Abstract: The present disclosure selects third party content based on feedback. A selector identifies several content items including first and second content items (or more) responsive to a request. A machine learning engine determines a first feature of the first content item, a second feature of the second content item, and a third feature of the web page or a device associated with the request. The machine learning engine determines, responsive to the first feature and the third feature, a first score for the first content item based on a machine learning model generated using historical signals received from devices via a metadata channel formed from an electronic feedback interface. The machine learning engine determines a second score for the second content item responsive to the second feature and the third feature. A bidding module determines a price for the first content item based on the first and second scores.

Abstract: This disclosure provides engineered tRNAs and the corresponding aminoacyl tRNA synthetase for efficient production of proteins containing non-standard amino acids. These engineered orthogonal tRNA (O-tRNA)/orthogonal aminoacyl tRNA synthetase (O-RS) pair, i.e., Orthogonal Translation Systems (OTSs) can be used to incorporate a non-standard amino acid in a specific position in a growing polypeptide in response to a selector codon that is recognized by the engineered tRNA.

Abstract: The present invention generally relates to sensitizer compounds and their use in combination with Tyrosine Kinase Inhibitors (TKIs) for sensitizing tumor, cancer or pre-cancerous cells to TKI treatment. In particular, the present invention relates to administration regimes that combine TKIs such as Gefitinib or Icotinib with TKI-sensitizing DZ1 esters and amides conjugated to statin or platin-based drugs, or to Artemisinin, including, without limitation: DZ1-Simvastatin amide, DZ1-Simvastatin ester, DZ1-Cisplatin ester, and DZ1-Cisplatin amide, DZ1-Artemisinin ester, and DZ1-Artemisinin amide. Furthermore, the present invention relates to improved TKI treatment of cancers by sensitizing tumor, cancer or pre-cancerous cells, in particular cancers that develop TKI resistance, including e.g. lung cancer and pancreatic cancer.

Abstract: A display panel, including a base substrate, a display layer, and a touch-control layer that are sequentially stacked; where a display region of the display panel is provided with a light-transmitting region; the touch-control layer is provided with a touch-control channel, the touch-control channel comprises a first signal channel extending along a first direction and a second signal channel extending along second direction, and the second direction is intersected with the first direction; where, the touch-control channel adjacent to the light-transmitting region is a heterogeneous touch-control channel, and at least one heterogeneous touch-control channel comprises a plurality of heterogeneous touch-control sub-channels adjacent to the light-transmitting region; and among the plurality of heterogeneous touch-control sub-channels of the heterogeneous touch-control channel, at least one of the heterogeneous touch-control sub-channels is kept continuous.

Abstract: Embodiments of the present application are related to a method and apparatus for physical uplink control channel (PUCCH) transmission. An exemplary method of the present application includes: receiving information for determining a plurality of beams; receiving a beam indication indicating at least one beam of the plurality of beams to be used for transmission of a PUCCH resource; and transmitting the PUCCH resource according to the beam indication.

Abstract: Methods and apparatus of Physical Downlink Shared Channel (PDSCH) processing procedure time derivation for Hybrid Automatic Repeat Request Acknowledgement (HARQ-ACK) feedback of PDSCH scheduled by enhanced Physical Downlink Control Channel (PDCCH) are disclosed.

Abstract: A display panel is provided. The display panel includes a touch control structure. The touch control structure includes a plurality of first mesh electrodes and a plurality of second mesh electrodes. A respective one of the plurality of first mesh electrodes includes a plurality of first mesh blocks consecutively electrically connected along a first direction. A respective one of the plurality of second mesh electrodes includes a plurality of second mesh blocks consecutively electrically connected along a second direction. Two adjacent first mesh blocks of the plurality of first mesh blocks are electrically connected to each other through a respective first conductive bridge. The respective first conductive bridge includes a plurality of first single mesh lines spaced apart from each other, and in a layer different from the plurality of first mesh blocks and the plurality of second mesh blocks.

Abstract: An optical fiber microwave frequency transmission method based on laser frequency offset-locking includes: generating, by a master laser and a slave laser respectively, a master laser signal and a slave laser signal; transmitting, by an optical fiber link, the master laser signal and the slave laser signal to a microwave frequency receiver, and locking a frequency difference between the master laser and the slave laser to a preset microwave frequency; receiving a return laser signal returned from the microwave frequency receiver, the return laser signal including the master laser signal, the slave laser signal and a noise of the optical fiber link; generating a reference signal, and adjusting the preset microwave frequency to compensate the noise of the optical fiber link, so that a microwave frequency subsequently received by the microwave frequency receiver approaches a frequency of the reference signal.

Abstract: Provided are novel treprostinil salts as well as methods for making treprostinil salts.

Abstract: A sealing device for sealing off a bearing unit from oil contaminants is disclosed herein. The sealing device comprises an annular metallic screen integral to a stationary inner ring, an annular metallic support integral to a rotatable outer ring, and an elastomeric element mounted on the support and comprises a radial lip and an axial lip that cooperate in a sliding and contacting manner with the screen.

Abstract: The disclosure discloses an optical imaging lens, which sequentially includes, from an object side to an image side along an optical axis, a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens and a seventh lens. The first lens has positive refractive power, the fourth lens has positive refractive power, and the seventh lens has negative refractive power. A total effective focal length f of the optical imaging lens and a maximum Field Of View (FOV) of the optical imaging lens meet f×tan(FOV/2)?5.5 mm. An effective focal length f4 of the fourth lens and an effective focal length f6 of the sixth lens meet 1.3?f4/f6<4.5.

Abstract: Disclosed a display panel comprising: a base substrate and a plurality of sub-pixels located on the base substrate; and each sub-pixel includes: a semiconductor layer located on the base substrate and including a first active layer of an initialization transistor, a second active layer of a reset transistor and a third active layer of a data writing transistor; a first conductive layer located on a side of the semiconductor layer and including a data signal line extending in a first direction; and a second conductive layer located on the base substrate and including a drive gate of a drive transistor; where the drive gate is electrically connected to a first conductive region of the first active layer; and an orthographic projection of the second active layer on the base substrate is located between an orthographic projection of the first active layer and an orthographic projection of the data signal line.

Abstract: A wireless communication system includes: a processing circuit, at least one linear amplification circuit, a switch amplification circuit, at least one first filter capacitor, and at least one power amplifier. An output end of the switch amplification circuit, an output end of the linear amplification circuit, and a power supply end of the power amplifier are coupled at a first node. The first filter capacitor is coupled to an input end of the linear amplification circuit or the output end of the linear amplification circuit.

Abstract: Embodiments of the present disclosure relate to devices, methods, apparatuses and media for communication. A device for communication is configured to generate target data for the optical network unit based on template data for an optical network unit set and instance data for an optical network unit in the optical network unit set. The device is further configured to perform validation on the target data of the optical network unit. In this way, an optical network unit data validation solution that supports an optical network unit to use template data is provided, which can significantly improve the validation speed of optical network unit data.

Abstract: The present disclosure provides a touch display substrate, a manufacturing method thereof, and a display device. The touch display substrate includes a base substrate and a touch layer, the touch layer includes a plurality of touch units, the plurality of touch units includes a plurality of first touch units with complete touch patterns and a plurality of second touch units with incomplete touch patterns, at least a part of the plurality of second touch units is arranged in an outer edge region of the touch layer, a ratio of an area of the touch pattern of the second touch unit to an area of the touch pattern of the first touch unit is greater than 0 and less than or equal to a first threshold, and/or greater than or equal to a second threshold and less than 100%, and the first threshold is less than the second threshold.

Abstract: A skill diagnosis device includes a question storage configured to store a question for skill diagnosis related to project management, a diagnosis executor configured to read the question for skill diagnosis from the question storage, transmit the question for skill diagnosis to a first terminal used by an organization member, and receive an answer result to the question for skill diagnosis from the first terminal, an answer result storage configured to store the answer result received from the first terminal, a diagnoser configured to diagnose a skill of the organization member based on the answer result stored in the answer result storage, and an outputter configured to output a diagnosis result of the diagnose. The diagnosis result includes a classification of a human resource type representing an ability or an action characteristic capable of taking a specific action.

Abstract: Compositions and method of reducing Tau phosphorylation in neurons of a subject in need thereof are provided. In some embodiments, the subject has a proteinopathy, amyloidosis, or a tauopathy. Thus, compositions and methods of treating a proteinopathy, amyloidosis, or a tauopathy are also provided. Also disclosed are compositions and methods of increasing learning and/or memory in a subject with a tauopathy. The methods typically include administering the subject an effective amount of a direct or indirect inhibitor of Pax6 (Pax6 inhibitor). The Pax6 inhibitor can be, for example, a small molecule or a functional nucleic acid. In some embodiments, the small molecule is palbociclib, apigenin, flavopiridol, abemaciclib, ribociclib, or ICCB280, or a derivative, stereoisomer, or pharmaceutically acceptable salt thereof. In some embodiments, the functional nucleic acid including but not limited to siRNA, shRNA, or miRNA, or a nucleic acid expression construct encoding an siRNA, shRNA, or miRNA.

Abstract: A touch structure, a touch display panel, and a display device are provided, which relate to the field of touch technology. The touch structure includes first touch electrodes and second touch electrodes. The first touch electrode includes first electrode blocks and transfer bridges. The second touch electrode includes second electrode blocks. The first and second touch electrodes are mesh structures. Grid lines of the first and second electrode blocks are channel lines, and the channel lines forming boundaries of the first electrode block are first boundary channel lines. Grid lines of the transfer bridge are transfer lines. The transfer bridge includes an opening part and a bridge part connected to the opening part. The opening part is connected to the first electrode block through a via hole. Some transfer lines are boundary transfer lines. The boundary transfer lines are overlapped with some first boundary channel lines.

Abstract: The disclosed technology facilitates User and Entity Behavior Analytics (UEBA) by classifying a file being transferred as encrypted or not. The technology involves monitoring movement of a files by a user over a wide area network, detecting file encryption for the files using a trained classifier, wherein the detecting includes processing by the classifier some or all of the following features extracted from each of the files: a chi-square randomness test; an arithmetic mean test; a serial correlation coefficient test; a Monte Carlo-Pi test; and a Shannon entropy test, counting a number of the encrypted files moved by the user in a predetermined period, comparing a predetermined maximum number of encrypted files allowed in the predetermined period to the count of the encrypted files moved by the user and detecting that the user has moved more encrypted files than the predetermined maximum number, and generating an alert.