Abstract: The present disclosure relates to Delgocitinib solid state forms, processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: A nanoparticle complex comprises a bifunctional binder capable of non-covalently binding to the lipid nanoparticle in the nanoparticle complex.

Abstract: The present disclosure relates to a medicament delivery device, the medicament delivery device having a proximal end pointing towards a dose delivery site during use of the medicament delivery device, and a distal end opposite the proximal end. The medicament delivery device includes a housing comprising a longitudinal axis, a medicament delivery member cover axially moveable within the housing between an extended position and a retracted position, and a cap. The cap comprises an outer housing and an inner housing concentrically provided radially inside the outer housing with respect to the longitudinal axis. A space between the outer housing and the inner housing is configured to receive a proximal end of the medicament delivery member cover extending towards a medicament delivery site. The medicament delivery member cover comprises a flexible medicament delivery member cover lock being flexible in the radial direction.

Abstract: The present disclosure provides a subassembly of a medicament delivery device. The subassembly includes a cover structure with a first latching element and a retaining structure having an envelope surface arranged radially outside of the cover structure and having a second latching element. In a first extended position of the cover structure, the first latching element is out of engagement and positioned distally with respect to the second latching element. In a second extended position, the first latching element is in mutual engagement with respect to the second latching element, such that the cover structure is prevented from moving towards a retracted position. In the second extended position, the envelope surface covers or surrounds the first and/or the second latching element, in order to prevent disengagement of the first latching element and the second latching element by a user.

Abstract: The present disclosure provides a plunger rod for a medicament delivery device, the plunger rod including a first section configured as shock absorber and a second section along a longitudinal axis of the plunger rod. A stiffness of the second section exceeds a stiffness of the first section by a factor of at least five two.

Abstract: The present application discloses examples of various apparatuses and systems that can be utilized for augmented reality. According to one example, a wearable device that can optionally comprise: a frame configured for wearing by a user; one or more optical elements mounted on the frame; an array having a plurality of light emitting diodes coupled to the one or more optical elements, wherein the one or more optical elements and the array are mounted within a field of view of the user when the frame is worn by the user; and additional onboard electronic components carried by the frame including at least a battery that is configured to provide for electrically powered operation of the array.

Abstract: The present disclosure relates to safe and efficient processes for the synthesis of Glasdegib or salts thereof, preferably Glasdegib Maleate. The present disclosure also encompasses solid state forms of Glasdegib maleate, in embodiments crystalline polymorphs of Glasdegib maleate, processes for preparation thereof, and pharmaceutical compositions thereof.

Abstract: The present disclosure encompasses solid state forms of AT-001, in embodiments crystalline polymorphs of AT-001 or salts or co-crystals of AT-001, processes for preparation thereof, and pharmaceutical compositions thereof.

Abstract: A solution for optimizing the deployment of applications in a cloud-based environment is provided. A method for optimizing the deployment of applications in a cloud-based environment is disclosed. The method is implemented by at least one processor. The method includes receiving at least one user artifacts file for direct deployment on a test environment. Next, the method includes deploying the at least one user artifacts file onto the test environment. Next, the method includes performing a set of testing events on artifacts included in the at least one user artifacts file. Thereafter, the method includes transmitting the at least one user artifacts file for pipeline deployment based on a successful result of the testing events.

Abstract: A computer-implemented method of controlling an energy dissipation means for dynamic braking in a power transmission network, the method including: monitoring one or more first parameters associated with the power transmission network; determining, based on the one or more first parameters, a fault status of the power transmission network; and controlling, based on the fault status, the energy dissipation means to perform dynamic braking for the power transmission network; wherein the controlling, based on the fault status, the energy dissipation means, includes adaptively controlling by either of: adjusting a threshold voltage for activating the energy dissipation means or controlling the energy dissipation means to perform dynamic braking until the MCB is determined to be in a non-conducting state.

Abstract: A method for configuring a digital light projector (DLP) of an augmented reality (AR) display device is described. A light source component of the DLP projector is configured to generate a single red-green-blue color sequence repetition per image frame. The AR display device identifies a color sequence of the light source component of the DLP projector and tracks a motion of the AR display device. The AR display device adjusts an operation of the DLP projector based on the single red-green-blue color sequence repetition, the color sequence of the light source component of the DLP projector, and the motion of the AR display device.

Abstract: Some embodiments of the invention provide a method for performing packet tracing in a RAN. The method receives a trace request that includes a tracing specification for performing a trace operation for a subset of messages exchanged between a base station component and a RAN application via a RIC that operates as an interface between the base station component and the RAN application, the trace operation for collecting state data associated with the RIC. Based on the tracing specification, the method performs the trace operation for the subset of messages. The method receives a set of trace information that was collected during the trace operation and that includes state data associated with the RIC. The method processes the set of trace information to generate multiple sets of state data associated with the RIC for use in responding to queries for state data associated with the RIC.

Abstract: Transistor structures with source and drain contact metal structures comprising a lower portion of a first lateral dimension that is coupled with underlying channel material layers and an upper portion of a second lateral dimension that is coupled with an overlying via. The second lateral dimension is smaller than the first lateral dimension, enabling edge placement error associated with via patterning to be better accommodated. In some embodiments, an intervening dielectric liner is formed between an adjacent gate spacer dielectric material and the contact metal structures. The intervening dielectric liner may be formed, for example, by etching back a source or drain contact structure to form a self-aligned recess of a predetermined depth, forming a thin dielectric material layer upon sidewalls of the recess, and at least partially back filling a remainder of the recess with additional contact metal.

Abstract: Some embodiments of the invention provide a method for implementing access controls in a RAN (radio access network) to limit access to base station components of the RAN by RAN applications. The method is performed at a RIC (RAN intelligent controller) that connects the RAN applications to the base station components. The method receives a set of access control data that specifies which RAN applications are allowed to access which base station components. From a particular RAN application, the method receives a data message destined for a particular base station component. Based on the set of access control data, the method determines that the particular RAN application is allowed to access the particular base station component. The method forwards the data message to the particular base station component.

Abstract: Various embodiments are directed to example system-on-chip integrated circuits configured to perform built-in self test operations on an embedded memory. An example system-on-chip integrated circuit includes dynamic BIST switching circuitry and an embedded memory. The dynamic BIST switching circuitry is configured to generate a dynamic BIST output based on a test state. The embedded memory is configured to receive the dynamic BIST output. The embedded memory includes fixed BIST switching circuitry configured to generate a fixed BIST output based on the test state. Wherein the fixed BIST switching circuitry is internal to the embedded memory, and the dynamic BIST switching circuitry is external to the embedded memory.

Abstract: A method for configuring a digital light projector (DLP) of an augmented reality (AR) display device is described. A light source component of the DLP projector is configured to generate a single red-green-blue color sequence repetition per image frame. The AR display device identifies a color sequence of the light source component of the DLP projector and tracks a motion of the AR display device. The AR display device adjusts an operation of the DLP projector based on the single red-green-blue color sequence repetition, the color sequence of the light source component of the DLP projector, and the motion of the AR display device.

Abstract: Disclosed are systems, software, and methods for providing event-based notifications to client devices. One system for such includes memory storing computer program instructions and one or more processors configured to execute the computer program instructions. The instructions cause operations that include receiving, at a gateway service module from an event-originating application, an event data packet comprising event information about an event. The gateway service module provides event information to an event-processing module. The event-processing module generates an event notification based at least on the event information. The gateway service module initiates a push notification to a client device that includes the event notification and instructions to display the event notification at the client device.

Abstract: The present disclosure includes systems and methods for multi-cloud network analysis and threat intelligence correlation. In various embodiments, systems are adapted to perform steps of retrieving network flow logs associated with one or more Virtual Private Cloud (VPC) networks; processing the network flow logs to identify new files and enriching critical fields from the network flow logs; transforming and aggregating the network flow logs for further processing; and identifying threats associated with the one or more VPC networks.

Abstract: The invention features polypeptides containing nuclear localization sequences that can be used to deliver polynucleotides to a cell. The polypeptides can be formulated with a polynucleotide and a lipid.

Abstract: Chemical mechanical polish processes on surfaces of semiconductor devices comprising tungsten layers can create nano-sized particles of tungsten. These particles can create manufacturing yield reductions. These particles can also be difficult to detect optically. Etched surfaces coated with a layer of material that can provide optical detection enhancement provide an ability to optically detect nano-sized particles.