Abstract: Methods and systems for providing continuous analyte monitoring including in vivo sensors that do not require any user calibration during in vivo use are provided. Also provided are methods and devices including continuous analyte monitoring systems that include in vivo sensors which do not require any system executed calibration or which do not require any factory based calibration, and which exhibit stable sensor sensitivity characteristics. Methods of manufacturing the no calibration sensors and post manufacturing packaging and storage techniques are also provided.

Abstract: Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned analyte sensor automatically or on demand upon request from a user.

Abstract: Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: Method and system for providing a substrate, forming a plurality of electrodes on the substrate, the electrodes including a thin gold layer on the substrate, the gold layer having a thickness of less than approximately 120 nm, and further, each of the formed plurality of electrodes are co-planar relative to each other, and providing a coverlay over at least a portion of the each of the plurality of electrodes are provided.

Abstract: In one aspect, there is provided assembling an analyte sensor with an analyte sensor insertion device, packaging the assembled analyte sensor and sensor insertion device in a substantially airtight seal, and irradiating the packaged assembled analyte sensor and sensor insertion device at a predetermined dose using one or more electron beam accelerators.

Abstract: The present invention provides N-3?-pyridyl-methyl or N-2?-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R1, R2, R3, Y, R5-R9, Ra-Rd, n and X? are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.

Abstract: A system that can intelligently drive down false positive rates with regard to identification and/or classification of spam correspondence is disclosed. Authentication information from sending domains can be stored and used to establish confidence and drive down the false positives related to acceptance and/or classification of communications. A correspondent database of known correspondents can be constructed using the authenticated information. Accordingly, decisions (e.g., white and black list) can be better informed by employing relationship and correspondent communication pattern data which is maintained within the correspondent database.

Abstract: Responding to an account reactivation request includes receiving an account reactivation request from a former subscriber having a deactivated account and automatically accessing stored account information related to the deactivated account based on the account reactivation request. The stored account information is compared with a reactivation standard to produce a comparison result. Based on the comparison result a response to the reactivation request is provided. The receiving, accessing, comparing, and responding may be performed by a computer without interaction between the former subscriber and a service representative.

Abstract: A method and apparatus for remotely performing a pipe handling operation is provided. In one aspect, the method and apparatus includes a false rotary table capable of supporting one or more tubulars during the pipe handling operation which is moveable between a position for landing one or more tubulars to a position for running one or more tubulars into a wellbore. In another aspect, the present invention provides a method and apparatus for remotely connecting elevator links alternatingly between interchangeable elevators which are capable of axially engaging one or more tubulars above the wellbore.

Abstract: The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.

Abstract: Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula I and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: A concrete mixer truck includes a truck chassis having a cab mounted at the front of the chassis. A mixing drum adapted to receive, mix and dispense concrete is mounted at a rear end of the chassis. The drum has a discharge end which faces the cab. A collector is located above the cab roof and is spaced apart from the mixing drum. A conveyor device mounted on a support frame is located generally between the cab and the drum and is utilized to transport concrete from the discharge end of said mixing drum up an inclined slope to the collector. A placement chute system directs a gravity flow of concrete from said collector to a desired location. The mixer truck utilizes the chassis, drum and other components of a standard rear discharge mixer truck to create a new type of front discharge mixer which has many of the advantages of existing front discharge mixer trucks at a reduced cost.

Abstract: A method for applying pressure to circuit components during a manufacturing operation. The method utilizes a plurality of compressed air pressure cylinders which are supported on a plurality of horizontal arms along different axes over a circuit board. Compressed air is supplied simultaneously to each of the cylinders, and the cylinders force the component onto a bonding position on the circuit board. The method permits heat sinks to be pressed against components located on the circuit board to bond the heat sinks to the components.

Abstract: An auxiliary screen unit is provided in conjunction with a desktop personal computer, for use in connection with editing a reading operations. The auxiliary screen unit has a touch-sensitive screen and stylus by means of which a user may operate a graphical user interface to select, highlight or otherwise edit text; edits may be performed on text displayed on the computer screen in the normal way using a mouse and a graphical user interface. The auxiliary screen unit and the computer are connected directly to each other so that text selected on one screen may be imported directly onto the other screen. Such an apparatus thus provides similar functional capability to that of paper, which is still the medium of choice for formulating edits.

Abstract: An image capture apparatus has a combined electronic camera and swipe scanner. The electronic camera has an optical system and detector array for remote capturing of a first image. The swipe scanner has an optical system and detector array for swipe capturing of a second image. The image capture apparatus further has a data storage arranged to store the first image and the second image in association with each other. The electronic camera may be a moderate resolution color camera, and the swipe scanner may have a grey-scale detector array capable of scanning an object at a higher resolution than the camera. A display is provided so that both images can be viewed separately in association with each other, or combined into a combination image, which has color information from the camera to colorize higher resolution pixels from the scanner.

Abstract: A method and apparatus for remotely performing a pipe handling operation is provided. In one aspect, the method and apparatus includes a false rotary table capable of supporting one or more tubulars during the pipe handling operation which is moveable between a position for landing one or more tubulars to a position for running one or more tubulars into a wellbore. In another aspect, the present invention provides a method and apparatus for remotely connecting elevator links alternatingly between interchangeable elevators which are capable of axially engaging one or more tubulars above the wellbore.

Abstract: A collapsible air vent closure is disclosed comprising a frame having a frame aperture. A closure is mounted to the frame for pivoting between a closed position and an open position. A movable vent wall having a vent orifice is interposed between the frame and the closure. The vent orifice provides an air flow path to the frame aperture when the closure is in the open position. The closure inhibits the air flow path to the frame aperture when the closure is in the closed position.

Abstract: Aspects of the present invention provide a tubular handling system for handling wellbore tubulars. In one aspect, the present invention provides a tubular handling system adapted to retain a tubular without damaging the outer surface of the tubular. In another aspect, the present invention provides a method of connecting tubulars by remotely controlling the connection process, including joint compensation, alignment, make up, and interlock. In one embodiment, the tubular handling system comprises an elevator adapted to support a tubular utilizing a first portion of an upset of the tubular and a spider adapted to support the tubular utilizing a second portion of the upset. In another embodiment, at least one of the elevator and the spider is remotely controllable. In yet another embodiment, the tubular handling system comprising a joint compensator system adapted to provide fluid communication to the elevator during rotation of the tubular.