Abstract: In some scenarios, the approach may be used with two or more vehicles travelling in formation where selected vehicles may be fully or partially autonomously controlled. Information is collected at each vehicle and from the drivers and it is shared with other vehicles and drivers to make a collective decision to enter or leave autonomy.

Abstract: A reflectometry instrument includes a light source for emitting an illumination beam that illuminates the macula. A portion of the illumination beam is reflected from the macula and forms a detection beam. The detection beam is indicative of macular pigment in the macula. The instrument also includes a first mirror for reflecting the illumination beam toward the macula and for reflecting the detection beam from the macula. The instrument is configured so that the illumination beam and the detection beam remain separated between the macula and the first mirror.

Abstract: A method for operating a pipeline system includes obtaining sensor data of a gas in the pipeline system from sensors of a sensing unit. The method also includes performing a real-time and closed loop control scheme using the sensor data and a material model of the gas to determine one or more control decisions. The method also includes operating one or more controllable pipeline elements to adjust a temperature, a pressure, a flow rate, or a composition of the gas according to the one or more control decisions.

Abstract: Techniques for continuous lock-minimal checkpointing and recovery with a distributed log-based datastore are described. A continuous, fault-tolerant checkpoint process is run on a node in a cluster in a compute-optimized or memory-optimized manner, thereby checkpointing the in-memory replica state of the node to a durable checkpoint datastore. A node can partially restore its replica state by obtaining checkpoint data, which includes an identifier of a low-water mark in a journal shard. The node can attach to the journal shard using the low-mater mark as the point of attachment, enabling the node to finalize the restoration of the replica state to be current.

Abstract: An excavation vehicle capable of autonomously actuating an excavation tool or navigating an excavation vehicle to perform an excavation routine within an excavation site is described herein. Sensors mounted to the excavation vehicle and the excavation tool produce signals representative of a position and orientation of the corresponding joint relative on the excavation vehicle relative to the excavation site, a position and orientation of the excavation vehicle relative to the excavation site, and one or more features of the excavation site based on the position of the excavation vehicle within the excavation site. A set of solenoids are configured to couple to corresponding hydraulic valves of the excavation tool to actuate the valve. A controller produces actuating signals to control the joints of the excavation tool to autonomously perform the excavation routine based on the signals produced by the sensors.

Abstract: Motion detection computing devices may have difficulty determining precise motions of a user who suffers from unintended movement, such as tremors, associated with a physical or medical condition. Aspects described herein relate to motion compensation for detected motion input, e.g., 3D motion, from such users. As described herein, a system may detect the presence of rhythmic motion and/or other input characteristics within captured motion input from a user. The system may determine one or more filters to apply to the captured motion input based on the rhythmic motion, other input characteristics, and/or information in a user profile. The one or more filters may be applied to the captured motion input in order to suppress or minimize the effects of the rhythmic motion and/or other input characteristics thereby resulting in an enhanced user experience in an interactive system, such as a 3D, virtual and/or augmented reality environment.

Abstract: Pharmaceutical intermediates and methods for efficiently preparing muscimol mono-BOC and derivatives thereof in the synthesis of muscimol and congeners and derivatives thereof.

Abstract: A set of the pulses of light in a light beam is passed through a mask toward a wafer during a single exposure pass; at least a first aerial image and a second aerial image on the wafer based on pulses of light in the set of pulses that pass through the mask is generated during a single exposure pass, the first aerial image is at a first plane on the wafer and the second aerial image is at a second plane on the wafer, the first plane and the second plane being spatially distinct from each other and separated from each other by a separation distance along the direction of propagation; and a three-dimensional semiconductor component is formed.

Abstract: A method of operating a vehicle may include determining if a vehicle speed is controlled by a driver, and if the vehicle speed is controlled by the driver, determining if the vehicle is operating during night conditions. If the vehicle is operating during night conditions, activating a night drive mode that limits a maximum speed of the vehicle without regard to road speed limits.

Abstract: A pipe end fitting assembly that includes an outer body having an outer surface, an inner surface defining a first bore, and an end surface, and an inner body having an inner surface defining a second bore and an outer surface. A portion of the inner body outer surface is secured to the outer body inner surface. A passage formed in the outer body includes a first portion extending from the end surface and parallel to the first bore, and a second portion extending from the outer body outer surface to the passage first portion. A pipe end is disposed around and secured to a portion of the inner body outer surface. A jacket is disposed around the pipe and has an end secured to the outer body outer surface. The passage portions are in fluid communication with each other and a space between the jacket and the pipe.

Abstract: Described herein are compositions and methods for the production and quantification of barcoded or unique molecular identifier (UMI)-labeled substrates. In one aspect, the substrate is a bead comprising a template oligonucleotide that is elongated by successive extension reactions to provide a bead with an oligonucleotide comprising a plurality of barcodes and conserved anchor regions. Methods are also described for quantifying the amount of template oligonucleotide loaded onto the substrate and the products of the extension reaction after each round and after the final extension.

Abstract: Methods and systems of displaying substring pairs where visual demarcations delineate adjacent substring pairs from each other. The method may comprise receiving a plurality of the primary substrings, a plurality of the secondary substrings, and a plurality of visual demarcations, displaying, on an electronic display, the primary substrings and the secondary substrings arranged into substring pairs, and one of the visual demarcations in each of the correspondence areas. Additional desired visual effects may be achieved through the use of specific demarcations, demarcation placements, and substring modifications.

Abstract: Images may be periodically captured from each of a plurality of content streams comprising programs. Each of the content streams may be associated with capture parameters. The capture parameters may include information on how frequently images from the stream may be captured. The captured images may be made available to various clients for various uses, such as for display of a schedule of available programs.

Abstract: An information handling system includes a first memory device that provides a first system physical address (SPA) space for the information handling system having a first capacity. Data is stored on the first memory device with a first interleave configuration. A second memory device provides a second SPA space for the information handling system that has a second capacity that is greater than or equal to the first capacity. Without rebooting the information handling system and without halting a process, the system de-interleaves the data stored on the first memory device, stores the data on the second memory device, and re-interleaves the data.

Abstract: Information sharing is initiated between devices based on identification, by one or more of the devices, of a context in which the information is to be shared. Services to provide the shared information are identified based on a mutually agreed level of sensitivity for the information sharing. Information is shared between the devices via the services. Use of the services to share information is stopped in response to a change in context identified by one or more of the devices.

Abstract: One aspect of the present invention relates to a double stranded iRNA agent comprising an antisense strand which is complementary to a target gene and one or more lipophilic moieties conjugated to one or more internal positions on at least one strand, which provides for targeting to, and uptake by, tissues and cells of the CNS via administration to a subarachnoid space, e.g., the cisterna magna. Another aspect of the invention relates to a method of gene silencing in tissues and cells of the CNS, that includes administering to the subarachnoid space of a subject in need thereof a therapeutically effective amount of the lipophilic moieties-conjugated double-stranded iRNAs.

Abstract: A scattered light polarimetry (LSP) sub-system of a hybrid system for characterizing stress in a chemically-strengthened (CS) substrate having a top-surface and a near-surface waveguide, includes a LSP light source system, an LSP light source actuator coupled to the LSP light source system, and an optical compensator within an optical path of a LSP laser beam emitted by the LSP light source system. The optical compensator includes a half-wave plate, a half-wave plate actuator, a diffuser, and a diffuser actuator. The LSP sub-system further includes a LSP detector system in optical communication with the optical compensator through an LSP coupling prism having a LSP coupling surface, a focusing lens and a focusing lens actuator, and a support plenum having a surface and a measurement aperture, the support plenum configured to support the CS substrate at a measurement plane at the measurement aperture, and to operably support the LSP coupling prism.

Abstract: A structural chassis for a pipe repair stent includes a first reinforcement ring configured to be received in a first circumferential groove of a gasket; a second reinforcement ring, wherein a chassis axis extends centrally through the first reinforcement ring and the second reinforcement ring, the second reinforcement ring axially spaced from the first reinforcement ring and configured to be received in a second circumferential groove of the gasket; a first groove cover axially aligned with and disposed radially outward of the first reinforcement ring, relative to the chassis axis, to cover and protect the first reinforcement ring; and a second groove cover axially aligned with and disposed radially outward of the second reinforcement ring, relative to the chassis axis, to cover and protect the second reinforcement ring.

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.