Patents by Inventor Allan Wissner

Allan Wissner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7982043
    Abstract: This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.
    Type: Grant
    Filed: June 10, 2008
    Date of Patent: July 19, 2011
    Assignee: Wyeth LLC
    Inventors: Allan Wissner, Sridhar Krishna Rabindran, Hwei-Ru Tsou
  • Patent number: 7781591
    Abstract: The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: August 24, 2010
    Assignee: Wyeth LLC
    Inventors: Derek Cecil Cole, Diane Harris Boschelli, Yanong Daniel Wang, Magda Asselin, Diane Marie Joseph-McCarthy, Amarnauth Shastrie Prashad, Allan Wissner, Russell Dushin, Biqi Wu, Lawrence Nathan Tumey, Chuan S. Niu, Joan Chen
  • Publication number: 20080319011
    Abstract: This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.
    Type: Application
    Filed: June 10, 2008
    Publication date: December 25, 2008
    Applicant: Wyeth
    Inventors: Allan Wissner, Sridhar Krishna Rabindran, Hwei-Ru Tsou
  • Publication number: 20080293712
    Abstract: The present invention relates to Benzo[c][2,7]naphthyridine Derivatives, compositions comprising an effective amount of a Benzo[c][2,7]naphthyridine Derivative, methods for treating or preventing a proliferative disorder or an autoimmune disease, comprising administering to a subject in need thereof an effective amount of a Benzo[c][2,7]naphthyridine Derivative, methods for modulating PDK-1 activity, PKA activity, Akt activity, S6K activity, or PKC activity, comprising administering to a subject in need thereof an effective amount of a Benzo[c][2,7]naphthyridine Derivative. The invention also relates to processes for preparing a Benzo[c][2,7]naphthyridine Derivative.
    Type: Application
    Filed: March 4, 2008
    Publication date: November 27, 2008
    Applicant: WYETH
    Inventors: Allan WISSNER, Middleton Brawner FLOYD, JR., Russell DUSHIN, Heidi L. FRASER, Yongbo HU, Andreas MADERNA, Thomas NITTOLI, Yanong Daniel WANG
  • Publication number: 20080268460
    Abstract: The present invention relates to a method of identifying an inhibitor of a receptor tyrosine kinase that irreversibly binds to the kinase. Specifically, the method comprises using a variety of assays, either alone or in combination, to identify compounds that irreversibly bind to tyrosine kinases. More specifically, there are four assays, which are novel variations of a basic enzyme assay and identify irreversible binding inhibitors.
    Type: Application
    Filed: May 11, 2005
    Publication date: October 30, 2008
    Applicant: Wyeth
    Inventors: Frank Loganzo, Lee M. Greenberger, Xingshi Tan, Allan Wissner
  • Publication number: 20080234300
    Abstract: The present invention relates to pyrimido[5,4-c]quinoline-2,4-diamine derivatives, compositions comprising an effective amount of a Pyrimido[5,4-c]quinoline-2,4-diamine Derivative, methods for treating or preventing a proliferative disorder, comprising administering to a subject in need thereof an effective amount of an Pyrimido[5,4-c]quinoline-2,4-diamine Derivative, methods for modulating PDK-1 activity, comprising administering to a subject in need thereof an effective amount of a Pyrimido[5,4-c]quinoline-2,4-diamine Derivative. The invention also relates to a process for preparing a Pyrimido[5,4-c]quinoline-2,4-diamine Derivative.
    Type: Application
    Filed: March 4, 2008
    Publication date: September 25, 2008
    Applicant: WYETH
    Inventors: Allan WISSNER, Aranapakam M. VENKATESAN
  • Patent number: 7399865
    Abstract: This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: July 15, 2008
    Assignee: Wyeth
    Inventors: Allan Wissner, Sridhar Krishna Rabindran, Hwei-Ru Tsou
  • Publication number: 20070299092
    Abstract: The present invention provides for compounds with the general formula: A compound of formula (1) having the structure (1) wherein Z is a radical selected from the group (a), (b), or (c) as well as methods and compositions containing these compounds useful for treatment of diseases that are characterized, at least in part, by excessive, abnormal, or inappropriate angiogenesis. These disease states, include but are not limited to, cancer, diabetic retinopathy, macular degeneration and rheumatoid arthritis. These compounds inhibit angiogenesis by inhibiting a tyrosine kinase receptor enzyme, specifically KDR, and binding to the KDR in an irreversible manner.
    Type: Application
    Filed: May 11, 2005
    Publication date: December 27, 2007
    Applicant: Wyeth
    Inventors: Middleton Floyd Jr, Thomas Nittoli, Allan Wissner, Russell Dushin, Ramaswamy Nilakantan, Charles Ingalls, Heidi Fraser, Bernard Johnson
  • Publication number: 20070287708
    Abstract: The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
    Type: Application
    Filed: June 13, 2007
    Publication date: December 13, 2007
    Inventors: Derek Cole, Diane Boschelli, Yanong Wang, Magda Asselin, Diane Joseph-McCarthy, Amarnauth Prashad, Allan Wissner, Russell Dushin, Biqi Wu, Lawrence Tumey, Chuan Niu, Joan Chen
  • Publication number: 20070287738
    Abstract: The present teachings provide compounds of formula I and their pharmaceutically acceptable salts, hydrates, and esters, wherein R1, R2, and X are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating autoimmune and inflammatory diseases by administering a therapeutically effective amount of a compound or compounds of formula I to a mammal including a human.
    Type: Application
    Filed: June 13, 2007
    Publication date: December 13, 2007
    Inventors: Derek Cecil Cole, Magda Asselin, Diane Harris Boschelli, Allan Wissner, Yanong Daniel Wang, Amarnauth Shastrie Prashad, Russell Dushin
  • Publication number: 20060270670
    Abstract: The present invention is directed to a method of synthizing compounds of formula (I): wherein X, Z, V, R1, R3, R4, G2, n, x, y, and z are defined herein. This invention also includes a method of preparing acid compounds of formula (VII): wherein R is H, and R4, x, y, and z are as defined herein and PG is a protecting group. This invention is also directed to (E)N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(methylamino)-2-butenamide, compositions containing it and methods of using the to treat cancer.
    Type: Application
    Filed: May 25, 2006
    Publication date: November 30, 2006
    Inventors: Warren Chew, Youchu Wang, Sridhar Rabindran, Carolyn Discafani-Marro, John McGinnis II, Allan Wissner
  • Publication number: 20060247217
    Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
    Type: Application
    Filed: June 29, 2006
    Publication date: November 2, 2006
    Inventors: Dan Berger, Minu Dutia, Frenel DeMorin, Diane Boschelli, Dennis Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Patent number: 7105531
    Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: September 12, 2006
    Assignee: WYETH
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Publication number: 20050059678
    Abstract: This invention provides compounds of formula 1, having the structure wherein R1, R2, R3, R4, and R5 are described within the specification.
    Type: Application
    Filed: September 10, 2004
    Publication date: March 17, 2005
    Applicant: Wyeth
    Inventors: Allan Wissner, Sridhar Rabindran, Hwei-Ru Tsou
  • Patent number: 6821988
    Abstract: This invention provides compounds of Formula (I), represented by the structure wherein G1, G2, G3, G4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: November 23, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Allan Wissner, Hwei-Ru Tsou, Middleton Brawner Floyd, Jr., Bernard D. Johnson, Elsebe Geraldine Overbeek-Klumpers
  • Publication number: 20040176602
    Abstract: This invention provides compounds of Formula (I), having the structure 1
    Type: Application
    Filed: January 9, 2004
    Publication date: September 9, 2004
    Applicant: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Publication number: 20040110762
    Abstract: This invention provides compounds of formula 1, having the structure 1
    Type: Application
    Filed: July 10, 2003
    Publication date: June 10, 2004
    Applicant: WYETH
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Patent number: 6689772
    Abstract: This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R1, R2a, R2b, R2c, R3, R4, and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: February 10, 2004
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Yanong Wang, Frank Charles Boschelli, Dan Maarten Berger, Nan Zhang, Dennis William Powell, Fei Ye, Ayako Yamashita, Frenel Fils DeMorin, Biqi Wu, Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner
  • Patent number: 6638929
    Abstract: This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: October 28, 2003
    Assignee: Wyeth
    Inventors: Dan M. Berger, Minu D. Dutia, Frenel F. DeMorin, Diane H. Boschelli, Dennis W. Powell, Hwei-Ru Tsou, Allan Wissner, Nan Zhang, Fei Ye, Biqi Wu
  • Patent number: RE42376
    Abstract: This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: May 21, 2010
    Date of Patent: May 17, 2011
    Assignee: Wyeth Holdings Corporation
    Inventors: Allan Wissner, Hwei-Ru Tsou, Dan M. Berger, Middleton B. Floyd, Jr., Philip R. Hamann, Nan Zhang, Philip Frost