Abstract: The present disclosure provides an N protein epitope mutation marker for preparing an epitope deletion-marked vaccine strain of type II porcine reproductive and respiratory syndrome virus (PRRSV) and use thereof, belonging to the technical field of biological products. In the mutation marker, one or more amino acids are mutated based on an epitope sequence at positions 92 to 103 of a C-terminal of an N protein of the type II PRRSV; and the epitope mutation marker has an amino acid sequence shown in SEQ ID NO: 1, where X1 is selected from the group consisting of T, P, and A; and X2 is selected from the group consisting of V and A.

Abstract: Real-time pre-encoding dithering techniques mitigate or eliminate banding and other graphical artifacts in video frames prior to such video frames being encoded for transmission to and display by one or more client devices. For each of one or more input video frames, one or more random seeds and a frame identifier are received, and a dithering process is initiated for each of one or more pixels of the input video frame. The dithering process includes generating a YUV noise vector based on the random seeds and on the frame identifier, computing a YUV representation of the input pixel based on RGB color information for the input pixel, and generating a dithered output pixel by adding the generated YUV noise vector to the YUV representation of the input pixel.

Abstract: The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

Abstract: Disclosed are an unblocking apparatus for a furnace discharging pipe and a use method. The unblocking apparatus includes a rail, a rail car that may move along the rail, an unblocking drive mechanism arranged on the rail car, a heat-unblocking component, a cold-unblocking component, and a material receiving component that is used to receive a blocking material in the discharging pipe, and a drive end of the unblocking drive mechanism is detachably connected with one end of the heat-unblocking component and the cold-unblocking component respectively. The present application effectively handles different blockage situations of the furnace discharging pipe by connecting the unblocking drive mechanism with an unblocking rod capable of heat-unblocking and a drilling rod capable of cold-unblocking, thereby two modes of heat-unblocking and cold-unblocking are performed on the furnace discharging pipe; and the discharging pipe may be unblocked by a remote operation.

Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I), or a pharmaceutically acceptable N salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting TYK2, and/or function of IL-12, IL-23 and/or INF-alpha, and/or in treating various associated diseases or disorders.

Abstract: Single cell protein (SCP) is produced by applying a voltage to a microbial electrolysis cell (MEC) under anaerobic conditions for a period of time, whereby SCP is produced. The MEC includes a cathode comprising a hydrogen evolution reaction material, an anode comprising a biofilm on a carbon support, an electrolyte comprising carbon, nitrogen, and phosphorus, and a Methanococcus or Acetobacterium species in the electrolyte.

Abstract: Systems and techniques are provided for part segmentation. For example, a process for performing part segmentation can include obtaining a three-dimensional capture of an object. The method can include generating one or more two-dimensional images of the object from the three-dimensional capture of the object. The method can further include processing the one or more two-dimensional images of the object to generate at least one two-dimensional bounding box associated with a part of the object. The method can include performing three-dimensional part segmentation of the part of the object based on a three-dimensional point cloud generated from the one or more two-dimensional images of the object and the at least one two-dimensional bounding box and based on semantically labeled super points which are merged into subgroups associated with the part of the object.

Abstract: A line current iM(k0) of an M side of a first direct-current transmission line is collected at a moment k0. A line current iM(k0?ts) thereof is collected at k0?ts. At a moment k0, a differential value diM(k0) of a current of the side of the first direct-current transmission line is calculated according to the line current iM(k0) and the line current iM(k0?ts). It is determined whether the differential value diM(k0) of the current meets a protection enabling criteria. If so, direct-current protection for the M side of the first direct-current transmission line is enabled. A line current iM(j) of the M side of the first direct-current transmission line is collected at a moment j. A line current iM(j?ts) thereof is collected at a moment j?ts. A differential value diM(j) of the current of the M side of the first direct-current transmission line at the moment j is calculated according to the line current iM(j) and the line current iM(j?ts).

Abstract: The present disclosure provides use of Clostridium ghonii combined with a tumor angiogenesis inhibitor in preparing a pharmaceutical product for treating a tumor. The present disclosure further provides a drug for treating a tumor, where the drug includes active ingredients of Clostridium ghonii and a tumor angiogenesis inhibitor.

Abstract: The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.

Abstract: The present disclosure relates to a NiTi alloy surface cutting process and a roughness adjustment method. Aiming at defects of difficult machining and unsatisfactory machining performance of Ni—Ti alloys, the present disclosure provides a surface cutting process of a difficult-to-machine nickel-titanium alloy, in which firstly, the nickel-titanium alloy is transformed from a two-phase state to a single-phase state using its transformation characteristic, and electrochemical nickel removal treatment is carried out on a surface of the alloy in the single-phase state so as to obtain a porous surface layer, and then a surface material with the porous surface layer is cut. The method provided by the present disclosure can effectively reduce machining difficulty of alloy materials, and can also obtain alloy workpieces with adjustable roughness, which is of great significance for NiTi alloy machining.

Abstract: Embodiments maintain a data pool that includes heterogeneous data sets, and receiving a first data batch of a data set from a data source into the data pool. Embodiments determine a current state of the data set based on a data set state diagram including a plurality of data set states, and identify a condition of the first data batch. Embodiments further set a data batch state for the first data batch, based on a data batch state diagram, and update the data batch state of a prior data batch received before the first data batch, based on the condition of the first data batch. Embodiments additionally transition the data set state diagram, based on the condition of the first data batch, to an updated data set state. Embodiments maintain a data state repository storing the data set state for each of the plurality of heterogeneous data sets.

Abstract: The present invention provides a joint optimization method and system for delay and spectrum occupation in a cloud-edge collaborative network. The method includes: initializing a cloud-edge collaborative network, and generating a set of user requests; establishing a target function of minimum average end-to-end delay and minimum spectrum slot occupation of a user request; during processing of each user request based on the target function, sequentially determining whether a node and path selection uniqueness constraint, a mobile edge computing (MEC) server load constraint, a spectrum resource occupation and uniqueness constraint, a spectrum continuity constraint, and a spectrum consistency constraint are satisfied, where if all constraints are satisfied, the user request is successfully processed, and the process turns to step S4; or if any constraint is not satisfied, the user request fails to be processed; and calculating average end-to-end delay and spectrum resource occupancy of the user request.

Abstract: Techniques support graph pattern matching queries inside a relational database management system (RDBMS) that supports SQL execution. The techniques compile a graph pattern matching query that includes a bounded recursive pattern query into a SQL query that can then be executed by the relational engine. As a result, techniques enable execution of graph pattern matching queries that include bounded recursive patterns on top of the relational engine by avoiding any change in the existing SQL engine.

Abstract: An interaction method and apparatus and an electronic device. The method comprises: displaying a first application interface, wherein the first application interface comprises an interface of a first application; and creating a second application account in the first application interface, wherein the second application account is used for logging in a second application. Therefore, a new interaction mode is provided.

Abstract: The application provides a display substrate, a method for manufacturing the same, and a display device. The display substrate includes a display region and a binding region located at a periphery of the display region. The binding region is provided with a drive circuit pin and a flexible circuit board pin, and a connecting trace for connecting the drive circuit pin and the flexible circuit board pin. The connecting trace includes a first connecting line and a second connecting line connected in parallel, the first connecting line and the second connecting line are in different layers, the first connecting line is between an interlayer insulating layer and a base substrate of the display substrate, the first connecting line and the interlayer insulating layer are separated by a first insulating layer, and the second connecting line is on a side of the interlayer insulating layer away from the base substrate.

Abstract: The present disclosure relates to use of a Clostridium ghonii spore combined with pembrolizumab in cancer treatment. It is found for the first time that the Clostridium ghonii spore combined with pembrolizumab can significantly improve a curative effect of colon cancer and reduce a dose of the pembrolizumab, and thus is efficient and low-toxic. Oncolysis by Clostridium ghonii can affect immunogenicity of a tumor microenvironment (TME) by various ways, converts an immunosuppressive state of the TME into an immune-activated state, adjusts the immunosuppressive TME, and breaks an immune tolerance. An optimal combination of the Clostridium ghonii spore and the pembrolizumab thoroughly removes about 20% of mouse tumor tissues. A benefit range of patients with tumors treated by a PD-1 antibody is expanded. The combination even has an obvious curative effect on patients failed the treatment by the PD-1 antibody.

Abstract: The present invention relates to a method for preparing high-purity vanadium pentoxide from vanadium-bearing shale by all-wet process. The technical solution is: the “Gradient continuous leaching system of vanadium-bearing shale” is used to wet activate and compound leach vanadium-bearing shale to obtain vanadium-containing acid leachate. The “pH adjusting device of the vanadium-containing acid leachate” is used to adjust the pH of vanadium-containing acid leaching leachate. The post-treatment solution is subjected to hydroxime countercurrent extraction after oxidation, and the raffinate returns to the water using in the wet activation and electrodialysis after neutralization, and the loaded organic phase is regenerated by countercurrent reduction stripping. The regenerated organic phase directly returns to hydroxime countercurrent extraction.

Abstract: The present invention relates to isolated polypeptides having pectinase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

Abstract: The present disclosure provides a detection method. The detection method includes inputting an image to be detected into a detection model being pre-constructed and detecting the image to be detected. The detection model includes a defect classification identification sub-model configured to identify a classification of a defect in the image to be detected, and the defect classification identification sub-model comprises a plurality of base models and a secondary model. The present disclosure further provides an electronic device and a non-transitory computer-readable storage medium.