Abstract: Systems and methods are provided for processing a fluid and then returning processed fluid and/or replacement fluid to a fluid recipient. The returning fluid is monitored to detect air therein and, if air is detected, steps are taken to automatically purge the air from the returning fluid without requiring the intervention of a system operator. The system may respond to detected air by pumping the processed fluid and/or replacement fluid away from the fluid recipient and into a processed fluid reservoir, where the air is purged from the processed fluid and/or replacement fluid. Thereafter, the weight of the processed fluid reservoir may be checked to confirm that sufficient fluid has been pumped back into the reservoir to remove the air. After it has been confirmed that the air has been purged from the fluid, the system may resume pumping the fluid toward the fluid recipient.

Abstract: Methods and systems for priming biological fluid processing systems are disclosed. In accordance with such methods and systems, the disposable fluid processing circuit is primed by introducing a first priming solution into a portion of the circuit and a second priming solution into a portion of the circuit. The amount of citrate returned to the biological flood source is minimized.

Abstract: A method is provided for calibrating a pump during a blood separation procedure that has at least a first and second state or phase where fluid is flowed to or from a reservoir by action of the pump. The state or phase of the procedure may be a priming state, a draw state, a separation state and a return state, and the pump calibration may be performed between consecutive performances of the same procedure state. The calibration is based on a variance between the volume of fluid predicted to be processed by the pump for the given state of the procedure and the actual volume processed based on the change of weight of the reservoir. Recalibration of the pump, if necessary, is accomplished before the performance of the second phase is commenced.

Abstract: A method is provided for the real time calibration of a pump that is part of a reuseable hardware component having a programmable controller during a blood separation procedure where fluid is flowed through a tubing in a tubing set by action of the pump. The method comprises programming the controller with a continuous function defining a relationship between pump inlet pressure and pump stroke volume; commencing the fluid processing procedure to operate the pump to draw fluid through the tubing; measuring fluid pressure in the tubing at the inlet of the pump; calculating a current pump stroke volume with the controller based on the continuous function and the pump rotational rate; and adjusting the pump rotational rate utilized by the controller to control the procedure to achieve a target fluid flow rate. The continuous function defining the relationship between pump inlet pressure and the pump stroke volume may be empirically determined over a predetermined range of inlet pressures.

Abstract: Methods and systems for processing biological fluid are disclosed. The methods and systems allow for processing of biological fluid to continue in the event that certain non-operator-correctable hardware errors of a non-critical nature are detected during such processing.

Abstract: Apparatus, system and method are provided for controlling flow through a biological fluid processing device. Pressure of fluid flow through a flow path is monitored and flow rate in the flow path is increased or decreased based on sensed pressure levels for selected periods of time. This has particular application in controlling flow in an infusion or return flow path of an apheresis device that separates whole blood into one or more blood components.

Abstract: A system is provided for separating a plasma-containing fluid into separated plasma and a concentrated fluid. The system cooperates with a fluid flow circuit including a fluid separation chamber and a plasma outlet line associated therewith for removing separated plasma from the fluid separation chamber. The system includes an optical sensor assembly to monitor the contents of the plasma outlet line and produce an output indicative of the concentration of free plasma hemoglobin in the plasma outlet line. A controller of the system calculates the amount of free plasma hemoglobin in at least a portion of the concentrated fluid based at least in part on the output of the optical sensor assembly. The controller may periodically calibrate the optical sensor assembly by determining an instrument-specific correlation between optic output and free hemoglobin concentration and comparing it to experimentally determined data to ensure continued reliability of the optical sensor assembly.

Abstract: A method is provided for controlling the return phase of a blood separation procedure having a draw phase in which blood is drawn through an access or donor line, is separated, and a fluid, such as a cellular concentrate, is flowed into a reservoir, and a return phase in which fluid is flowed from the reservoir through the donor line. The method comprises flowing fluid from the reservoir through the donor line in a steady state return; monitoring the donor line for the presence of air; and, upon detecting air in the donor line, determining the amount of fluid remaining in the reservoir. Then, either i) the donor line is purged, if the amount of fluid remaining in the reservoir exceeds a predetermined amount, and the steady state return of fluid from the reservoir through the donor line is resumed; or ii) if the amount of fluid remaining in the reservoir does not exceed the predetermined amount, the return phase is ended by terminating the flow of fluid from the reservoir through the donor line.

Abstract: Systems and methods are provided for processing a fluid and then returning processed fluid and/or replacement fluid to a fluid recipient. The returning fluid is monitored to detect air therein and, if air is detected, steps are taken to automatically purge the air from the returning fluid without requiring the intervention of a system operator. The system may respond to detected air by pumping the processed fluid and/or replacement fluid away from the fluid recipient and into a processed fluid reservoir, where the air is purged from the processed fluid and/or replacement fluid. Thereafter, the weight of the processed fluid reservoir may be checked to confirm that sufficient fluid has been pumped back into the reservoir to remove the air. After it has been confirmed that the air has been purged from the fluid, the system may resume pumping the fluid toward the fluid recipient.

Abstract: A system highlights search terms in documents distributed over a network. The system generates a search query that includes a search term and, in response to the search query, receives a list of one or more references to documents in the network. The system receives selection of one of the references and retrieves a document that corresponds to the selected reference. The system then highlights the search term in the retrieved document.

Abstract: Instead of accepting competing ads and using an arbitration function (e.g., an auction) to choose winning ads to be served with a document, sets of ads (perhaps having different characteristics) can be generated, and an arbitration function can be used to select the winning set of ads. Such arbitrations on sets of ads can consider how ads, search results, colors, positions, fonts, etc., all interact with each other and affect the usefulness of the sets of ads to advertisers, end users, document publishers, and/or an ad serving entity.

Abstract: A system highlights search terms in documents distributed over a network. The system generates a search query that includes a search term and, in response to the search query, receives a list of one or more references to documents in the network. The system receives selection of one of the references and retrieves a document that corresponds to the selected reference. The system then highlights the search term in the retrieved document.

Abstract: A system highlights search terms in documents distributed over a network. The system generates a search query that includes a search term and, in response to the search query, receives a list of one or more references to documents in the network. The system receives selection of one of the references and retrieves a document that corresponds to the selected reference. The system then highlights the search term in the retrieved document.

Abstract: A computer-implemented system and method for verifying access to a network account are provided. A first user communication portal is associated with a user network account. A request to access the user network account is received from a second user communication portal. Security criteria related to the second user communication portal is determined. Access to the user network account is enabled upon receipt of a communication associated with the first user communication portal when the security criteria is of a predetermined value.

Abstract: Methods, systems, and apparatus, including computer program products, for detecting events of interest. In one aspect, a method includes generating a network traffic model that includes forecasted time series data representative of a frequency of actions related to a network traffic entity, and identifying that an event of interest has occurred based on a comparison of actual time series data related to the network traffic entity with the forecasted time series data.

Abstract: Methods, systems, and apparatus, including computer program products, for detecting events of interest. In one aspect, a method includes generating a network traffic model that includes forecasted time series data representative of a frequency of actions related to a network traffic entity, and identifying that an event of interest has occurred based on a comparison of actual time series data related to the network traffic entity with the forecasted time series data.

Abstract: A computer-implemented system and method for verifying access to a network account are provided. A first user communication portal is associated with a user network account. A request to access the user network account is received from a second user communication portal. Security criteria related to the second user communication portal is determined. Access to the user network account is enabled upon receipt of a communication associated with the first user communication portal when the security criteria is of a predetermined value.

Abstract: A system provides advertising links. The system may received a query and provide a number of advertising links in response to the query. The number of advertising links may be dynamically adjusted based at least in part on the commercial-ness of the query. The display format of the advertising links may also be altered based at least in part on the commercial-ness of the query.

Abstract: A computer-implemented system and method for verifying access to a network account are provided. A first user communication portal is associated with a user network account. A request to access the user network account is received from a second user communication portal. Security criteria related to the second user communication portal is determined. Access to the user network account is enabled upon receipt of a communication associated with the first user communication portal when the security criteria is of a predetermined value.

Abstract: Methods, systems, and apparatus, including computer program products, for detecting events of interest. In one aspect, a method includes generating a network traffic model that includes forecasted time series data representative of a frequency of actions related to a network traffic entity, and identifying that an event of interest has occurred based on a comparison of actual time series data related to the network traffic entity with the forecasted time series data.