Patents by Inventor Allen T. Hopper

Allen T. Hopper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TRE
    Publication number: 20240002375
    Abstract: The present disclosure features compounds of formula (1-a) and of formula (II) and pharmaceutical compositions thereof. The present disclosure further discloses the compounds of formula (I-a) and (II) and their compositions for use in methods of modulating nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as said compounds for use in methods of treating e.g.: ?proliferative diseases, such as e.g. cancer, benign neoplasms or angiogenesis, ?neurological diseases or disorders, such as e.g. Huntington's disease, ?autoimmune diseases or disorders, immunodeficiency diseases or disorders, lysosomal storage disease or disorder, cardiovascular diseases or disorders, metabolic diseases or disorders, respiratory diseases or disorders, renal diseases or disorders, or infectious diseases. Exemplary compounds are e.g. 2-(indazol-5-yl)-6-(piperidin-4-yl)-1,7-naphthyridine derivatives and similar compounds.
    Type: Application
    Filed: July 2, 2021
    Publication date: January 4, 2024
    Inventors: Dominic Reynolds, Michael W. Seiler, Anant A. Agrawal, Frederic Vaillancourt, Peter Smith, Stepan Vyskocil, Allen T. Hopper, Sudeep Prajapati
  • PYRIDAZINE DERIVATIVES FOR MODULATING NUCLEIC ACID SPLICING
    Publication number: 20230365526
    Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.
    Type: Application
    Filed: February 28, 2021
    Publication date: November 16, 2023
    Inventors: Dominic Reynolds, Michael W. Seiler, Anant A. Agrawal, Frederic Vaillancourt, Peter Smith, Allen T. Hopper
  • COMPOUNDS AND METHODS FOR MODULATING SPLICING
    Publication number: 20230167093
    Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.
    Type: Application
    Filed: April 8, 2021
    Publication date: June 1, 2023
    Applicants: REMIX THERAPEUTICS INC., REMIX THERAPEUTICS INC.
    Inventors: Dominic Reynolds, Serge Leger, Michael W. Seiler, Anant A. Agrawal, Frederic Vaillancourt, Peter Smith, Allen T. Hopper, Olivier Soueidan
  • COMPOUNDS AND METHODS FOR MODULATING SPLICING
    Publication number: 20230159496
    Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.
    Type: Application
    Filed: April 8, 2021
    Publication date: May 25, 2023
    Inventors: Dominic Reynolds, Serge Leger, Michael W. Seiler, Anant A. Agrawal, Frederic Vaillancourt, Peter Smith, Allen T. Hopper, Sudeep Prajapati, Olivier Soueidan
  • COMPOUNDS AND METHODS FOR MODULATING SPLICING
    Publication number: 20230148184
    Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.
    Type: Application
    Filed: February 28, 2021
    Publication date: May 11, 2023
    Inventors: Dominic Reynolds, Michael W. Seiler, Anant A. Agrawal, Frederic Vaillancourt, Peter Smith, Allen T. Hopper
  • PYRIDAZINE DERIVATIVES FOR MODULATING NUCLEIC ACID SPLICING
    Publication number: 20230140983
    Abstract: The present disclosure features compounds and related compositions that, inter alia, modulate nucleic acid splicing, e.g., splicing of a pre-mRNA, as well as methods of use thereof.
    Type: Application
    Filed: February 28, 2021
    Publication date: May 11, 2023
    Inventors: Dominic Reynolds, Michael W. Seiler, Anant A. Agrawal, Frederic Vaillancourt, Allen T. Hopper, Peter Smith
  • Compositions and methods for treating infections
    Patent number: 11530198
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: December 20, 2022
    Assignee: Vyera Pharmaceuticals, LLC
    Inventors: Stephen B. Thomas, Allen T. Hopper, Matthew Welsch
  • CDPK1 inhibitors, compositions, and methods related thereto
    Patent number: 11518761
    Abstract: The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: December 6, 2022
    Assignees: Vyera Pharmaceuticals, LLC, Washington University
    Inventors: Allen T. Hopper, L. David Sibley, James W. Janetka, Jon Helander
  • CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
    Publication number: 20210347780
    Abstract: The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: September 19, 2019
    Publication date: November 11, 2021
    Inventors: Allen T. HOPPER, L. David SIBLEY, James W. JANETKA
  • CDPK1 INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO
    Publication number: 20210115047
    Abstract: The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: March 15, 2018
    Publication date: April 22, 2021
    Inventor: Allen T. Hopper
  • CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
    Publication number: 20210032240
    Abstract: The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: August 17, 2018
    Publication date: February 4, 2021
    Inventors: Allen T. Hopper, L. David Sibley, James W. Janetka, Jon Helander
  • COMPOSITIONS AND METHODS FOR TREATING INFECTIONS
    Publication number: 20200407345
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: September 10, 2020
    Publication date: December 31, 2020
    Inventors: Stephen B. Thomas, Allen T. Hopper, Matthew Welsch
  • Compositions and methods for treating infections
    Patent number: 10774073
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: September 15, 2020
    Assignee: Vyera Pharmaceuticals, LLC
    Inventors: Stephen B. Thomas, Allen T. Hopper, Matthew Welsch
  • DHFR INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
    Publication number: 20200270233
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: August 6, 2018
    Publication date: August 27, 2020
    Inventors: Allen T. Hopper, Stephen B. Thomas, Mattthew Welsch
  • BENZAMIDES-CONTAINING COMPOUNDS AND THEIR USE IN THE TREATMENT OF DEPRESSION
    Publication number: 20200054630
    Abstract: The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of depression.
    Type: Application
    Filed: February 25, 2019
    Publication date: February 20, 2020
    Inventors: JOHN PAUL KILBURN, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohamed Eldemenky, Bin Chen, Yu Jiang, Allen T. Hopper
  • Benzamides-containing compounds and their use in the treatment of epilepsy
    Patent number: 10238654
    Abstract: The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of epilepsy.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: March 26, 2019
    Assignee: MINDIMMUNE THERAPEUTICS, INC.
    Inventors: John Paul Kilburn, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohamed Eldemenky, Bin Chen, Yu Jiang, Allen T. Hopper
  • COMPOSITIONS AND METHODS FOR TREATING INFECTIONS
    Publication number: 20190077794
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: February 2, 2017
    Publication date: March 14, 2019
    Applicants: Vyera Pharmaceuticals, LLC, Vyera Pharmaceuticals, LLC
    Inventors: Stephen Thomas, Allen T. Hopper, Matthew Welsch
  • INHIBITOR OF THE P2X7 RECEPTOR
    Publication number: 20180319786
    Abstract: The present invention provides (S)-N-(2-(4-chlorophenyl)-2-morpholinoethyl)-2-(pyrimidin-2-yl)-4-(trifluoro-methyl)thiazole-5-carboxamide as P2X7 inhibitor, its use as a medicament, and a convenient enantiomeric synthesis protocol for the preparation of (S)-N-(2-(4-chlorophenyl)-2-morpholinoethyl)-2-(pyrimidin-2-yl)-4-(trifluoromethyl)thiazole-5-carboxamide.
    Type: Application
    Filed: November 1, 2016
    Publication date: November 8, 2018
    Inventors: John Paul KILBURN, Allen T. HOPPER, Martin JUHL
  • Benzamides-Containing Compounds and Their Use in the Treatment of Epilepsy
    Publication number: 20170202836
    Abstract: The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of epilepsy.
    Type: Application
    Filed: April 5, 2017
    Publication date: July 20, 2017
    Applicant: H. Lundbeck A/S
    Inventors: John Paul Kilburn, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohamed Eldemenky, Bin Chen, Yu Jiang, Allen T. Hopper
  • Benzamide-containing compounds and their use in the treatment of pain
    Patent number: 9649308
    Abstract: The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of pain.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: May 16, 2017
    Assignee: H. Lundbeck A/S
    Inventors: John Paul Kilburn, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohamed Eldemenky, Bin Chen, Yu Jiang, Allen T. Hopper