Abstract: A secondary routing device is configured as a backup routing device for a primary routing device. The primary routing device performs asynchronous socket replication with the secondary routing device. The secondary routing device includes a transmission buffer, in memory, for storing replicated socket data transmitted between the primary routing device and the standby routing device and one or more processors implemented in circuitry and configured to execute a replication driver to: determine a threshold value; determine that an amount of data equaling or exceeding the threshold value has been read from the transmission buffer; in response to determining that the amount of data equaling or exceeding the threshold value has been read from the transmission buffer, schedule a window update for the transmission buffer at a scheduled time; and send the window update at the scheduled time.

Abstract: The present disclosure provides systems and methods for communication efficient distributed mean estimation. In particular, aspects of the present disclosure can be implemented by a system in which a number of vectors reside on a number of different clients, and a centralized server device seeks to estimate the mean of such vectors. According to one aspect of the present disclosure, a client computing device can rotate a vector by a random rotation matrix and then subsequently perform probabilistic quantization on the rotated vector. According to another aspect of the present disclosure, subsequent to quantization but prior to transmission, the client computing can encode the quantized vector according to a variable length coding scheme (e.g., by computing variable length codes).

Abstract: A magnetic impulse ring having a central axis that includes a target holder and a target that is fixed to the target holder. The target provides a plurality of alternating South and North magnetic poles. The target is adapted to cooperate with magnetic detection means for tracking the rotation of the magnetic impulse ring around its central axis. The Total Pitch Deviation (TPD) of the magnetic impulse ring is less than or equal to 0.5%.

Abstract: An example network device includes a primary node and a standby node. The primary node engages in a routing session with a peer network device via a connected socket. The standby node includes one or more processors implemented in circuitry and configured to execute a backup replication module to receive, from the primary node, data to be written to a backup socket for the connected socket, and, in response to a switchover, to send a representation of the data to the peer network device via the backup socket.

Abstract: In one example, a system comprises a plurality of non-last-hop routers (non-LHRs) of a network, the non-LHRs configured with a multicast distribution tree for a multicast group to transport first multicast packets of a multicast flow toward one or more LHRs, wherein a router of the non-LHR routers is configured to receive unicast packets for an application session associated with the multicast group, encapsulate the unicast packets in a multicast header to generate the first multicast packets for distribution using the multicast distribution tree, and output the first multicast packets; and the one or more LHRs, wherein the one or more LHRs are interested receivers of the multicast group, and wherein the one or more LHRs are configured to receive the first multicast packets of the multicast flow, extract the unicast packets for the application session, and send the unicast packets to one or more clients of the application session.

Abstract: A secondary routing device is configured as a backup routing device for a primary routing device. The primary routing device performs asynchronous socket replication with the secondary routing device. The secondary routing device includes a transmission buffer, in memory, for storing replicated socket data transmitted between the primary routing device and the standby routing device and one or more processors implemented in circuitry and configured to execute a replication driver to: determine a threshold value; determine that an amount of data equaling or exceeding the threshold value has been read from the transmission buffer; in response to determining that the amount of data equaling or exceeding the threshold value has been read from the transmission buffer, schedule a window update for the transmission buffer at a scheduled time; and send the window update at the scheduled time.

Abstract: An example network device includes a primary node and a standby node. The primary node engages in a routing session with a peer network device via a connected socket. The standby node includes one or more processors implemented in circuitry and configured to execute a backup replication module to receive, from the primary node, data to be written to a backup socket for the connected socket, and, in response to a switchover, to send a representation of the data to the peer network device via the backup socket.

Abstract: An example network device includes a primary node and a standby node. The primary node engages in a routing session with a peer network device via a connected socket. The standby node includes one or more processors implemented in circuitry and configured to execute a backup replication module to receive, from the primary node, data to be written to a backup socket for the connected socket, and, in response to a switchover, to send a representation of the data to the peer network device via the backup socket.

Abstract: Neurokinin-1 (NK-1) receptor-binding agent delivery conjugates, compositions comprising NK-1 receptor-binding agent delivery conjugates, and methods for making and administering NK-1 receptor-binding agent delivery conjugates are provided. A conjugate may include an NK-1 receptor-binding moiety, a tinker group containing at least one linker selected from the group of a releasable linker and a spacer linker, and an active agent linked to the linker group. The active agent may be selected from the group of fluorophore-containing compounds, radionuclide-containing compounds, and therapeutic agents for treatment of tumor cells characterized by over-expression of the NK-1 receptor.

Abstract: A disclosed method may include (1) detecting, on a primary node within a network, a change made to an object replicated across the primary node and a backup node within the network, (2) modifying a state-update message destined for the backup node to account for the change made to the object on the primary node, (3) inspecting a status flag of the state-update message destined for the backup node, (4) determining, based at least in part on the status flag of the state-update message, that the state-update message is ready for transmission to the backup node, and then in response to determining that the state-update message is ready for transmission, (5) transmitting the state-update message to the backup node to facilitate replicating the change to the object on the backup node. Various other apparatuses, systems, and methods are also disclosed.

Abstract: Neurokinin-1 (NK-1) receptor-binding agent delivery conjugates, compositions comprising NK-1 receptor-binding agent delivery conjugates, and methods for making and administering NK-1 receptor-binding agent delivery conjugates are provided. A conjugate may include an NK-1 receptor-binding moiety, a linker group containing at least one linker selected from the group of a releasable linker and a spacer linker, and an active agent linked to the linker group. The active agent may be selected from the group of fluorophore-containing compounds, radionuclide-containing compounds, and therapeutic agents for treatment of tumor cells characterized by over-expression of the NK-1 receptor.

Abstract: In one example, a system comprises a plurality of non-last-hop routers (non-LHRs) of a network, the non-LHRs configured with a multicast distribution tree for a multicast group to transport first multicast packets of a multicast flow toward one or more LHRs, wherein a router of the non-LHR routers is configured to receive unicast packets for an application session associated with the multicast group, encapsulate the unicast packets in a multicast header to generate the first multicast packets for distribution using the multicast distribution tree, and output the first multicast packets; and the one or more LHRs, wherein the one or more LHRs are interested receivers of the multicast group, and wherein the one or more LHRs are configured to receive the first multicast packets of the multicast flow, extract the unicast packets for the application session, and send the unicast packets to one or more clients of the application session.

Abstract: Techniques are described for redundantly forwarding encapsulated multicast traffic of a multicast distribution tree, using reliable overlay connections established between adjacent nodes of the multicast distribution tree. An example router of this disclosure is configured to receive first multicast packets of a multicast flow via a multicast distribution tree, to receive second multicast packets of the multicast flow via a transmission control protocol (TCP) connection of a connection-oriented distribution tree implemented in parallel to the multicast distribution tree, and in response to determining that the LHR has received a multicast packet of the first multicast packets via the multicast distribution tree out of order to create a gap of one or more of the first multicast packets for the multicast flow, forward, to at least one interested receiver positioned downstream of the router, the second multicast packets.

Abstract: System and method for processing heartbeat messages. A first network device receives heartbeat response messages from two or more of a plurality of network devices. Each heartbeat response message respectively corresponds to one network device of the plurality of network devices. The first network device processes the received heartbeat response messages in kernel space and determines, for each of the plurality of heartbeat response messages, an index value identifying the network device that sent the respective heartbeat response message. The first network device updates heartbeat response message fields in a health check data structure in kernel space based on the generated index values and subsequently processes, in a user space, information received from at least one of the heartbeat response message fields of the health check data structure to obtain health status associated with one or more of the plurality of network devices.

Abstract: A magnetic impulse ring having a central axis that includes a target holder and a target that is fixed to the target holder. The target provides a plurality of alternating South and North magnetic poles. The target is adapted to cooperate with magnetic detection means for tracking the rotation of the magnetic impulse ring around its central axis. The Total Pitch Deviation (TPD) of the magnetic impulse ring is less than or equal to 0.5%.

Abstract: Techniques are described for redundantly forwarding encapsulated multicast traffic of a multicast distribution tree, using reliable overlay connections established between adjacent nodes of the multicast distribution tree. An example router of this disclosure is configured to receive first multicast packets of a multicast flow via a multicast distribution tree, to receive second multicast packets of the multicast flow via a transmission control protocol (TCP) connection of a connection-oriented distribution tree implemented in parallel to the multicast distribution tree, and in response to determining that the LHR has received a multicast packet of the first multicast packets via the multicast distribution tree out of order to create a gap of one or more of the first multicast packets for the multicast flow, forward, to at least one interested receiver positioned downstream of the router, the second multicast packets.

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Abstract: A method of testing source code for a computer application includes: monitoring a source code repository to detect when a changed version of one or more source code files is saved to the repository; identifying, for a source code file that has changed, one or more changed features of the file, by comparing a changed version of the file with a previous version of the file; generating, based on the one or more changed features, a source code artifact for use in testing the file; generating, based on the source code artifact, a test case framework artifact for use in testing the file; executing one or more test cases based on the one or more changed features, the source code artifact, and the test case framework artifact; and compiling a report including details of the executed test cases.