Abstract: The disclosure includes non-naturally occurring or engineered DNA- or RNA-guided nuclease systems, comprising CRISPR enzymes associated with at least one destabilization domain (DD) and photocaged stabilization ligands with at least one photocage molecule, along with compositions, systems and complexes involving such systems, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses thereof.

Abstract: Systems, apparatuses, and methods for providing a more effective customer service support system. In some embodiments, the systems, apparatuses, and methods include a user interface (UI) and process flow for implementing a conversation-based customer service support system. The user interface and associated processing enable a user/customer to quickly and accurately select an intent, goal, or purpose of their customer service request. In some embodiments, this is achieved by a set of user interface displays or screens and an underlying logic that provide a user with multiple ways of selecting, identifying, or describing the intent, goal, or purpose of their request for service or assistance.

Abstract: Systems, apparatuses, and methods for providing a more effective customer service support system. A trained model may be created or generated by a process that includes acquiring a corpus of documents (such as customer generated messages), generating keyphrases from each document in the corpus of documents, generating word embeddings from each document in the corpus of documents, performing a clustering operation on the word embeddings, assigning each document in the corpus to a duster and labeling each duster, and training a machine learning or text classification model using the most relevant documents in a cluster and the label assigned to that cluster. The methods include a processing flow that provides multiple ways for a customer to navigate and select their desired intent or purpose in seeking customer assistance. As part of the processing flow, the trained machine learning model and intent tree data are provided to a customer seeking assistance.

Abstract: The disclosure includes non-naturally occurring or engineered DNA- or RNA-guided nuclease systems, comprising guide-binding adaptors each associated with at least one destabilization domain (DD), along with compositions, systems and complexes involving such systems, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses therefor.

Abstract: The present inventions generally relate to site-specific delivery of nucleic acid modifiers and includes novel DNA-binding proteins and effectors that can be rapidly programmed to make site-specific DNA modifications. The present inventions also provide a synthetic all-in-one genome editor (SAGE) systems comprising designer DNA sequence readers and a set of small molecules that induce double-strand breaks, enhance cellular permeability, inhibit NHEJ and activate HDR, as well as methods of using and delivering such systems.

Abstract: Compositions and methods for inhibiting the activity of RNA-guided endonucleases, and methods for identifying such compositions are included. Methods of treatment using the inhibitory compounds, formulations and methods are also detailed, as well as control of nucleic acid editing systems and methods using said compounds.

Abstract: The disclosure includes non-naturally occurring or engineered CRISPR Cas9, each associated with at least one destabilization domain (DD), along with compositions, systems and complexes involving the DD-CRISPR Cas9, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses therefor.

Abstract: The disclosure includes zinc prodrugs for targeted delivery of therapeutic, diagnostic or imaging agents to ?-cells and methods of use therefor. The disclosure also includes targeted delivery of small molecules to ?-cells that stabilize and activate CRISPR effector proteins comprising at least one destabilization domain, to enable CRISPR-based genome editing and transcriptional activation or repression in ?-cells.

Abstract: The embodiments disclosed herein utilize fluorescence polarization based preliminary screen to identify a putative set of Cas inhibitors from an initial set of candidate inhibitors. The primary screening assay is followed by secondary screening assay to validate the putative set of inhibitors selected by the preliminary screen. In some embodiments, the present disclosure includes compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.

Abstract: Compositions and methods for conditionally regulating activities of CRISPR-Cas systems. In some embodiments, the methods comprise providing an inactive guide RNA comprising a regulatory domain bound by a lock nucleic acid different from the guide RNA; and displacing the lock nuclei acid from the regulatory domain by a trigger nucleic acid, thereby activating the guide RNA, wherein the activated guide RNA forms a complex with a Cas enzyme.

Abstract: Wireless communication devices capable of both wireless local area network (WLAN) and Bluetooth (BT) network communication, and related methods, are provided. In some implementations, the BT network includes a plurality of BT connections. One wireless communication device is configured to determine an aggregated time schedule for the plurality of BT connections and determine a WLAN schedule based on the aggregated time schedule. The device is configured to remap a BT scan schedule based on a WLAN traffic type, a selected duty cycle of the BT connection, and a remapping window.

Abstract: Compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.

Abstract: Wireless communication devices capable of both wireless local area network (WLAN) and Bluetooth (BT) network communication, and related methods, are provided. In some implementations, the BT network includes a plurality of BT connections. One wireless communication device is configured to determine an aggregated time schedule for the plurality of BT connections and determine a WLAN schedule based on the aggregated time schedule. The device is configured to remap a BT scan schedule based on a WLAN traffic type, a selected duty cycle of the BT connection, and a remapping window.

Abstract: A system and method to communicate in a wireless local area network (WLAN) device having a first Media Access Control (MAC) and a second MAC is provided. The method includes determining whether the first MAC and the second MAC are transmitting and receiving on the same frequency band, determining whether transmission by the first MAC overlaps with reception by the second MAC, and relaxing a reception criteria by the second MAC when transmission by the first MAC overlaps with reception by the second MAC.

Abstract: The disclosure includes non-naturally occurring or engineered CRISPR Cas9, each associated with at least one destabilization domain (DD), along with compositions, systems and complexes involving the DD-CRISPR Cas9, nucleic acid molecules and vectors encoding the same, delivery systems involving the same, uses therefor.

Abstract: A system and method to communicate in a wireless local area network (WLAN) device having a first Media Access Control (MAC) and a second MAC is provided. The method includes determining whether the first MAC and the second MAC are transmitting and receiving on the same frequency band, determining whether transmission by the first MAC overlaps with reception by the second MAC, and relaxing a reception criteria by the second MAC when transmission by the first MAC overlaps with reception by the second MAC.

Abstract: Example embodiments generally relate to adapting a transmission via first wireless technology to avoid interference with a reception via a second wireless technology. For example, a user equipment (e.g. cell phone) can include radios operating according to first and second wireless radio technologies, which can include Long Term Evolution (LTE) and a technology using the industrial, scientific and medical (ISM) frequency band. When a priority request is asserted by a radio operating in the ISM frequency band, the LTE radio may abort a scheduled transmission when certain “transmission abort criteria” are satisfied.

Abstract: Example embodiments generally relate to adapting a reception via first wireless technology to reduce or avoid interference with a transmission via a second wireless technology. For example, a user equipment (e.g. cell phone) can include radios operating according to first and second wireless radio technologies, which can include Long Term Evolution (LTE) and a technology using the industrial, scientific and medical (ISM) frequency band. In this example, the LTE radio may adapt, delay, or avoid the reception of certain scheduled system information from the network to reduce or avoid interference with transmission from the ISM radio.

Abstract: Example embodiments generally relate to adapting a transmission via first wireless technology to avoid interference with a reception via a second wireless technology. For example, a user equipment (e.g. cell phone) can include radios operating according to first and second wireless radio technologies, which can include Long Term Evolution (LTE) and a technology using the industrial, scientific and medical (ISM) frequency band. When a priority request is asserted by a radio operating in the ISM frequency band, the LTE radio may abort a scheduled transmission when certain “transmission abort criteria” are satisfied.

Abstract: Embodiments of the disclosure generally relate to a system and method for traffic offload from a first access technology to a second access technology. For example, packets originally destined for transmission over a bearer channel associated with Long Term Evaluation (LTE) can be offloaded to a Wi-FI bearer channel in a seamless manner when available, or a non-seamless manner.