Patents by Inventor Amanda Johns

Amanda Johns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ethylene diamine derivatives and their use as orexin-receptor antagonists
    Patent number: 7468367
    Abstract: This invention relates to heterocyclic substituted ethylene diamine derivatives and their use as pharmaceuticals.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: December 23, 2008
    Assignee: Smithkline Beecham p.l.c.
    Inventors: Steven Coulton, Amanda Johns, Roderick Alan Porter
  • N-aroyl cyclic amines
    Patent number: 7432270
    Abstract: This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3; m represents 1, 2, or 3; p represents ) or 1; X is NR, wherein R is H or (C1-4)alkyl; Ar1 is aryl, or a mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S; any of which may be optionally substituted; A2 represents phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S, wherein the phenyl or heterocyclyl group is substituted by R1 and further optional substituents; or Ar2 represents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group containing up to 3 heteroatoms selected from N, O and S; R1 represents hydrogen, optionally substituted (C1-4)alkoxy, halo, cyano, optionally substituted (C1-6)alkyl, optionally substituted phenyl, or an optionally substituted 5- or 6-membered heterocyclyl group containing up to 4 het
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: October 7, 2008
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Clive Leslie Branch, Steven Coulton, Amanda Johns, Christopher Norbert Johnson, Roderick Alan Porter, Geoffrey Stemp, Kevin Thewlis
  • Piperidine compounds for use as orexin receptor antagoinst
    Patent number: 7423052
    Abstract: A invention relates to N aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: September 9, 2008
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, Riccardo Novelli, Roderick Alan Porter
  • Benzamide derivatives as antagonists of orexin receptors
    Patent number: 7078565
    Abstract: Disclosed are phenyl-alkylene benzamides useful as orexin antagonists
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: July 18, 2006
    Assignee: SmithKline Beecham plc
    Inventors: Wai Ngor Chan, Amanda Johns, Roderick Alan Porter, Rachel Elizabeth Anne Stead, Mythily Vimal
  • N-aroyl cyclic amines as orexin receptor antagonists
    Publication number: 20060040937
    Abstract: This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals.
    Type: Application
    Filed: September 17, 2003
    Publication date: February 23, 2006
    Applicant: Glaxo Group Limited
    Inventors: Clive Branch, Steven Coulton, Amanda Johns, David Nash, Roderick Porter, Geoffrey Stemp
  • Ethylene diamine derivatives and their use as orexin-receptor antagonists
    Publication number: 20050159421
    Abstract: This invention relates to heterocyclic substituted ethylene diamine derivatives and their use as pharmaceuticals.
    Type: Application
    Filed: December 13, 2002
    Publication date: July 21, 2005
    Inventors: Steven Coulton, Amanda Johns, Roderick Porter
  • Benzamide derivatives as antagonists of orexin receptors
    Publication number: 20050020584
    Abstract: This invention relates to certain benzamide derivatives and their use as pharmaceuticals.
    Type: Application
    Filed: October 30, 2002
    Publication date: January 27, 2005
    Inventors: Wai Chan, Amanda Johns, Roderick Porter, Rachel Stead, Mythily Vimal
  • Piperidine compounds for use as orexin receptor antagonist
    Publication number: 20040215014
    Abstract: A invention relates to N auroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Application
    Filed: December 17, 2003
    Publication date: October 28, 2004
    Inventors: Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, Riccardo Novelli, Roderick Alan Porter
  • N-aroyl cyclic amine derivatives as orexin receptor antagonists
    Publication number: 20040180887
    Abstract: This invention relates to N-aroyl cyclic amine derivatives of formula (1), wherein X represents a bond, oxygen, NR3 or a group (CH2), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an optionally substituted bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; Ar2 represents an optionally substituted phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S and their use as pharmaceuticals, specifically as orexin receptor antagonists.
    Type: Application
    Filed: April 26, 2004
    Publication date: September 16, 2004
    Inventors: Clive Leslie Branch, Wai Ngor Chan, Amanda Johns, Christopher Norbert Johnson, David John Nash, Riccardo Novelli, Jean-Pierre Pilleux, Roderick Porter, Rachel Elizabeth Anne Stead, Geoffrey Stemp
  • N-aroyl cyclic amines
    Publication number: 20040143115
    Abstract: This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists 1
    Type: Application
    Filed: November 5, 2003
    Publication date: July 22, 2004
    Inventors: Clive Leslie Branch, Steven Coulton, Amanda Johns, Christopher Norbert Johnson, Roderick Alan Porter, Geoffrey Stemp, Kevin Thewlis
  • Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
    Patent number: 6699879
    Abstract: The present invention provides phenyl urea and phenyl thiourea derivatives which are non-peptide antagonists of human orexin receptors, in particular orexin-1 receptors, of formula (I) in which: Z represents oxygen or sulfur; and R1 to R7 represent various substituent groups; and pharmaceutically acceptable salts thereof. In particular, these compounds are of potential use in the treatment of obesity including obesity observed in Type 2(non-insulin-dependent) diabetes patients and/or sleep disorders.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: March 2, 2004
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Steven Coulton, Amanda Johns, Roderick Alan Porter
  • Phenyl urea and phenyl thiourea derivatives
    Patent number: 6596730
    Abstract: Compounds of formula (I): in which: one of X and Y is N and the other is CH; Z represents oxygen or sulfur; and R1 to R7 represent various substituent groups; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: July 22, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Steven Coulton, Amanda Johns, Roderick Alan Porter
  • Phenyl urea and phenyl thiourea derivatives as HFGAN72 antagonists
    Patent number: 6410529
    Abstract: Phenyl urea and phenylthiourea derivatives, processes for their production and their uses as pharmaceuticals are disclosed.
    Type: Grant
    Filed: May 10, 2000
    Date of Patent: June 25, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: George Chan, Amanda Johns, Anthony Jurewicz, Roderick Alan Porter, Katherine Widdowson
  • Phenylurea and phenylthio urea derivatives
    Patent number: 6372757
    Abstract: Phenyl urea and phenyl thiourea derivatives and their use as pharmaceuticals.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: April 16, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Amanda Johns, Roderick Alan Porter
  • Substituted tetrahydro isoquinolines as modulators of dopamine D3 receptors
    Patent number: 6274593
    Abstract: The present invention provides compounds of formula (I): which are useful as antipsychotic agents.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: August 14, 2001
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Amanda Johns, David John Nash, Geoffrey Stemp
  • Tetrahydroisoquinoline derivatives as modulators of dopamine D.sub.3 receptors
    Patent number: 6046210
    Abstract: This invention relates to compounds of formula (I): ##STR1## which are useful as modulators of D.sub.3 receptors, in particular in the treatment of psychoses.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: April 4, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Geoffrey Stemp, Amanda Johns