Abstract: The present disclosure generally relates to nanoparticles comprising an endo-lysosomal escape agent, a nucleic acid, and a polymer. Other aspects include methods of making and using such nanoparticles.

Abstract: Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

Abstract: According to examples, an apparatus may include a processor and a memory on which are stored machine readable instructions that when executed by the processor cause the processor to access a voice command file pertaining to a data file and to send the voice command file to at least one of a server and a voice services provider, in which the voice services provider is to translate the voice command file to a workflow task message and to send the workflow task message to the server. The instructions may also cause the processor to receive the workflow task message from the server and execute a workflow task on the data file corresponding to the received workflow task message.

Abstract: Tools and method for automatically controlling torque when making-up and/or breaking-down threaded connections between downhole assets such as drill pipe, drill collars, and BHA components. An iron roughneck may be controlled by, for instance, automatically monitoring and adjusting the fluid pressure of cylinders that ultimately provide the torque to the downhole assets. The torque may further be automatically controlled by automatically identifying the downhole assets and selecting a corresponding torque profile or target torque. Clamping force may also be controlled, and is optionally proportional to the target torque.

Abstract: Tools and method for automatically controlling torque when making-up and/or breaking-down threaded connections between downhole assets such as drill pipe, drill collars, and BAH components. An iron roughneck may be controlled by, for instance, automatically monitoring and adjusting the fluid pressure of cylinders that ultimately provide the torque to the downhole assets. The torque may further be automatically controlled by automatically identifying the downhole assets and selecting a corresponding torque profile or target torque. Clamping force may also be controlled, and is optionally proportional to the target torque.

Abstract: Systems and methods for location-based online content sharing using unique identifiers are provided. A server and a plurality of clients may be connected to one or more networks. A first client may send a shared content to the server. The first client may also send a first location of the first client as well as a unique identifier for the shared content. The server may store the shared content. A second client may request the shared content, and the request may include the unique identifier and a second location of the second client. The server may determine that the second location is within a predefined distance from the first location. Upon such determination, the server may send the shared content to the second client.

Abstract: Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user.

Abstract: Systems and methods for location-based online content sharing using unique identifiers are provided. A server and a plurality of clients may be connected to one or more networks. A first client may send a shared content to the server. The first client may also send a first location of the first client as well as a unique identifier for the shared content. The server may store the shared content. A second client may request the shared content, and the request may include the unique identifier and a second location of the second client. The server may determine that the second location is within a predefined distance from the first location. Upon such determination, the server may send the shared content to the second client.

Abstract: Systems and methods for location-based online content sharing using unique identifiers are provided. A server and a plurality of clients may be connected to one or more networks. A first client may send a shared content to the server. The first client may also send a first location of the first client as well as a unique identifier for the shared content. The server may store the shared content. A second client may request the shared content, and the request may include the unique identifier and a second location of the second client. The server may determine that the second location is within a predefined distance from the first location. Upon such determination, the server may send the shared content to the second client.

Abstract: Systems and methods for location-based online content sharing using unique identifiers are provided. A server and a plurality of clients may be connected to one or more networks. A first client may send a shared content to the server. The first client may also send a first location of the first client as well as a unique identifier for the shared content. The server may store the shared content. A second client may request the shared content, and the request may include the unique identifier and a second location of the second client. The server may determine that the second location is within a predefined distance from the first location. Upon such determination, the server may send the shared content to the second client.

Abstract: A dry polymer powder for use in enhanced petroleum recovery without being prehydrated before being added to water or brine to be introduced into a wellhead. The dry polymer powder consisting of at least one of a polyacrylamide, a copolymer of acrylamide and acrylic acid, a galactomannan, or cellulosic polymer or derivatives thereof, and the polymer can be crosslinked or not crosslinked, provided that if they are homo- or co-polymers of acrylic acid, they are not crosslinked. The dry polymer powder has a polymer size range distribution of 6.6%<40 mesh and 85.4% of 40 to 200 mesh and 8%>200 mesh, and wherein the polymer size range ensures that the dry polymer powder will efficiently hydrate in the water or brine within about one minute without forming fisheyes.

Abstract: Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user.

Abstract: A safe configured for holding valuables (137) includes a safe body (141) which bounds an interior area (270). The safe body is comprised of a plurality of engageable panels. A door (272) is releasable engageable with the body. The door includes a lock (284) that is changeable between locked and unlocked conditions.

Abstract: A dry polymer powder for use in enhanced petroleum recovery without being prehydrated before being added to water or brine to be introduced into a wellhead. The dry polymer powder consisting of at least one of a polyacrylamide, a copolymer of acrylamide and acrylic acid, a functionalized derivatives thereof, a galactomannan, or cellulosic polymer or derivatives thereof, and the polymer can be crosslinked or not crosslinked, provided that if they are homo- or co-polymers of acrylic acid, they are not crosslinked. The dry polymer powder is sized between two size limits, namely at least about 85 wt % of particles of a size smaller than about 40-mesh, and at least 75 wt % of particles of a size greater than 200-mesh, which size range ensures that the dry polymer powder will efficiently hydrate in the water or brine within about one minute without forming fisheyes.

Abstract: A hole opener includes a shaft including a plurality of axial slots formed in an outer periphery and spaced circumferentially about the shaft, a plate coupled to the outer periphery between each pair of slots, the plate including fastening wings that extend radially outwardly from each circumferential end of the plate, and a blade extending radially outwardly from a respective one of the plurality of axial slots between a fastening wing of each of adjacent plates, the blade coupled to each fastening wing.

Abstract: Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

Abstract: Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

Abstract: Systems and methods for location-based online content sharing using unique identifiers are provided. A server and a plurality of clients may be connected to one or more networks. A first client may send a shared content to the server. The first client may also send a first location of the first client as well as a unique identifier for the shared content. The server may store the shared content. A second client may request the shared content, and the request may include the unique identifier and a second location of the second client. The server may determine that the second location is within a predefined distance from the first location. Upon such determination, the server may send the shared content to the second client.

Abstract: The present disclosure generally relates to nanoparticles comprising an endo-lysosomal escape agent, a nucleic acid, and a polymer. Other aspects include methods of making and using such nanoparticles.

Abstract: Provided herein in part is a therapeutic nanoparticle that includes a biocompatible polymer; a polymer-EGFR ligand conjugate, wherein the EGFR ligand is covalently bound directly or through a chemical linker to the polymer, and a therapeutic agent.