Abstract: An in vivo imaging device comprises a viewing window, an illumination unit, a lens holder and a light guide. The light guide may be positioned to create uniformly dispersed illumination and to eliminate backscatter from the viewing window. The light guide may guide light from the illumination unit to a desired position within the in vivo device. In one embodiment, the light guide may be embedded into the lens holder.

Abstract: An optical system for preventing shaded areas and method of manufacturing the optical system include an imager, at least one illumination source, and an optical window, behind which the imager and the at least one illumination source are positioned. The optical window may include a diffusing element on a portion thereof, for scattering illumination passing through it, such that light scattered from that portion of the window illuminates an otherwise under-illuminated region of impingement of the illumination. The portion on which the diffusing element is located, is positioned outside a field of view of the imager and within a field of illumination of the at least one illumination source.

Abstract: A device, system and method for detecting bile and blood are provided. The device may comprise a housing having a gap through which in-vivo fluids may flow, illumination sources on one side of the gap, a light detector which is facing the illumination sources and is positioned on the opposite side of the gap for detecting light which passes through the in-vivo fluids, and a transmitter to transmit the detected signals generated according to the detected light. The system may further comprise a receiver to receive the detected signals transmitted by the transmitter, and a processor. The method may comprise comparing the detected signals with a predetermined threshold calculated from the transmission spectra of bile and of blood and determining the presence and/or concentration of bile and blood in-vivo.

Abstract: An in-vivo sensing device for detecting in-vivo pathology may include an illumination source for illuminating light onto a tissue external to the device and an optical system for collecting fluorescent light emitted from the tissue onto a light sensor also provided within the device. A method of detecting in-vivo pathology by collecting fluorescent light emitted from a tissue is provided.

Abstract: A device and method for capturing in-vivo images allows for size or distance estimations for objects within the images. According to one embodiment of the present invention there may be provided, in an in-vivo device, at least an imager, an illumination source to provide illumination for the imager, an irradiation source to emit for example a light beam or a laser beam in a body lumen and a processor to calculate, based on image illumination parameter values, an estimate of the size of objects in a body lumen.

Abstract: An in-vivo imaging device incorporating a double field of view imaging system, having a wide field of view with moderate magnification, and a narrow field of view with substantially higher magnification, axially superimposed thereon. A single imaging array is used for both fields of view. At least some of the optical elements are shared between both of the two different field of view imaging systems. The imaging elements for the high magnification system, being of substantially smaller diameters than those of the low magnification system, are disposed coaxially with the imaging elements of the low magnification system, and can thus use the same imaging array without the need for deflection mirrors, beam combiners or motion systems. Their location on the axis of the low magnification system means that a small part of the imaging plane, around its central axis, is blocked out by the high magnification components.

Abstract: The present invention provides an in-vivo imaging device comprising at least one imager and an associated optical system, at least the optical system located in an optical dome of the imaging device, the optical dome having a tip, the optical system comprising an optical lens, the optical system having a given effective focal length f, the optical lens being located at a distance D? from the tip; wherein D?/f?6.

Abstract: An in-vivo device, system and a method for imaging a body lumen, typically liquid filled body lumen. The in-vivo device may have a specific gravity of about 1 or a volume to weight ratio that enables it to float. The in-vivo device may include an optical system for viewing through a body lumen liquid and another optical system for viewing through a non liquid medium. The in-vivo device may be moved through the body lumen by the liquid movement in that lumen.

Abstract: An in-vivo examining device, system and method for identifying the presence of strictures in the small bowel are provided. The in-vivo examining device includes a monitoring mechanism that becomes deactivated when exposed to in-vivo substances native to the small bowel or the colon, and a degradable device body that includes at least a first body portion which degrades at a slow rate when exposed to in-vivo substances native to the small bowel and at a fast rate when exposed to in-vivo substances native to the colon. The degradation of the degradable device body exposes the monitoring mechanism to substances native to the small bowel or the colon and thus indicates whether the examining device has safely passed through the small bowel or whether it is retained in the small bowel due to strictures in the small bowel.

Abstract: An in vivo imaging device comprises a viewing window, an illumination unit, a lens holder and a light guide. The light guide may be positioned to create uniformly dispersed illumination and to eliminate backscatter from the viewing window. The light guide may guide light from the illumination unit to a desired position within the in vivo device. In one embodiment, the light guide may be embedded into the lens holder.

Abstract: A device, system and method for capturing in-vivo images allows for size or distance estimations for objects within the images. According to one embodiment of the present invention there may be provided, in an in-vivo device at least an imager, an illumination source to provide illumination for the imager, an energy source to emit for example a light beam or a laser beam in a body lumen and a processor to, based on the light beam or laser beam image, estimate, for example the size of objects in a body lumen.

Abstract: Devices, systems and methods for detecting in vivo pathology are provided. An in vivo sensing device comprises a reacting layer with at least one type of binding agent attached thereon, a sensor configured for sensing an optical change occurring on the reacting substrate, and at least one illumination source. In-vivo fluids are in constant contact with the reacting substrate so that in vivo marker indicating pathology may bind to the binding agent attached onto the reacting layer and may be viewed by the sensor.

Abstract: A device and method for capturing in-vivo images allows for size or distance estimations for objects within the images. According to one embodiment of the present invention there may be provided, in an in-vivo device, at least an imager, an illumination source to provide illumination for the imager, an irradiation source to emit for example a light beam or a laser beam in a body lumen and a processor to calculate, based on image illumination parameter values, an estimate of the size of objects in a body lumen.

Abstract: A device and method for viewing a body lumen are provided. An assembly of a capsule endoscope and an endoscope is inserted into a body lumen. The capsule endoscope is positioned within the body lumen at a predetermined distance from the endoscope, and images are obtained from opposite sides of a desired location in the body lumen. In vivo procedures may be performed, while images of the procedure are obtained from opposite sides of the procedure location.

Abstract: A device and method for capturing images of the gastrointestinal tract, or other body lumens or cavities of a patient, captured using one or more illumination sources having different fields of illumination.

Abstract: An autonomous in vivo sensing device may include a polarizing filter to polarize light emitted by an illumination unit, and to block light specularly reflected from a turbid media from reaching an imager of such device. An autonomous in vivo sensing device with monochromatic illumination units to alternatingly illuminate a target area with light of different wavelengths, and to subtract an image illuminated by light in a first wavelength from an image illuminated by light in a second wavelength, to produce an image of a sub-surface layer of such target area.

Abstract: The invention provides a device for in-vivo imaging, for example, using an in-vivo imaging device including an imager a lens and an illumination source, all positioned behind a single viewing window. The in-vivo imaging device may include an element to block light from reaching a point of reflection on the inner surface of the viewing window, thereby preventing the light from being received by the imager.

Abstract: The invention provides a device and method for in-vivo imaging, for example, using an in-vivo imaging device including an imager a lens and an illumination source, all positioned behind a single viewing window. The in-vivo imaging device may include an element to block light from reaching a known point on the inner surface of the viewing window, such known point being a point from which light will be internally reflected.

Abstract: An in vivo imaging device having an illumination unit, where the illumination unit may include a light source and a beam shaping unit. The beam shaping unit may provide a high intensity focused illumination field that has a uniform appearance across the entire near field of view of the imaging device.

Abstract: An in vivo imaging device having an illumination unit, the illumination unit may include a light source and a beam shaping unit. The beam shaping unit may provide a high intensity focused illumination field that has a uniform appearance across the entire near field of view of the imaging device.