Abstract: A biodegradable and biocompatible barrier membrane of piezoelectric nano composites of Metallic Oxide (MO) (e.g., Magnesium oxide, Zinc oxide and iron oxide)-PLLA (Poly-L-lactide), which can be subjected to acoustic pressure from ultrasound, to generate useful electrical charge for enhanced bone regeneration and enhanced antibacterial effects for guided bone regeneration to treat dental diseases, such as periodontitis.

Abstract: This disclosure describes a technique to fingerprint TLS connection information to facilitate bot detection. The notion is referred to herein as “TLS fingerprinting.” Preferably, TLS fingerprinting herein comprises combining different parameters from the initial “Hello” packet send by the client. In one embodiment, the different parameters from the Hello packet that are to create the fingerprint (the “TLS signature”) are: record layer version, client version, ordered TLS extensions, ordered cipher list, ordered elliptic curve list, and ordered signature algorithms list. Preferably, the edge server persists the TLS signature for the duration of a session.

Abstract: Embodiments for electronic device fasteners that enable an electronic device to be reliably and quickly secured on a host board are presented. In one exemplary embodiment, a fastening assembly includes a glider component that supports an electronic device such as an M.2 solid state drive, and slides on tracks installed on a host board to bring a handle bar in a locking position above the electronic device securing the electronic device in place. The glider component and the tracks are designed with sloped surfaces such that as the glider component slides over the tracks, when it reaches an end of the track, a stable engagement secures the electronic device in place without the need for any additional fastening mechanisms.

Abstract: A cutting edge of a punch includes side segments and a central segment disposed between the side segments. When the punch head slides into a hollow blade, the central segment of the cutting edge meets the punch head before the side segments meet the punch head. The central segment starts cutting first, which can help avoid a dog-bone shaped hole when the punch is used on a blood vessel, such as the aorta.

Abstract: A therapeutic bandage includes a bandage matrix and an array of microneedles extending from the bandage matrix. Each of the microneedles includes a first layer that encapsulates a first immunomodulatory compound and a second layer that encapsulates a second immunomodulatory compound. The array of microneedles is configured to guide foreign agents affected by the first immunomodulatory compound, the second immunomodulatory compound, or the first and second immunomodulatory compounds from one or more skin layers of a user to the bandage matrix such that the bandage matrix absorbs and captures the foreign agents.

Abstract: An implantable blood pump system is disclosed herein. The implantable blood pump system includes an implantable blood pump, a controller coupled to the blood pump, a connector receptacle, and a connector insert. The connector receptacle can include a plurality of contacts, and a following surface. The connector insert can be received within the connector receptacle to couple a plurality of insert contacts with the plurality of contacts of the connector receptacle. The connector insert can include walls defining a follower receptacle that can receive a portion of the following surface when the connector insert is in a desired alignment with respect to the connector receptacle, and a cam surface that can engage with the following surface to bias the connector insert to the desired alignment with respect to the connector receptacle when the connector insert is inserted into the connector receptacle.

Abstract: A method recognizes objects in an environment of a vehicle including a sensor system having at least one sensor unit for registering the environment and an evaluation unit for evaluating sensor data provided by the at least one sensor unit. The method includes receiving the sensor data in the evaluation unit, the sensor data including a plurality of chronologically successive measurements; inputting the sensor data into a machine learning module; and outputting an object state of at least one object estimated based on the sensor data by way of the machine learning module. The method further includes determining a plurality of chronologically successive future object states based on the estimated object state; ascertaining deviations between the future object states and measurements chronologically corresponding to the future object states based on the sensor data; and correcting a machine learning algorithm of the module based on the deviations.

Abstract: A method and a computer software for managing a database of a computer network are disclosed which comprises: selecting a data sample, dividing the data sample into an N×M matrix having equal cells, grouping adjacent cells into a plurality of memory blocs by a least differential sum method, constructing a decision tree based on the partitions of the memory blocs, labeling each of the memory blocs based on the decision tree; storing and retrieving data points into the memory blocs; and linking the memory blocs together by a set of resolution nets.

Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

Abstract: An implantable blood pump system is disclosed herein. The implantable blood pump system includes an implantable blood pump, a controller coupled to the blood pump, a connector receptacle, and a connector insert. The connector receptacle can include a plurality of contacts, and a following surface. The connector insert can be received within the connector receptacle to couple a plurality of insert contacts with the plurality of contacts of the connector receptacle. The connector insert can include walls defining a follower receptacle that can receive a portion of the following surface when the connector insert is in a desired alignment with respect to the connector receptacle, and a cam surface that can engage with the following surface to bias the connector insert to the desired alignment with respect to the connector receptacle when the connector insert is inserted into the connector receptacle.

Abstract: Embodiments for electronic device fasteners that enable an electronic device to be reliably and quickly secured on a host board are presented. In one exemplary embodiment, a fastening assembly includes a glider component that supports an electronic device such as an M.2 solid state drive, and slides on tracks installed on a host board to bring a handle bar in a locking position above the electronic device securing the electronic device in place. The glider component and the tracks are designed with sloped surfaces such that as the glider component slides over the tracks, when it reaches an end of the track, a stable engagement secures the electronic device in place without the need for any additional fastening mechanisms.

Abstract: A biodegradable pressure sensor for measuring vital physiological pressures and for preventing the buildup of dangerous internal forces in impaired organs. The pressure sensor is constructed by depositing Mg or Mo on both sides of a PLLA film. This layered configuration (Mg/PLLA/Mg) or (Mo/PLLA/Mo) may then be encapsulated by layers of high molecular weight PLA. These materials are biodegradable such that after implantation, the sensor does not require invasive removal surgery that can damage directly interfaced tissues.

Abstract: At least some embodiments of the disclosure may advantageously limit bleeding and the occurrence of blood leaks after heart pump implantation. In some embodiments, a base may be provided that includes a flexible layer mechanically coupled with a conduit. The flexible layer may be coupled with the proximal end of the conduit. The conduit may be configured to receive a cannula of the heart pump therethrough. The outer surface of the conduit may be configured to engage a surface of the heart formed after coring the heart. The conduit may be metal and may have a flared and/or beveled distal end. The conduit may be a flexible material. A distal flexible layer may be provided at a distal end of the conduit that is configured to engage with an inner surface of the heart.

Abstract: Embodiments describe an electronic device fastener including a base link bar, and a pair of corner retaining features coupled to the base link bar. Each corner retaining feature includes a base being formed of a planar structure and having a base top surface, a support rail extending from a portion of the base top surface and having a support rail top surface, a fastening feature defined by surfaces of the base and support rail and comprising vacant space extending through the base and at least a portion of the support rail, a guide wall extending from a portion of the support rail top surface, a retaining protrusion extending from the guide wall toward a center line of the electronic device fastener, and a stopper positioned beside the base link bar and at back ends of the base, the support rail, the guide wall, and the base link bar.

Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.

Abstract: A method and a computer software for managing a database of a computer network are disclosed which comprises: selecting a data sample, dividing the data sample into an N×M matrix having equal cells, grouping adjacent cells into a plurality of memory blocs by a least differential sum method, constructing a decision tree based on the partitions of the memory blocs, labeling each of the memory blocs based on the decision tree; storing and retrieving data points into the memory blocs; and linking the memory blocs together by a set of resolution nets.

Abstract: Embodiments describe an electronic device fastener including a base link bar, and a pair of corner retaining features coupled to the base link bar. Each corner retaining feature includes a base being formed of a planar structure and having a base top surface, a support rail extending from a portion of the base top surface and having a support rail top surface, a fastening feature defined by surfaces of the base and support rail and comprising vacant space extending through the base and at least a portion of the support rail, a guide wall extending from a portion of the support rail top surface, a retaining protrusion extending from the guide wall toward a center line of the electronic device fastener, and a stopper positioned beside the base link bar and at back ends of the base, the support rail, the guide wall, and the base link bar.

Abstract: Characteristics of molecules and/or biomolecular complexes may be predicted using differential geometry based methods in combination with trained machine learning models. Element specific and element interactive manifolds may be constructed using element interactive number density and/or element interactive charge density to represent the atoms or the charges in selected element sets. Feature data may include element interactive curvatures of various types derived from element specific and element interactive manifolds at various scales. Element interactive curvatures computed from various element interactive manifolds may be input to trained machine learning models, which may be derived from corresponding machine learning algorithms.

Abstract: A crimping frame or crimping base for a charge air cooler may include a circumferential raised rim including a plurality of crimping slots. The plurality of crimping slots may each include two longitudinal sides and two narrow sides. The two longitudinal sides may be disposed opposite one another and may extend parallel to the rim. The two narrow sides may be stiffened via a bent reinforcement. The bent reinforcement and the rim may be structured as a single piece.