Patents by Inventor Allan S. Myerson

Allan S. Myerson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240066443
    Abstract: Devices and methods for filtering, drying, and mechanically processing active pharmaceutical ingredients are generally described.
    Type: Application
    Filed: September 1, 2023
    Publication date: February 29, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: David Brancazio, Allan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, Gerard Capellades Mendez, Clemence Neurohr, Kersten Rapp, Naomi Elizabeth Barbara Briggs
  • Patent number: 11911719
    Abstract: Devices and methods for filtering, drying, and mechanically processing active pharmaceutical ingredients are generally described.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: February 27, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: David Brancazio, Allan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, Gerard Capellades Mendez, Clemence Neurohr, Kersten Rapp, Naomi Elizabeth Barbara Briggs
  • Patent number: 11786846
    Abstract: Devices and methods for filtering, drying, and mechanically processing active pharmaceutical ingredients are generally described.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: October 17, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: David Brancazio, Allan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, Gerard Capellades Mendez, Clemence Neurohr, Kersten Rapp, Naomi Elizabeth Barbara Briggs
  • Patent number: 11565230
    Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: January 31, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Klavs F. Jensen, Timothy F. Jamison, Allan S. Myerson, Jean-Christophe M. Monbaliu, Mohsen Behnam, Shin Yee Wong, Nopphon Weeranoppanant, Eve Marie Revalor, Torsten Stelzer, Jie Chen, Andrea Adamo, David R. Snead, Ping Zhang
  • Patent number: 11020352
    Abstract: Systems and methods for fabricating ingestible pharmaceutical tablets are provided. Certain of the systems and methods described herein are capable of manufacturing tablets of different dosages without the need to fluidically connect or disconnect unit operations when switching from a tablet having a first dosage to a tablet having a second, different dosage. Certain of the systems and methods described herein are capable of manufacturing compositionally tablets, e.g., tablets with different active pharmaceutical ingredients (APIs).
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: June 1, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Allan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, David Brancazio, Juan Guillermo Osorio Caicedo
  • Publication number: 20210086112
    Abstract: Devices and methods for filtering, drying, and mechanically processing active pharmaceutical ingredients are generally described.
    Type: Application
    Filed: July 20, 2020
    Publication date: March 25, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: David Brancazio, Allan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, Gerard Capellades Mendez, Clemence Neurohr, Kersten Rapp
  • Patent number: 10870619
    Abstract: The present application relates to a method for preparing L-methionine crystals with an improved bulk density. As the L-methionine crystals prepared according to the method for preparing L-methionine crystals of the present application may have a bulk density of up to 800 g/L, the L-methionine crystals are expected to reduce storage and transport costs of L-methionine powder and improve working conditions due to improved fluidity of the powder.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: December 22, 2020
    Assignee: CJ CHEILJEDANG CORPORATION
    Inventors: Jun-Woo Kim, In Sung Lee, Kee Kahb Koo, Wang Soo Kim, Allan S. Myerson
  • Publication number: 20200368710
    Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
    Type: Application
    Filed: August 10, 2020
    Publication date: November 26, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Klavs F. Jensen, Timothy F. Jamison, Allan S. Myerson, Jean-Christophe M. Monbaliu, Mohsen Behnam, Shin Yee Wong, Nopphon Weeranoppanant, Eve Marie Revalor, Torsten Stelzer, Jie Chen, Andrea Adamo, David R. Snead, Ping Zhang
  • Publication number: 20200352865
    Abstract: Systems and methods for fabricating ingestible pharmaceutical tablets are provided. Certain of the systems and methods described herein are capable of manufacturing tablets of different dosages without the need to fluidically connect or disconnect unit operations when switching from a tablet having a first dosage to a tablet having a second, different dosage. Certain of the systems and methods described herein are capable of manufacturing compositionally tablets, e.g., tablets with different active pharmaceutical ingredients (APIs).
    Type: Application
    Filed: May 26, 2020
    Publication date: November 12, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Allan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, David Brancazio, Juan Guillermo Osorio Caicedo
  • Patent number: 10828578
    Abstract: Aspects of the disclosure relate to methods and compositions of altering a solution through the use of readily retrievable agents (e.g., a nanoparticle) having one or more functional groups configured to undergo a solvation interaction with a component of the solution. Compositions, systems, and methods for crystallizing organic and inorganic compounds from solutions using nanoparticles surface coated with functional groups that create a supersaturated state in the solution and reversal thereof. Compositions, systems, and methods for purifying water or active pharmaceutical ingredients. Compositions, systems, and methods for increasing the solubility of a solution and reversal of the same. Compositions, systems, and methods for decreasing the solubility of a crystallized compound and reversal of the same.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: November 10, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Allan S. Myerson, Samir Kulkarni
  • Patent number: 10780410
    Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: September 22, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Klavs F. Jensen, Timothy F. Jamison, Allan S. Myerson, Jean-Christophe M. Monbaliu, Mohsen Behnam, Shin Yee Wong, Nopphon Weeranoppanant, Eve Marie Revalor, Torsten Stelzer, Jie Chen, Andrea Adamo, David R. Snead, Ping Zhang
  • Patent number: 10702481
    Abstract: Systems and methods for fabricating ingestible pharmaceutical tablets are provided. Certain of the systems and methods described herein are capable of manufacturing tablets of different dosages without the need to fluidically connect or disconnect unit operations when switching from a tablet having a first dosage to a tablet having a second, different dosage. Certain of the systems and methods described herein are capable of manufacturing compositionally tablets, e.g., tablets with different active pharmaceutical ingredients (APIs).
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: July 7, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Allan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, David Brancazio, Juan Guillermo Osorio Caicedo
  • Publication number: 20190337978
    Abstract: Methods of forming crystals including, for example, methods of forming crystals using a nanoporous matrix, and associated materials, articles, and systems are generally provided. Advantageously, in some embodiments, the methods of forming crystals described herein provide crystal formation of a target molecule from a solution initially at an undersaturated state with respect to the target molecule. In some embodiments, a method involves obtaining a solution of a target molecule, where in some cases the solution is at an undersaturated state with respect to the target molecule; and exposing the solution to a functionalized nanoporous matrix under conditions that promote crystal formation of the target molecule. In some cases, the nanoporous matrix is functionalized with an antisolvent group.
    Type: Application
    Filed: May 3, 2019
    Publication date: November 7, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Allan S. Myerson, Leia Dwyer
  • Publication number: 20190160392
    Abstract: Aspects of the disclosure relate to methods and compositions of altering a solution through the use of readily retrievable agents (e.g., a nanoparticle) having one or more functional groups configured to undergo a solvation interaction with a component of the solution. Compositions, systems, and methods for crystallizing organic and inorganic compounds from solutions using nanoparticles surface coated with functional groups that create a supersaturated state in the solution and reversal thereof. Compositions, systems, and methods for purifying water or active pharmaceutical ingredients. Compositions, systems, and methods for increasing the solubility of a solution and reversal of the same. Compositions, systems, and methods for decreasing the solubility of a crystallized compound and reversal of the same.
    Type: Application
    Filed: April 6, 2017
    Publication date: May 30, 2019
    Applicant: Massachusetts Institute of Technology
    Inventors: Allan S. Myerson, Samir Kulkarni
  • Patent number: 10155786
    Abstract: The present invention generally relates to systems and methods for pressure driven flow crystallization. In some embodiments, the system comprises a comprising a cavity and a mixing mechanism. In some embodiments, one or more inlets facilitate the transfer of one or more reagent streams to the cavity. In some such embodiments, the mixing mechanism mixes the first and second reagent streams such that a continuous crystallization and/or generation of a product (e.g., solid particles) in the fluid.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: December 18, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Allan S. Myerson, Marcus O'Mahony, Torsten Stelzer, Yuqing Cui
  • Publication number: 20180271791
    Abstract: Systems and methods for fabricating ingestible pharmaceutical tablets are provided. Certain of the systems and methods described herein are capable of manufacturing tablets of different dosages without the need to fluidically connect or disconnect unit operations when switching from a tablet having a first dosage to a tablet having a second, different dosage. Certain of the systems and methods described herein are capable of manufacturing compositionally tablets, e.g., tablets with different active pharmaceutical ingredients (APIs).
    Type: Application
    Filed: February 15, 2018
    Publication date: September 27, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Allan S. Myerson, Mohammad A. Azad, Gregory J. Hammersmith, David Brancazio, Juan Guillermo Osorio Caicedo
  • Publication number: 20180207604
    Abstract: Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.
    Type: Application
    Filed: August 14, 2015
    Publication date: July 26, 2018
    Applicant: Massachusettts Institute of Technology
    Inventors: Klavs F. Jensen, Timothy F Jamision, Allan S Myerson, Mohsen Behnam, Shin Yee Wong, Nopphon Weeranoppanant, Marie REvalor Rognes
  • Publication number: 20180071215
    Abstract: Compositions, methods, and systems for controlling crystallization of an agent are generally described. In some embodiments, an agent is crystallized in the presence of polymer matrices, such as polymer particles. The polymer matrix may influence at least a portion of the crystallization process and/or the resulting composition. In some such embodiments, the polymer matrix allows one or more aspect of the process and/or composition to be controlled and/or altered. For instance, the polymer matrix may act as a crystallization promoter and/or acceptable carriers of the crystallized agent. In certain embodiments, the polymer matrix described herein, can be used with any agent regardless of its chemical and/or physical properties.
    Type: Application
    Filed: September 22, 2017
    Publication date: March 15, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Bernhardt Levy Trout, Patrick S. Doyle, Allan S. Myerson, Paul Douglas Godfrin, Abu Zayed Md Badruddoza
  • Publication number: 20170354609
    Abstract: The disclosure describes an injection molding process for coating a tablet core to produce a coated pharmaceutical tablet, wherein the injection-molded coating is substantially continuous (e.g., completely covers the tablet core with no openings), and describes the resulting coated pharmaceutical tablet. The disclosure describes compositions for coatings and tablet cores and equipment suitable for performing the process.
    Type: Application
    Filed: June 12, 2017
    Publication date: December 14, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Vibha Puri, Parind Mahendrakumar Desai, Keith D. Jensen, David Brancazio, Eranda Harinath, Alexander Racine Martinez, Jung Hoon Chun, Richard Dean Braatz, Allan S. Myerson, Bernhardt Levy Trout
  • Publication number: 20170166601
    Abstract: The present invention generally relates to systems and methods for pressure driven flow crystallization. In some embodiments, the system comprises a comprising a cavity and a mixing mechanism. In some embodiments, one or more inlets facilitate the transfer of one or more reagent streams to the cavity. In some such embodiments, the mixing mechanism mixes the first and second reagent streams such that a continuous crystallization and/or generation of a product (e.g., solid particles) in the fluid.
    Type: Application
    Filed: December 8, 2016
    Publication date: June 15, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Allan S. Myerson, Marcus O'Mahony, Torsten Stelzer, Yuqing Cui