Abstract: A device for generating and delivering Nitric Oxide (NO) to a treatment site includes a main unit, an applicator, a connector hose, and a mobile stand. The main unit provides power and a gas to the applicator via the connector hose. The applicator includes a plasma generator for generating NO in a plasma state. The main unit including a user interface to enable a user to control at least one operational aspect of the device. The applicator includes a pistol grip handle, a trigger for actuating the plasma generator, a hose connection for coupling to the connector hose, and a cowl portion for spacing a tip of the plasma generator at a predetermined distance from a treatment site. Sensors are provided with the applicator for sending feedback and monitoring application site temperature, proximity to the application, applicator motion and the like.

Abstract: Described herein are devices and methods for treating degenerative joint diseases with electromagnetic fields using one or more waveforms that are configured to modulate Ca2+ binding to calmodulin and thereby modulate calmodulin-dependent nitric oxide signaling within joint and other affected tissue for the purpose of reducing pain and inflammation, as well as enhancing the healing and regeneration of such tissue.

Abstract: A pulsed electromagnetic field (PEMF) treatment apparatus having electrically-conductive loops arranged within an enclosure to form an array, each of the electrically-conductive loops having a generally circular circumference with one or more indentations aligned with a corresponding indentation of an adjacent electrically-conductive loop, where PEMF signals are generated through the array of electrically-conductive loops based on proximity detection conducted by a corresponding wireless device.

Abstract: A device and method for forming NO-containing gas flow to treat a biological object is disclosed. The device may include an anode, a cathode, an interelectrode area between the cathode and the anode, an NO-containing gas flow outlet channel leading from the interelectrode area to a nozzle for directing and releasing the NO-containing gas flow from the device and a mechanism to adjust a relative position between the anode and the cathode to produce varying concentrations of NO. In addition, the device may include one or more features for interconnecting the various components to ensure proper and consistent assembly of the device.

Abstract: Pulsed electromagnetic field (PEMF) apparatuses and methods of making and using them. In particular, described herein are two-part PEMF apparatuses that include a self-contained, lightweight, small, compact (e.g., in some variations, wearable) generator unit that is adapted to releasably and replaceably mate with an applicator unit. The generator unit typically includes a power source and a controller that generated PEMF waveforms to be applied, including the shape and timing of the PEMF waveforms. The applicator unit typically includes a radio frequency (RF) power amplifier, a loop antenna, and impedance matching circuitry for matching the impedances for the connection between the antenna loop and the RF power amplifier. Thus, the generator module may control the application of PEMF signals without requiring impedance matching between the separable generator unit and the applicator unit. The applicator unit can include a plurality of variable capacitors that can be used to tune the PEMF signals.

Abstract: An apparatus for treating a biologic object includes a device for forming NO-containing gas flow to treat the biologic object and a plasma cooling mechanism coupled to a distal end of the device. The plasma cooling mechanism may include a cooling member and/or a cooling apparatus. The cooling member is coupled to a distal end of the device and includes a fluid conduit and a cooling chamber surrounding the fluid conduit. The cooling apparatus is coupled to a distal end of the cooling member so that the NO-containing gas flow travels from a discharge aperture formed in the device through the fluid conduit and passed the cooling apparatus before reaching the biologic object.

Abstract: Described herein are electromagnetic treatment devices for treatment of tissue. In particular, described herein are lightweight, wearable, low-energy variations that are specifically configured to specifically and sufficiently apply energy within a specific bandpass of frequencies of a target biological pathway, such as the binding of Calcium to Calmodulin, and thereby regulate the pathway. Methods and systems for treating biological tissue are also described.

Abstract: The present invention generally pertains to an apparatus and a method for uroflowmetry. Uroflowmetry can generally be defined as the collection and measurement of a patient's urination for the purpose of determining urine flow data that are necessary to analyze the patient's urination by comparing the patient's urine flow data to standardized urine flow data of healthy individuals. The present invention allows medical professionals to non-invasively diagnose a patient's urination by collecting, measuring and computing urine flow data to determine if any medical conditions and symptoms that affect urine flow are present. The within invention is designed and constructed in such a manner as to allow for the collection and measurement of urination to be done quickly, easily and at a reduced cost.

Abstract: A device for generating and delivering Nitric Oxide (NO) to a treatment site includes a main unit, an applicator, a connector hose, and a mobile stand. The main unit provides power and a gas to the applicator via the connector hose. The applicator includes a plasma generator for generating NO in a plasma state. The main unit including a user interface to enable a user to control at least one operational aspect of the device. The applicator includes a pistol grip handle, a trigger for actuating the plasma generator, a hose connection for coupling to the connector hose, and a cowl portion for spacing a tip of the plasma generator at a predetermined distance from a treatment site. Sensors are provided with the applicator for sending feedback and monitoring application site temperature, proximity to the application, applicator motion and the like.

Abstract: Described herein are methods of treating neurological injury and conditions, in particular symptoms and complications arising from or caused by a stroke. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source and applying the pulsed electromagnetic field in proximity to a target region.

Abstract: Pulsed electromagnetic field (PEMF) apparatuses and methods of making and using them. In particular, described herein are two-part PEMF apparatuses that include a self-contained, lightweight, small, compact (e.g., in some variations, wearable) generator unit that is adapted to releasably and replaceably mate with an applicator unit. The generator unit typically includes a power source and a controller that generated PEMF waveforms to be applied, including the shape and timing of the PEMF waveforms. The applicator unit typically includes a radio frequency (RF) power amplifier, a loop antenna, and impedance matching circuitry for matching the impedances for the connection between the antenna loop and the RF power amplifier. Thus, the generator module may control the application of PEMF signals without requiring impedance matching between the separable generator unit and the applicator unit. The applicator unit can include a plurality of variable capacitors that can be used to tune the PEMF signals.

Abstract: The present invention relates to a device for the topical treatment of pain affecting the vulvar area of the female human genital organ, a formulation for use in the device according to the invention, and a kit comprising the device according to the present intention. Additionally, the present invention relates to a method of topical treatment of pain affecting the vulvar area of the female human genital organ, said method using the device according to the present invention. The device is a layered article shaped to be placed in use inside a female undergarment and at least partially in skin contact with the female vulvar area and comprises a topical formulation.

Abstract: Described herein are methods of treating neurological injury and conditions, in particular symptoms and complications arising from or caused by a stroke. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source and applying the pulsed electromagnetic field in proximity to a target region.

Abstract: Described herein are methods of treating neurological injury and conditions, in particular neurodegenerative conditions. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source and applying the pulsed electromagnetic field in proximity to a target region.

Abstract: Described herein are methods of treating neurological injury and conditions, in particular neurological pain. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source and applying the pulsed electromagnetic field in proximity to a target region.

Abstract: Pulsed electromagnetic field (PEMF) apparatuses and methods of making and using them. In particular, described herein are two-part PEMF apparatuses that include a self-contained, lightweight, small, compact (e.g., in some variations, wearable) generator unit that is adapted to releasably and replaceably mate with an applicator unit. The generator unit typically includes a power source and a controller that generated PEMF waveforms to be applied, including the shape and timing of the PEMF waveforms. The applicator unit typically includes a radio frequency (RF) power amplifier, a loop antenna, and impedance matching circuitry for matching the impedances for the connection between the antenna loop and the RF power amplifier. Thus, the generator module may control the application of PEMF signals without requiring impedance matching between the separable generator unit and the applicator unit. The applicator unit can include a plurality of variable capacitors that can be used to tune the PEMF signals.

Abstract: Pulsed electromagnetic field (PEMF) apparatuses and methods of making and using them. In particular, described herein are two-part PEMF apparatuses that include a self-contained, lightweight, small, compact (e.g., in some variations, wearable) generator unit that is adapted to releasably and replaceably mate with an applicator unit. The generator unit typically includes a power source and a controller that generated PEMF waveforms to be applied, including the shape and timing of the PEMF waveforms. The applicator unit typically includes a radio frequency (RF) power amplifier, a loop antenna, and impedance matching circuitry for matching the impedances for the connection between the antenna loop and the RF power amplifier. Thus, the generator module may control the application of PEMF signals without requiring impedance matching between the separable generator unit and the applicator unit. The applicator unit can include a plurality of variable capacitors that can be used to tune the PEMF signals.

Abstract: Described herein are devices and methods for treating degenerative joint diseases with electromagnetic fields using one or more waveforms that are configured to modulate Ca2+ binding to calmodulin and thereby modulate calmodulin-dependent nitric oxide signaling within joint and other affected tissue for the purpose of reducing pain and inflammation, as well as enhancing the healing and regeneration of such tissue.