Abstract: An operating system, or operating system update, management service uses a shared read-only multi-attach volume of a block-based storage service to distribute operating systems or operating system updates to a set of virtualized computing instances. Also, to store launch specific information, that is specific to a given virtualized computing instance, additional writable volumes are used, wherein a write volume is attached to each of the computing instances of the set. This eliminates the need to provide a full copy of an OS volume to each of the computing instances.

Abstract: A first set of instructions, which is provided access to a first address space, is scheduled for execution at a first hardware thread of a processor. Prior to executing an instruction of a second set of instructions, which accesses a second address space, at the first hardware thread, a determination is made that the second address space is accessible from a second hardware thread of the processor.

Abstract: Executing workflows with different computations on different types of remote computing devices is difficult and time consuming, sometimes taking days. A system of computing devices is provided to generate a workflow of computing tasks that specify different types of computing hardware resources, including quantum computing and classical computing resources, and to generate a schedule of jobs to be executed that is consistent with the workflow. The schedule of jobs is automatically executed, as computational tasks are dispatched to different computing resource providers at different times. Two or more computational tasks can be dispatched in parallel and at the same time, according to parallel tasks in the workflow.

Abstract: Methods and systems for monitoring of sensor data for processing by machine-learning models to generate event predictions to estimate a risk a medical event are provided. An electronic device or wearable smart device may monitor the output of various sensors to collect data related to a person's activity level, location changes, and communications and may use this information as input to a personalized trained machine-learning model to predict a likelihood of an event.

Abstract: Disclosed are gastroretentive, sustained-release tablet formulations comprising an active agent, such as pregabalin or a pharmaceutically acceptable form thereof, crospovidone, and a cationic copolymer based on dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate random copolymer.

Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

Abstract: A first set of instructions, which is provided access to a first address space, is scheduled for execution at a first hardware thread of a processor. Prior to executing an instruction of a second set of instructions, which accesses a second address space, at the first hardware thread, a determination is made that the second address space is accessible from a second hardware thread of the processor.

Abstract: A first set of instructions, which is provided access to a first address space, is scheduled for execution at a first hardware thread of a processor. Prior to executing an instruction of a second set of instructions, which accesses a second address space, at the first hardware thread, a determination is made that the second address space is accessible from a second hardware thread of the processor.

Abstract: Sunscreen-active mixtures, methods of forming treated mixtures for sunscreen compositions, sunscreen compositions, and methods of forming sunscreen compositions are disclosed herein. The sunscreen-active mixtures include an inorganic, sunscreen-active material, a first water-soluble polymer with a first glass transition temperature of at least 45° C., a second water-soluble polymer that has a second glass transition temperature that is less than the first glass transition temperature, and a surfactant. The sunscreen compositions include sunscreen-active material particles, which include the sunscreen-active mixture, and a cosmetic emulsion. An average particle size of the sunscreen-active material particles is at least 100 nm and at most 15 micrometers. The methods of forming the treated mixture include heating an untreated mixture and grinding the untreated mixture to generate the treated mixture.

Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

Abstract: Disclosed is an electro-hydraulic actuator for providing mechanical actuation. The electro-hydraulic actuator comprises a housing having a first chamber and a second chamber and a gear pump arranged within the first chamber. The gear pump is configured to pump fluid from the first chamber into the second chamber. Furthermore, the electro-hydraulic actuator comprises a piston assembly comprising a piston-head slidably arranged within the second chamber, a piston-rod coupled to the piston-head, and a rack configured as piston-rod. The rack comprises a plurality of teeth and the rack is configured to move linearly corresponding to the linear movement of the piston-rod. Moreover, the electro-hydraulic actuator comprises a shaft arranged within the first chamber and orthogonally to the piston-rod and a pinion mounted on the shaft. The pinion is configured to rotate upon linear movement of the rack to cause rotation of the shaft, for providing the mechanical actuation.

Abstract: Techniques for implementing a non-relational database that makes efficient use of collections within the database. For one or more collections, two or more sub-collections can be created for storing documents. Each collection can be configured as a single partition entity or a partitioned entity within the database. Each sub-collection is identified by a sub-collection identifier. If the collection is configured as a partitioned entity, then a partition key can be determined for documents to be accessed in the collection. The partition key can be extended with the sub-collection ID to form a compound property (sub-collection ID, partition key) that determines placements of the respective documents in the identified sub-collection across partitions of the collection. If the collection is configured as a single partition entity, then a field for the partition key is ignored and the respective documents are placed in the identified sub-collection within the single partition of the collection.

Abstract: The present invention is a simple-to-use IV placement assist device with an added safety feature. A catheter advancer is slidably integrated with a base to guide advancement of a catheter linearly along the insertion path of the needle and catheter. A safety feature is engaged by a movable component moving from a first position to a second position, such movable enabling relative movement between the base and catheter advancer and/or catheter assembly, rotation of the needle about its length axis, and/or minor advancement of the catheter assembly to sheath the tip of the needle. The IV placement assist device stabilizes and guides the critical needle insertion and catheter advancement steps of a complication-prone and very common procedure.

Abstract: A time transfer modem includes a radio frequency integrated circuit (RFIC), a radio frequency (RF) front end, and processing circuitry. The RF front end is configured to receive and up-convert an input for time transfer with a remote station to generate an up-converted timing signal centered at a select frequency that is outside of a frequency range of interest but within an operational frequency range of the RFIC. The RF front end may also be configured to attenuate, via a pre-selection filter, up-converted adjacent signals to generate a filtered timing signal at the select frequency. The RFIC may be configured to down-convert and digitize the filtered timing signal to generate a digitized timing signal for signal processing by the processing circuitry to determine a clock difference between a local clock signal and the digitized timing signal that originated from the remote station.

Abstract: A time transfer modem includes a radio frequency integrated circuit (RFIC), a radio frequency (RF) front end, and processing circuitry. The RF front end is configured to receive and up-convert an input for time transfer with a remote station to generate an up-converted timing signal centered at a select frequency that is outside of a frequency range of interest but within an operational frequency range of the RFIC. The RF front end may also be configured to attenuate, via a pre-selection filter, up-converted adjacent signals to generate a filtered timing signal at the select frequency. The RFIC may be configured to down-convert and digitize the filtered timing signal to generate a digitized timing signal for signal processing by the processing circuitry to determine a clock difference between a local clock signal and the digitized timing signal that originated from the remote station.

Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

Abstract: Systems, methods, and computer-readable media for classifying a PTSD status. In an embodiment, an example method for using a classifier can comprise receiving information from electrocardiography performed on an individual; determining features from the information; comparing the features to the a logistic regression classifier trained using features determined from median quiescent segments of RR interval information from individuals with and without PTSD, wherein the median quiescent segments are non-overlapping time periods of lowest median HR for each individual, and the features include one or more of the following: deceleration capacity (DC), low frequency (LF) power, very low frequency (VLF) power, and standard deviation of all normal RR intervals (SDNN); and determining a posttraumatic stress disorder (PTSD) status of the individual based on the comparison of the features to the classifier, wherein the PTSD status is a severity of PTSD based on a probability of PTSD.

Abstract: A fluid flow control valve with swiveled & compensated stroke (100) comprising a solenoid coil assembly (60), a permanent magnet (181), a bridge mounted solenoid assembly (120), a compensated swivel fulcrum (150), a counterweight arrangement (160), and a base unit arrangement (180), wherein a slender cylindrical rod (70) of the compensated swiveled fulcrum (150) is non-rotatably trapped in a fulcrum receptacle (33) of a bridge (30), a compensating spring (85) continuously presses a pair of the plurality of spherical balls (80) against a conical surface (72) of the lender cylindrical rod (70), the bridge mounted solenoid assembly (120) swivels around an axis (121), an electric supply impressed at the electrical terminals of the solenoid coil assembly (60) generates a magnetic field and the solenoid coil assembly (60) moves in an arc (61), the swiveled valve with the compensated precision stroke (100) is mountable in any orientation.

Abstract: Methods and systems for monitoring of sensor data for processing by machine-learning models to generate event predictions to estimate a risk a medical event are provided. An electronic device or wearable smart device may monitor the output of various sensors to collect data related to a person's activity level, location changes, and communications and may use this information as input to a personalized trained machine-learning model to predict a likelihood of an event.