Abstract: A wearable device has a flexible and extendable body configured to encircle a portion of a body of a user, an electronics module with a concave space between two ends, each end attachable to the flexible and extendable body with a flexible retention mount to allow rotation of the flexible and extendable body relative to the electronics module and to transfer tension force from the flexible and extendable body to the electronics module, and a bio-signal sensor disposed on the flexible and extendable body to contact at least part of the body of the user and to receive bio-signals from the user.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat depression, neurocognitive disorders, autism spectrum disorder, and/or attention-deficit/hyperactivity disorder.

Abstract: A system and method for isolating electronic data and generating enhanced data. A data subscription unit receives data having plural data formats from data source devices. The data may be received pre-filtered or filtered by the data subscription unit. A modeling unit may receive the filtered data from the storage databases, may determine eligibility of the stored data based on eligibility criteria, sort the eligible data based on at least one sorting parameter, adjust and/or normalize the eligible data based on at least one adjustment parameter and/or an aggregate value for a data attribute, generate data metrics over a defined set of time periods based on the eligible data, generate further data metrics based on the data metrics, and derive specified values from these metrics. A data distribution device may transmit or make available the data metrics, further data metrics and values to remote devices.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

Abstract: Provided herein are certain compounds useful as HTT modulators. Such compound are useful in the treatment of Huntington's disease.

Abstract: There is described a system for providing an interface with activity recommendations by monitoring user activity in which user data relating to a user is received at a user device. The user data comprises at least image data, text input, biometric data, and audio data, and may have been captured using one or more sensors on the user device. The user data is processed using at least: facial analysis; body analysis; eye tracking; voice analysis; behavioural analysis; social network analysis; location analysis; user's activities analysis; and text analysis. Based on the user data, one or more states of one or more cognitive-affective competencies of the user may be determined. An emotional signature of the user is determined, based on the one or more states of the one or more cognitive-affective competencies of the user. Based on the emotional signature, one or more recommendations for improving the emotional signature may be recommended.

Abstract: A method for determining that a patient interface component comprising a vent has been replaced between therapy sessions of treatment of sleep disordered breathing, the method comprising: acquiring or receiving first vent flow rate data representing one or more estimated first vent flow rates of gas through a first vent of a patient interface in use during a first therapy session; acquiring or receiving second vent flow rate data representing one or more estimated second vent flow rates of gas through a second vent of a patient interface in use during a second therapy session after the first therapy session; and identifying, by comparison of the second vent flow rate data to the first vent flow rate data, a difference in resistance to flow through the first vent than through the second vent indicating that the second vent is not the same vent as the first vent.

Abstract: Methods and systems are provided for facilitating comparison of gemstones having multiple attributes that characterize the gemstones. A facilitated comparison system receives from a user a selection of a gemstone in a collection of the gemstones. Each gemstone in the collection is associated with a selling index indicating a probability of the gemstone being bought by a customer. For each of a predetermined set of the attributes, the system determines one or more comparable ranges. The system identifies alternate gemstones to recommend using the comparable ranges for the attributes and the selling indices of the gemstones. The system displays to the user the selected gemstone and one or more of the alternate gemstones for comparison.

Abstract: A system and method for isolating electronic data and generating enhanced data. A data subscription unit receives data having plural data formats from data source devices. The data may be received pre-filtered or filtered by the data subscription unit. A modeling unit may receive the filtered data from the storage databases, may determine eligibility of the stored data based on eligibility criteria, sort the eligible data based on at least one sorting parameter, adjust and/or normalize the eligible data based on at least one adjustment parameter and/or an aggregate value for a data attribute, generate data metrics over a defined set of time periods based on the eligible data, generate further data metrics based on the data metrics, and derive specified values from these metrics. A data distribution device may transmit or make available the data metrics, further data metrics and values to remote devices.

Abstract: Methods and systems are provided for facilitating comparison of gemstones having multiple attributes that characterize the gemstones. A facilitated comparison system receives from a user a selection of a gemstone in a collection of the gemstones. Each gemstone in the collection is associated with a selling index indicating a probability of the gemstone being bought by a customer. For each of a predetermined set of the attributes, the system determines one or more comparable ranges. The system identifies alternate gemstones to recommend using the comparable ranges for the attributes and the selling indices of the gemstones. The system displays to the user the selected gemstone and one or more of the alternate gemstones for comparison.

Abstract: Methods and systems are provided for facilitating comparison of gemstones having multiple attributes that characterize the gemstones. A facilitated comparison system receives from a user a selection of a gemstone in a collection of the gemstones. Each gemstone in the collection is associated with a selling index indicating a probability of the gemstone being bought by a customer. For each of a predetermined set of the attributes, the system determines one or more comparable ranges. The system identifies alternate gemstones to recommend using the comparable ranges for the attributes and the selling indices of the gemstones. The system displays to the user the selected gemstone and one or more of the alternate gemstones for comparison.

Abstract: This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists.

Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.

Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.

Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.

Abstract: Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.