Patents by Inventor Allen T. Hopper

Allen T. Hopper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CDPK1 INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
    Publication number: 20210032240
    Abstract: The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: August 17, 2018
    Publication date: February 4, 2021
    Inventors: Allen T. Hopper, L. David Sibley, James W. Janetka, Jon Helander
  • COMPOSITIONS AND METHODS FOR TREATING INFECTIONS
    Publication number: 20200407345
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: September 10, 2020
    Publication date: December 31, 2020
    Inventors: Stephen B. Thomas, Allen T. Hopper, Matthew Welsch
  • Compositions and methods for treating infections
    Patent number: 10774073
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: September 15, 2020
    Assignee: Vyera Pharmaceuticals, LLC
    Inventors: Stephen B. Thomas, Allen T. Hopper, Matthew Welsch
  • DHFR INHIBITORS, COMPOSITIONS, AND METHODS RELATED THERETO
    Publication number: 20200270233
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: August 6, 2018
    Publication date: August 27, 2020
    Inventors: Allen T. Hopper, Stephen B. Thomas, Mattthew Welsch
  • BENZAMIDES-CONTAINING COMPOUNDS AND THEIR USE IN THE TREATMENT OF DEPRESSION
    Publication number: 20200054630
    Abstract: The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of depression.
    Type: Application
    Filed: February 25, 2019
    Publication date: February 20, 2020
    Inventors: JOHN PAUL KILBURN, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohamed Eldemenky, Bin Chen, Yu Jiang, Allen T. Hopper
  • Benzamides-containing compounds and their use in the treatment of epilepsy
    Patent number: 10238654
    Abstract: The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of epilepsy.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: March 26, 2019
    Assignee: MINDIMMUNE THERAPEUTICS, INC.
    Inventors: John Paul Kilburn, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohamed Eldemenky, Bin Chen, Yu Jiang, Allen T. Hopper
  • COMPOSITIONS AND METHODS FOR TREATING INFECTIONS
    Publication number: 20190077794
    Abstract: The invention relates to inhibitors of dihydrofolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. brucei, or L. major infections, using the novel inhibitors of the invention.
    Type: Application
    Filed: February 2, 2017
    Publication date: March 14, 2019
    Applicants: Vyera Pharmaceuticals, LLC, Vyera Pharmaceuticals, LLC
    Inventors: Stephen Thomas, Allen T. Hopper, Matthew Welsch
  • INHIBITOR OF THE P2X7 RECEPTOR
    Publication number: 20180319786
    Abstract: The present invention provides (S)-N-(2-(4-chlorophenyl)-2-morpholinoethyl)-2-(pyrimidin-2-yl)-4-(trifluoro-methyl)thiazole-5-carboxamide as P2X7 inhibitor, its use as a medicament, and a convenient enantiomeric synthesis protocol for the preparation of (S)-N-(2-(4-chlorophenyl)-2-morpholinoethyl)-2-(pyrimidin-2-yl)-4-(trifluoromethyl)thiazole-5-carboxamide.
    Type: Application
    Filed: November 1, 2016
    Publication date: November 8, 2018
    Inventors: John Paul KILBURN, Allen T. HOPPER, Martin JUHL
  • Benzamides-Containing Compounds and Their Use in the Treatment of Epilepsy
    Publication number: 20170202836
    Abstract: The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of epilepsy.
    Type: Application
    Filed: April 5, 2017
    Publication date: July 20, 2017
    Applicant: H. Lundbeck A/S
    Inventors: John Paul Kilburn, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohamed Eldemenky, Bin Chen, Yu Jiang, Allen T. Hopper
  • Benzamide-containing compounds and their use in the treatment of pain
    Patent number: 9649308
    Abstract: The present invention is directed to benzamide-containing compounds of formula I or pharmaceutically acceptable salts thereof which inhibit the P2X7 receptor, and their use in the treatment of pain.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: May 16, 2017
    Assignee: H. Lundbeck A/S
    Inventors: John Paul Kilburn, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohamed Eldemenky, Bin Chen, Yu Jiang, Allen T. Hopper
  • Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
    Patent number: 9265734
    Abstract: This invention relates to compounds of Formula (I) wherein Cy1, L1, Y, R1, L2, and Ar2 are defined herein, for the treatment of cancers, inflammatory disorders, and neurological conditions.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: February 23, 2016
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventors: James R. Rusche, Norton P. Peet, Allen T. Hopper
  • Benzamides
    Publication number: 20150283134
    Abstract: The present invention is directed to benzamide containing compounds which inhibit the P2X7 receptor
    Type: Application
    Filed: June 19, 2015
    Publication date: October 8, 2015
    Inventors: John Paul Kilburn, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohamed Eldemenky, Bin Chen, Yu Jiang, Allen T. Hopper
  • Benzamides
    Patent number: 9102591
    Abstract: The present invention is directed to benzamide containing compounds which inhibit the P2X7 Receptor.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: August 11, 2015
    Assignee: H. Lundbeck A/S
    Inventors: John Paul Kilburn, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohammed Eldemenky, Bin Chen, Yu Jiang, Allen T. Hopper
  • Benzamides
    Publication number: 20140107340
    Abstract: The present invention is directed to benzamide containing compounds which inhibit the P2X7 receptor
    Type: Application
    Filed: October 10, 2013
    Publication date: April 17, 2014
    Applicant: H. Lundbeck A/S
    Inventors: John Paul Kilburn, Lars Kyhn Rasmussen, Mikkel Jessing, Eman Mohammed Eldemenky, Bin Chen, Yu Jiang, Allen T. Hopper
  • Compositions Including 6-Aminohexanoic Acid Derivatives As HDAC Inhibitors
    Publication number: 20120094971
    Abstract: This invention relates to compounds of Formula (I) wherein Cy1, L1, Y, R1, L2, and Ar2 are defined herein, for the treatment of cancers, inflammatory disorders, and neurological conditions.
    Type: Application
    Filed: September 3, 2009
    Publication date: April 19, 2012
    Applicant: REPLIGEN CORPORATION
    Inventors: James R. Rusche, Norton P. Peet, Allen T. Hopper
  • Heterocyclic compounds, methods for the preparation thereof, and uses thereof
    Patent number: 7994199
    Abstract: The compounds of the present invention are of formula I: wherein A, R3, R4 is as defined herein, are useful as ligands for nicotinic receptors.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: August 9, 2011
    Assignee: Memory Pharmaceuticals Corporation
    Inventors: Brian Herbert, Wenge Xie, Truc Minh Nguyen, Allen T Hopper, Ashok Tehim
  • PHOSPHODIESTERASE 4 INHIBITORS
    Publication number: 20100173942
    Abstract: PDE4 inhibition is achieved by novel nitroxide compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formulas I-III: wherein A, B, D, R1, R2, R3, R7, R8, R9, R10 and R6 are as defined herein.
    Type: Application
    Filed: March 16, 2010
    Publication date: July 8, 2010
    Inventors: Richard A. Schumacher, Elizabeth Doorly Graham, Allen T. Hopper, Ashok Tehim
  • HETEROCYCLIC COMPOUNDS, METHODS FOR THE PREPARATION THEREOF, AND USES THEREOF
    Publication number: 20100173891
    Abstract: The compounds of the present invention are of formula I: wherein A, R3, R4 is as defined herein, are useful as ligands for nicotinic receptors.
    Type: Application
    Filed: March 16, 2010
    Publication date: July 8, 2010
    Inventors: Brian Herbert, Wenge Xie, Truc Minh Nguyen, Allen T. Hopper, Ashok Tehim
  • Heterocyclic compounds, methods for the preparation thereof, and uses thereof
    Patent number: 7700630
    Abstract: The compounds of the present invention are of formula I: wherein A, R3, R4 is as defined herein, are useful as ligands for nicotinic receptors.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: April 20, 2010
    Assignee: Memory Pharmaceuticals Corporation
    Inventors: Brian Herbert, Wenge Xie, Truc Minh Nguyen, Allen T Hopper, Ashok Tehim
  • Phosphodiesterase 4 inhibitors
    Patent number: 7700631
    Abstract: PDE4 inhibition is achieved by novel nitroxide compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formulas I-III: wherein A, B, D, R1, R2, R3, R7, R8, R9, R10 and R6 are as defined herein.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: April 20, 2010
    Assignee: Memory Pharmaceuticals Corporation
    Inventors: Richard A. Schumacher, Elizabeth Doorly Graham, Allen T. Hopper, Ashok Tehim