Abstract: Compositions and method of the present invention comprise novel formulations for increasing the effectiveness of antiviral agents and for preventing and treating symptoms associated with the common cold and viral infections. The present invention is directed to treating symptoms resulting from viral infections and diseases associated with Picomaviridae, Coronaviridae, Orthomyxoviridae, Paramyxovirinae, Reoviridae, and Adenoviridae. The novel formulations provided herein improve the therapeutic ratio of antiviral agents such as pleconaril.

Abstract: Systems and methods for efficient lossless compression of captured raw image information are presented. A method can comprise: receiving raw image data from an image capture device, segregating the pixel data into a base layer portion and an enhanced layer portion, reconfiguring the base layer portion expressed in the first color space values from a raw capture format into a pseudo second color space compression mechanism compatible format, and compressing the reconfigured base layer portion of first color space values. The raw image data can include pixel data are expressed in first color space values. The segregation can be based upon various factors, including a compression benefits analysis of a boundary location between the base layer portion and enhanced layer portion. The reconfiguring the base layer portion can include separating the base layer portion based upon multiple components within the raw data; and forming base layer video frames from the multiple components.

Abstract: Compositions and method of the present invention comprise novel formulations for increasing the effectiveness of antiviral agents and for preventing and treating symptoms associated with the common cold and viral infections. The present invention is directed to treating symptoms resulting from viral infections and diseases associated with Picomaviridae, Coronaviridae, Orthomyxoviridae, Paramyxovirinae, Reoviridae, and Adenoviridae. The novel formulations provided herein improve the therapeutic ratio of antiviral agents such as pleconaril.

Abstract: Systems and methods for efficient lossless compression of captured raw image information are presented. A method can comprise: receiving raw image data from an image capture device, segregating the pixel data into a base layer portion and an enhanced layer portion, reconfiguring the base layer portion expressed in the first color space values from a raw capture format into a pseudo second color space compression mechanism compatible format, and compressing the reconfigured base layer portion of first color space values. The raw image data can include pixel data are expressed in first color space values. The segregation can be based upon various factors, including a compression benefits analysis of a boundary location between the base layer portion and enhanced layer portion. The reconfiguring the base layer portion can include separating the base layer portion based upon multiple components within the raw data; and forming base layer video frames from the multiple components.

Abstract: In an aspect, the invention relates to compositions and methods for treating sepsis, including but not limited neonatal sepsis and sepsis related to infection. In an aspect, the invention relates to compositions and methods for attenuating adverse conditions of sepsis resulting from enterovirus infection. In an aspect, the invention relates to improved formulations of antiviral agents such as pleconaril for the treatment, alleviation and prevention of conditions associated with sepsis.

Abstract: Compositions and method of the present invention comprise novel formulations for increasing the effectiveness of antiviral agents and for preventing and treating symptoms associated with the common cold and viral infections. The present invention is directed to treating symptoms resulting from viral infections and diseases associated with Picornaviridae, Coronaviridae, Orthomyxoviridae, Paramyxovirinae, Reoviridae, and Adenoviridae. The novel formulations provided herein improve the therapeutic ratio of antiviral agents such as pleconaril.

Abstract: Compositions and method of the present invention comprise novel formulations for increasing the effectiveness of antiviral agents and for preventing and treating symptoms associated with the common cold and viral infections. The present invention is directed to treating symptoms resulting from viral infections and diseases associated with Picomaviridae, Coronaviridae, Orthomyxoviridae, Paramyxovirinae, Reoviridae, and Adenoviridae. The novel formulations provided herein improve the therapeutic ratio of antiviral agents such as pleconaril.

Abstract: In an aspect, the invention relates to compositions and methods for treating sepsis, including but not limited neonatal sepsis and sepsis related to infection. In an aspect, the invention relates to compositions and methods for attenuating adverse conditions of sepsis resulting from enterovirus infection. In an aspect, the invention relates to improved formulations of antiviral agents such as pleconaril for the treatment, alleviation and prevention of conditions associated with sepsis.

Abstract: Compositions and method of the present invention comprise novel formulations for increasing the effectiveness of antiviral agents and for preventing and treating symptoms associated with the common cold and viral infections. The present invention is directed to treating symptoms resulting from viral infections and diseases associated with Picomaviridae, Coronaviridae, Orthomyxoviridae, Paramyxovirinae, Reoviridae, and Adenoviridae. The novel formulations provided herein improve the therapeutic ratio of antiviral agents such as pleconaril.

Abstract: An inhaler for dispensing a pharmaceutical to infants and respiratory compromised patients is disclosed.

Abstract: A dry inhaler system includes a vibrating mechanism. A supply of a dry powder is operatively coupled to the vibrating mechanism. A power source communicates with the vibrating mechanism. A sensor communicates with the vibrating mechanism. A feedback control communicates with the sensor and the power source. The feedback control controls power delivered to the vibrating mechanism relative to information provided by the sensor about the performance of the vibrating mechanism.

Abstract: A laboratory animal pharmaceutical testing device comprising a substantially closed animal holding cell, having a dry powder generator communicating through a wall of the cell, and one or more filtered inlets for permitting exchange of fresh air into the cell.

Abstract: Disclosed is a method, system, and computer program product for implementing efficient access to stream data. The present approach implements a stream reader that supports either reading the entire layout (e.g., loading the contents of the user-specified top cell and all its progeny) into memory, or just a portion of it (e.g., loading only the contents of the user-specified top cell and its progeny that overlapped a user-specified bounding box). Some approaches provide a mechanism to implement parallelized or multithreaded reads of the stream data.

Abstract: A dry inhaler system includes a vibrating mechanism. A supply of a dry powder is operatively coupled to the vibrating mechanism. A power source communicates with the vibrating mechanism. A sensor communicates with the vibrating mechanism. A feedback control communicates with the sensor and the power source. The feedback control controls power delivered to the vibrating mechanism relative to information provided by the sensor about the performance of the vibrating mechanism.

Abstract: A dry inhaler system includes a vibrating mechanism. A supply of a dry powder is operatively coupled to the vibrating mechanism. A power source communicates with the vibrating mechanism. A sensor communicates with the vibrating mechanism. A feedback control communicates with the sensor and the power source. The feedback control controls power delivered to the vibrating mechanism relative to information provided by the sensor about the performance of the vibrating mechanism.

Abstract: An inhaler for dispensing a pharmaceutical to infants and respiratory compromised patients is disclosed.

Abstract: A dry inhaler system includes a vibrating mechanism. A supply of a dry powder is operatively coupled to the vibrating mechanism. A power source communicates with the vibrating mechanism. A sensor communicates with the vibrating mechanism. A feedback control communicates with the sensor and the power source. The feedback control controls power delivered to the vibrating mechanism relative to information provided by the sensor about the performance of the vibrating mechanism.

Abstract: A dry inhaler system includes a vibrating mechanism. A supply of a dry powder is operatively coupled to the vibrating mechanism. A power source communicates with the vibrating mechanism. A sensor communicates with the vibrating mechanism. A feedback control communicates with the sensor and the power source. The feedback control controls power delivered to the vibrating mechanism relative to information provided by the sensor about the performance of the vibrating mechanism.

Abstract: An inhaler is disclosed wherein medicament in a flat-bottomed container is aerosolized with a vibrator piezoelectric transducer. The transducer is driven by a signal that excites multiple harmonic frequencies to create a complex pattern of oscillations. A circuit for generating the drive signal to the transducer is also disclosed.

Abstract: A pediatric nebulizer is described.