Abstract: Disclosed is an aminopyrimidine compound as a CDK2/4/6 inhibitor, and specifically disclosed are the compound represented by formula (I) and a pharmaceutically acceptable salt thereof, and an application of the compound represented by formula (I) and the pharmaceutically acceptable salt thereof in the preparation of a medicament for treating solid tumor.

Abstract: A system, a method, and a computer program product may be provided for generating navigation instructions. The system may include a memory configured to store computer executable instructions and a processor configured to execute the computer executable instructions to retrieve sensor data associated with at least one vehicle travelling along a route having at least one intersection and map data associated with the route from a map database. The sensor data indicates intersection information relating to the at least one intersection. The intersection information comprises an intersection category and an intersection type. The map data comprises traffic-related information for a plurality of intersection connected links. The processor may be further configured to determine a turn cost correction factor for the at least one intersection, based on the sensor data and the map data. The processor may be further configured to store the turn cost correction factor within the map database.

Abstract: KRASG12D mutant protein inhibitors, as shown by formula (I), a composition containing the inhibitor and pharmaceutically acceptable salt, syntheses, intermediates, formulations, and the use thereof. The compounds of the invention have good activity and safety in inhibiting tumor growth.

Abstract: A method for analyzing flow matrix data includes: acquiring and sampling a forward-scattered light pulse signal outputted by a flow matrix analyzer and a plurality of fluorescence pulse signals; performing fluorescence compensation on three pieces of fluorescence pulse data after the sampling, and mapping true data of two classification fluorescence pulses to a scatter plot so as to form a two-dimensional array; converting the two-dimensional array into a binary image, and constructing an ellipse gate related to the gathering region; obtaining intrinsic characteristics and movement characteristics of the ellipse gate; and obtaining coordinates of two focuses on the ellipse gate; calculating a distance between each microsphere particle and the two focuses on each ellipse gate; and calculating a median value of true data of calibration fluorescence pulses on all microsphere particles.

Abstract: The disclosure provides a system, a method, and a computer program product for updating map data. The system, for example, receives, from one or more user equipment, at least one road works observation. The at least one road works observation is associated with a road works object. Further, the system, determines a first lane and a second lane. Further, the first lane is associated with the at least one road works observation and the second lane is associated with the road works object. Further, the system determines traffic density associated with a region in vicinity of the road works object. Further, the system detects the road works zone based on the first lane, the second lane and the traffic density.

Abstract: Disclosed herein are methods and dose metrics for evaluating the performance and/or quality of a radiotherapy treatment plan and/or radiotherapy system. Dose metrics may be used in a quality assurance (QA) procedure to evaluate (e.g., test, confirm, validate, etc.) the quality of a treatment plan and/or radiotherapy system before radiation is delivered to a patient. One example of a dose metric is a coverage margin metric. The coverage margin metric may provide a way to quantify how tumor motion affects dose coverage and facilitate the determination of whether the tumor contour defined in the treatment plan has a margin that is sufficient to compensate for tumor motion and/or positional changes during radiation therapy.

Abstract: Methods and systems are described for removing carbon dioxide from the atmosphere by adding CO2-reactive chemical base to a body of water in contact with the atmosphere, and determining the quantity of carbon dioxide removed from the atmosphere or prevented from reaching the atmosphere. The alkalinity addition to the body of water is controlled by a dosing apparatus capable of determining an amount of CO2-reactive alkalinity required for achieving a permissible target carbon dioxide removal. A rate of alkalinity flow is affected by input from sensors that monitor conditions in the body of water.

Abstract: The method for forming the monodisperse granular film includes: providing an initial substrate having a first surface and a second surface opposite to the first surface, forming a sacrificial layer, an adhesive layer and a monodisperse granular layer over the first surface, where the monodisperse granular layer includes multiple granules arranged dispersedly over the first surface, the sacrificial layer is between the multiple granules and the initial substrate, the adhesive layer is between adjacent granules of the multiple granules, and the adhesive layer is exposed between adjacent granules on a side of the multiple granules away from the initial substrate, dissolving and removing the initial substrate, and dissolving and removing the sacrificial layer. The embodiments of the present application are at least conducive to reducing the difficulty in forming the monodisperse granular film, and extending application scenarios of the stacked solar cell.

Abstract: An all-in-one sensing apparatus for transformer bushing tap monitoring includes: a tap lead device connected to a grounding wire of a transformer bushing through a mounting bracket and configured to lead out the grounding wire; a sensor assembly provided on the mounting bracket, connected to an oil taking port of the bushing, and configured to detect a temperature, a pressure, a partial discharge current and a hydrogen content of the bushing and upload the temperature, the pressure, the partial discharge current and the hydrogen content of the bushing; and a power module provided on the mounting bracket, and configured to supply power to the sensor assembly through coil induction, where an output terminal of the tap lead device is connected to the power module, and an output terminal of the power module is connected to the sensor assembly.

Abstract: A display device includes a substrate and a first common electrode layer, a pixel electrode layer and a second common electrode layer which are stacked on the substrate in turn; wherein an orthographic projection of the first common electrode layer on the substrate is at least partially overlapped with an orthographic projection of the pixel electrode layer on the substrate, and a first storage capacitor is formed on an overlapping portion of the first common electrode layer and the pixel electrode layer; an orthographic projection of the second common electrode layer on the substrate is at least partially overlapped with the orthographic projection of the pixel electrode layer on the substrate, and a second storage capacitor is formed on an overlapping portion of the second common electrode layer and the pixel electrode layer.

Abstract: The disclosure provides a system and a method for virtual lane generation for a vehicle. The system may determine one or more paths associated with a lane pair of the vehicle. The lane pair may correspond to an ingress lane and an egress lane associated with a traffic signal intersection. The system may further aggregate the determined one or more paths corresponding to the lane pair, to generate a bounding path associated with the lane pair. The system may further generate a virtual lane based on the generated bounding path. The generation of the virtual lane may be based on determination of a plurality of lane shape points corresponding to the generated bounding path. The system may further store data associated with the generated virtual lane in a map database.

Abstract: A method for transferring funds in a peer-to-peer transaction through a messaging application is provided. The method includes receiving, in a server hosting a messaging application, a selection of a transaction recipient by a user of the messaging application, verifying a validity of the transaction based on at least one of a user attribute and a transaction recipient setting in the messaging application. When the transaction is validated, the method includes providing the user of the messaging application with an approval button for accepting the transaction, applying the transaction when the user of the messaging application accepts the transaction, and disabling the approval button when the transaction is not validated. A system including a memory storing instructions and one or more processors to execute the instructions and cause the system to perform the above method is also provided.

Abstract: A rapid mining method for sandstone-type uranium resources in a uranium and coal superposed area, which relates to the technical field of mining engineering is provided. The method includes: arranging a high-density adjustable well pattern in an in-situ leaching mining area; determining a length and a position of a filter located on the in-situ leaching mining area through a digital well construction technology; and in a production stage, carrying out operations such as pumping/injection centralized filtration, intensified leaching, high-intensity extraction, high-intensity injection, and change of layout of the high-density adjustable well pattern to rapidly obtain sandstone-type uranium resources in a uranium and coal superposed area. A recovery speed of the sandstone-type uranium resources can be improved, and service life of the in-situ leaching mining area can be shortened.

Abstract: An embodiment of the present disclosure discloses an interaction method, which includes playing first video media content; in response to detecting a screen capturing operation at a first time, acquiring a played screenshot corresponding to the first time; and acquiring second video media content corresponding to the first time, wherein the second video media content includes part of the first video media content.

Abstract: Very high refractive index (n>2.2) lightguide substrates enable the production of 70° field of view eyepieces with all three color primaries in a single eyepiece layer. Disclosed herein are viewing optics assembly architectures that make use of such eyepieces to reduce size and cost, simplifying manufacturing and assembly, and better-accommodating novel microdisplay designs.

Abstract: Methods, systems, and storage media for managing digital entitlements are disclosed. Exemplary implementations may: determine at least one digital entitlement; generate a digital backpack; select a third party platform; generate an application program interface (API) call associated with the at least one digital entitlement to a third party application; and store the at least one entitlement in the digital backpack.

Abstract: The present technology includes receiving, by an evaluation service, a request from a web service regarding a subject entity performing a current transaction, where the current transaction is dependent on a parameter of a user account associated with the subject entity meeting a criterion, receiving, by the evaluation service, historical account data from the user account associated with the subject entity, predicting, by the evaluation service, a projected parameter at a future time of the user account associated with the subject entity, where the evaluation service includes a trained machine learning model configured to receive the historical account data for the user account and to predict the projected parameter, and generating, by the evaluation service, a probability that the projected parameter at the future time is correct.

Abstract: This application provides a die package structure including a package substrate, a die, and a first package body. The package substrate has a first surface and a second surface opposite each other. The die is coupled to the package substrate, and the die has a hotspot. A heat dissipation connection point is disposed on the first surface of the package substrate, and a heat conduction channel that communicates the heat dissipation connection point with the hotspot is formed in the package substrate. A first connection terminal for connecting to an external device is disposed on the second surface. The first package body is disposed on the first surface, a heat conduction structure is formed in the first package body, and the heat conduction structure extends from the heat dissipation connection point to a surface of the first package body.

Abstract: Generating a multi-dimensional video using a multi-dimensional video generative model for, including, but not limited to, at least one of static portrait animation, video reconstruction, or motion editing. The method including providing data into the multi-dimensionally aware generator of the multi-dimensional video generative model, and generating the multi-dimensional video from the data by the multi-dimensionally aware generator.

Abstract: Embodiments of the present disclosure provide a solution for video processing. A method for video processing is proposed. The method comprises: determining, during a conversion between a target video block of a video and a bitstream of the video, a prediction of coding time for the target video block, the coding time representing a time duration during which a coding process of the target video block being performed; adjusting the coding process for the target video block based at least in part on the prediction of coding time; and performing the conversion between the target video block and the bitstream by using the adjusted coding process.