HOFFMAN, PATRICK STAYTON, OLIVER W. PRESS, DAVID TIRRELL, NIREN MURTHY, CHANTAL LACKEY, LAWRENCE A. CRUM, PIERRE D. MOURAD, TYRONE M. PORTER
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Patent number: 6180617Abstract: A composition is disclosed for use in reducing the availability of undesired lipids, such as cholesterol, in the fluid media of the gastrointestinal tract prior to absorption of the lipids across the cells lining the tract. The composition is a nontoxic, substantially nondigestible polymer to which ligands are chemically bonded through biologically stable ether groups. The ligands scavenge the undesired lipids from the fluid media.Type: GrantFiled: June 7, 1995Date of Patent: January 30, 2001Inventors: Allan S. Hoffman, N. S. Choi
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Patent number: 6165509Abstract: PEGylated drugs complexed with bioadhesive polymers, wherein the PEGylated drugs comprise a polyethylene glycol covalently bonded to the drugs are disclosed. The PEGylated drug/bioadhesive polyner complex and compositions thereof may be topically administered to body fluids or mucosal tissues. Methods of administering the PEGylated drug/bioadhesive polymer complex and compositions thereof to an animal are also disclosed.Type: GrantFiled: September 1, 1998Date of Patent: December 26, 2000Assignee: University of WashingtonInventors: Allan S. Hoffman, Yoshiki Hayashi
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Patent number: 5998588Abstract: The combination of the capabilities of stimuli-responsive components such as polymers and interactive molecules to form site-specific conjugates which are useful in a variety of assays, separations, processing, and other uses is disclosed. The polymer chain conformation and volume can be manipulated through alteration in pH, temperature, light, or other stimuli. The interactive molecules can be biomolecules like proteins or peptides, such as antibodies, receptors, or enzymes, polysaccharides or glycoproteins which specifically bind to ligands, or nucleic acids such as antisense, ribozymes, and aptamers, or ligands for organic or inorganic molecules in the environment or manufacturing processes.Type: GrantFiled: August 30, 1996Date of Patent: December 7, 1999Assignee: University of WashingtonInventors: Allan S. Hoffman, Patrick S. Stayton