Abstract: GDF15 polypeptides, constructs comprising GDF15, and mutants thereof are provided. In various embodiments the GDF15 polypeptides, constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Abstract: At least on or near one of its edges a plastic floor includes a chamfer formed during a rolling press and plate press forming process. During the rolling press and plate press forming process of the plastic floor, a chamfer is formed at the periphery on the front surface of the plastic floor. The wear-resistant layer and color film layer at the chamfer are not damaged. When splicing, the chamfers on the two pieces of plastic floor are connected to each other to form a joint seam, and there is no need to cut chamfers at the edge of the floor before grooving, thereby reducing the production process, and improving the appearance of the joint seam.

Abstract: A silicon based photodetector and method of manufacturing the same are provided. The photodetector comprising: a silicon substrate; a buried oxide layer, above the silicon substrate; and a waveguide, above the buried oxide layer. The waveguide includes a silicon, Si, containing region and a germanium tin, GeSn, containing region, both located between a first doped region and a second doped region of the waveguide, thereby forming a PIN diode. The first doped region and the second doped region are respectively connected to first and second electrodes, such that the waveguide is operable as a photodetector.

Abstract: Provided is a project success probability calculation system including a performance influencing pre-element holder that holds a performance influencing pre-element which is a pre-element that influences the performance of a project, a questioner that outputs a question for associating a performance pre-status value with the performance influencing pre-element assuming a specific project in which the project is specifically specified and prompts an input, a probability distribution derivation function holder that holds a probability distribution derivation function which is a function for calculating a probability distribution of success of the specific project using the performance pre-status value associated with the performance influencing pre-element, a success probability distribution calculator that calculates a success probability distribution of the specific project, based on the performance pre-status value obtained by the input and the held probability distribution derivation function, and a success

Abstract: Methods and apparatuses for jointly reporting CSI in multi-TRP based DL transmission are disclosed. In one embodiment, a method comprises transmitting a CSI reporting setting linked to two or more Resource Settings for channel measurement, wherein the two or more Resource Settings for channel measurement have the same number of CSI-RS resources, and receiving a joint CSI report corresponding to the CSI reporting setting.

Abstract: Apparatuses, methods, and systems are disclosed for transmission using DMRS from two code division multiplexing groups. One method (500) includes transmitting (502) information on a physical downlink shared channel to a user equipment, wherein: the information on the physical downlink shared channel is transmitted by: first demodulation reference signal ports of a first code division multiplexing group having a first number of demodulation reference signal ports; and second demodulation reference signal ports of a second code division multiplexing group having a second number of demodulation reference signal ports, wherein the first code division multiplexing group is different from the second code division multiplexing group, and the first number of demodulation reference signal ports is the same as the second number of demodulation reference signal ports.

Abstract: Methods and apparatuses for determining default spatial relation and default PL-RS are disclosed. A method comprises determining a default spatial relation and a default pathloss reference RS (PL-RS) for transmission of uplink resource on a serving cell without configured CORESET, the uplink resource is configured with neither higher layer parameter related to spatial relation nor higher layer parameter related to PL-RS, and the higher layer parameter related to enable default beam for the uplink resource is set to ‘enable’, and transmitting the uplink resource according to the determined default spatial relation and the power determined by the determined default PL-RS.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: Methods and apparatuses for determining default beam(s) are disclosed. A method comprises receiving an activation command for the activated BWP of a serving cell, wherein the activation command contains codepoints pointing to TCI state (s) for PDSCH, and at least one codepoint points to two TCI states; and determining default TCI states for the reception of multiple PDSCH transmission occasions scheduled by a single DCI according to a scheduling offset between the reception of the DCI and the nth PDSCH transmission occasion, wherein n is larger than 1.

Abstract: A method of providing an ad extension includes selecting an advertisement for display. The method also includes selecting additional information related to the advertisement. The method also includes transmitting data representing the advertisement to a browser. The browser interacts with an expandable API to render an inline frame having an advertisement slot. The browser renders and displays the advertisement in the frame. The method also includes transmitting display data representing the additional information related to the advertisement to the browser. The browser receives an input to activate the ad extension. In response to the input, the browser interacts with the expandable API system to expand and render the frame. The browser renders, in the frame, the advertisement slot containing the advertisement. The browser also renders, in the frame, the additional information. The browser displays the expanded inline frame, such that the displayed frame covers a portion of the content.

Abstract: An array substrate is provided. A first virtual line and a second virtual line respectively cross over a first voltage supply line, a second voltage supply line, and a third voltage supply line. The first voltage supply line, the second voltage supply line, and the third voltage supply line respectively include a first voltage supply line portion, a second voltage supply line portion, and a third voltage supply line portion, respectively between the first virtual line and the second virtual line. An orthographic projection of a third anode of a third light emitting element on a base substrate completely covers an orthographic projection of the third voltage supply line portion on the base substrate. The third voltage supply line portion has a line width greater than a line width of the first voltage supply line portion, and greater than a line width of the second voltage supply line portion.

Abstract: Systems, apparatuses, and methods for placing cells in an integrated circuit are described. In various embodiments, an integrated circuit is divided into many partitions. In a first set of partitions susceptible to transistor latch-up, the many transistor gate stripes are connected to one of the power rails rather than left floating. The lengths of the transistor gate stripes are shortened for well tap cells in the first partition, but increased in a second partition susceptible for poor signal integrity. One or more implant layers are formed underneath the transistor gate stripes in each of the first and second partitions to adjust an amount of protection against transistor latch-up and poor signal integrity. An electrostatic discharge transistor is included with at least one source region of multiple source regions formed in a well with a same doping polarity as the at least one source region.

Abstract: A touch control structure is provided. The touch control structure includes a plurality of first touch electrodes arranged in a plurality of rows and a plurality of second touch electrodes arranged in a plurality of columns. The plurality of rows of the plurality of first touch electrodes respectively extend to a first edge of the touch control structure. A respective one of a plurality of edge-adjacent electrode blocks directly adjacent to multiple first edge electrode blocks respectively from a plurality of rows of the plurality of first touch electrodes includes a truncated protrusion. An edge of the truncated protrusion is spaced apart from the first edge by a gap. An average width of the truncated protrusion along a direction perpendicular to the first direction is less than an average width of a respective one of the multiple non-truncated protrusions along the direction perpendicular to the first direction.

Abstract: A background audio construction method is provided. The background audio construction method includes: performing semantic segmentation on to-be-processed video data to generate a corresponding semantic segmentation map, and extracting a semantic segmentation feature of the to-be-processed video data based on the semantic segmentation map; extracting an audio feature of each audio file in a pre-established audio set; and aligning the audio feature and the semantic segmentation feature, selecting a target audio file from the audio set based on an alignment result, and constructing background audio for the to-be-processed video data based on the target audio file.

Abstract: A computer-implemented method of determining effects of drug combinations on treatment outcomes. A plurality of genomic and clinical variables are generated from the combination of comprehensive genomic data, EHR data, and clinical treatment data. Based on Cox Proportional Hazards model, independent risk factors, cumulative hazard-ratios, and p-values for the combination of a first drug and a second drug (or a biomarker) are calculated to determine the nature of the combination of the first drug and the second drug (or the biomarker) with respect to treating the disease.

Abstract: A display panel, a manufacture method thereof and a display apparatus are provided. The display panel includes a display area, which includes a plurality of pixel units, wherein the pixel units include electroluminescent display devices and pixel drive circuits for driving the electroluminescent display devices to emit light; the electroluminescent display devices include light-emitting devices and virtual light-emitting devices; the light-emitting devices are electrically connected with the pixel drive circuits, while the virtual light-emitting devices are not connected with the corresponding pixel drive circuits; the display area includes a first display area and a second display area; and in the first display area and the second display area, the distribution density of the electroluminescent display devices is the same, and the density of the pixel drive circuits in the second display area is less than that of the pixel drive circuits in the first display area.

Abstract: There is provided a laser, and/or a reflector for a laser cavity comprising: a ring resonator structure; and a Fabry-Perot filter connected in cascade to the ring resonator structure by a coupling waveguide. The coupling waveguide is configured to propagate light having a frequency corresponding to any of the resonant frequencies of the ring resonator structure to the Fabry-Perot filter, and the Fabry-Perot filter is configured to select one or more frequencies and return light having a frequency matching any of the selected frequencies to the ring resonator structure via the coupling waveguide.

Abstract: The present invention discloses an electric heating thermal management system for an oil and gas transportation pipeline based on renewable energy and CO2 energy storage. It transmits the feedback data value through a data collection device arranged in the pipeline to the early warning device by the control device. After analysis and processing, the early warning device can feed back the data value to the control device and the remote operation device in two modes. Different degrees of heating amount can be generated for the oil and gas transportation pipelines at different positions in different modes. Hierarchical and distributed management control for the oil and gas transportation pipelines can be targetedly conducted in unblocked, easily blocked and blocked positions of the oil and gas transportation pipeline. The present invention couples the renewable energy electricity supply device and the CO2 energy storage device.

Abstract: The present invention generally relates to artemisinin/dihydroartemisinin (DHA) derivatives, and their use for therapy, in particular cancer therapy. These tumor-homing artemisinin derivatives (THAD) comprise three moieties: an artemisinin/DHA or a derivative thereof, a heptamethine carbocyanine dye (HMCD) residue, and a linker that conjugates the HMCD dye residue to the artemisinin residue. The THAD include compounds wherein the linker is linked to one or two DHA residue(s) via one or more ether bonds, and wherein the linker is linked to two DHA residues via two bonds independently selected from ester, carbamate and thiocarbamate. The THAD of the invention provide improved growth inhibition of cancer cells. The present invention also relates to improved methods of cancer therapy wherein a THAD is administered to a cancer patient. In embodiments, one or more THAD may be co-administered in a coordinated administration schedule.