Patents by Inventor Allan S. Hoffman

Allan S. Hoffman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110143435
    Abstract: Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.
    Type: Application
    Filed: May 13, 2009
    Publication date: June 16, 2011
    Applicants: UNIVERSITY OF WASHINGTON, PHASERX, INC.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Craig L. Duvall, Danielle Benoit, Robert W. Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20110129921
    Abstract: Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer.
    Type: Application
    Filed: May 13, 2009
    Publication date: June 2, 2011
    Applicants: UNIVERSITY OF WASHINGTON, PHASERX, INC.
    Inventors: Paul H. Johnson, Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Craig L. Duvall, Danielle Benoit, Chen-Chang Lee, Robert W. Overell, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20110123636
    Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.
    Type: Application
    Filed: May 13, 2009
    Publication date: May 26, 2011
    Applicants: UNIVERSITY OF WASHINGTON, PHASERX, INC.
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert W. Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
  • Publication number: 20100215749
    Abstract: Temperature- and pH-responsive copolymer compositions, and drug delivery devices, conjugates, nanoparticles, and micelles that include the compositions.
    Type: Application
    Filed: April 8, 2010
    Publication date: August 26, 2010
    Applicant: WASHINGTON, UNIVERSITY OF
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Xiangchun Yin, Lakeshia J. Taite, Jessica Garbern
  • Publication number: 20100210504
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: April 30, 2010
    Publication date: August 19, 2010
    Applicant: University of Washington
    Inventors: Allan S. Hoffman, Patrick S. Stayton, Niren Murthy
  • Publication number: 20100160216
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: January 5, 2001
    Publication date: June 24, 2010
    Inventors: Allan S. Hoffman, Patrick S. Stayton, Niren Murthy
  • Publication number: 20100150952
    Abstract: pH-Responsive polymer-based protein delivery carriers and compositions, methods for making the carriers and compositions, and methods for using the carriers and compositions for intracellular protein antigen delivery, inducing a cytotoxic T-lymphocyte response, introducing a tumor-specific protein antigen to an antigen presenting cell to induce an immune response, and providing tumor protection to a subject.
    Type: Application
    Filed: November 9, 2009
    Publication date: June 17, 2010
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Patrick S. Stayton, Suzanne Foster, Allan S. Hoffman
  • Patent number: 7737108
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes (at physiologic pH, but can become active toward cell membranes if the environment is acidified below ca. pH 6.8), coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: June 15, 2010
    Assignee: University of Washington
    Inventors: Allan S. Hoffman, Patrick S. Stayton, Niren Murthy
  • Patent number: 7718193
    Abstract: Temperature- and pH-responsive copolymer compositions, and drug delivery devices, conjugates, nanoparticles, and micelles that include the compositions.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: May 18, 2010
    Assignee: University of Washington
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Xiangchun Yin, Lakeshia J. Taite, Jessica Garbern
  • Patent number: 7625764
    Abstract: Conjugates that include polymers that are reversibly self-associative in response to a stimulus and methods for using the conjugates.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: December 1, 2009
    Assignee: University of Washington
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Noah Malmstadt, Tsuyoshi Shimoboji, Samarth Kulkarni
  • Publication number: 20080220531
    Abstract: Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles.
    Type: Application
    Filed: March 8, 2007
    Publication date: September 11, 2008
    Applicant: Washington, University of
    Inventors: Patrick S. Stayton, Allan S. Hoffman, Jr-iuan Lai, John Hoffman, Mitsuhiro Ebara
  • Publication number: 20080199957
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: April 18, 2008
    Publication date: August 21, 2008
    Applicant: WASHINGTON, UNIVERSITY OF
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Patent number: 7374778
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: May 20, 2008
    Assignees: University of Washington, University of Massachusetts
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, Niren Murthy, Chantal Lackey Reed, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter, David Tirrell
  • Patent number: 6835393
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: December 28, 2004
    Assignees: University of Washington, University of Massachusetts
    Inventors: Allan S. Hoffman, Patrick Stayton, Oliver W. Press, David Tirrell, Niren Murthy, Chantal Lackey, Lawrence A. Crum, Pierre D. Mourad, Tyrone M. Porter
  • Patent number: 6486213
    Abstract: There is disclosed block and graft copolymers, and hydrogels thereof, which, in one embodiment, contain both a temperature-sensitive polymer component and a pH-sensitive polymer component, and the use of such copolymers for topical drug delivery to a treatment area. The block and graft copolymers may be physically mixed with one or more drugs (or with other polymers) to form a copolymer-drug mixture. These mixtures may be applied as solid particles suspended in a pharmaceutically acceptable carrier, or as a liquid which gels upon contact with the treatment area. Upon contact with the treatment area, the pH-sensitive polymer component hydrates and swells, thereby causing release of the drug from the mixture. In addition, such hydration and swelling causes the pH-sensitive polymer component to adhere to the tissue of the treatment area, thus prolonging contact time.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 26, 2002
    Assignee: University of Washington
    Inventors: Guohua Chen, Allan S. Hoffman
  • Publication number: 20010007666
    Abstract: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof.
    Type: Application
    Filed: January 5, 1999
    Publication date: July 12, 2001
    Inventors: ALLAN S. HOFFMAN, PATRICK STAYTON, OLIVER W. PRESS, DAVID TIRRELL, NIREN MURTHY, CHANTAL LACKEY, LAWRENCE A. CRUM, PIERRE D. MOURAD, TYRONE M. PORTER
  • Patent number: 6180617
    Abstract: A composition is disclosed for use in reducing the availability of undesired lipids, such as cholesterol, in the fluid media of the gastrointestinal tract prior to absorption of the lipids across the cells lining the tract. The composition is a nontoxic, substantially nondigestible polymer to which ligands are chemically bonded through biologically stable ether groups. The ligands scavenge the undesired lipids from the fluid media.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 30, 2001
    Inventors: Allan S. Hoffman, N. S. Choi
  • Patent number: 6165509
    Abstract: PEGylated drugs complexed with bioadhesive polymers, wherein the PEGylated drugs comprise a polyethylene glycol covalently bonded to the drugs are disclosed. The PEGylated drug/bioadhesive polyner complex and compositions thereof may be topically administered to body fluids or mucosal tissues. Methods of administering the PEGylated drug/bioadhesive polymer complex and compositions thereof to an animal are also disclosed.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: December 26, 2000
    Assignee: University of Washington
    Inventors: Allan S. Hoffman, Yoshiki Hayashi
  • Patent number: 5998588
    Abstract: The combination of the capabilities of stimuli-responsive components such as polymers and interactive molecules to form site-specific conjugates which are useful in a variety of assays, separations, processing, and other uses is disclosed. The polymer chain conformation and volume can be manipulated through alteration in pH, temperature, light, or other stimuli. The interactive molecules can be biomolecules like proteins or peptides, such as antibodies, receptors, or enzymes, polysaccharides or glycoproteins which specifically bind to ligands, or nucleic acids such as antisense, ribozymes, and aptamers, or ligands for organic or inorganic molecules in the environment or manufacturing processes.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: December 7, 1999
    Assignee: University of Washington
    Inventors: Allan S. Hoffman, Patrick S. Stayton
  • Patent number: 5770627
    Abstract: Hydrophobically-modified bioadhesive polyelectrolytes containing a bioadhesive polyelectrolyte and a hydrophobic component are disclosed. Also disclosed are polyelectrolyte-agent compositions wherein the hydrophobically-modified bioadhesive polyelectrolyte is loaded with a pharmaceutically, cosmetically, or prophylactically acceptable agent. Suitable agents have hydrophobic and/or ionic character, and include drugs. The polyelectrolyte-agent compositions may be formulated for administration by topical, oral and/or systemic routes. Methods of administering such agents to an animal are also disclosed, and include administration of an effective amount of the polyelectrolyte-agent composition to the animal.
    Type: Grant
    Filed: August 16, 1995
    Date of Patent: June 23, 1998
    Assignees: University of Washington, Green Cross Corporation
    Inventors: Tadaaki Inoue, Guohua Chen, Allan S. Hoffman