Patents by Inventor Allan Smith

Allan Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12240814
    Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds (collectively referred to herein as CHMSA compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, e.g., multiple myeloma, diffuse large B-cell lymphoma, acute myeloid leukemia, eosinophilic leukemia, glioblastoma, melanoma, ovarian cancer, chemotherapy resistant cancer, radiation resistant cancer, inflammatory arthritis, rheumatoid arthritis, psoriatic arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus (SLE), lupus nephritis, asthma, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), autoimmune hepatitis, hidradenitis suppurativa, etc.
    Type: Grant
    Filed: October 24, 2023
    Date of Patent: March 4, 2025
    Assignee: Istesso Therapeutics Limited
    Inventors: Lisa Patel, Stephen Allan Smith
  • Patent number: 12162836
    Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain N-acyl-{4-[(4-aryl-phenyl)sulfonylmethyl]piperidine} compounds of the following formula (collectively referred to herein as NASMP compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, e.g., multiple myeloma, diffuse large B-cell lymphoma, acute myeloid leukemia, eosinophilic leukemia, glioblastoma, melanoma, ovarian cancer, chemotherapy resistant cancer, radiation resistant cancer, inflammatory arthritis, rheumatoid arthritis, psoriatic arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus (SLE), lupus nephritis, asthma, chronic obstructive pulmonary disease (COPD), Hidradenitis suppurativa, autoimmune hepatitis, etc. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: December 10, 2024
    Assignee: Modern Biosciences Limited
    Inventors: Lisa Patel, Stephen Allan Smith, Stephen Paul Collingwood
  • Publication number: 20240351108
    Abstract: An imaging system is provided. The imaging system includes an additively manufactured three-dimensional (3D) collimator manufactured out of one or more materials, the one or more materials comprise a metal, and the additively manufactured (3D) collimator is configured to provide collimation on a beam emitted from an X-ray source of the imaging system and a coating disposed over surfaces of the additively manufactured 3D collimator, wherein the coating is configured to keep metal particles from leaking from the additively manufactured 3D collimator.
    Type: Application
    Filed: July 2, 2024
    Publication date: October 24, 2024
    Inventors: Yanju Wang, Jaroslaw Kurzac, Chad Allan Smith
  • Patent number: 12053822
    Abstract: A method is provided for mitigating metal particle leakage from a three-dimensional printed part. The method includes providing an additively manufactured part manufactured out of one or more materials, and the one or more materials comprise a metal. The method also includes applying a coating over surfaces of the additively manufactured part to keep metal particles from leaking from the additively manufactured part.
    Type: Grant
    Filed: January 5, 2021
    Date of Patent: August 6, 2024
    Assignee: GE Precision Healthcare LLC
    Inventors: Yanju Wang, Jaroslaw Kurzac, Chad Allan Smith
  • Publication number: 20240182418
    Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds (collectively referred to herein as CHMSA compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, e.g., multiple myeloma, diffuse large B-cell lymphoma, acute myeloid leukemia, eosinophilic leukemia, glioblastoma, melanoma, ovarian cancer, chemotherapy resistant cancer, radiation resistant cancer, inflammatory arthritis, rheumatoid arthritis, psoriatic arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus (SLE), lupus nephritis, asthma, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), autoimmune hepatitis, hidradenitis suppurativa, etc.
    Type: Application
    Filed: October 24, 2023
    Publication date: June 6, 2024
    Applicant: Modern Biosciences Limited
    Inventors: Lisa PATEL, Stephen Allan SMITH
  • Publication number: 20240122777
    Abstract: Systems are provided for an imaging system isolation enclosure for use with a medical imaging system includes a pathogen impermeable enclosure for use with one or more of radiation imaging systems and magnetic resonance imaging systems, the pathogen impermeable enclosure is configured to provide a barrier between the imaging system and at least one of a patient user and an imaging room, and an air filtration system including an inlet to supply a cooling air flow to an interior of the imaging system isolation enclosure and an outlet to output exhaust air from an interior of the imaging system isolation enclosure.
    Type: Application
    Filed: October 17, 2022
    Publication date: April 18, 2024
    Inventors: Paul Francis FitzGerald, Uwe Wiedmann, Ross Christopher Stalter, Stephen Lorenco Araujo, Michael James Rishel, Chad Allan Smith
  • Publication number: 20240061321
    Abstract: An underwater camera system includes a camera assembly configured to scan a seabed while submerged under water and moving in a direction of travel. A buoyant support is coupled to the camera assembly and configured to position the camera assembly under water during the moving in the direction of travel. A stabilization assembly is coupled to the camera assembly and configured for adjusting an orientation of the camera assembly relative to the direction of travel.
    Type: Application
    Filed: August 17, 2023
    Publication date: February 22, 2024
    Inventors: Anne LaBine, Samuel Gregory, Bianca Bahman, Terry Allan Smith
  • Publication number: 20240062539
    Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for aquatic biomass estimation. One of the methods includes obtaining an image of an aquatic environment including aquatic grass; providing the image to a network model trained to construct a point cloud indicating a portion of the image that represents the aquatic grass; generating a floor model indicating a floor of the aquatic environment where the aquatic grass grows; identifying, using (i) the floor model and (ii) the point cloud indicating the aquatic grass, (i) a first subset of points in the point cloud as indicating aquatic grass and (ii) a second subset of points in the point cloud as indicating the floor of the aquatic environment; and generating, using the first subset of points in the point cloud, an indication of biomass within the aquatic environment.
    Type: Application
    Filed: August 21, 2023
    Publication date: February 22, 2024
    Inventors: Yangli Hector Yee, Terry Allan Smith, Bianca Bahman
  • Patent number: 11864941
    Abstract: A method for verifying aperture positions of a pre-patient collimator of a computed tomography (CT) imaging system includes obtaining data collected by an X-ray measurement device having detector elements subjected to X-rays emitted from an X-ray source of the CT imaging system with the pre-patient collimator at an expected aperture position. The method also includes calculating a measured collimator aperture position for the pre-patient collimator based on the obtained data. The method further includes comparing the measured collimator aperture position to a system specification for the expected aperture position for the CT imaging system. The method even further includes generating an output based on the comparison of the measured collimator aperture position to the system specification.
    Type: Grant
    Filed: October 4, 2021
    Date of Patent: January 9, 2024
    Assignee: GE Precision Healthcare LLC
    Inventors: Arka Datta, John Moore Boudry, Brandon Allan Smith
  • Patent number: 11832979
    Abstract: Various methods and systems are provided for stationary CT imaging. In one embodiment, an imaging system comprises a stationary distributed x-ray source unit comprising a plurality of emitters positioned to emit x-ray beams through the imaging volume, one or more detector arrays extending around at least a portion of an imaging volume, each detector array comprising a plurality of detector elements, each detector element configured to receive x-ray beams from more than one emitter, and an anti-scatter device configured to be positioned between one or more emitters of the plurality of emitters and an object in the imaging volume.
    Type: Grant
    Filed: June 8, 2021
    Date of Patent: December 5, 2023
    Assignee: GE PRECISION HEALTHCARE LLC
    Inventors: Bruno Kristiaan Bernard De Man, Jed Douglas Pack, Mingye Wu, Chad Allan Smith, Jean-Baptiste Thibault
  • Patent number: 11834414
    Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds (collectively referred to herein as CHMSA compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, e.g., multiple myeloma, diffuse large B-cell lymphoma, acute myeloid leukemia, eosinophilic leukemia, glioblastoma, melanoma, ovarian cancer, chemotherapy resistant cancer, radiation resistant cancer, inflammatory arthritis, rheumatoid arthritis, psoriatic arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus (SLE), lupus nephritis, asthma, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), autoimmune hepatitis, hidradenitis suppurativa, etc.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: December 5, 2023
    Assignee: Modern Biosciences Limited
    Inventors: Lisa Patel, Stephen Allan Smith
  • Publication number: 20230263484
    Abstract: A scan window for an imaging system includes at least one flexible sheet made of an X-ray transparent material and having a first end and a second end. The scan window also includes at least one tapered joint formed between the first end and the second end and secured via a bonding agent to form a joined member with the at least one flexible sheet.
    Type: Application
    Filed: February 23, 2022
    Publication date: August 24, 2023
    Inventors: Michael Eric Smith, Brandon Allan Smith, Wesley George Heiman
  • Patent number: 11633163
    Abstract: Various methods and systems are provided for stationary CT imaging. In one embodiment, a method for an imaging system includes activating an emitter of a plurality of emitters of a stationary distributed x-ray source unit to emit an x-ray beam toward an object within an imaging volume, where the x-ray source unit does not rotate around the imaging volume, receiving the x-ray beam at a subset of detector elements of a plurality of detector elements of one or more detector arrays, sampling the plurality of detector elements to generate a total transmission profile, an attenuation profile, and a scatter measurement, generating a scatter-corrected attenuation profile by entering the total transmission profile, the attenuation profile, and the scatter measurement as inputs to a model, and reconstructing one or more images from the scatter-corrected attenuation profile.
    Type: Grant
    Filed: June 8, 2021
    Date of Patent: April 25, 2023
    Assignee: GE Precision Healthcare LLC
    Inventors: Bruno Kristiaan Bernard De Man, Jed Douglas Pack, Mingye Wu, Chad Allan Smith, Jean-Baptiste Thibault
  • Publication number: 20230109837
    Abstract: A method for verifying aperture positions of a pre-patient collimator of a computed tomography (CT) imaging system includes obtaining data collected by an X-ray measurement device having detector elements subjected to X-rays emitted from an X-ray source of the CT imaging system with the pre-patient collimator at an expected aperture position. The method also includes calculating a measured collimator aperture position for the pre-patient collimator based on the obtained data. The method further includes comparing the measured collimator aperture position to a system specification for the expected aperture position for the CT imaging system. The method even further includes generating an output based on the comparison of the measured collimator aperture position to the system specification.
    Type: Application
    Filed: October 4, 2021
    Publication date: April 13, 2023
    Inventors: Arka Datta, John Moore Boudry, Brandon Allan Smith
  • Publication number: 20230022917
    Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain N-acyl-{4-[(4-aryl-phenyl)sulfonylmethyl]piperidine} compounds of the following formula (collectively referred to herein as NASMP compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, e.g., multiple myeloma, diffuse large B-cell lymphoma, acute myeloid leukemia, eosinophilic leukemia, glioblastoma, melanoma, ovarian cancer, chemotherapy resistant cancer, radiation resistant cancer, inflammatory arthritis, rheumatoid arthritis, psoriatic arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus (SLE), lupus nephritis, asthma, chronic obstructive pulmonary disease (COPD), Hidradenitis suppurativa, autoimmune hepatitis, etc. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, in therapy.
    Type: Application
    Filed: April 17, 2020
    Publication date: January 26, 2023
    Inventors: Lisa PATEL, Stephen Allan SMITH, Stephen Paul COLLINGWOOD
  • Patent number: 11524453
    Abstract: Various methods and systems are provided for manufacturing a radiation shielding component of an imaging apparatus. In one embodiment, the radiation shielding component may be manufactured by infiltrating metal particles with a binder solution and then curing the binder solution impregnated with the metal particles. In another embodiment, the radiation shielding component may be printed with metal powder, infiltrated with a binding agent, and then cured to polymerize the binding agent.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: December 13, 2022
    Assignee: GE Precision Healthcare LLC
    Inventors: Yanju Wang, Jimmie Autrey Beacham, Chad Allan Smith, Paul Michael Wervey
  • Publication number: 20220363642
    Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted 1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds (collectively referred to herein as CHMSA compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, e.g., multiple myeloma, diffuse large B-cell lymphoma, acute myeloid leukemia, eosinophilic leukemia, glioblastoma, melanoma, ovarian cancer, chemotherapy resistant cancer, radiation resistant cancer, inflammatory arthritis, rheumatoid arthritis, psoriatic arthritis, psoriasis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus (SLE), lupus nephritis, asthma, chronic obstructive pulmonary disease (COPD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), autoimmune hepatitis, hidradenitis suppurativa, etc.
    Type: Application
    Filed: August 15, 2019
    Publication date: November 17, 2022
    Inventors: Lisa PATEL, Stephen Allan SMITH
  • Patent number: 11439361
    Abstract: Various methods and systems are provided for reducing vibration in a rotating body of a medical imaging system. In an example, a dynamic vibration absorber (DVA) for a medical imaging system includes a mount portion including one or more apertures and adapted to fixedly couple to a mount surface within the imaging system; a sprung portion; and a vibrational tuner, where when the mount portion is mounted to the mount surface and during operation of the imaging system, the sprung portion moves relative to the mount surface, an amount of movement of the sprung portion based at least in part on the vibrational tuner.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: September 13, 2022
    Assignee: GE Precision Healthcare LLC
    Inventors: Mark Reznicek, Chad Allan Smith, Charles Smith, James Kluth
  • Publication number: 20220233156
    Abstract: A system is provided for fasting switching a filter of an imaging system during a scan. In one embodiment, a system comprises a computation device with instructions stored in a non-transient memory to emit an X-ray beam via an X-ray source; move an imaging subject via a motorized table at a nonzero speed; while moving the imaging subject, acquire a dataset of the imaging subject by detecting attenuated X-rays transmitted through the imaging subject via an X-ray detector, wherein a first filter is positioned within the X-ray beam, between the X-ray source and the imaging subject; and while acquiring the dataset, responsive to a change in an anatomy of the imaging subject to be imaged, operate a filter driving system to switch from the first filter to a second filter, wherein during filter switching, the X-ray source does not emit X-rays.
    Type: Application
    Filed: April 18, 2022
    Publication date: July 28, 2022
    Inventors: Brandon Allan Smith, Holly Ann McDaniel
  • Publication number: 20220212260
    Abstract: A method is provided for mitigating metal particle leakage from a three-dimensional printed part. The method includes providing an additively manufactured part manufactured out of one or more materials, and the one or more materials comprise a metal. The method also includes applying a coating over surfaces of the additively manufactured part to keep metal particles from leaking from the additively manufactured part.
    Type: Application
    Filed: January 5, 2021
    Publication date: July 7, 2022
    Inventors: Yanju Wang, Jaroslaw Kurzac, Chad Allan Smith