Patents by Inventor Amedeo A. Failli

Amedeo A. Failli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7691848
    Abstract: This invention provides pyrrolobenzodiazepine arylcarboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists, as well as pharmaceutical compositions and methods of treatment utilizing these compounds.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: April 6, 2010
    Assignee: Wyeth
    Inventors: Amedeo A. Failli, Dominick Quagliato, Patrick Andrae, Gavin D. Heffernan, Richard D. Coghlan, Emily S. Shen
  • Patent number: 7687623
    Abstract: The invention provides compounds of formula or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, and B are as defined in the accompanying specification. Methods of making such compounds are also provided.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: March 30, 2010
    Assignee: Wyeth LLC
    Inventors: Amedeo A. Failli, Dominick A. Quagliato, Gavin Heffernan, Richard D. Coghlan, Emily S. Shen
  • Patent number: 7678787
    Abstract: This invention provides pyrrolobenzodiazepine pyridine carboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists. The invention also provides pharmaceutical compositions and methods of treatment utilizing the compounds of Formulae (1) and (2).
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: March 16, 2010
    Assignee: Wyeth
    Inventors: Amedeo A. Failli, Gavin D. Heffernan, Arthur A. Santilli, Dominick A. Quagliato, Richard D. Coghlan, Patrick M. Andrae, Susan C. Croce, Emily S. Shen, Eugene J. Trybulski
  • Publication number: 20090227565
    Abstract: A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 5-membered aromatic (unsaturat
    Type: Application
    Filed: November 10, 2008
    Publication date: September 10, 2009
    Applicant: WYETH
    Inventors: Amedeo A. FAILLI, John P. DUSZA, Thomas J. CAGGIANO, Jay S. SHUMSKY, Kevin A. MEMOLI, Eugene J. TRYBULSKI
  • Publication number: 20090042874
    Abstract: The invention provides compounds of the Formula: that are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Application
    Filed: May 29, 2008
    Publication date: February 12, 2009
    Applicant: WYETH
    Inventors: Amedeo A. Failli, Deborah Evrard, Yanfang Li, Nicole T. Hatzenbuhler, Juliann Mogish, Iwan S. Gunawan, Antonina Nikitenko, Ping Zhou
  • Patent number: 7465722
    Abstract: A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 5-membered aromatic (unsaturated
    Type: Grant
    Filed: August 11, 2006
    Date of Patent: December 16, 2008
    Assignee: Wyeth
    Inventors: Amedeo A. Failli, John P. Dusza, Thomas J. Caggiano, Jay S. Shumsky, Kevin A. Memoli, Eugene J. Trybulski
  • Patent number: 7378427
    Abstract: Synthetic methods are provided for production of compounds of the formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are as defined in the specification.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: May 27, 2008
    Assignee: Wyeth
    Inventors: Brian Hugh Ridgway, William Jay Moore, Mark Anthony Ashwell, William Ronald Solvibile, Amy Tsai-Ting Lee, Molly Elizabeth Hoke, Madelene Antane, Amedeo A. Failli
  • Publication number: 20080081910
    Abstract: The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HT1A receptors and modulating serotonin levels.
    Type: Application
    Filed: October 11, 2007
    Publication date: April 3, 2008
    Applicant: Wyeth
    Inventors: Annmarie Sabb, Robert Vogel, Gary Stack, Deborah Evrard, Amedeo Failli, Lalitha Krishnan, Anita Chan, Jianxin Ren, Charles Guinosso, Reinhardt Baudy, Jean Sze, Yanfang Li, Charles Stanton, Antonia Nikitenko
  • Patent number: 7329653
    Abstract: The present invention provides compounds of the general formulas: wherein Y is NR or —(CH2)n; R is H or alkyl; “Z” represents optionally substituted phenyl or a 6-membered aromatic ring having one nitrogen atom; “W” represents a optionally substituted phenyl or 5-membered aromatic ring having one nitrogen atom; “X” represents an optionally substituted 5-membered aromatic ring having one sulfur atom; as well as methods and pharmaceutical compositions utilizing these compounds for the inducing temporary delay of urination or treatment of disorders remedied by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, or bleeding and coagulation disorders.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: February 12, 2008
    Assignee: Wyeth
    Inventors: Amedeo A. Failli, Jay S. Shumsky, Thomas J. Caggiano, John P. Dusza, Kevin A. Memoli
  • Patent number: 7153849
    Abstract: Compounds of the formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: December 26, 2006
    Assignee: Wyeth
    Inventors: Deborah Ann Evrard, Dahui Zhou, Gary Paul Stack, Aranapakam Madumbai Venkatesan, Amedeo A. Failli, Susan Christman Croce
  • Publication number: 20060287522
    Abstract: This invention provides pyrrolobenzodiazepine pyridine carboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists. The invention also provides pharmaceutical compositions and methods of treatment utilizing the compounds of Formulae (1) and (2).
    Type: Application
    Filed: June 8, 2006
    Publication date: December 21, 2006
    Applicant: WYETH
    Inventors: Amedeo Failli, Gavin Heffernan, Arthur Santilli, Dominick Quagliato, Richard Coghlan, Patrick Andrae, Susan Croce, Emily Shen, Eugene Trybulski
  • Publication number: 20060276481
    Abstract: Compounds of the formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
    Type: Application
    Filed: August 16, 2006
    Publication date: December 7, 2006
    Applicant: Wyeth
    Inventors: Deborah Evrard, Dahui Zhou, Gary Stack, Aranapakam Venkatesan, Amedeo Failli, Susan Croce
  • Publication number: 20060276456
    Abstract: A compound of the formulae (I) or (II): wherein: Y is a moiety selected from NR or —(CH2)n; wherein R is hydrogen or (C1-C6) lower alkyl, and n is 1; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 6-membered aromatic (unsaturated) heterocyclic ring having one nitrogen atom, optionally substituted by (C1-C6) lower alkyl, halogen or (C1-C6) lower alkoxy; represents: (1) a phenyl ring optionally substituted with one or two substituents selected, independently, from the group comprising hydrogen, (C1-C6) lower alkyl, halogen, cyano, CF3, hydroxy, (C1-C6) lower alkoxy, or (C1-C6) lower alkoxy carbonyl, carboxy, —CONH2, —CONH[(C1-C6) lower alkyl], —CON[(C1-C6) lower alkyl]2; or (2) a 5-membered aromatic (unsaturated) hete
    Type: Application
    Filed: August 11, 2006
    Publication date: December 7, 2006
    Applicant: Wyeth
    Inventors: Kevin Memoli, Amedeo Failli, Thomas Caggiano, Jay Shumsky, Eugene Trybulski, John Dusza
  • Publication number: 20060258645
    Abstract: The invention provides compounds of formula or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, and B are as defined in the accompanying specification. Methods of making such compounds are also provided.
    Type: Application
    Filed: May 11, 2006
    Publication date: November 16, 2006
    Applicant: Wyeth
    Inventors: Amedeo Failli, Dominick Quagliato, Gavin Heffernan, Richard Coghlan, Emily Shen
  • Publication number: 20060258644
    Abstract: The invention provides compounds of formula or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, A, and B are as defined in the accompanying specification. Methods of making such compounds are also provided.
    Type: Application
    Filed: May 11, 2006
    Publication date: November 16, 2006
    Applicant: Wyeth
    Inventors: Amedeo Failli, Arthur Santilli, Dominick Quagliato, Emily Shen
  • Publication number: 20060205759
    Abstract: The present invention provides cycloalkylfused indole, benzothiophene, benzofuran, and indene derivatives, and methods for using them to, for example, treat, prevent and/or ameliorate central nervous system diseases by antagonizing 5-HT1A receptors and modulating serotonin levels.
    Type: Application
    Filed: February 16, 2006
    Publication date: September 14, 2006
    Applicant: Wyeth
    Inventors: Annmarie Sabb, Robert Vogel, Gary Stack, Deborah Evrard, Amedeo Failli, Lalitha Krishnan, Anita Chan, Jianxin Ren, Charles Guinosso, Reinhardt Baudy, Jean Sze, Yanfang Li, Charles Stanton, Antonia Nikitenko
  • Publication number: 20060199806
    Abstract: This invention provides pyrrolobenzodiazepine arylcarboxamides selected from those of Formula (1), which act as follicle stimulating hormone receptor antagonists, as well as pharmaceutical compositions and methods of treatment
    Type: Application
    Filed: March 1, 2006
    Publication date: September 7, 2006
    Applicant: Wyeth
    Inventors: Amedeo Failli, Dominick Quagliato, Patrick Andrae, Gavin Heffernan, Richard Coghlan, Emily Shen
  • Publication number: 20060183734
    Abstract: The present invention provides compounds of the general formulas: wherein Y is NR or —(CH2)n; R is H or alkyl; “Z” represents optionally substituted phenyl or a 6-membered aromatic ring having one nitrogen atom; “W” represents a optionally substituted phenyl or 5-membered aromatic ring having one nitrogen atom; “X” represents an optionally substituted 5-membered aromatic ring having one sulfur atom; as well as methods and pharmaceutical compositions utilizing these compounds for the inducing temporary delay of urination or treatment of disorders remedied by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, or bleeding and coagulation disorders.
    Type: Application
    Filed: April 11, 2006
    Publication date: August 17, 2006
    Applicant: Wyeth
    Inventors: Amedeo Failli, Jay Shumsky, Thomas Caggiano, John Dusza, Kevin Memoli
  • Publication number: 20060025436
    Abstract: Synthetic methods are provided for production of compounds of the formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are as defined in the specification.
    Type: Application
    Filed: June 17, 2005
    Publication date: February 2, 2006
    Applicant: Wyeth
    Inventors: Brian Ridgway, William Moore, Mark Ashwell, William Solvibile, Amy Lee, Molly Hoke, Madelene Antane, Amedeo Failli
  • Patent number: 6936630
    Abstract: Antiatherosclerotic agents are provided which are represented by Formulas I or II: wherein R is wherein R9, R10, R11, R12, R13, and R14 are each, independently, hydrogen or a lower alkyl of 1-6 carbon atoms; R6, and R7 are each, independently, hydrogen, lower alkyl of 1-6 carbon atoms, or CH2COOR8, where R8 is a lower alkyl of 1-6 carbon atoms; and X is O or S; R1 is hydrogen or a lower alkyl of 1-6 carbon atoms; R2, R3, and R4 are each, independently, hydrogen or halogen; and R5 is a lower alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: August 30, 2005
    Assignee: Wyeth
    Inventors: Robert J. Steffan, Amedeo A. Failli