Abstract: Fusion Protein compositions comprising masked IFNs and methods of making masked IFNs are disclosed herein. Consequently, the masked IFNs can be fused to a Mab or binding fragment thereof and be administered to patients as a therapeutic modality and provide a method of treating cancer, immunological disorders and other disease.

Abstract: Pinch devices and access systems that can be used to secure a prosthetic heart valve to a heart valve annulus and to treat valvular insufficiency. A pinch device can be a separate expandable element from the prosthetic heart valve that is first advanced to the annulus and deployed, after which an expandable prosthetic heart valve can be advanced to within the annulus and deployed. The two elements can clamp/pinch the heart valve leaflets to hold the prosthetic heart valve in place. The pinch device can have a flexible, expandable annular frame. A combined delivery system can deliver the pinch device and prosthetic heart valve with just a single access point and aid more accurate coaxial deployment. The pinch device can be mounted near distal end of an access sheath, and a catheter for delivering the prosthetic heart valve can be passed through a lumen of the same access sheath.

Abstract: A system and method for seamless exchange and interaction of multimedia content between communication devices in a network are disclosed. The method can include the discovery and identification of devices within proximity of a sending device. The found devices can be authenticated through unique identifiers established during registration. Connection requirements can be determined based on the identifiers associated with the found devices and the sending device. In turn, the sender can establish a connection with the found devices using the connection requirements. The sending device can share or serve as a remote control to redirect and navigate the content, with a simple action or a gesture command, to the found device. The shared multimedia content, can either reside on the sender's mobile device or on a remote server within a connected network.

Abstract: The present disclosure relates to a resistive random access memory (RRAM) device. In some embodiments, the RRAM device includes a first electrode disposed over a substrate and a second electrode over the first electrode. A doped data storage structure is disposed between the first electrode and the second electrode. The doped data storage structure has a dopant with a doping concentration profile that is asymmetric over a height of the doped data storage structure and that has a maximum dopant concentration at non-zero distances from a top surface and a bottom surface of the doped data storage structure.

Abstract: Provided are systems, devices, and methods to calculate and display information pertaining to a space. Information pertaining to the space may include a number of one or more objects that are permitted to enter the space and a wait time to enter the space.

Abstract: Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 2,3-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 2,3-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

Abstract: Systems and method for producing a small-scale mixer are provided. In some implementations, a method for includes obtaining dimensions of an at-scale mixer. The method also includes determining first dimensions of the small-scale mixer based on respective dimensions of the at-scale mixer. The method further includes determining second dimensions of the small-scale mixer independent of the dimensions of the at-scale mixer. Additionally, the method includes generating the small-scale mixer using the first dimensions and the second dimensions using a three-dimensional printer.

Abstract: Various embodiments of the present disclosure are directed towards a memory device including a data storage structure overlying a substrate. A bottom electrode overlies the substrate and a top electrode overlies the bottom electrode. The data storage structure is disposed between the bottom electrode and the top electrode. The data storage structure comprises a dielectric material doped with a first dopant and a second dopant, where the first dopant is different from the second dopant.

Abstract: A shaft arrangement for a vehicle. The shaft arrangement includes a shaft having a fluid channel extending along an axial direction of the shaft. The shaft includes at least one fluid inlet arranged at an axial distance from a first end of the shaft and extends radially between an outside surface of the shaft and the fluid channel. The shaft arrangement further has a sensor including a first sensor part and a second sensor part, wherein the first sensor part is attached to a first end part of the shaft at the first end of the shaft and the second sensor part is arranged to be attached to a first shaft housing part.

Abstract: An electrically conductive contact element for an electrical connector comprises a contact surface having a plurality of caverns arranged under the contact surface in a microstructure and an auxiliary material filled in the plurality of caverns.

Abstract: A method includes forming a bottom electrode layer, and depositing a first ferroelectric layer over the bottom electrode layer. The first ferroelectric layer is amorphous. A second ferroelectric layer is deposited over the first ferroelectric layer, and the second ferroelectric layer has a polycrystalline structure. The method further includes depositing a third ferroelectric layer over the second ferroelectric layer, with the third ferroelectric layer being amorphous, depositing a top electrode layer over the third ferroelectric layer, and patterning the top electrode layer, the third ferroelectric layer, the second ferroelectric layer, the first ferroelectric layer, and the bottom electrode layer to form a Ferroelectric Random Access Memory cell.

Abstract: Bushings and methods for supporting electrical wiring extending through a hole in a support structure, and aircraft including such bushings are provided. In one example, the bushing includes a grommet. The grommet includes a grommet body portion surrounding an opening that extends through the hole. A grommet collar portion extends from the grommet body portion about the opening. The grommet collar covers an interior edge surrounding the hole of the support structure. An attachment flange extends from the grommet away from the opening. The attachment flange is attached to the support structure adjacent to the hole. A shelf extends from the grommet adjacent to the opening to help support the electrical wiring extending through the opening.

Abstract: The subject invention provides methods of treating neurological disease or disorder, such as brain injuries, such as stroke, traumatic brain injury (TBI), or other ischemic events that cause brain injury by inhibiting or down-regulating Let-7i activity or function. The disclosed methods may have the potential to extend the “window of opportunity” for treatment of such injuries and enhance the effectiveness of existing therapeutics.

Abstract: A printing device is implemented to activate a hidden function by inputting tap sequences on a tap screen. The hidden function includes displaying an icon of a title of a secret document on a display screen without showing the content of the secret document. A method for activating the hidden function using tap sequences is also disclosed. The method compares the input tap sequences with a plurality sets of predetermined codes, each of which corresponds to a hidden function. When the input tap sequences match one set of predetermined codes, the method activates and executes the hidden function. By executing the hidden function, the secret document is printed. The tap sequences are tapping actions that do not generate tangible symbols that are reviewable on the tap screen. By doing so, the confidential document is further protected.

Abstract: Numerous embodiments of analog neural memory arrays are disclosed. Certain embodiments comprise an adaptive bias decoder for providing additional bias to array input lines to compensate for instances where ground floats above 0V. This is useful, for example, to minimize the voltage drop for a read, program, or erase operation while maintaining accuracy in the operation.

Abstract: A delivery assembly comprises a delivery apparatus and a prosthetic valve releasably connected to a cord-retaining device of the delivery apparatus by a plurality of cords or tethers. The cords desirably have a multi-stranded construction formed from a plurality of strands of material. The multi-stranded construction can be, for example, a braided construction, a twisted construction, or a whip-stitch construction. The multi-stranded construction can include integral openings along opposing end portions of each cord. Each cord can extend through an aperture in an apex of the frame of the prosthetic valve or around an apex with one end portion of the cord being retained on the cord-retaining device and another end portion of the cord being retained on a slideable release member of the delivery apparatus.

Abstract: Disclosed embodiments of introducer devices provide hemostatic sealing and allow a delivery catheter to be inserted through the introducer seals without the use of a separate loader device that covers a medical device that is mounted on the catheter. Some disclosed introducers comprise a housing, a distal sheath extending distally from the housing and adapted to be inserted into a patient's vasculature, a distal hemostatic seal mounted within the housing and a proximal hemostatic seal mounted within the housing, and a slidable tube positioned within the housing that is movable longitudinally relative to the distal hemostatic seal between a proximal position and a distal position, wherein in the proximal position a distal end of the tube is positioned proximal to the distal hemostatic seal with the distal hemostatic seal closed, and wherein in the distal position the distal end of the tube extends through the distal hemostatic seal.

Abstract: Apparatus and methods for supplying a vapor to a processing chamber such as a film deposition chamber are described. The vapor delivery apparatus comprises an inlet conduit and an outlet conduit, in fluid communication with an ampoule. A needle valve device restricts flow through the outlet conduit.

Abstract: A user annotation entered in association with a content document of a workflow process executed in association with a metadata context-driven processing system is detected. The user annotation entered in association with the content document is analyzed according to a process-level context associated with the content document within the workflow process. Process-level metadata of the workflow process is inferred based upon the analysis of the user annotation according to the process-level context. The inferred process-level metadata is stored as part of the process-level context of the workflow process.

Abstract: The present disclosure is drawn to devices and systems for target detection in samples, particularly allergen detection in food samples. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. The allergen detection utilizes nucleic acid molecules as detection agents and detection probes.