Abstract: A steerable guide catheter includes a tip ring at a distal end and one or more pullwires configured to engage with the tip ring when put in tension, the pullwire(s) thereby subjecting the steerable guide catheter to a curving or turning force. The tip ring includes a saddle and one or more pullwire channels allowing the pullwire to be looped over the saddle such that when the pullwire is placed under tension, it abuts against the saddle of the tip ring. Some embodiments include additional catheters axially aligned within or outside of the steerable guide catheter, and include a keying feature aligning the rotation of the multiple catheters. The keys of the keying feature can be formed of a polyamide with a glass microsphere filler, and can be thermally welded to the catheter.

Abstract: A self-closing device for implantation within a patient's body includes base material including an inner surface area for securing the base material to a tissue structure, and a plurality of support elements surrounding or embedded in the base material. The support elements are separable to accommodate creating an opening through the base material for receiving one or more instruments through the base material, and biased to return towards a relaxed state for self-closing the opening after removing the one or more instruments. The device may be provided as a patch, cuff, or integrally attached to a tubular graft or in various shapes.

Abstract: Disclosed herein are organoids, or compositions thereof, produced through a process of aggregating gut endoderm monolayer and culturing the resultant gut endoderm aggregate. Examples of these aggregated organoids include but are not limited to aggregated liver organoids, aggregated gastric organoids, aggregated intestinal organoids, and aggregated colonic organoids.

Abstract: A storage device for adaptive wear leveling within a data storage system is provided. The storage device includes a host interface configured to receive storage operations for storage and retrieval of data on storage media, a media interface configured to read and write data to the storage media, and a storage controller configured to provide wear leveling for the storage media using a plurality of partitions within the storage media.

Abstract: The present invention provides a tooth whitening film. The tooth whitening film comprises a dental bleaching agent comprising one or both of a non-hydrogen peroxide bleaching agent and hydrogen peroxide in a hydrogen peroxide-polymer complex, one or more polyphosphates, said one or more polyphosphates comprising one or more cyclic polyphosphates, one or more water soluble film-forming polymers, one or more plasticizers and one or more emulsifiers, wherein the film has a thickness from about 50 ?m to about 500 ?m. A kit comprising one or more such films having a thickness from about 50 ?m to about 150 ?m and a dental aligner is also provided. A process for the manufacture of the film is also provided, together with a method of using such a film to bleach teeth.

Abstract: A vacuum freshness preservation container that can be pressed on two sides provided in this application includes a container body and container cove. The container cover has chambers disposed symmetrically, a piston is slidably disposed in each chamber, and each chamber has an air outlet which communicates with an interior of the container body and where a first check valve is disposed. The piston is provided with an air discharge structure that communicates the chamber with an outside when the piston moves toward the first check valve, and the container cover is provided with a linkage mechanism such that the two pistons move in opposite directions. By alternately pressing pistons in two chambers, the chambers always keep in a vacuumizing state, thereby achieving a higher efficiency.

Abstract: The present invention provides devices to access the suprachoroidal space or sub-retinal space in an eye via a minimally invasive transconjunctival approach. The devices may also be used after a partial dissection, for example after dissection of the outer scleral layer of the eye, and using the device within the dissection to access the suprachoroidal space or the sub-retinal space.

Abstract: The present invention provides devices to access the suprachoroidal space or sub-retinal space in an eye via a minimally invasive transconjunctival approach. The devices may also be used after a partial dissection, for example after dissection of the outer scleral layer of the eye, and using the device within the dissection to access the suprachoroidal space or the sub-retinal space.

Abstract: A system for treating an aneurysm comprises at least a first double-walled filling structure having an outer wall and an inner wall and the filling structure is adapted to be filled with a hardenable fluid filling medium so that the outer wall conforms to the inside surface of the aneurysm and the inner surface forms a generally tubular lumen to provide blood flow. The first filling structure comprises a sealing feature which forms a fluid seal between the filling structure and the aneurysm or an adjacent endograft when the filling structure is filled with the hardenable fluid filling medium, thereby minimizing or preventing blood flow downstream of the seal.

Abstract: Aneurysms are treated by filling at least one double-walled filling structure with a curable medium within the aneurysm. The filling structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Scaffolds are placed into the tubular lumens in order to help maintain the shape, anchor the filling structures in place, and provide improved blood flow transition into and out of the tubular lumens.

Abstract: This disclosure describes systems and methods for a graphical interface including a graphical representation of medical data. The graphical interface platform may receive medical data and provide medical safety reporting capabilities including reporting of history data and real-time visual monitoring data. The graphical interface platform may be configured to identify potential problems and corrections to medical devices in operation while a reporting cycle is underway through visual representation of performance metrics.

Abstract: This application provides, inter alia, antibodies or antigen-binding fragments thereof, targeting cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor initiating cancer cells. These anti-GRP78 antibodies, or antigen-binding fragments thereof, have a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in a given species, e.g., a human, and function to inhibit GRP78. Importantly, these isolated novel antibodies and antigen-binding fragments thereof, attenuate PI3K signaling and promote apoptosis in tumor cells, while leaving normal cells unaffected. The antibodies and antigen-binding fragments are useful for UPR-targeted cancer therapeutic treatments.

Abstract: A method of operating a telemetry capture system within a data storage system comprising storage devices is provided. The method includes generating a telemetry packet, and providing the telemetry packet to one or more taps via a telemetry path independent of data and control paths within the storage devices. The method also includes capturing the telemetry packet in one or more of the taps, and generating real-time telemetry data based at least on the telemetry packet.

Abstract: A storage device for adaptive wear leveling within a data storage system is provided. The storage device includes a host interface configured to receive storage operations for storage and retrieval of data on storage media, a media interface configured to read and write data to the storage media, and a storage controller configured to provide wear leveling for the storage media using a plurality of partitions within the storage media.

Abstract: A vacuum freshness preservation container that can be pressed on two sides provided in this application includes a container body and container cove. The container cover has chambers disposed symmetrically, a piston is slidably disposed in each chamber, and each chamber has an air outlet which communicates with an interior of the container body and where a first check valve is disposed. The piston is provided with an air discharge structure that communicates the chamber with an outside when the piston moves toward the first check valve, and the container cover is provided with a linkage mechanism such that the two pistons move in opposite directions. By alternately pressing pistons in two chambers, the chambers always keep in a vacuumizing state, thereby achieving a higher efficiency.

Abstract: This disclosure describes systems and methods for a graphical interface including a graphical representation of medical data. The graphical interface platform may receive medical data and provide medical safety reporting capabilities including reporting of history data and real-time visual monitoring data. The graphical interface platform may be configured to identify potential problems and corrections to medical devices in operation while a reporting cycle is underway through visual representation of performance metrics.

Abstract: Provided herein are nucleic acid molecules, proteins, compositions and methods for treating brain cancer in a subject. In some embodiments, the compositions comprise cancer antigens hTERT, WT-1, and PSMA. In some embodiments, the compositions also comprise an adjuvant. The methods comprise administering to a subject in need thereof the cancer antigens. According to certain embodiments, the methods further involve administering the adjuvant and an anti-PD-1 antibody. In certain embodiments, the methods further comprise administering radiation therapy and/or a chemotherapeutic agent. In certain embodiments, the methods are clinically proven safe, clinically proven effective, or both.

Abstract: Embodiments provide methods and systems for treating aneurysms using filling structures filled with a curable medium An embodiment of a method comprises positioning at least one double-walled filling structure across the aneurysm and filling the structure(s) with a filling medium so that an outer wall conforms to the inside of the aneurysm and an inner wall forms a generally tubular lumen to provide for blood flow. The lumen is supported with a balloon or other expandable device while and/or after filling. The pressure within the structure and/or in the space between an external wall of the structure and the aneurysm wall is monitored and a flow of the medium into the structure is controlled responsive to the pressure. The pressure can also be used to determine a filling endpoint. The medium is hardened while the lumen remains supported by the balloon. The balloon is then removed after the medium hardens.

Abstract: The present invention provides devices to access the suprachoroidal space or sub-retinal space in an eye via a minimally invasive transconjunctival approach. The devices may also be used after a partial dissection, for example after dissection of the outer scleral layer of the eye, and using the device within the dissection to access the suprachoroidal space or the sub-retinal space.