Abstract: Provided herein are compounds and methods for modulating claudin-1 (CLDN1). More particularly, provided are inhibitors claudin-1 and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer.

Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

Abstract: The various implementations described herein include methods and devices for constructing phrases for data visualizations. In one aspect, a method includes presenting a data visualization page to a user including a visualization region and a phrase region; obtaining a dataset including a plurality of fields; displaying a phrase affordance for constructing a phrase; in response to a user selection of the phrase affordance, presenting a phrase construction menu including a set of fields; in response to a user selection of a field, presenting a set of aggregation operators selected based on a field type of the field; in response to a user selection of an aggregation operator, generating a first phrase using the selected field and the selected aggregation operator; presenting a data visualization generated using the first phrase; and displaying the first phrase as an active phrase in the phrase region.

Abstract: One or more video creation configuration parameters may be selected based on user input. A plurality of remote computing devices may be selected based at least in part on the video creation configuration parameters. A respective video creation request message may be transmitted to each of the remote computing devices. A plurality of video creation response messages may be received from the remote computing device. Each response message may include a respective input video. An aggregate video may be rendered based on the input videos and stored on a storage device.

Abstract: A roof structure for an agricultural vehicle includes an upper roof assembly and a lower roof assembly connectable to the upper roof assembly. The lower roof assembly or the upper roof assembly includes a ventilation opening for guiding air-conditioned air and a circulation opening for supplying recirculated air. An air-guiding element is arranged between the lower and upper roof assembly. The air-guiding element is further disposed at the circulation opening and the ventilation opening such that a region sealed in relation to an external environment is formed.

Abstract: Embodiments are directed to managing visualizations of data using a network computer. A modeling engine may provide a data model that includes a plurality of data objects and a display model that includes a plurality of display objects based on the plurality of data objects. Parameter action objects may be associated with display objects in the display model. In response to an activation of the parameter action objects, values associated with display objects may be assigned to the parameter associated with a parameter action object and actions associated with the parameter may be executed to modify the display model.

Abstract: In various embodiments methods of distinguishing Crohn's disease from ulcerative colitis are provided. In certain embodiments the methods comprise determining, or causing to be determined, the level of IgG antibodies that bind a malondialdehyde-acetaldehyde adduct (MAA adduct) in a biological sample from a mammal, where an elevated level of said antibodies as compared to the average level found in a mammal with Crohn's disease is an indicator that the mammal has ulcerative colitis rather than Crohn's disease.

Abstract: One or more video creation configuration parameters may be selected based on user input. A plurality of remote computing devices may be selected based at least in part on the video creation configuration parameters. A respective video creation request message may be transmitted to each of the remote computing devices. A plurality of video creation response messages may be received from the remote computing device. Each response message may include a respective input video. An aggregate video may be rendered based on the input videos and stored on a storage device.

Abstract: In certain embodiments, the present invention provides methods of identifying and treating a transplant recipient patient having transplantation tolerance induced by apoptotic donor leukocytes infused under cover of transient immunotherapy.

Abstract: A vapor dispensing apparatus includes a housing configured to support a refill therein. The housing has a vent formed therein. The refill includes a bottle having a body defining an interior volume for storing a vaporizable liquid. A wick, configured to draw the vaporizable liquid out of the bottle, includes an inferior portion disposed in the interior volume and a superior portion extending from the inferior portion and terminating outside the bottle adjacent the vent. The wick is an elongated member having a hollow wick core formed in the superior portion to provide a tubular wick section. An electric warmer is supported in the housing and configured to couple with a power supply. The electric warmer includes a heating element received in the hollow wick core for warming the wick above an ambient temperature.

Abstract: Embodiments are directed to managing visualizations of data using a network computer. A modeling engine may provide a data model that includes a plurality of data objects and a display model that includes a plurality of display objects based on the plurality of data objects. Parameter action objects may be associated with display objects in the display model. In response to an activation of the parameter action objects, values associated with display objects may be assigned to the parameter associated with a parameter action object and actions associated with the parameter may be executed to modify the display model.

Abstract: Embodiments are directed to managing visualizations of data using a network computer. A modeling engine may provide a data model that includes a plurality of data objects and a display model that includes a plurality of display objects based on the plurality of data objects. Parameter action objects may be associated with display objects in the display model. In response to an activation of the parameter action objects, values associated with display objects may be assigned to the parameter associated with a parameter action object and actions associated with the parameter may be executed to modify the display model.

Abstract: The invention provides a method of treating an adult subject having a hematological cancer, comprising administering to the subject selected dosage regimens comprising a plurality of immune effector cells expressing a CAR molecule in combination with a BTK inhibitor.

Abstract: The present invention relates to a process for the preparation of apalutamide. In particular, the present invention relates to a process for the preparation of apalutamide and its intermediates. The present invention also relates to pharmaceutical compositions comprising apalutamide.

Abstract: Presented herein is a high-throughput (HTP) genomic engineering platform for improving the production of therapeutic proteins in Chinese hamster ovary (CHO) cells. The disclosed HTP genomic engineering platform is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. The platform utilizes a unique suite of HTP genetic engineering tools to explore the genomic landscape associated with therapeutic protein production pathways, in order to unravel the biological drivers and disentangle the uncharacterized genetic architecture responsible for optimizing therapeutic protein production in CHO cells.

Abstract: The present invention relates to a process for the preparation of apalutamide. In particular, the present invention relates to a process for the preparation of apalutamide and its intermediates. The present invention also relates to pharmaceutical compositions comprising apalutamide.

Abstract: Embodiments are directed to managing visualizations of data using a network computer. A modeling engine may provide a data model that includes a plurality of data objects and a display model that includes a plurality of display objects based on the plurality of data objects. Parameter action objects may be associated with display objects in the display model. In response to an activation of the parameter action objects, values associated with display objects may be assigned to the parameter associated with a parameter action object and actions associated with the parameter may be executed to modify the display model.

Abstract: The present invention relates to triaminopyrimidine compound 1, or pharmaceutically acceptable salts thereof, or hydrates, or solvates, or polymorphs, or optically active forms thereof, in solid state forms. The invention also relates to a process for preparation of triaminopyrimidine compound and intermediates thereof. The present invention also relates to a pharmaceutical composition comprising pure triaminopyrimidine compound, useful for preventing or treating malaria.

Abstract: The present invention relates to a process for the preparation of apalutamide. In particular, the present invention relates to a process for the preparation of apalutamide and its intermediates. The present invention also relates to pharmaceutical compositions comprising apalutamide.