Abstract: The present invention relates to a method for reducing localized fat deposits in a subject in need thereof in need thereof by topically treating the subject with rare-earth element doped calcium carbonate particles in combination with low-intensity ultrasound. The rare-earth element doped calcium carbonate particles have good biocompatibility and can increase reactive oxygen species (ROS) production and produce carbon dioxide (CO2) and calcium ions (Ca2+) in the region of administration under the ultrasonic irradiation. The method of the present invention is effective in inducing adipocyte necrosis, inhibiting adipogenesis, and decreasing body weight and useful for body sculpture.

Abstract: The disclosure provides for compounds and methods for modulating or inhibiting TEAD. Further provided herein are pharmaceutical compositions comprising the TEAD inhibitors and methods of treatment using the TEAD inhibitors or the pharmaceutical compositions.

Abstract: Provided are an array substrate and a manufacturing method thereof, and a display device. The array substrate includes a plurality of data lines and sub-pixels. At least one sub-pixel includes: a first insulating layer; a gate; an active layer located on one side of the first insulating layer away from the gate; a pixel electrode; a first electrode located connected to the active layer and in contact with the pixel electrode; a second electrode connected to the active layer and a data line; a second insulating layer having a first opening, wherein the orthographic projection of the first opening partially overlaps with the orthographic projections of the pixel electrode and the first electrode; a connection electrode in contact with the pixel electrode and the first electrode through the first opening; and a common electrode located on one side of the second insulating layer away from the pixel electrode.

Abstract: A method and device for in-situ enriching Anammox bacteria by conventional activated sludge, which belongs to a biological wastewater treatment technology. The device comprises a raw water tank, an anammox reactor and a water outlet tank.

Abstract: A system may comprise a first catheter having a first steerable segment and a second catheter disposed within the first catheter. The second catheter may have a second steerable segment. The system may also comprise an imaging element supported at a distal end of the second catheter, a coil reference sensor supported at a distal portion of the second catheter, and a processor in electrical communication with the coil reference sensor. The processor may be configured to determine a position of a distal portion of the first catheter with reference to the coil reference sensor.

Abstract: A glass manufacturing apparatus includes a forming apparatus forming a glass ribbon. An enclosure is positioned downstream from the forming apparatus and includes a first chamber, a first end defining an inlet opening, and a second end defining an outlet opening. A first enclosure wall of the enclosure includes an enclosure wall opening defining a gas travel path from the first chamber to an exterior of the enclosure. A ribbon travel path extends through the first chamber. A first conduit extends along a first side of the enclosure and includes a second chamber. A gas opening provides fluid communication between the first chamber and the second chamber. A first gas source is in fluid communication with the second chamber. The first gas source delivers a first gas to the first chamber through the second chamber. Methods of manufacturing a glass ribbon are provided.

Abstract: Provided is a microfluidic chip. The microfluidic chip includes a first substrate and a second substrate disposed opposite to each other, a microfluidic channel formed between the first substrate and the second substrate and configured to accommodate at least one droplet, drive electrodes arranged in an array and sensing electrodes disposed on a side of the first substrate. Each sensing electrode includes at least one first branch electrode and at least one second branch electrode. The first branch electrode extends along a first direction, and the second branch electrode extends along a second direction. Different drive voltage signals are applied to adjacent drive electrodes to drive the droplet to move. Detection signals are applied to the sensing electrodes, and a position of the droplet is determined according to a change in capacitance between one sensing electrode and an electrode corresponding thereto when the droplet flows by.

Abstract: The present disclosure provides a method for performing a programming operation on a memory cell connected to a bit line and controlled by a word line. The method includes applying a first programming voltage signal to the word line to program the memory cell into a first state, applying a first voltage to the bit line, performing a verify operation when the memory cell is in a second state, determining a classification of the memory cell based on the verify operation, applying a second voltage to the bit line based on the determined classification, applying a second programming voltage signal to the word line to program the memory cell into the first state, applying a third voltage to the bit line, applying a third programming voltage signal to the word line to program the memory cell into the first state, and applying a fourth voltage to the bit line.

Abstract: Disclosed are a processing apparatus, a corrugated plate, and a storage container. The processing apparatus includes a pair of slide plates, a pair of press plates, a shaping block, and a driving mechanism. The driving mechanism includes a slide plate driving portion linked to a shaping block driving portion, allowing the slide plate driving portion drives the pair of slide plates to approach each other at a first predetermined speed, the shaping block driving portion moves the shaping block downward at a second predetermined speed, and the first and second predetermined speed are specifically correlated with respect to a predetermined forming profile of an intersection portion. The processing apparatus of the present disclosure causes running speeds of various portions that move in different directions to extrude a blank plate to be specifically associated, so that the formation process is particularly applicable to a corrugated plate having the predetermined corrugated shape.

Abstract: Disclosed herein are methods and compositions for generation of cell lines to promote unnatural amino acid-containing protein production using genome engineering technology.

Abstract: The present disclosure relates to highly sensitive methods for determining the identity and quantity of one or more proteins in a sample. For example, the present disclosure provides methods for the highly sensitive identification and quantitation of residual host cell proteins in protein samples and can be adapted to identify and quantify proteins in either a targeted or a target-agnostic manner and can be modified to achieve a range of sensitivities appropriate for distinct use cases.

Abstract: The application relates to a deep scanning mutagenesis library to interrogate phenotypic changes in a population of cells comprising a plurality of CRISPR-Cas system guide RNAs targeting genomic sequences within at least one continuous genomic region, wherein the guide RNAs target at least 100 genomic sequences upstream of a PAM sequence for every 1000 base pairs within the continuous genomic region and methods for their use.

Abstract: An optical lens module configured to receive at least one image light beam from an image source side is provided. The optical lens module includes a plurality of lens elements. The plurality of lens elements includes a first lens element to a fifth lens element arranged in sequence along an optical axis from an object side to the image source side, and the plurality of lens elements have a semi-reflective layer, a phase retardation layer and a polarization reflection layer respectively formed on the surfaces of the plurality of lens elements. The optical lens module has an aperture on the object side. Wherein, the optical lens module is a secondary imaging optical system, and the at least one image light beam is transmitted through the optical lens module to form an intermediate image between the aperture and the image source side.

Abstract: Provided herein are safe harbor loci that can be utilized as sites for genetic modification. Safe harbor loci of the disclosure are shown to support sustained transgene expression with minimal silencing, and minimal impact on local or global gene expression. Safe harbor loci disclosed herein can be used in various genetic and cell engineering applications.

Abstract: A hybrid display device and a spliced display device are provided. The hybrid display device includes a display panel and a light-emitting module. The light-emitting module includes a backlight module and a display module. The backlight module is disposed corresponding to a display area, and the display module is disposed corresponding to a border area and is configured for image display in the border area. The light-emitting module integrates the backlight module for providing backlight to the display area and the display module for displaying images in the border area.

Abstract: An optical lens module configured to receive at least one image light beam from an image source side, and includes a first to ninth lens elements sequentially arranged along an optical axis from an object side to the image source side. Each of the first to ninth lens elements includes an object-side surface facing the object side and an image-side surface facing the image source side. The optical lens module has an aperture at the object side. The optical lens module is a secondary imaging optical system. Refractive powers of the first to ninth lens elements are respectively positive, negative, positive, negative, positive, negative, positive, negative, and positive. The at least one image light beam is transmitted through the optical lens module and forms an intermediate image between the aperture and the image source side. An optical engine module and a head-mounted display device are also provided.

Abstract: Disclosed are a display module and a display device. The display module includes at least two display panels that are spliced; The display module further includes a groove disposed between two adjacent display panels and a light guiding portion disposed in the groove. The light guiding portion includes a light-incident surface near a bottom of the groove and a light-exiting surface away from the bottom of the groove.

Abstract: Disclosed are systems and methods for superimposing a virtual image on a real-time image. A system for superimposing a virtual image on a real-time image comprises a real-time image module and a virtual image module. The real-time image module comprises a magnification assembly to generate a real-time image of an object at a first location and a first depth, with a predetermined magnification. The virtual image module generates a virtual image by respectively projecting a right light signal to a viewer's right eye and a corresponding left light signal to a viewer's left eye. The right light signal and the corresponding left light signal are perceived by the viewer to display the virtual image at a second location and a second depth. The second depth is related to an angle between the right light signal and the corresponding left light signal projected to the viewer's eyes. The second depth may be approximately the same as the first depth.

Abstract: A display panel includes: a substrate, sub-pixels and a gate drive circuit. The sub-pixel includes a pixel drive circuit. The gate drive circuit includes cascaded shift registers, and a shift register is electrically connected to pixel drive circuits in a row of sub-pixels. The gate drive circuit further includes cascade input signal lines and cascade display reset signal lines. The cascade input signal line is configured to connect a shift signal terminal and an input signal terminal of two different shift register; and the cascade display reset signal line is configured to connect a shift signal terminal and a display reset signal terminal of two different shift register. The display panel has sub-pixel regions for arranging the sub-pixels and first gap regions each located between two adjacent columns of sub-pixel regions; the cascade display reset signal lines and the cascade input signal lines are disposed in different first gap regions.

Abstract: Glasses with gesture recognition function include a glasses frame and a gesture recognition system. The gesture recognition system is disposed on the glasses frame and configured to detect hand gestures in front of the glasses thereby generating a control command. The gesture recognition system transmits the control command to an electronic device to correspondingly control the electronic device.