Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Abstract: An applicator device includes a photo-active formulation assembly and a photo-dose assembly operably coupled to the photo-active formulation assembly. The photo-active formulation assembly includes one or a plurality of dispenser portions and one or more photo-activatable formulation reservoirs. The photo-active formulation assembly is operable to dispense a photo-activatable formulation from the one or more photo-activatable formulation reservoirs onto one or more regions of a biological surface. The photo-dose assembly includes at least one illuminator oriented to focus electromagnetic energy onto one or more focal regions of a biological surface. The focused electromagnetic energy is of a character and for a duration sufficient to photo-activate the photo-activatable formulation dispensed from the one or more photo-activatable formulation reservoirs.

Abstract: Systems, methods and computer readable media for material separation and conveying using tuned waves are disclosed.

Abstract: Sunscreen formulations and systems for sun protection and related methods of use are described herein.

Abstract: Forward and/or backward compatibility between an invoking program and the invoked program can be maintained by using compatibility indicators and/or annotations to configuration settings that specify the desired behavior of the invoked program. Compatibility indicators and/or annotations can be used to override default behavior to ensure compatibility between a version of a program and a version or revision of a dependency of the program. Annotations can be made to configuration settings or to initialization programs and/or files. Configuration and/or initialization settings for the program can be annotated to indicate when default behavior of the dependency is to be overridden to provide alternate behavior. Configuration settings for the program can be annotated to indicate when future revisions to the dependency are to be applied.

Abstract: A system, including an adaptive noise cancellation sub-system, wherein the system is configured to adjust operation of the sub-system from a first operating state to a second operating state upon a determination that operation of the adaptive noise cancellation sub-system will be effectively affected by an own voice body conducted noise phenomenon.

Abstract: Techniques are described for automatically and dynamically modifying ongoing operation of computing devices in device-specific manners, such as to improve ongoing performance of the computing devices by modifying configuration settings on the computing devices or on associated systems in communication with the computing devices. The techniques may include generating one or more decision structures that are each specific to a type of measured performance effect, and using the decision structure(s) to improve corresponding performance of a computing device, with the generating of the decision structure(s) including analyzing training data that associates prior measured performance effects with corresponding attributes of computing devices and of modification actions that were performed for the computing devices.

Abstract: A container constructed from paperboard, card board stock, etc., includes at least one panel that is configured to be removed from the container. The panel is configured, for example, with a plurality of score lines, to enable the panel to transition from its primary configuration to a different, secondary configuration. The secondary configuration can form a handle, a stirrer or mixing stick, etc., for use with the contents of the packaging. The container can be included as part of a kit that is presented at a point of sale.

Abstract: A system for treating a surface and applying adhesive to an already treated portion of the surface concurrently is presented. The system comprises surface treatment equipment, adhesive application equipment, and a common feed system. The surface treatment equipment is configured to treat the surface of an elongated member. The adhesive application equipment is configured to apply adhesive to the already treated portion of the surface. The common feed system feeds the elongated member beneath the surface treatment equipment and the adhesive application equipment concurrently.

Abstract: An automated rover device removes material from opposite surfaces of an elongate part, such as a composite stiffener. The device includes a pair of material removal tools along with a vacuum assembly for vacuuming away material removed by the tools.

Abstract: Systems and methods for manufacturing eyelash prostheses are described.

Abstract: Optical connectors may include various portions, or structures, to provide a plurality of degrees of movement to optical ferrules. The optical ferrules may be linearly movable along one or more axes and rotationally moveable about one or more axes for alignment and coupling to corresponding optical ferrules. The optical connectors may be integrated with, or in conjunction with, other non-optical connectors such as electrical connectors, e.g., located on a drive carrier.

Abstract: A device, including a vibratory apparatus having an actuator configured to generate vibrations upon actuation of the actuator, including plurality of lever arms, wherein the vibratory apparatus is configured such that at least a respective portion of respective lever arms of the plurality of lever arms move about at least one of a single or a respective hinge when the vibratory apparatus is generating vibrations.

Abstract: Volatile liquid applicator systems and fume-filtering apparatuses and related method of use are described.

Abstract: The invention provides an optical connector for coupling with a complementary optical connector and for supporting an optical component. The connector comprises a cover moveable between a first and second position. The cover may also comprise a moveable shield and biasing components. There is also provided an optical connector assembly comprising covers that sequentially open. A PCB comprising waveguides and an optical component sub-mount for integrating with the PCB is also presented.

Abstract: An end effector is capable of being used to stimulate a portion of skin at a stimulation frequency. The end effector includes a base portion that is couplable to a motor and an end portion having a plurality of contact points at which the end effector is configured to contact the portion of skin. The plurality of contact points are located at a target distance from each other that is based on an inverse of the stimulation frequency. The end effector is configured such that, when the base portion is coupled to the motor and the motor is operating, the end effector has a resonant frequency based on the stimulation frequency. When the motor is operating and a force is applied to bias the end effector toward the portion of skin, a cyclical stimulus is produced within the portion of skin at about the stimulation frequency.

Abstract: The disclosed embodiments provide skin stimulating devices and methods that address the aging effects of skin at a protein level. Particularly, cyclical mechanical strain is used to regulate specific proteins within the skin, so as to produce specific effects. As a non-limiting example, the disclosed embodiments can be used to increase the production of certain proteins (e.g., hyaluronan synthase 3 (HAS3); fibronectin; tropoelastin; procoll1; integrin, etc.) in the skin, which results in anti-aging effects by increasing epidermal cohesion.

Abstract: An applicator includes a roller, a treatment composition component, a cutaneous measurement component, and a controller. The roller contacts a portion of skin at a contact location and subsequently a target location. The treatment composition component selectively deposits a composition on a roller surface at a deposition location that is on the roller surface a circumferential distance away from the contact location. The cutaneous measurement component generates one or more parameters associated with the target location on the portion of skin. The target location is a target distance from the contact location that is equal to or greater than the circumferential distance. The controller controls the treatment composition component to selectively deposit the treatment composition on the roller surface in response to the one or more parameters associated with the target location on the portion of skin generated by the cutaneous measurement component.

Abstract: A system for manufacturing a drive shaft assembly comprises a welding apparatus configured to weld a tube to an end fitting to form the drive shaft assembly having an annular weld. A transport apparatus is configured to transport the drive shaft assembly away from the welding apparatus. A knurling apparatus receives the drive shaft assembly from the transport apparatus. The knurling apparatus is configured to knurl the weld of the drive shaft assembly. The knurling apparatus includes a pair of knurling plates having textured surfaces in facing relationship. One of the knurling plates is configured to move relative to the other of the knurling plates to roll the drive shaft assembly between the textured surfaces, thereby knurling the weld to improve an appearance and texture of the outer surface of the drive shaft assembly.

Abstract: An applicator for treating skin conditions includes at least one treatment composition component and a discontinuity identification component. The at least one treatment composition component is configured to selectively deposit a treatment composition at a deposit location on the portion of skin. The discontinuity identification component is operably coupled to an electromagnetic energy detector. The discontinuity identification component includes circuitry configured to monitor a level of the one or more parameters as the applicator traverses the portion of skin and to control the at least one treatment composition component to selectively deposit the treatment composition to the deposit location on the portion of skin based on one or more inputs indicative of a decrease in reflection of an electromagnetic energy interrogation stimulus from the portion of skin at the deposit location.