Patents by Inventor Amy H. Chu
Amy H. Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11180790Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.Type: GrantFiled: May 13, 2020Date of Patent: November 23, 2021Assignee: Ascensia Diabetes Care Holdings AGInventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
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Patent number: 11091790Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.Type: GrantFiled: December 14, 2018Date of Patent: August 17, 2021Assignee: ASCENSIA DIABETES CARE HOLDINGS AGInventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
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Publication number: 20200270668Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.Type: ApplicationFiled: May 13, 2020Publication date: August 27, 2020Inventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
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Patent number: 10696998Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.Type: GrantFiled: August 21, 2017Date of Patent: June 30, 2020Assignee: ASCENSIA DIABETES CARE HOLDINGS AGInventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
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Publication number: 20190249214Abstract: A reagent composition containing GDH-PQQ as an enzyme-co-factor and screen-printed on working and counter electrodes of electrochemical biosensors, maintains activity of the enzyme reagents by proper selection of components. A preferred composition includes hydrophilic polymers, amorphous untreated silica, buffers, surfactants, and a mediator.Type: ApplicationFiled: April 24, 2019Publication date: August 15, 2019Inventors: Amy H. Chu, Hope G. Spradlin
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Publication number: 20190106728Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.Type: ApplicationFiled: December 14, 2018Publication date: April 11, 2019Inventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
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Patent number: 10190150Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.Type: GrantFiled: March 10, 2015Date of Patent: January 29, 2019Assignee: ASCENSIA DIABETES CARE HOLDINGS AGInventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
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Publication number: 20170349929Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.Type: ApplicationFiled: August 21, 2017Publication date: December 7, 2017Inventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
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Patent number: 9664638Abstract: A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%.Type: GrantFiled: December 3, 2015Date of Patent: May 30, 2017Assignee: Ascensia Diabetes Care Holdings AGInventors: Amy H. Chu, Mary Ellen Warchal-Windham
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Publication number: 20160084790Abstract: A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%.Type: ApplicationFiled: December 3, 2015Publication date: March 24, 2016Inventors: Amy H. Chu, Mary Ellen Warchal-Windham
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Patent number: 9233788Abstract: A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%.Type: GrantFiled: July 19, 2012Date of Patent: January 12, 2016Assignee: Bayer HealthCare LLCInventors: Amy H. Chu, Mary Ellen Warchal-Windham
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Publication number: 20150176054Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.Type: ApplicationFiled: March 10, 2015Publication date: June 25, 2015Inventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
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Publication number: 20150104561Abstract: A test sensor reagent for measuring the concentration of analytes in body fluids includes cellulose polymers for improving the stability of the test sensor and reducing the total assay time. The test sensor reagent also includes an enzyme, an electron transfer mediator and a rheological additive.Type: ApplicationFiled: December 18, 2014Publication date: April 16, 2015Inventors: Amy H. Chu, Andrew J. Edelbrock, Hope G. Spradlin
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Patent number: 9005527Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.Type: GrantFiled: May 29, 2013Date of Patent: April 14, 2015Assignee: Bayer Healthcare LLCInventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
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Publication number: 20150076003Abstract: A reagent composition containing GDH-PQQ as an enzyme-co-factor and screen-printed on working and counter electrodes of electrochemical biosensors, maintains activity of the enzyme reagents by proper selection of components. A preferred composition includes hydrophilic polymers, amorphous untreated silica, buffers, surfactants, and a mediator.Type: ApplicationFiled: November 26, 2014Publication date: March 19, 2015Inventors: Amy H. Chu, Hope G. Spradlin
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Patent number: 8940153Abstract: A test sensor reagent for measuring the concentration of analytes in body fluids includes cellulose polymers for improving the stability of the test sensor and reducing the total assay time. The test sensor reagent also includes an enzyme, an electron transfer mediator and a rheological additive.Type: GrantFiled: November 13, 2006Date of Patent: January 27, 2015Assignee: Bayer Healthcare LLCInventors: Amy H. Chu, Andrew J. Edelbrock, Hope G. Spradlin
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Patent number: 8921065Abstract: A reagent composition containing GDH-PQQ as an enzyme-co-factor and screen-printed on working and counter electrodes of electrochemical biosensors, maintains activity of the enzyme reagents by proper selection of components. A preferred composition includes hydrophilic polymers, amorphous untreated silica, buffers, surfactants, and a mediator. For example, the biosensor is useful in the amperometric determination of glucose.Type: GrantFiled: March 3, 2006Date of Patent: December 30, 2014Assignee: Bayer HealthCare LLCInventors: Amy H. Chu, Hope G. Spradlin
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Patent number: 8871069Abstract: A biosensor system for determining the concentration of an analyte in a sample is disclosed that includes a reaction means for selectively performing a redox reaction of an analyte, and a measurement means for measuring a rate of the redox reaction of the analyte. The reaction means includes a binder, a buffer salt, a mediator including at most 20% (w/w) of an inorganic, non-transition metal salt, and an enzyme system. The measurement means includes at least two conductors. The measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, and the measurement means determines at least one ?S value responsive to at least one error parameter.Type: GrantFiled: June 6, 2011Date of Patent: October 28, 2014Assignee: Bayer HealthCare LLCInventors: Amy H. Chu, Huan-Ping Wu, Boru Zhu
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Publication number: 20130334066Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.Type: ApplicationFiled: May 29, 2013Publication date: December 19, 2013Inventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
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Publication number: 20130186755Abstract: A biosensor system for determining the concentration of an analyte in a sample includes a plurality of test sensors, and includes a container including a desiccant and the plurality of test sensors, sealed in the container. When the container is stored for two weeks at a temperature of 50° C., and each test sensor is subsequently removed from the container, connected through the at least two conductors to a measurement device and then contacted with one of a plurality of samples including an analyte, where the plurality of samples has analyte concentrations that span the range of 50 mg/dL-600 mg/dL, and the analyte concentration in each sample is determined by the test sensor and the measuring device, the bias of each determined analyte concentration may be within ±10 mg/dL or ±10%, and the coefficient of variation of the determined analyte concentrations may be at most 2.5%.Type: ApplicationFiled: July 19, 2012Publication date: July 25, 2013Applicant: BAYER HEALTHCARE LLC - DIABETES CAREInventors: Amy H. Chu, Mary Ellen Warchal-Windham