Abstract: An integrated device for rapid detection of SARS-CoV-2 is disclosed. The integrated device includes a front-end system, a back-end system, and a microfluidic channel. The front-end system includes a detection region and a control region. The detection region and the control region have similar structures, each including an interdigital electrode and a graphene film. The microfluidic channel is arranged to cover the detection region so as to allow the interdigital electrode of the detection region to be exposed to the breath sample. The graphene film of the detection region has a surface resistance higher than that of the graphene film of the control region when the detection region is exposed to a selected virus. The back-end system is configured to detect and compare the surface resistance of the graphene films of the detection region and the control region for determining whether the selected virus is present in the breath sample.

Abstract: The present disclosure includes a method for processing distributed data. In the method, the distributed data of a first main body is obtained. The distributed data has a transfer identifier. The distributed data is transferred, in response to a second main body different from the first main body, to a management address based on the transfer identifier when the distributed data meets a first condition. The first condition is that the distributed data includes abnormal information. The distributed data transferred to the management address freezes transfer of the distributed data by the first main body.

Abstract: A cloud computing resource extension method, a Smart Local Compute Cluster (SLCC), and a storage medium are suggested, which relate to the field of artificial intelligence. The method of cloud computing resource extension includes: acquiring registration information of an extended Availability Zone (AZ), the extended AZ being located in a user's local computer room; sending the registration information to a public cloud, the public cloud being configured to register, based on the registration information, the extended AZ with an AZ set managed and controlled by the public cloud and generate deployment information of a target cloud service pre-designated by the user; receiving the deployment information sent by the public cloud; and deploying the target cloud service in the extended AZ based on the deployment information.

Abstract: A catalytic converter including a catalyst, the catalyst comprising a material of olivine composition, an engine comprising this catalytic converter and an method of producing nitrogen from NOx comprising the catalytic reduction of NOx by a catalyst comprising of a material of olivine composition. In addition, the use of a material of olivine composition in a catalytic reduction of NOx and a method of manufacture of a catalytic converter comprising adding the catalyst to a wash coat, applying the catalyst containing wash coat to a substrate and annealing the coated substrate.

Abstract: Disclosed is a simple synthesis method of lactam derivatives, comprising: with formamide functioning as both an amine source and a hydrogen source (hydrolyzed to produce formic acid), carrying out a cycloamination reaction on a raw material keto acid in the absence of a solvent or a catalyst to simply synthesize a lactam derivative. Compared with previous reports, the present disclosure has the following advantages: the time required for the reaction is greatly shortened, the selectivity is remarkably improved, a conversion rate of a keto acid derivative is greater than 99%, and the yield of the lactam derivative can reach 70% to 94%.

Abstract: The present invention relates to an antibody-drug conjugate and an application thereof, and specifically provides the antibody-drug conjugate, a pharmaceutically acceptable salt and solvate thereof, or a solvate of the salt. The antibody-drug conjugate has the structure represented by formula I, wherein Ab is an anti-Claudin 18.2 antibody. The antibody-drug conjugate of the present invention has good tumor cell growth inhibition activity in vivo and in vitro, low toxicity, and good application prospects.

Abstract: An aqueous dispersion of a polymer additive having a weight average molecular weight of from 2,000 to 25,000 g/mol and comprising, by weight based on the weight of the polymer additive, (i) from 20% to 85% of structural units of an ethylenically unsaturated siloxane monomer; (ii) from 0.1% to 10% of structural units of an ethylenically unsaturated functional monomer carrying at least one functional group selected from an amide, ureido, carboxyl, carboxylic anhydride, hydroxyl, phosphorus acid, or sulfonic acid group, a salt thereof, or mixtures thereof; and (iii) from 5% to 79.9% of structural units of an additional ethylenically unsaturated nonionic monomer. The aqueous dispersion has a coagulum content less than 2,000 ppm after filtration through a 44 micron sieve. A coating composition comprises the aqueous dispersion of the polymer additive can provide coatings with anti-corrosion and/or stain removal properties.

Abstract: The present disclosure provides formulations of an HGF/SF mimetic, terevalefim, as well as methods of preparing and using the formulations. The present disclosure also provides methods of synthesizing terevalefim.

Abstract: An air conditioner indoor unit includes a housing, a panel, a fan assembly, a first air guide assembly, and a first driving assembly. The panel includes a first air outlet. The first air guide assembly is located on a side of the panel away from the housing, and a second air outlet is constituted between an edge of the first air guide assembly and an edge of the first air outlet. The first driving assembly is configured to drive the first air guide assembly to move relative to the panel, so as to change a size of the second air outlet to adjust a flow direction of air flowing out from the second air outlet. The first air guide assembly includes a flow direction changing structure, and the flow direction changing structure is configured to move in a direction different from a moving direction of the first air guide assembly.

Abstract: The present disclosure provides compounds of Formula (I); or a pharmaceutically acceptable salt thereof, wherein each of Ring A, Ring B, Ra, Rb, L, R1, R2, m, and n is defined herein, pharmaceutical compositions thereof, methods of inhibiting ROCK1 and/or ROCK2, and methods of treating a ROCK1- and/or ROCK2-mediated disease or disorder.

Abstract: Provided are an anti-CD20 antibody-drug conjugate, a preparation comprising the antibody-drug conjugate, a composition comprising the antibody-drug conjugate, and a pharmaceutical use of the antibody-drug conjugate.

Abstract: The present disclosure discloses a method for multi-view point cloud registration for a whole aircraft based on a spherical harmonic feature (SHF). Gaussian sphere projection is mainly performed on a local point cloud. An SHF of each point is obtained by using a spherical harmonic transform technology. A constraint correspondence between feature points is found based on an SHF of each point in the point cloud. Multi-view point cloud data registration is performed according to an optimization graph method under a constraint of the SHF. A key of multi-view point cloud registration is to search for feature constraint relationships between different observation stations and perform non-linear solution based on these relationships, so as to obtain a pose parameter of a point cloud in each viewing angle.

Abstract: The present application provides a method for monitoring bubble breakup during CMP, wherein a bonded wafer is formed by bonding of respective first surfaces of first and second wafers, and the magnitude of the current required to drive rotation of the bonded wafer is monitored from the start of the polishing; according to the change of the monitored current driving the rotation of the first wafer, it is determined whether there is bubble rupture at a bonding surface; if the current is increased instantaneously before the bonding surface is exposed by the polishing, bubbles generated at the bonding surface rupture; and if the magnitude of the current is constant before the end of the polishing, no bubble is generated at the bonding surface or generated bubbles do not rupture.

Abstract: A method and an apparatus for real-time analysis of the district heating network is disclosed. According to an embodiment of the present disclosure, a method for analyzing a district heating network including pipes and fluids inside the pipes includes receiving, by a processor, pipe data representing a structure of the pipes; receiving, by the processor, input data on at least one of the physical state of the district heating network and the flow of fluids; calculating, by the processor, data for at least one of the physical state of the district heating network or the flow of fluids using the pipe data and the input data.

Abstract: The present disclosure provides a communication method, and an electronic device. The method includes: obtaining, by an electronic device, a plurality of 2D images and/or a plurality of depth maps for a current scene, the plurality of 2D images and/or the plurality of depth maps being aligned in time; and transmitting, by the electronic device, the plurality of 2D images and/or the plurality of depth maps to the server by means of wireless communication.

Abstract: A hydrophobic palladium/metal organic framework (MOF) material, which is a solid catalyst material obtained by taking a porous MOF as a carrier, introducing elementary palladium by means of an immersion-reduction method, and performing polydimethylsiloxane coating layer processing. A method which uses hydrophobic palladium/MOF material to selectively catalyze hexoses to prepare 2,5-dimethylfuran comprises: dissolving a hexose into an alcohol; using the hydrophobic palladium/MOF material as a catalyst and polymethylhydrosiloxane as a hydrogen donor, reacting at 70 to 130° C. for 0.25 to 12 h under the action of an acidic additive; the concentration of the hexose in the alcohol is 0.2 to 10 wt %, and the total amount of Pd contained in the hydrophobic palladium/MOF material relative to a hexose is 0.1 to 5 mol %.

Abstract: The present invention provides compounds having formula (I): and pharmaceutically acceptable salts thereof, wherein Cy1, Cy2, Cy3, R, R1, R2, R3, A1 and A2 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which inhibiting ROCK1, ROCK2, or ROCK1/2 has a therapeutically useful role.

Abstract: Provided herein are compounds, compositions, and methods useful for inhibiting PERK and for treating related conditions, diseases, and disorders.

Abstract: Provided herein are compounds, compositions, and methods useful for inhibiting PERK and for treating related conditions, diseases, and disorders.

Abstract: Provided herein are compounds, compositions, and methods useful for inhibiting PERK and for treating related conditions, diseases, and disorders.