Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.

Abstract: The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.

Abstract: A multimode physical (MMP) layer circuit for physical (PHY) layer handling of signals transported over a high-definition multimedia interface (HDMI) cable in a home multimedia network, wherein the signals are compliant with at least two different PHY layer modes. The MMP layer circuits comprises a plurality of PHY transceivers respectively coupled to a plurality of TP channels of the HDMI cable through a HDMI connector, wherein each PHY transceiver of the plurality of PHY transceivers handles signals transported over its respective TP channel according to a PHY layer mode of the transported signals; and a controller is coupled to the HDMI connector and to each of the plurality of PHY transceivers, the controller recognizes the PHY layer mode of signals transported over each of the plurality of TP channels and sets each of the plurality of PHY transceivers according to the recognized PHY layer mode.

Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.

Abstract: A multimedia interface cable for achieving complete interoperability between different types of multimedia display interfaces. The cable comprises a first multimedia connector including a plurality of contact pins of at least high-speed multimedia signals and control signals; a second multimedia connector including a plurality of contact pins of least high-speed multimedia signals and control signals; a plurality of un-crossing conducting wires for coupling the plurality of contact pins of the high-speed multimedia signals in the first multimedia connector to the plurality of contact pins of the high-speed multimedia signals in the second multimedia connector; and a plurality of conducting wires for coupling the plurality of contact pins of the control signals in the first multimedia connector to the plurality of contact pins of the control signals in the second multimedia connector.

Abstract: A triple-mode connectivity apparatus for enabling interoperability between a multimedia display interface and a data interface. The apparatus comprises a universal connector installed in a first device and structured to enable connectivity between the multimedia display interface and the data interface of a second device, the first device is connected to the second device using a cable having a first connector compliant with the universal connector and a second connecter compliant with the data interface of the second device; a physical layer interface for processing signals compliant with the multimedia display interface and the data interface; and a detector for detecting an interface type of the second device and setting the apparatus to process signals according to the determined interface type.

Abstract: The present disclosure is directed to a system for inspecting a sample with multiple wavelengths of illumination simultaneously via parallel imaging paths. The system may include at least a first detector or set of detectors configured to detect illumination reflected, scattered, or radiated along a first imaging path from a selected portion of the sample in response to the first wavelength of illumination and a second detector or set of detectors configured to concurrently detect illumination reflected, scattered, or radiated along a second imaging path from the selected portion of the sample (i.e. the same location on the sample) in response to the second wavelength of illumination, where the second imaging path may at least partially share illumination and/or detection optics with an autofocus channel.

Abstract: Systems, methods, and apparatus by which solar energy may be collected to provide electricity or a combination of heat and electricity are disclosed herein.

Abstract: Systems, methods, and apparatus by which solar energy may be collected to provide electricity, heat, or a combination of heat and electricity are disclosed herein.

Abstract: The present invention relates to compositions and methods for inhibiting loss of a retinal ganglion cell in a subject, comprising non-invasively applying to the surface of the eye of the subject an ophthalmic composition comprising a therapeutically effective amount of at 5 least one siRNA which down regulates expression of a target gene associated with loss of the retinal ganglion cell, thereby inhibiting loss of the retinal ganglion cell in the subject. The methods of the invention also relate to the use of chemically modified siRNA compounds possessing structural motifs which down-regulate the expression of human genes expressed in retinal tissue in the mammalian eye.

Abstract: An apparatus for enabling simultaneous multimedia content and user data streaming from a handheld device to a display device is disclosed. The apparatus enables power charging of the handheld device while streaming the multimedia content and the user data from the handheld device. The apparatus comprises a data-multimedia-power interface (DMPI) connector installed in the handheld device and designed to enable the transport of at least high definition multimedia signals, data signals, a power signal, and control signals between the handheld device and the display device; and a DMPI circuit for multiplexing the high definition multimedia signals with the data signals, to enable simultaneous streaming of the respective multimedia content and the user data to the display device, wherein the DMPI circuit further extracts a power signal from the display device for power charging of the display device.

Abstract: A concentrating solar energy collector comprises a linearly extending receiver comprising solar cells, a plurality of linearly extending reflective elements arranged in side-by-side rows, oriented parallel to a long axis of the receiver, and fixed in position with respect to each other and with respect to the receiver to form a linearly extending reflector, and a linearly extending support structure supporting the receiver and the reflector and pivotally mounted to accommodate rotation of the support structure, the reflector, and the receiver about a rotation axis parallel to the long axis of the receiver.

Abstract: Systems, methods, and apparatus by which solar energy may be collected to provide electricity, heat, or a combination of heat and electricity are disclosed herein.

Abstract: The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.

Abstract: There are provided a computing system capable of allocating an advertisement budget of an advertisement campaign between a plurality of advertisement entities and a method of operating thereof. The method comprises: obtaining, for each of the plurality of advertisement entities, a respective optimal target frontier function representing for each given advertising cost an optimal value of return and configured to follow the law of diminishing return; receiving a budget constraint for the advertisement budget; generating a global target frontier function by summing each of the received optimal target frontier functions; processing the generated global target frontier function to determine for each of the plurality of advertisement entities an optimal, with respect of at least the received budget constrain, advertising cost value such that a sum of the optimal advertising cost values meets the budget constraint; and reporting the determined values.

Abstract: A Fast Ethernet and HDMI Ethernet channel (HEC) physical layer circuit. The physical layer circuit comprises a Fast Ethernet physical layer module implementing a physical layer specification of a Fast Ethernet communication standard; a hybrid circuit connected to the fast Ethernet physical layer module using a first twisted-pair wire and a second twisted-pair wire and capable of processing transmit and receive HDMI Ethernet channel (HEC) signals concurrently transported over a third twisted-pair wire; a switch for bypassing the hybrid circuit; and a controller for controlling the operation the hybrid circuit and the switch according to the operating mode of the physical layer circuit, wherein the operation mode of the physical layer circuit is any of a fast Ethernet and a HEC.

Abstract: The present invention relates to pharmaceutical compositions useful for topical, non-invasive delivery of an oligonucleotide to the ear and to methods for the treatment of an ear disorder, including hearing loss arising from chemical-induced ototoxicity, acoustic trauma and presbycusis; and microbial infections. The method comprises topically administering to the ear of a subject in need thereof a pharmaceutical composition comprising an inhibitory oligonucleotide, a permeability enhancer and a pharmaceutically acceptable carrier, wherein the oligonucleotide reduces or inhibits expression of a gene associated with the ear disorder in the subject.

Abstract: Systems, methods, and apparatus by which solar energy may be collected to provide heat, electricity, or a combination of heat and electricity are disclosed herein.

Abstract: Provided are techniques for pipeline optimization based on polymorphic schema knowledge. A hierarchical document to be processed by a pipeline of transformations is received. It is determined whether a next downstream transformation accesses content of each schema node in an associated input schema, wherein the input schema is a polymorphic schema. In response to determining that the next downstream transformation is not accessing the content of each schema node in the associated input schema, data items corresponding to each schema node that the next downstream transformation is not accessing are collected into a single compressed event. The collected items are passed to the next downstream transformation as the single compressed event.

Abstract: In one embodiment, the present invention is directed to an adjustable stroller, comprising: a central axle, which is an axle attached to the chassis of the adjustable stroller such that the axis of the central axle is disposed substantially vertically; a pedestal, attached in the center thereof to the central axle such that the edges thereof are substantially at the same elevation; two side axles, each being an axle attached to an opposite side of the pedestal such that the axis thereof is disposed vertically; and two baby seats, each attached to one of the side axles; thereby allowing arranging the seats in a manner selected from a group comprising: side by side, and in tandem mode. Preferably, each of the axles further comprises a securing mechanism, for securing the outer cylinder of the axle in a desired manner with regard to the inner cylinder thereof.