Abstract: The invention provides adenosine deaminase variants that are capable of deaminating adenine and/or cytosine in a target polynucleotide (e.g., DNA). The disclosure also provides multi-molecular complexes, fusion proteins, base editors, and base editor systems comprising the adenosine deaminase variants with adenine and cytosine deaminase activity and/or cytosine deaminase specificity, and methods of use thereof.

Abstract: The present invention provides a method of reducing a high mannose glycan (HMG) content of a protein (e.g., monoclonal antibody) expressed during a mammalian cell culture (e.g., CHO cell culture) process, as well as a cell culture medium for reducing an HMG content of a protein (e.g., monoclonal antibody) expressed during a mammalian cell culture (e.g., CHO cell culture) process.

Abstract: Configuration devices in a module. In some embodiments a radio-frequency module includes a serial bus including a first serial data line and a second serial data line. The radio-frequency module also includes a control component coupled to the serial bus and the first switch, the control component configured to determine whether first data is detected on the first serial data line, determine whether second data is detected on the second serial data line, and decode a command based on the first data and second data when the first data is detected on the first serial data line and when the second data is detected on the second serial data line.

Abstract: Disclosed herein is an identity network that can provide a universal, digital identity for users that can be used to authenticate the user by an identity provider for relying parties. The identity network receives a request from a relying party that includes deep linking to an identity provider selected by the user. The request specifies the user as well as any other information about the user the relying party is requesting. A service of the identity network launches the application for the identity provider on the user's device using a software development kit. The user can log into the identity provider's application, which validates the user and provides the user authentication/validation and information about the user to the identity network. The identity network can then provide the indication of the user's authentication and the user information to the relying party.

Abstract: This disclosure provides systems, methods, and apparatus for implementing multiple test and measurement devices into a single multi-instrument device (102). The device can include at least one field programmable gate array, FPGA (112), that allows partial reconfiguration. One or more dynamic reconfigurable portions of the FPGA can be configured to function as one or more test and measurement devices. The device can provide outputs of each of the test and measurement instruments to a client device, which can display the outputs to a user. The device can be reconfigured by loading bitstreams (122,136) associated with the desired test and measurement device. The bitstreams can be loaded from the client device (104), a server (106), or from a memory storage unit (114) of the device itself.

Abstract: A data item is programmed to a first set of physical management units (MUs) associated with a memory sub-system in accordance with a first pass programming operation of a multi-pass programming scheme. An entry of a data structure is updated to include a mapping that associates a first physical address associated with the first set of physical MUs with a set of virtual MUs associated with the memory sub-system. A detection is made that a second pass programming operation of the multi-pass programming scheme is initiated to program the data item to a second set of physical MUs associated with the memory sub-system. Responsive to the detecting, the entry of the data structure is updated to include an additional mapping that associates the set of virtual MUs with a second physical address associated with the second set of physical MUs.

Abstract: Disclosed are polynucleotide constructs having a strand linked to a moiety carrying one or more auxiliary moieties. Also disclosed are polynucleotide constructs interrupted with a sugar analogue, and polynucleotide constructs with stereochemical{circumflex over (?)} enriched phosphorothioates. The polynucleotide constructs may be provided as hybridized polynucleotide constructs. Also featured are methods of delivery a polynucleotide construct to a cell and methods of reducing the expression of a protein in a cell by contacting the cell with the disclosed polynucleotide construct or hybridized polynucleotide construct.

Abstract: The present disclosure involves systems, software, and computer implemented methods for performing identity validation using a digital ID shared and trusted among a coalition of institutions. One example method includes receiving, via a communications module and from a first consortium member system, a set of input credentials from a first consortium member system associated with an operation, where the set of input credentials is associated with a user. A digital ID is identified corresponding to the set of input credentials and the first user, wherein each digital ID uniquely identifies a particular user and corresponds to at least one user account associated with other consortium member systems in a trusted consortium network. Using the other user accounts, additional user account information associated with the user is obtained and used in a verification operation.

Abstract: A method for object avoidance by a motor vehicle includes: detecting objects located in the surroundings of the motor vehicle; acquiring data characterizing the position and/or dynamics of each object, then, if several objects have been detected; verifying whether at least one criterion of proximity between at least two of the detected objects is met and, if so; combining the two objects into one group; calculating the data characterizing the position and/or dynamics of the group; and activating a system for obstacle avoidance and/or determining an avoidance trajectory, according to the data characterizing the position and/or dynamics of the group.

Abstract: The invention provides a compound of compound of formula (I): or a salt thereof, wherein R1, n, L, and X have any of the values described herein, as well as compositions and lipid nanoparticles comprising a compound of formula I, and their use for delivering therapeutic agents such as siRNA and mRNA.

Abstract: Disclosed herein are methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for modeling agents in multi-agent systems as reinforcement learning (RL) agents and training control policies that cause the agents to cooperate towards a common goal. A method can include generating, for each of a group of simulated local agents in an agent network in which the simulated local agents share resources, information, or both, experience tuples having a state for the simulated local agent, an action taken by the simulated local agent, and a local result for the action taken, updating each local policy of each simulated local agent according to the respective local result, providing, to each of the simulated local agents, information representing a global state of the agent network, and updating each local policy of each simulated local agent according to the global state of the agent network.

Abstract: An appliance management system for facilitating the dispersal of parts of a chore among users may include an appliance configured to be controlled at least partially automatically according to a routine created by a primary user, who will be away from the appliance (e.g., out of the house) during at least part of the time the routine is being carried out. The routine includes at least one task to be performed by a secondary user, who is in the same general location as the appliance. The task comprises at least one action that cannot practically be performed remotely. Remote control of the appliance is assigned to the primary user in response to the task being completed. Accordingly, the secondary user performs a task that the remote primary user cannot practically perform, but has little or no input into other parts of the chore.

Abstract: The present technology provides a low latency stateful serverless networking protocol to support persistent multiplayer state synchronization. The fundamental system is a key-value data store that uses transactions to ensure state coherency synchronized across many clients. Each client subscribes to state updates as well as orchestrates state writes by attempting to lock and write the next available key and then assumes that its state update will succeed to reduce perceived latency. If the key was incorrectly assumed to be submitted in the right order, the client rolls back its assumption and tries the process again.

Abstract: This application provides a data switching apparatus and a data switching method. The data switching apparatus includes a plurality of dies, the plurality of dies include a plurality of die sets. Each die in the plurality of die sets is coupled to a die in a same die set and a die in a different die set through corresponding interfaces.

Abstract: A paint spraying system includes a paint spray gun, a spray tip removably coupled to the paint spray gun and having a tip orifice configured to output paint atomized in a spray pattern, the spray tip further including a readable element, a pump configured to pump the paint from a paint source to the paint spray gun, and a reader coupled to the paint spray gun and configured to read the readable element and to generate a signal indicative of an identifier of the spray tip. The system includes one or more processors configured to determine an identity of the spray tip based on the signal generated by the reader, identify a characteristic of the spray tip based on the identity of the spray tip, and generate a control signal based, at least in part, on the identified characteristic of the spray tip.

Abstract: Compounds, compositions and methods are provided for modulating the activity of EP2 and EP4 receptors, and for the treatment, prevention and amelioration of one or more symptoms of diseases or disorders related to the activity of EP2 and EP4 receptors. In certain embodiments, the compounds are antagonists of both the EP2 and EP4 receptors.

Abstract: A breech release for a shotgun includes a push button, a return spring, a spring retainer, a threaded steel rod, and a release slide. the return spring is located between the push button and spring retainer. when the breech release engages with a breech, the breech release bisects an outer breech which hinged an inner breech, holding the breech closed in its default position. When the button is depressed, the button moves the slide out of the inner breech, allowing the breech to open.

Abstract: Systems and methods are provided for the management of cooking programs associated with one or more cooking appliances associated with a user. An electronic device receives one or more food purchase records including information relating to food items. Based on the food item information, one or more relevant cooking programs are determined, those programs being suitable for automatically preparing the food item(s) using the one or more cooking appliances. The electronic device communicates the cooking programs to the cooking appliance(s), and causes the cooking appliance(s) to display shortcuts to the one or more cooking programs on a user interface.

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.