Abstract: Systems and methods for transacting over a network. A first agent operating on a first computing system is operable to transact on behalf of a first entity. The first agent transacts with a second agent operating on a second computing system for a first cryptographically verifiable credential, transmits the first cryptographically verifiable credential to a third agent, and transacts with the third agent based on the first cryptographically verifiable credential for a second cryptographically verifiable credential to facilitate transacting with a fourth agent for a service. The second agent is operable to receive telemetry data of the first computing system which is configured to monitor the telemetry data, determine an assessment of the first entity based on the telemetry data, generate the first cryptographically verifiable credential based on the assessment of the first entity by the second agent, and transmit the first cryptographically verifiable credential to the first agent.

Abstract: Systems are provided for an imaging system isolation enclosure for use with a medical imaging system includes a pathogen impermeable enclosure for use with one or more of radiation imaging systems and magnetic resonance imaging systems, the pathogen impermeable enclosure is configured to provide a barrier between the imaging system and at least one of a patient user and an imaging room, and an air filtration system including an inlet to supply a cooling air flow to an interior of the imaging system isolation enclosure and an outlet to output exhaust air from an interior of the imaging system isolation enclosure.

Abstract: Embodiments of apparatuses and methods for determining a positioning of sensors in a wound dressing are disclosed. In some embodiments, a wound monitoring and/or therapy system can include a wound dressing and a plurality of sensors configured to measure one or more wound characteristics. The wound monitor system can also include at least one positioning device configured to indicate position and/or orientation in the wound of a sensor of the plurality of sensors. In some embodiments, a detector can be configured to determine, based on the positioning data, the position and/or orientation in the wound of the sensor of the plurality of sensors. In some embodiments, the plurality of sensors can be positioned on a strip or string of material in communication with the positioning device.

Abstract: Compounds useful as linker-payload compounds are disclosed. The compounds have the following Structure (I): as a stereoisomer, enantiomer or tautomer thereof or a mixture thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X1, X2, X3, X4, X5, R4a, and R4b are as defined herein. Additional compounds, conjugates, methods of preparation, pharmaceutical compositions, and methods of treatment related to conjugates of compounds of Structure (I) and a targeting moiety, or binding fragment thereof, are also provided.

Abstract: An underwater camera system includes a camera assembly configured to scan a seabed while submerged under water and moving in a direction of travel. A buoyant support is coupled to the camera assembly and configured to position the camera assembly under water during the moving in the direction of travel. A stabilization assembly is coupled to the camera assembly and configured for adjusting an orientation of the camera assembly relative to the direction of travel.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for aquatic biomass estimation. One of the methods includes obtaining an image of an aquatic environment including aquatic grass; providing the image to a network model trained to construct a point cloud indicating a portion of the image that represents the aquatic grass; generating a floor model indicating a floor of the aquatic environment where the aquatic grass grows; identifying, using (i) the floor model and (ii) the point cloud indicating the aquatic grass, (i) a first subset of points in the point cloud as indicating aquatic grass and (ii) a second subset of points in the point cloud as indicating the floor of the aquatic environment; and generating, using the first subset of points in the point cloud, an indication of biomass within the aquatic environment.

Abstract: A method for verifying aperture positions of a pre-patient collimator of a computed tomography (CT) imaging system includes obtaining data collected by an X-ray measurement device having detector elements subjected to X-rays emitted from an X-ray source of the CT imaging system with the pre-patient collimator at an expected aperture position. The method also includes calculating a measured collimator aperture position for the pre-patient collimator based on the obtained data. The method further includes comparing the measured collimator aperture position to a system specification for the expected aperture position for the CT imaging system. The method even further includes generating an output based on the comparison of the measured collimator aperture position to the system specification.

Abstract: Various methods and systems are provided for stationary CT imaging. In one embodiment, an imaging system comprises a stationary distributed x-ray source unit comprising a plurality of emitters positioned to emit x-ray beams through the imaging volume, one or more detector arrays extending around at least a portion of an imaging volume, each detector array comprising a plurality of detector elements, each detector element configured to receive x-ray beams from more than one emitter, and an anti-scatter device configured to be positioned between one or more emitters of the plurality of emitters and an object in the imaging volume.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds (collectively referred to herein as CHMSA compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, e.g., multiple myeloma, diffuse large B-cell lymphoma, acute myeloid leukemia, eosinophilic leukemia, glioblastoma, melanoma, ovarian cancer, chemotherapy resistant cancer, radiation resistant cancer, inflammatory arthritis, rheumatoid arthritis, psoriatic arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus (SLE), lupus nephritis, asthma, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), autoimmune hepatitis, hidradenitis suppurativa, etc.

Abstract: A scan window for an imaging system includes at least one flexible sheet made of an X-ray transparent material and having a first end and a second end. The scan window also includes at least one tapered joint formed between the first end and the second end and secured via a bonding agent to form a joined member with the at least one flexible sheet.

Abstract: Various methods and systems are provided for stationary CT imaging. In one embodiment, a method for an imaging system includes activating an emitter of a plurality of emitters of a stationary distributed x-ray source unit to emit an x-ray beam toward an object within an imaging volume, where the x-ray source unit does not rotate around the imaging volume, receiving the x-ray beam at a subset of detector elements of a plurality of detector elements of one or more detector arrays, sampling the plurality of detector elements to generate a total transmission profile, an attenuation profile, and a scatter measurement, generating a scatter-corrected attenuation profile by entering the total transmission profile, the attenuation profile, and the scatter measurement as inputs to a model, and reconstructing one or more images from the scatter-corrected attenuation profile.

Abstract: A method for verifying aperture positions of a pre-patient collimator of a computed tomography (CT) imaging system includes obtaining data collected by an X-ray measurement device having detector elements subjected to X-rays emitted from an X-ray source of the CT imaging system with the pre-patient collimator at an expected aperture position. The method also includes calculating a measured collimator aperture position for the pre-patient collimator based on the obtained data. The method further includes comparing the measured collimator aperture position to a system specification for the expected aperture position for the CT imaging system. The method even further includes generating an output based on the comparison of the measured collimator aperture position to the system specification.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain N-acyl-{4-[(4-aryl-phenyl)sulfonylmethyl]piperidine} compounds of the following formula (collectively referred to herein as NASMP compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, e.g., multiple myeloma, diffuse large B-cell lymphoma, acute myeloid leukemia, eosinophilic leukemia, glioblastoma, melanoma, ovarian cancer, chemotherapy resistant cancer, radiation resistant cancer, inflammatory arthritis, rheumatoid arthritis, psoriatic arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus (SLE), lupus nephritis, asthma, chronic obstructive pulmonary disease (COPD), Hidradenitis suppurativa, autoimmune hepatitis, etc. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy.

Abstract: Various methods and systems are provided for manufacturing a radiation shielding component of an imaging apparatus. In one embodiment, the radiation shielding component may be manufactured by infiltrating metal particles with a binder solution and then curing the binder solution impregnated with the metal particles. In another embodiment, the radiation shielding component may be printed with metal powder, infiltrated with a binding agent, and then cured to polymerize the binding agent.

Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds (collectively referred to herein as CHMSA compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, e.g., multiple myeloma, diffuse large B-cell lymphoma, acute myeloid leukemia, eosinophilic leukemia, glioblastoma, melanoma, ovarian cancer, chemotherapy resistant cancer, radiation resistant cancer, inflammatory arthritis, rheumatoid arthritis, psoriatic arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus (SLE), lupus nephritis, asthma, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), autoimmune hepatitis, hidradenitis suppurativa, etc.

Abstract: Various methods and systems are provided for reducing vibration in a rotating body of a medical imaging system. In an example, a dynamic vibration absorber (DVA) for a medical imaging system includes a mount portion including one or more apertures and adapted to fixedly couple to a mount surface within the imaging system; a sprung portion; and a vibrational tuner, where when the mount portion is mounted to the mount surface and during operation of the imaging system, the sprung portion moves relative to the mount surface, an amount of movement of the sprung portion based at least in part on the vibrational tuner.

Abstract: A system is provided for fasting switching a filter of an imaging system during a scan. In one embodiment, a system comprises a computation device with instructions stored in a non-transient memory to emit an X-ray beam via an X-ray source; move an imaging subject via a motorized table at a nonzero speed; while moving the imaging subject, acquire a dataset of the imaging subject by detecting attenuated X-rays transmitted through the imaging subject via an X-ray detector, wherein a first filter is positioned within the X-ray beam, between the X-ray source and the imaging subject; and while acquiring the dataset, responsive to a change in an anatomy of the imaging subject to be imaged, operate a filter driving system to switch from the first filter to a second filter, wherein during filter switching, the X-ray source does not emit X-rays.

Abstract: A method is provided for mitigating metal particle leakage from a three-dimensional printed part. The method includes providing an additively manufactured part manufactured out of one or more materials, and the one or more materials comprise a metal. The method also includes applying a coating over surfaces of the additively manufactured part to keep metal particles from leaking from the additively manufactured part.

Abstract: The present disclosure relates to compounds of the Formula (I) which have shown utility in modulating AMPA receptor signaling and thus preventing AMPA receptor-mediated toxicity, which may find use in the treatment of diseases in which AMPA receptor activation plays a role in neurodegeneration, including the treatment of multiple sclerosis and other diseases.

Abstract: Methods and systems are provided for fasting switching a filter of an imaging system during scan. In one embodiment, a method comprises determining a first contrast enhancement of an injected contrast agent; responsive to the first contrast enhancement being higher than a first threshold, acquiring a first dataset by transmitting a radiation beam to an imaging subject via a first filter; switching to a different, second filter; acquiring a second dataset by transmitting the radiation beam to the imaging subject via the second filter, wherein an average contrast enhancement of the injected contrast agent during the acquisition of the first dataset is substantially the same as an average contrast enhancement of the injected contrast agent in the imaging subject during the acquisition of the second dataset.