Abstract: Some embodiments of the invention advantageously leverage the expansion, dilation or by-pass of the Schlemm's canal using adjustable reversible self-expanding eye stents (SES) or eye tension rings (ETRs) of desired sizes to control and improve aqueous flow throughout the range of the uveolymphatic canal. As such, some embodiments include tension ring(s) or cylinders that sits either inside or outside the Schlemm's canal wall and is at least partially within the canal and/or is partially or fully anchored, attached, adhered, or otherwise held in place with respect to the wall and/or elsewhere in the canal. The partial or complete expansion of the canal can be pre-configured based on pre-operative metrology of the Schlemm's canal to a customized and adjustable fit across the various zones within the uveolymphatic canal and based on the patient specific and evolving needs.

Abstract: This disclosure relates to thermal thrombectomy systems and methods. The thermal thrombectomy systems can apply heat to a thrombus, softening and/or melting the thrombus, which can include one or more proteins and/or biopolymers of the thrombus, to ease removal. The thermal thrombectomy systems can include a heated wire that can be navigated to the thrombus. The distal portion of the wire can apply heat to the thrombus while the proximal portion may be insulated. The heated wire can include coils and or other features to facilitate engagement with the thrombus.

Abstract: This disclosure relates to thermal emulsification systems and methods for cataract removal. The thermal emulsification systems can apply heat to the crystalline lens of the eye, resulting in the emulsification of the crystalline lens. The emulsified crystalline lens can be aspirated from the capsular bag of the eye. The thermal emulsification systems can include one or more elements that can be heated to apply localized heat to the crystalline lens to avoid unintentional damage to other ocular components and cellular structures of the eye, such as the capsular bag. The thermal emulsification systems can supply heated fluid to the lens to apply localized heat to the lens to avoid unintentional damage to other ocular components and cellular structures of the eye, such as the capsular bag.

Abstract: A device for maintaining patency of a prostatic urethra includes a stent having a proximal end, a distal end, and a passageway therebetween. The device includes longitudinal and angled struts and nodes, each longitudinal strut coupled to at least one angled strut at a corresponding node, the struts and nodes coupled to each other to form a plurality of cells, circumferentially adjacent cells forming stent regions. The stent includes a nose region, a body region, and a tail region. The stent is configured to expand from a compressed configuration to an expanded configuration within a bodily lumen. The stent includes a collapsibility gradient along its length such that it provides a nose region radial force at the nose region, a body region radial force at the body region, and a tail region radial force at the tail region, wherein the nose region radial force is less than the tail region radial force, and the tail region radial force is less than the body region radial force.

Abstract: A stent is disclosed that is configured to maintain patency of the prostatic urethra despite an enlarged prostate. The stent can include a handle that, in an undeflected position, is disposed outside of the flow path of the stent. When the handle is pulled, the handle can deflect to generally aligned with a central axis of the stent. A capture device is disclosed that includes a tapered tip to navigate a working channel of a delivery device and a hook that can capture the stent handle and be moved into a tube to retain the stent handle to facilitate maneuvering of the stent in and out of the working channel of the delivery device. A loading adapter with a tapered port is disclosed that can be disposed on the delivery device to distribute compressive forces applied by the port on the stent during loading into the working channel.

Abstract: Some embodiments of the invention advantageously leverage the expansion, dilation or by-pass of the Schlemm's canal using adjustable reversible self-expanding eye stents (SES) or eye tension rings (ETRs) of desired sizes to control and improve aqueous flow throughout the range of the uveolymphatic canal. As such, some embodiments include tension ring(s) or cylinders that sits either inside or outside the Schlemm's canal wall and is at least partially within the canal and/or is partially or fully anchored, attached, adhered, or otherwise held in place with respect to the wall and/or elsewhere in the canal. The partial or complete expansion of the canal can be pre-configured based on pre-operative metrology of the Schlemm's canal to a customized and adjustable fit across the various zones within the uveolymphatic canal and based on the patient specific and evolving needs.

Abstract: Systems relating to a mechanical closure or locking device configured to allow for quick connect and disconnect. The systems can be used in conjunction with compression garments. The systems can include a buckle that couples to an anchor. The buckle and anchor can include complementary features that can mechanically interface to secure the buckle and anchor together. The buckle and anchor can include complementary magnetic elements to secure the buckle and anchor together. The buckle can be manipulated to tighten or loosen an adjustable strap.

Abstract: This disclosure relates to compression garments, specifically to compression garments to promote lymphatic circulation and/or circulation of other bodily fluids. The garments can include compression actuator units that can apply a pull force on a strap of the compression garment to apply compression to an anatomical feature of the user. The compression actuator units can be actuated via contraction of a wire made of shape memory material. The compression actuator units can include a plurality of levers to amplify the effect of the contraction of the wire to provide a wide range of compressive forces to the user.

Abstract: A compression garment having one or more flex frames that can be shortened or lengthened to apply or release a compressive force to the limb or other anatomical feature of a user. The compression garment can have a wire made of shape memory material (shape memory alloy). A controller of the compression garment can supply an electrical input to the wire, generating heat that can cause the wire to contract such that the flex frame deflects to a shorter length to apply a compressive force to the limb or other anatomical feature of the user. The one or more flex frames can be contracted in unison or in sequence to direct the flow of bodily fluids in the limb or other anatomical feature of the user.

Abstract: Systems relating to a mechanical closure or locking device configured to allow for quick connect and disconnect. The systems can be used in conjunction with compression garments. The systems can include a buckle that couples to an anchor. The buckle and anchor can include complementary features that can mechanically interface to secure the buckle and anchor together. The buckle and anchor can include complementary magnetic elements to secure the buckle and anchor together. The buckle can be manipulated to tighten or loosen an adjustable strap.

Abstract: This disclosure relates to diagnostic devices for diagnosing lymphedema. The diagnostic devices may include an array of sensors, which can at least include a durometer, temperature sensor, and dielectric sensor, to measure parameters of tissue. The measurements may be used to generate a tissue health score to diagnose lymphedema and monitor tissue heath.

Abstract: This disclosure relates to compression garments, specifically to compression garments to promote lymphatic circulation. The garments can include flow directing units that have one or more angled teeth, struts, and/or lattices. A compressive force applied to the outer surface of the garment can be translated through the one or more angled teeth, struts, and/or lattices to urge fluid within a user to flow in one or more directions.

Abstract: A compression garment having one or more flex frames that can be shortened or lengthened to apply or release a compressive force to the limb or other anatomical feature of a user. The compression garment can have a wire made of shape memory material (shape memory alloy). A controller of the compression garment can supply an electrical input to the wire, generating heat that can cause the wire to contract such that the flex frame deflects to a shorter length to apply a compressive force to the limb or other anatomical feature of the user. The one or more flex frames can be contracted in unison or in sequence to direct the flow of bodily fluids in the limb or other anatomical feature of the user.

Abstract: Some embodiments of the invention advantageously leverage the expansion, dilation or by-pass of the Schlemm's canal using adjustable reversible self-expanding eye stents (SES) or eye tension rings (ETRs) of desired sizes to control and improve aqueous flow throughout the range of the uveolymphatic canal. As such, some embodiments include tension ring(s) or cylinders that sits either inside or outside the Schlemm's canal wall and is at least partially within the canal and/or is partially or fully anchored, attached, adhered, or otherwise held in place with respect to the wall and/or elsewhere in the canal. The partial or complete expansion of the canal can be pre-configured based on pre-operative metrology of the Schlemm's canal to a customized and adjustable fit across the various zones within the uveolymphatic canal and based on the patient specific and evolving needs.

Abstract: Systems relating to a mechanical closure or locking device configured to allow for quick connect and disconnect. The systems can be used in conjunction with compression garments. The systems can include a buckle that couples to an anchor. The buckle and anchor can include complementary features that can mechanically interface to secure the buckle and anchor together. The buckle and anchor can include complementary magnetic elements to secure the buckle and anchor together. The buckle can be manipulated to tighten or loosen an adjustable strap.

Abstract: A compression garment having one or more flex frames that can be shortened or lengthened to apply or release a compressive force to the limb or other anatomical feature of a user. The compression garment can have a wire made of shape memory material (shape memory alloy). A controller of the compression garment can supply an electrical input to the wire, generating heat that can cause the wire to contract such that the flex frame deflects to a shorter length to apply a compressive force to the limb or other anatomical feature of the user. The one or more flex frames can be contracted in unison or in sequence to direct the flow of bodily fluids in the limb or other anatomical feature of the user.

Abstract: Some embodiments of the invention advantageously leverage the expansion of the prostatic urethra using adjustable lumen tension rings (ALTRs) of desired sizes to control and improve flow throughout the range of the urethra. As such, some embodiments include tension ring(s) or cylinders that sits either inside or outside the prostatic wall and is at least partially within the lumen and/or is partially or fully anchored, attached, adhered, or otherwise held in place with respect to the bladder or other locations within the urethra and/or elsewhere in the urethra. The expansion of the lumen can be pre-configured based on pre-operative metrology of the prostatic urethra to a customized and adjustable fit across the various zones within the urethra and based on the patient specific and evolving needs.

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

Abstract: Described herein are polymer formulations for facilitating electrical stimulation of nasal or sinus tissue. The polymer formulations may be hydrogels that are prepared by a UV cross-linking process. The hydrogels may be included as a component of nasal stimulator devices that electrically stimulate the lacrimal gland to improve tear production and treat dry eye. Additionally, devices and methods for manufacturing the nasal stimulators, including shaping of the hydrogel, are described herein.

Abstract: Systems and methods can advantageously leverage the pupillary accommodation reflex to provide improved quality of vision throughout the range of focus distances. As such, some embodiments include an accommodating pupillary lens (APL) that sits at least partially within the pupil and/or is partially or fully attached, adhered, or otherwise held in place with respect to the iris, and/or is anchored in the sulcus and/or elsewhere in the eye. The optical power of the lens can be configured to change with changes in pupil diameter.