Patents by Inventor Anastassios Giannakopulos

Anastassios Giannakopulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130221216
    Abstract: A method of increasing ion throughput within an accumulator, an energy lift and a pulsed ion extractor, operated in that order upon a batch of ions, comprising the steps of: firstly loading a batch of ions into the accumulator; secondly changing the electrical potential of the energy lift to raise the energy of the batch of ions contained therein; and thirdly ejecting the batch of ions from the pulsed ion extractor; and wherein: the energy lift is a separate device from the accumulator and the pulsed ion extractor, and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator and/or a previous batch of ions is prepared for ejection in the pulsed ion extractor; or the energy lift is incorporated into the pulsed ion extractor and whilst changing the electrical potential in the second step a fresh batch of ions is loaded into the accumulator; or the energy lift is incorporated into the accumulator and whilst changing the electrical potential in the second st
    Type: Application
    Filed: September 29, 2011
    Publication date: August 29, 2013
    Inventors: Alexander Makarov, Anastassios Giannakopulos
  • Publication number: 20130180893
    Abstract: A method and apparatus for high resolution separation of ions based on their high field and low-field mobility properties is described. An elongate ion separation channel is defined by a plurality of channel walls. First and second channel walls have first and second spaced ion separation electrode assemblies respectively. A power supply applies a periodic asymmetric potential to one or both of the electrode assemblies so as to generate a periodically asymmetric electric field in the channel for ion mobility separation. The channel walls define an ion separation channel of substantially helical shape.
    Type: Application
    Filed: September 8, 2011
    Publication date: July 18, 2013
    Inventor: Anastassios Giannakopulos
  • Publication number: 20130062518
    Abstract: Methods and analyzers useful for time of flight mass spectrometry are provided.
    Type: Application
    Filed: May 24, 2011
    Publication date: March 14, 2013
    Inventors: Alexander Makarov, Anastassios Giannakopulos
  • Publication number: 20120138785
    Abstract: Methods and analysers useful for time of flight mass spectrometry are provided.
    Type: Application
    Filed: May 27, 2010
    Publication date: June 7, 2012
    Inventors: Alexander A. Makarov, Anastassios Giannakopulos
  • Publication number: 20120091332
    Abstract: A method of separating charged particles using an analyser is provided, the method comprising: causing a beam of charged particles to fly through the analyser and undergo within the analyser at least one full oscillation in the direction of an analyser axis (z) of the analyser whilst orbiting about the axis (z) along a main flight path; constraining the arcuate divergence of the beam as it flies through the analyser; and separating the charged particles according to their flight time. An analyser for performing the method is also provided. At least one arcuate focusing lens is preferably used to constrain the divergence, which may comprise a pair of opposed electrodes located either side of the beam.
    Type: Application
    Filed: May 27, 2010
    Publication date: April 19, 2012
    Inventors: Alexander A. Makarov, Anastassios Giannakopulos
  • Patent number: 7999223
    Abstract: This invention relates to a method of operating a charged particle trap in which ions undergo multiple reflections back and forth and/or follow a closed orbit around, usually, a set of electrodes. The invention allows high-performance isolation of multiple ion species for subsequent detection or fragmentation by deflecting ions out of the ion trap according to a timing scheme calculated with reference to the ions' periods of oscillation within the ion trap.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: August 16, 2011
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Alexander Alekseevich Makarov, Anastassios Giannakopulos
  • Publication number: 20110095178
    Abstract: Embodiments of the invention provide a detection apparatus for detecting charged particles having a charged particle detector for receiving and detecting either incoming charged particles or secondary charged particles generated from the incoming charged particles, a photon generator for generating photons in response to receiving at least some of the same incoming charged particles or secondary charged particles generated from the incoming charged particles as are received and detected by the charged particle detector, and a photon detector for detecting photons generated by the photon generator.
    Type: Application
    Filed: October 21, 2010
    Publication date: April 28, 2011
    Inventors: Anastassios GIANNAKOPULOS, Alexander A. MAKAROV
  • Publication number: 20110095177
    Abstract: Embodiments of the invention provide a detection apparatus for detecting charged particles having a secondary particle generator for generating secondary charged particles in response to receiving incoming charged particles, a charged particle detector for receiving and detecting secondary charged particles generated by the secondary particle generator, a photon generator for generating photons in response to receiving secondary charged particles generated by the secondary particle generator, and a photon detector for detecting the photons generated by the photon generator.
    Type: Application
    Filed: October 21, 2010
    Publication date: April 28, 2011
    Inventors: Anastassios GIANNAKOPULOS, Alexander A. Makarov
  • Publication number: 20100059673
    Abstract: This invention relates to a method of operating a charged particle trap in which ions undergo multiple reflections back and forth and/or follow a closed orbit around, usually, a set of electrodes. The invention allows high-performance isolation of multiple ion species for subsequent detection or fragmentation by deflecting ions out of the ion trap according to a timing scheme calculated with reference to the ions' periods of oscillation within the ion trap.
    Type: Application
    Filed: November 14, 2007
    Publication date: March 11, 2010
    Inventors: Alexander Alekseevich Makarov, Anastassios Giannakopulos
  • Patent number: 7375344
    Abstract: An ion focusing and conveying device 10 comprises a plurality of electrodes 12 in series. Means is provided to apply a first alternating voltage waveform to each electrode 12, the phase of the alternating voltage in the first waveform is applied to each electrode 12 in the series being ahead of the phase of the first alternating voltage waveform applied to the preceding electrode 12 in the series by less than 180°, preferably by 90° or less, such that ions are focused onto an axis of travel and impelled along the series of electrodes 12.
    Type: Grant
    Filed: April 15, 2005
    Date of Patent: May 20, 2008
    Assignee: Peter Derrick
    Inventors: Peter John Derrick, Alexander William Colburn, Anastassios Giannakopulos
  • Patent number: 7075065
    Abstract: Mass spectrometry apparatus 105 comprises a serial arrangement of an ion source 110, first time of flight means, a field free region 120, means to fragment the molecules, a second time of flight means and a large area detector 160. The second time of flight means includes an ion mirror 150, the ion mirror 150 being arranged to produce a reflecting substantially quadratic field. The first time of flight means is arranged to provide spatial focusing concomitant with time focusing of ions at or near the entrance to the ion mirror 150. The means provided to fragment the ions front the first time of flight means can be a collision cell 140 or in the field free region 220 or in the first time of flight means. The means to fragment the molecules has a potential which is different from the potential at the entrance to the ion mirror 150, and the detecting surface of the detector 160 is mounted in the time focal surface of the ion mirror 150.
    Type: Grant
    Filed: August 24, 2004
    Date of Patent: July 11, 2006
    Assignee: University of Warwick
    Inventors: Alexander William Colburn, Peter John Derrick, Anastassios Giannakopulos
  • Publication number: 20050178973
    Abstract: An ion focussing and conveying device 10 comprises a plurality of electrodes 12 in series. Means is provided to apply a first alternating voltage waveform to each electrode 12, the phase of the alternating voltage in the first waveform is applied to each electrode 12 in the series being ahead of the phase of the first alternating voltage waveform applied to the preceding electrode 12 in the series by less than 180°, preferably by 90° or less, such that ions are focussed onto an axis of travel and impelled along the series of electrodes 12.
    Type: Application
    Filed: April 15, 2005
    Publication date: August 18, 2005
    Inventors: Peter Derrick, Alexander Colburn, Anastassios Giannakopulos
  • Patent number: 6894286
    Abstract: An ion focussing and conveying device 10 comprises a plurality of electrodes 12 in series. Means is provided to apply a first alternating voltage waveform to each electrode 12, the phase of the alternating voltage in the first waveform is applied to each electrode 12 in the series being ahead of the phase of the first alternating voltage waveform applied to the preceding electrode 12 in the series by less than 180°, preferably by 90° or less, such that ions are focussed onto an axis of travel and impelled along the series of electrodes 12.
    Type: Grant
    Filed: November 23, 2001
    Date of Patent: May 17, 2005
    Assignee: University of Warwick
    Inventors: Peter John Derrick, Alexander William Colburn, Anastassios Giannakopulos
  • Publication number: 20050023459
    Abstract: Mass spectrometry apparatus 105 comprises a serial arrangement of an ion source 110, first time of flight means, a field free region 120, means to fragment the molecules, a second time of flight means and a large area detector 160. The second time of flight means includes an ion mirror 150, the ion mirror 150 being arranged to produce a reflecting substantially quadratic field. The first time of flight means is arranged to provide spatial focusing concomitant with time focusing of ions at or near the entrance to the ion mirror 150. The means provided to fragment the ions front the first time of flight means can be a collision cell 140 or in the field free region 220 or in the first time of flight means. The means to fragment the molecules has a potential which is different from the potential at the entrance to the ion mirror 150, and the detecting surface of the detector 160 is mounted in the time focal surface of the ion mirror 150.
    Type: Application
    Filed: August 24, 2004
    Publication date: February 3, 2005
    Inventors: Alexander Colburn, Peter Derrick, Anastassios Giannakopulos
  • Patent number: 6781122
    Abstract: Mass spectrometry apparatus 105 comprises a serial arrangement of an ion source 110, first time of flight means, a field free region 120, means to fragment the molecules, a second time of flight means and a large area detector 160 The second time of flight means includes an ion mirror 150, the ion mirror 150 being arranged to produce a reflecting substantially quadratic field. The first time of flight means is arranged to provide spatial focusing concomitant with time focusing of ions at or near the entrance to the ion mirror 150. The means provided to fragment the ions from the first time of flight means can be a collision cell 140 or in the field free region 220 or in the first time of flight means. The means to fragment the molecules has a potential which is different from the potential at the entrance to the ion mirror 150, and the detecting surface of the detector 160 is mounted in the time focal surface of the ion mirror 150.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: August 24, 2004
    Assignee: University of Warwick
    Inventors: Alexander William Colburn, Peter John Derrick, Anastassios Giannakopulos
  • Publication number: 20040046124
    Abstract: An ion focussing and conveying device 10 comprises a plurality of electrodes 12 in series. Means is provided to apply a first alternating voltage waveform to each electrode 12, the phase of the alternating voltage in the first waveform is applied to each electrode 12 in the series being ahead of the phase of the first alternating voltage waveform applied to the preceding electrode 12 in the series by less than 180°, preferably by 90° or less, such that ions are focussed onto an axis of travel and impelled along the series of electrodes 12.
    Type: Application
    Filed: September 17, 2003
    Publication date: March 11, 2004
    Inventors: Peter John Derrick, Alexander William Colburn, Anastassios Giannakopulos
  • Publication number: 20030183758
    Abstract: Mass spectromctry apparatus 105 comprises a serial arrangement of an ion source 110, first time of flight means, a field frce region 120, means to fragment the molecules, a second time of flight means and a large area detector 160 The second time of flight means includes an ion mirror 150, the ion mirror 150 being arranged to produce a reflecting substantially quadratic field. The first time of flight means is arranged to provide spatial focusing concomitant with time focusing of ions at or near the entrance to the ion mirror 150. The means provided to fragment the ions from the first time of flight means can be a collision cell 140 or in the field free region 220 or in the first time of flight means. The means to fragment the molecules has a potential which is different from the potential at the entrance to the ion mirror 150, and the detecting surface of the detector 160 is mounted in the time focal surface of the ion mirror 150.
    Type: Application
    Filed: November 25, 2002
    Publication date: October 2, 2003
    Inventors: Alexander William Colburn, Peter John Derrick, Anastassios Giannakopulos