Patents by Inventor Amber A. Mael

Amber A. Mael has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for differentiating stem cells into cell populations comprising beta-like cells
    Patent number: 10526576
    Abstract: Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: January 7, 2020
    Assignee: REGENERATIVE MEDICAL SOLUTIONS, INC.
    Inventors: Xiaofang Xu, Jon Odorico, Erik Forsberg, Amber A. Mael
  • COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO CELL POPULATIONS COMPRISING BETA-LIKE CELLS
    Publication number: 20190093083
    Abstract: Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
    Type: Application
    Filed: November 26, 2018
    Publication date: March 28, 2019
    Inventors: Xiaofang Xu, Jon Odorico, Erik Forsberg, Amber A. Mael
  • Compositions and methods for differentiating stem cells into cell populations comprising beta-like cells
    Patent number: 10138466
    Abstract: Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: November 27, 2018
    Assignee: REGENERATIVE MEDICAL SOLUTIONS, INC.
    Inventors: Xiaofang Xu, Jon Odorico, Erik Forsberg, Amber A. Mael
  • INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20180320143
    Abstract: This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.
    Type: Application
    Filed: July 2, 2018
    Publication date: November 8, 2018
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Yasuhiro Ikeda, Andre Terzic, Timothy J. Nelson, Amber A. Mael, Almudena J. Martinez Fernandez, Satsuki Yamada
  • Method of treating heart tissue using induced pluripotent stem cells
    Patent number: 10047346
    Abstract: This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.
    Type: Grant
    Filed: August 10, 2009
    Date of Patent: August 14, 2018
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Yasuhiro Ikeda, Andre Terzic, Timothy J. Nelson, Amber A. Mael, Almudena J. Martinez Fernandez, Satsuki Yamada
  • COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO CELL POPULATIONS COMPRISING BETA-LIKE CELLS
    Publication number: 20180087033
    Abstract: Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
    Type: Application
    Filed: September 15, 2017
    Publication date: March 29, 2018
    Inventors: Xiaofang Xu, Jon Odorico, Erik Forsberg, Amber A. Mael
  • MARKERS FOR DIFFERENTIATION OF STEM CELLS INTO DIFFERENTIATED CELL POPULATIONS
    Publication number: 20180080077
    Abstract: Provided herein are systems and methods for identifying cell-specific differentiation markers. In particular, provided herein are systems and methods for generating induced pluripotent cells (IPS) from human cells, differentiating the IPS into differentiated cells, and identifying differentiation specific markers.
    Type: Application
    Filed: November 28, 2017
    Publication date: March 22, 2018
    Inventors: XIAOFANG XU, JON ODORICO, ERIK FORSBERG, AMBER A. MAEL, GUY TAGLIAVIA
  • Markers for differentiation of stem cells into differentiated cell populations
    Patent number: 9828634
    Abstract: Provided herein are systems and methods for identifying cell-specific differentiation markers. In particular, provided herein are systems and methods for generating induced pluripotent cells (IPS) from human cells, differentiating the IPS into differentiated cells, and identifying differentiation specific markers.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: November 28, 2017
    Assignee: REGENERATIVE MEDICAL SOLUTIONS, INC.
    Inventors: Xiaofang Xu, Jon Odorico, Erik Forsberg, Amber A. Mael, Guy Tagliavia
  • Compositions and methods for differentiating stem cells into cell populations comprising beta-like cells
    Patent number: 9765302
    Abstract: Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: September 19, 2017
    Assignee: REGENERATIVE MEDICAL SOLUTIONS, INC.
    Inventors: Xiaofang Xu, Jon Odorico, Erik Forsberg, Amber A. Mael
  • COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO CELL POPULATIONS COMPRISING BETA-LIKE CELLS
    Publication number: 20160298088
    Abstract: Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
    Type: Application
    Filed: June 20, 2016
    Publication date: October 13, 2016
    Inventors: Xiaofang Xu, Jon Odorico, Erik Forsberg, Amber A. Mael
  • MARKERS FOR DIFFERENTIATION OF STEM CELLS INTO DIFFERENTIATED CELL POPULATIONS
    Publication number: 20160230225
    Abstract: Provided herein are systems and methods for identifying cell-specific differentiation markers. In particular, provided herein are systems and methods for generating induced pluripotent cells (IPS) from human cells, differentiating the IPS into differentiated cells, and identifying differentiation specific markers.
    Type: Application
    Filed: January 22, 2016
    Publication date: August 11, 2016
    Inventors: XIAOFANG XU, JON ODORICO, ERIK FORSBERG, AMBER A. MAEL, GUY TAGLIAVIA
  • Compositions and methods for differentiating stem cells into cell populations comprising beta-like cells
    Patent number: 9371516
    Abstract: Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: June 21, 2016
    Assignee: REGENERATIVE MEDICAL SOLUTIONS, INC.
    Inventors: Xiaofang Xu, Jon Odorico, Erik Forsberg, Amber A. Mael
  • COMPOSITIONS AND METHODS FOR DIFFERENTIATING STEM CELLS INTO CELL POPULATIONS COMPRISING BETA-LIKE CELLS
    Publication number: 20160083693
    Abstract: Methods, kits, compositions, and systems are provided for culturing pluripotent stem cells to produce populations of cells comprising beta-like cells (e.g., pancreatic lineage, glucose-responsive, and/or insulin-producing). In particular, culture conditions are provided that result in the generation of beta-like cells from a starting culture of human pluripotent stem cells.
    Type: Application
    Filed: September 18, 2015
    Publication date: March 24, 2016
    Inventors: Xiaofang Xu, Jon Odorico, Erik Forsberg, Amber A. Mael
  • INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20110200568
    Abstract: This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.
    Type: Application
    Filed: August 10, 2009
    Publication date: August 18, 2011
    Inventors: Yasuhiro Ikeda, Andre Terzic, Timothy J. Nelson, Amber A. Mael, Almudena J. Martinez Fernandez, Satsuki Yamada