Abstract: The present invention discloses a culture medium and method for inducing differentiation of pluripotent stem cells into neuroepithelial cells. The culture medium comprises at least two agents for neural induction, wherein the agents includes a Wnt signal agonist and a Smad2/3 inhibitor and the culture medium is a feeder free culture. The method is to culture pluripotent stem cells in the culture medium to differentiate into neuroepithelial cells. The neuroepithelial cells can further differentiate into mature neurons for practical applications, including regeneration medicine and drug discovery for neural disorders.

Abstract: A top housing having a back slot and a front slot parallel with each other, and both stacked on top of a row of lower slots, which is perpendicular to the back and front slots. In this way, the juxtaposition of the back and front slots and the row of lower slots forms two rows of virtual rectangular through-openings. The back of these rows receives a row of first contacts extended through them. The front of these rows receives a row of second contacts extended through them. The through-openings thus guide the contacts at a position of the contacts that is very close to where they contact the lead of the DUT. Hence, there is a very high amount of precision and control of the contact tip that contacts the lead of the DUT.

Abstract: The present invention relates to a temperature-controlled dimming film with a function of shielding near-infrared light, which comprises a polymer network skeleton and liquid crystal molecules, wherein the polymer network skeleton consists of a polymer-dispersed liquid crystal network structure and a polymer-stabilized liquid crystal network structure and comprises a polymer matrix with pores inside which polymer networks are vertically aligned; and the liquid crystal molecules are dispersed in the polymer network skeleton and have smectic (SmA)-cholesteric (N*) phase transition. Between the skeleton and the liquid crystal molecules, nanoparticles, having absorption at 800-3000 nm, are dispersed. In the invention, a stepwise polymerization method is utilized to construct a PD&SLC network structure between two substrates, which greatly improve the bonding strength between the two substrates and the heat insulation performance of the temperature-controlled liquid crystal dimming film.

Abstract: The present disclosure provides methods of treating epidermolysis bullosa, and/or preventing, preventing the progression of, or delaying the onset of one or more symptom associated with scarring, e.g., of blisters, in subjects with epidermolysis bullosa through chronic systemic administration of collagen 7.

Abstract: An aqueous coating material is provided. The aqueous coating material includes an aqueous resin and a surfactant. The surfactant having a hydrophilic segment of poly(alkylene glycol), a hydrophobic segment of siloxane, and a terminal hydrophilic group. The aqueous resin and the surfactant may have a weight ratio of 100:1 to 100:25.

Abstract: Disclosed are compositions arid methods for accelerating wound closure and preventing inhibiting or reducing scarring or fibrosis. The methods of the present invention include administering to a person in need thereof an effective amount of a pharmaceutical composition comprising collagen 7 and/or one: or snore functional fragments or variants thereof. The functional fragments generally comprise at last one of the nine Fibronectin Type III-like Region of the NC1 region of collagen 7.

Abstract: A sample and hold (S/H) circuit includes a capacitor coupling a sample node to a first voltage and an input line carrying a signal from an input. The S/H circuit also can include one or more transistors coupling the input line to the sample node. The S/H circuit also can include a switch coupled to one or more sources or drains of the one or more transistors and to a second voltage. The S/H circuit also can include a hold circuit coupled to the switch and to one or more gates of the one or more transistors, the hold circuit configured to open, during a sample period, the input line between the input and the sample node.

Abstract: An aqueous coating material is provided. The aqueous coating material includes an aqueous resin and a surfactant. The surfactant having a hydrophilic segment of poly(alkylene glycol), a hydrophobic segment of siloxane, and a terminal hydrophilic group. The aqueous resin and the surfactant may have a weight ratio of 100:1 to 100:25.

Abstract: The drug component of an antibody-drug conjugate having a structure according to formula (II), where Ab, m, n, R1, R2, R3, R4, and R5 are as defined in the application, exhibits unexpectedly improved stability.

Abstract: Packaging method and wafer structures are described. A semiconductor wafer having dies, scribe streets surrounding the dies and between the dies and test pads in the scribe streets is provided. Wafer testing is performed to the semiconductor wafer through the test pads. A laser grooving process is performed to the semiconductor wafer along the scribe streets and the test pads in the scribe streets are removed to form laser scanned regions in the scribe streets. A mechanical dicing process is performed cutting through the semiconductor wafer along the scribe streets to singulate the dies. The singulated dies are packaged.

Abstract: To provide a modified forward osmosis (FO) membrane module for flow regime improvement, the FO membrane module includes but not limited to: a water inlet; a water outlet; a forward osmosis (FO) membrane; a frame; and folded plates for improving flow regime in which draw solution is introduced into the water inlet of membrane module, then flowed through flow channels composed by three opposite folded plates vertically arranged on upper and bottom portions of the frame alternatively along horizontal direction with equal space; and drawn out from the water outlet. The flow regime improvement is achieved by increasing number of flow-guide folded plate, which results in the decrease of internal concentration polarization and membrane fouling. Structure of frame is modified to improve flow regime and to satisfy requirement of convenient and reliable connections between numbers of membrane modules in the FO membrane system.

Abstract: Described herein are compositions that include monoclonal antibodies that specifically bind Hsp90? and methods of using the same to treat HIF-1?-overexpressing cancer. In some embodiments, the cancers are breast cancer or lung cancer. The monoclonal antibodies bind the epitope TKPIWTRNP (SEQ ID NO: 1) in Hsp90? or VKHFSVEGQ (SEQ ID NO: 2) in Hsp90?.

Abstract: This invention provides methods of inducing and maintaining osteogenic potential in mesenchymal stem cells and compositions for doing the same. The compositions this invention comprise collagen 7 (C7), the NC1 domain of C7, or the 27 kD fragment of C7. Also provided are methods for treating bone diseases and correcting bone defects by applying compositions of this invention or by first priming ex vivo mesenchymal stem cells with compositions of this invention and then applying the primed mesenchymal stem cells to the patient. The invention further provides a mesenchymal stem cell osteogenesis induction kit.

Abstract: The present invention relates to a high performance cross-linked triblock cationic functionalized polymer for electrochemical applications, and methods of making and using the same. The invention also relates to a tunable hydrogenated polymer, that can be functionalized with a particular cation for a particular application, and the method of making the hydrogenated polymer and tuning the hydrogenated polymer for the application.

Abstract: A sample and hold (S/H) circuit includes a capacitor coupling a sample node to a first voltage and an input line carrying a signal from an input. The S/H circuit also can include one or more transistors coupling the input line to the sample node. The S/H circuit also can include a switch coupled to one or more sources or drains of the one or more transistors and to a second voltage. The S/H circuit also can include a hold circuit coupled to the switch and to one or more gates of the one or more transistors, the hold circuit configured to open, during a sample period, the input line between the input and the sample node.

Abstract: An ADC device comprises a comparator having an output, a first input, and a second input. And the ADC includes a SAR configured to receive the output of the comparator as an input and to generate based thereon a parallel digital output having a most significant bit (MSB) and a plurality of less significant bits associated with a reference voltage. The ADC also includes a DAC configured to receive the parallel digital output from the SAR and to generate based thereon an internal analog signal, the internal analog signal applied as the first input to the comparator. The DAC further includes a capacitor network coupled to the first input having a redistribution capacitor coupled to a first voltage that is greater than the reference voltage such that a ratio N is equal to the reference voltage divided by the first voltage. The DAC also includes one or more first capacitors also coupled to the first voltage, where at least one first capacitor is associated with the MSB.

Abstract: A method and system of providing customizable service for an asset. The method including generating a predictive model for each asset of a fleet, each predictive model based on an operational profile for the asset and including a probability density function associated with the operational durability of the asset, establishing a maintenance strategy associated with the asset, and combining each of the predictive models to generate a compound fleet performance model, the fleet performance model including a combined probability density function. The method also includes collecting actual asset performance and maintenance data to generate actual asset metrics, determining a fleet performance profile based on the actual asset metrics indicative of a health assessment of the fleet, comparing the predicted fleet performance with the actual fleet performance, and ascertaining actionable choices for managing the assets based on a deviation of the predicted and actual fleet performance.

Abstract: The invention relates to a method of making fluoropolymers without excessive degradation of the polymer backbone. The invention also relates to the fluoropolymers made by this method, and method of using the fluoropolymers.

Abstract: Systems and methods for the configuration of service policies for aircraft fleets and gas turbine engines are disclosed. One or more engine performance profiles may be generated based on historical engine performance data. The historical engine performance data may be retrieved based on one or more engine service parameters. A fleet performance profile may be generated based on the engine performance profiles. The engine service parameters may be varied to generate a configured engine performance profile. A configured fleet performance profile may be generated based on the configured engine performance profile.

Abstract: Disclosed are compositions and methods for accelerating wound closure and preventing inhibiting or reducing scarring or fibrosis. The methods of the present invention include administering to a person in need thereof an effective amount of a pharmaceutical composition comprising collagen 7 and/or one or more functional fragments or variants thereof. The functional fragments generally comprise at least one of the nine Fibronectin Type III-like Region of the NC1 region of collagen 7.