Abstract: In certain embodiments, the present invention provides a method of treating an IP10-related disease in a subject, comprising: (a) administering to the subject a predetermined dosage of an anti-IPIO antibody; (b) detecting the level of the anti-IPIO antibody in a sample of the subject; and (c) if the level of the anti-IPIO antibody from step (b) is below a threshold exposure level, increasing the dosage of the anti-IPIO antibody in the subject such that the IP-10 related disease in the subject is treated.

Abstract: A wrench for action on a work piece is provided. The wrench is a box end socket wrench. The socket wrench has an elongated handle with a box head. The box head has a top and a bottom surface and an inner wall defining an inner aperture. The inner wall is shaped to receive the work piece and has a receiving groove spaced apart from the top surface of the box head to receive a biased member. The biased member extends into the inner aperture of the box head to releasably secure the work piece. When the work piece is inserted in the inner aperture of the box head, the work piece sits flush with the corresponding top and bottom surface of the box head of the wrench.

Abstract: An ESD protection device including second P-type wells, first P+-type doped regions, first N+-type doped regions and a P-type substrate having a first P-type well, an N-type well and an N-type deep well is provided. The second P-type wells are disposed in the N-type deep well. The first P+-type doped regions and the first N+-type doped regions are respectively disposed in the first P-type well, the N-type well and the second P-type wells in alternation. The first P+-type doped region in the N-type well and the N-type deep well are electrically connected to the first connection terminal. The doped regions in the first P-type well and the P-type substrate are electrically connected to the second connection terminal. The second P-type wells and the first N+-type doped regions therein form a diode string connected in series between the first N+-type doped region of the N-type well and the second connection terminal.

Abstract: An electrostatic discharge protection device electrically connected between a pad and an internal circuit is provided and includes a capacitor, a first resistor, a voltage-drop element and an NMOS transistor. A first end of the capacitor is electrically connected to the pad. A first end of the first resistor is electrically connected to a second end of the capacitor, and a second end of the first resistor is electrically connected to ground. The NMOS transistor and the voltage-drop element are connected in series between the pad and the ground, a gate of the NMOS transistor is electrically connected to the second end of the capacitor, and a bulk of the NMOS transistor is electrically connected to the ground.

Abstract: A semiconductor device, an electrostatic discharge protection device and manufacturing method thereof are provided. The electrostatic discharge protection device includes a gate, a gate dielectric layer, an N-type source region, an N-type drain region, an N-type doped region and a P-type doped region. The gate dielectric layer is disposed on a substrate. The gate is disposed on the gate dielectric layer. The N-type source region and the N-type drain region are disposed in the substrate at two sides of the gate, respectively. The N-type doped region is disposed in the N-type drain region and connects to the top of the N-type drain region. The P-type doped region is disposed under the N-type drain region and connects to the bottom of the N-type drain region.

Abstract: A method for evenly preparing filament by using high-shearing solution of ultrahigh-molecular-weight polyethylene is disclosed. The method involves mixing an ultrahigh-molecular-weight polyethylene with a solvent in a predetermined ratio, and processing the mixture through a high-shear method to prepare an ultrahigh-molecular-weight polyethylene emulsion solution that is extruded by a dual-screw extruder and quenched in chilled water into a gel protofilament. The gel protofilament is then cleaned by a hydrocarbon cleaning agent before undergoing extraction drawing, drying and hot drawing multiple times so as to form high-tenacity, high-modulus polyethylene fiber. The resultant fiber has good mechanical properties and less fiber misalignment while its production enjoys advantages of low energy consumption, good production conditions, and short production cycle.

Abstract: A wrench for action on a work piece is provided. The wrench is a box end socket wrench. The socket wrench has an elongated handle with a box head. The box head has a top and a bottom surface and an inner wall defining an inner aperture. The inner wall is shaped to receive the work piece and has a receiving groove spaced apart from the top surface of the box head to receive a biased member. The biased member extends into the inner aperture of the box head to releasably secure the work piece. When the work piece is inserted in the inner aperture of the box head, the work piece sits flush with the corresponding top and bottom surface of the box head of the wrench.

Abstract: In accordance with one aspect of the present invention, a combination ratcheting and helical driver is disclosed. In the unlocked position the hand tool coverts downward linear force into rotary motion. In the locked position the hand tool operates as a ratcheting driver. The locking device locks the helical drive shaft of the hand tool in a retracted position such that the helical drive shaft is substantially positioned within the handle body. A locking main body is adjacent to a chuck assembly. The locking main body selectively combines with a shoulder abutment adjacent to the handle assembly to lock the helical drive shaft in the retracted position.

Abstract: Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone.

Abstract: An automatic custom block composition tool for composing custom blocks of an integrated circuit (IC) design that may include non-standard library cells. The tool includes program instructions that are executable to create and use a placement control file that includes instructions for use by the custom block composition tool to place the one or more non-standard library cells into the custom block layout. In addition, the program instructions may instantiate a leafcell for each non-standard and each standard library cell included in a netlist. The program instructions may access the placement control file and place each leafcell in a row of the custom block layout according to the placement control file. The program instructions may also pre-route power, clock and critical network signals, and generate a router control file used during remaining routing of the custom block by a conventional router tool.

Abstract: In accordance with one aspect of the present invention, a combination ratcheting and helical driver is disclosed. In the unlocked position the hand tool coverts downward linear force into rotary motion. In the locked position the hand tool operates as a ratcheting driver. The locking device locks the helical drive shaft of the hand tool in a retracted position such that the helical drive shaft is substantially positioned within the handle body. A locking main body is adjacent to a chuck assembly. The locking main body selectively combines with a shoulder abutment adjacent to the handle assembly to lock the helical drive shaft in the retracted position.

Abstract: A video clip is processed by selecting a plurality of video frames of the video clip. A plurality of the pixels of the selected video frames are modified to form modified video frames. The modification to each of the plurality of the pixels is based on the intensity of the pixel, a change in the intensity of the pixel from the corresponding pixel in at least one related video frame, and the intensity of the corresponding pixel. A second video clip is formed that comprises the modified video clips.

Abstract: An automatic custom block composition tool for composing custom blocks of an integrated circuit (IC) design that may include non-standard library cells. The tool includes program instructions that are executable to create and use a placement control file that includes instructions for use by the custom block composition tool to place the one or more non-standard library cells into the custom block layout. In addition, the program instructions may instantiate a leafcell for each non-standard and each standard library cell included in a netlist. The program instructions may access the placement control file and place each leafcell in a row of the custom block layout according to the placement control file. The program instructions may also pre-route power, clock and critical network signals, and generate a router control file used during remaining routing of the custom block by a conventional router tool.

Abstract: A method and system for decoding data on a medium that is captured by an input device is described. The method decodes a symbol design, such as an embedded interaction code (EIC), on a display screen, such as a liquid crystal display (LCD). An image that is captured by an input device, such as a universal pen-type input device with a camera, is received. The captured image is processed to output an extracted bit stream. Position data and/or metadata information is decoded from the extracted bit stream and a position of the captured image with respect to a screen of the LCD is determined based upon the decoded position data. The EIC pattern may be recognized from LCD pixel grids and a bit stream of EIC bits may be extracted based upon the recognized EIC pattern.

Abstract: A video clip is processed by selecting a plurality of video frames of the video clip. A plurality of the pixels of the selected video frames are modified to form modified video frames. The modification to each of the plurality of the pixels is based on the intensity of the pixel, a change in the intensity of the pixel from the corresponding pixel in at least one related video frame, and the intensity of the corresponding pixel. A second video clip is formed that comprises the modified video clips.

Abstract: A method and system for decoding data on a medium that is captured by an input device is described. The method decodes a symbol design, such as an embedded interaction code (EIC), on a display screen, such as a liquid crystal display (LCD). An image that is captured by an input device, such as a universal pen-type input device with a camera, is received. The captured image is processed to output an extracted bit stream. Position data and/or metadata information is decoded from the extracted bit stream and a position of the captured image with respect to a screen of the LCD is determined based upon the decoded position data. The EIC pattern may be recognized from LCD pixel grids and a bit stream of EIC bits may be extracted based upon the recognized EIC pattern.

Abstract: The universal input device provides a common user interface for a variety of different computing platforms including printed documents. Using the present system, one may use the universal input device to control various computing devices as well as capture handwritten electronic ink and have the electronic ink be associated with new or stored documents. The universal input device can be identified by a specific identification in order to allow for multiple users to operate on a document and/or within an application program simultaneously or not. An off-set optical system with infrared illumination handles perspective and helps detect positional encoding which can be covered by existing ink under common visible light illumination.