Patents by Inventor Amy H. Chu
Amy H. Chu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8470604Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.Type: GrantFiled: August 16, 2011Date of Patent: June 25, 2013Assignee: Bayer HealthCare LLCInventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
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Publication number: 20120031776Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.Type: ApplicationFiled: August 16, 2011Publication date: February 9, 2012Applicant: BAYER HEALTHCARE LLCInventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
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Publication number: 20110297540Abstract: A biosensor system for determining the concentration of an analyte in a sample is disclosed that includes a reaction means for selectively performing a redox reaction of an analyte, and a measurement means for measuring a rate of the redox reaction of the analyte. The reaction means includes a binder, a buffer salt, a mediator including at most 20% (w/w) of an inorganic, non-transition metal salt, and an enzyme system. The measurement means includes at least two conductors. The measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, and the measurement means determines at least one ?S value responsive to at least one error parameter.Type: ApplicationFiled: June 6, 2011Publication date: December 8, 2011Applicant: BAYER HEALTHCARE LLCInventors: Amy H. Chu, Huan-Ping Wu, Boru Zhu
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Patent number: 8026104Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.Type: GrantFiled: October 21, 2007Date of Patent: September 27, 2011Assignee: Bayer HealthCare LLCInventors: Huan-Ping Wu, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
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Publication number: 20090152128Abstract: A test sensor reagent for measuring the concentration of analytes in body fluids includes cellulose polymers for improving the stability of the test sensor and reducing the total assay time. The test sensor reagent also includes an enzyme, an electron transfer mediator and a rheological additive.Type: ApplicationFiled: November 13, 2006Publication date: June 18, 2009Inventors: Amy H. Chu, Andrew J. Edelbrock, Hope G. Spradlin
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Publication number: 20090145775Abstract: A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.Type: ApplicationFiled: December 10, 2008Publication date: June 11, 2009Inventors: Amy H. Chu, Karen L. Marfurt, Brenda L. Tudor, Mary Ellen Warchal-Windham, Boru Zhu
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Publication number: 20090068754Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the ?0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.Type: ApplicationFiled: October 21, 2007Publication date: March 12, 2009Applicant: BAYER HEALTHCARE LLCInventors: Huan-Ping WU, Steven C. Charlton, Amy H. Chu, Andrew J. Edelbrock, Sung-Kwon Jung, Dijia Huang
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Publication number: 20080248581Abstract: A device and method for determining a correction factor for correcting the blood glucose assay bias based on sample hematocrit interference in a testing device using the blood hemoglobin concentration. The hemoglobin assay and the glucose assay may be performed using a single combination monitoring device.Type: ApplicationFiled: March 26, 2008Publication date: October 9, 2008Inventors: Amy H. Chu, Mary Ellen Warchal-Windham
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Publication number: 20080199937Abstract: A reagent composition containing GDH-PQQ as an enzyme-co-factor and screen-printed on working and counter electrodes of electrochemical biosensors, maintains activity of the enzyme reagents by proper selection of components. A preferred composition includes hydrophilic polymers, amorphous untreated silica, buffers, surfactants, and a mediator For example, the biosensor is useful in the amperometric determination of glucose.Type: ApplicationFiled: March 3, 2006Publication date: August 21, 2008Inventors: Amy H. Chu, Hope G. Spradlin
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Patent number: 7132041Abstract: A method of determining the concentration of an analyte in a fluid test sample that includes providing an electrochemical sensor adapted to measure the analyte in the test sample. The test sample sufficiently covers a counter and working electrode of the electrochemical sensor. A first potential is applied between the counter and working electrodes for a first predetermined time period and the current is measured and the time is recorded. After the first potential is removed or substantially reduced, a second potential is applied between the counter and working electrodes and the current is measured. The concentration of the analyte is determined in the test sample as a function of the current measured. An index is calculated and compared to at least one predetermined parameter to identify when a bias, if any, exceeds a threshold. An error signal or analyte concentration is displayed depending on the comparison.Type: GrantFiled: February 2, 2004Date of Patent: November 7, 2006Assignee: Bayer HealthCare LLCInventors: Yingping Deng, Amy H. Chu
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Publication number: 20040154932Abstract: A method of determining the concentration of an analyte in a fluid test sample that includes providing an electrochemical sensor adapted to measure the analyte in the test sample. The test sample sufficiently covers a counter and working electrode of the electrochemical sensor. A first potential is applied between the counter and working electrodes for a first predetermined time period and the current is measured and the time is recorded. After the first potential is removed or substantially reduced, a second potential is applied between the counter and working electrodes and the current is measured. The concentration of the analyte is determined in the test sample as a function of the current measured. An index is calculated and compared to at least one predetermined parameter to identify when a bias, if any, exceeds a threshold. An error signal or analyte concentration is displayed depending on the comparison.Type: ApplicationFiled: February 2, 2004Publication date: August 12, 2004Inventors: Yingping Deng, Amy H. Chu
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Patent number: 6190918Abstract: The present invention provides a device and a process for detecting an analyte in a biological fluid. The device comprises a separating matrix for separating analyte from the fluid and means for detecting the analyte, where the separating matrix contains HEPES buffer, preferably in an amount between 70 and 150 millimolar. The process comprises applying the sample to the device having a separating matrix and then detecting analyte in the sample using the detection means. The presence of HEPES in the separation layer shortened the detection time.Type: GrantFiled: March 6, 1995Date of Patent: February 20, 2001Assignee: Bayer CorporationInventors: Amy H. Chu, Michael J. Wilcox
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Patent number: 5610073Abstract: Disclosed is an improvement to the method for the detection of creatinine in which creatinine, in aqueous solution, is contacted with a dry reagent system of an indicator for creatinine. The assay is carried out at a pH above about 11.5 which is maintained by an alkaline material. The improvement involves packaging the reagent system with a material capable of absorbing CO.sub.2 and at least some ambient water vapor. This inhibits the formation of carbonic acid thereby reducing the neutralization of the alkaline reagent system during storage to increase the shelf life and decrease the variability of the system.Type: GrantFiled: September 26, 1995Date of Patent: March 11, 1997Assignee: Bayer CorporationInventors: Amy H. Chu, Wei-Sen Chu, Howard A. Cooper
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Patent number: 5558834Abstract: An improved device and method of separating the cellular components of whole blood from plasma or serum and assaying the plasma or serum for a predetermined soluble constituent are disclosed. The device includes a filter pad, that separates the cellular components of whole blood from the serum or plasma, and a test pad, that assays the serum or plasma for a predetermined soluble constituent. The filter pad effectively separates and retains cellular components of the whole blood sample, thereby eliminating assay interference by the cellular components of whole blood.Type: GrantFiled: May 31, 1995Date of Patent: September 24, 1996Assignee: Bayer CorporationInventors: Amy H. Chu, Lon R. Stover
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Patent number: 5453378Abstract: Disclosed is a serum free control reagent formulation useful for the determination of a pre-selected analyte. The formulation involves an aqueous solution of a predetermined amount of the analyte together with a polymerized quaternary salt of di- or mono- allyl, di- or tri- alkyl ammonium characterized by the formulae: ##STR1## where R is straight or branched chain alkyl of 1 to 4 carbon atoms, n is a number of at least 9 and .theta. represents a counteranion. The formulation typically contains a buffer to maintain its pH at a level of about 7.5 and a preservative.Type: GrantFiled: February 24, 1994Date of Patent: September 26, 1995Assignee: Miles Inc.Inventors: Douglas E. Bell, Amy H. Chu, Karen L. Marfurt
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Patent number: 5385847Abstract: Disclosed is a method for the determination of urinary protein and creatinine in a single reaction vessel using a continuous process. The method involves adjusting the pH to a level suitable for carrying out an immuno assay for the protein and making such a determination by an immuno agglutination technique. Raising the pH to a level suitable for determining the creatinine quickly dissipates the cloudiness caused by the agglutination reaction, so that the creatinine determination can be carried out without delay.Type: GrantFiled: December 2, 1993Date of Patent: January 31, 1995Assignee: Miles Inc.Inventors: Kin F. Yip, Amy H. Chu, Brenda Tudor
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Patent number: 5360595Abstract: Disclosed is an improved procedure for the manufacture of a diagnostic test device comprising a matrix having uniformly dispersed a tetrazolium salt and a reagent system designed to convert the tetrazolium to its colored formazan upon contacting the matrix with a fluid containing an analyte whose presence and/or concentration is being sought. The procedure involves applying the tetrazolium salt to the matrix from its solution in an organic solvent and, after drying, applying the reagent system to the matrix from its aqueous solution to which has been added hexanesulfonate as wetting agent.Type: GrantFiled: August 19, 1993Date of Patent: November 1, 1994Assignee: Miles Inc.Inventors: Douglas E. Bell, Amy H. Chu