Patents by Inventor Andrés Francesch
Andrés Francesch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110237520Abstract: Compounds of general formula I: wherein R1-R15 and n take permitted meanings for use in the treatment of cancer.Type: ApplicationFiled: December 18, 2009Publication date: September 29, 2011Applicant: Pharma Mar, SAInventors: Laura Coello Molinero, Rogelio Fernández Rodriguez, José Fernando Reyes Benitez, Andrés Francesch Solloso, Maria del Carmen Cuevas Marchante
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Publication number: 20110118343Abstract: Antitumoral compounds of general formula I: wherein R1-R14 and the lines take permitted meanings for use in the treatment of cancer.Type: ApplicationFiled: July 2, 2009Publication date: May 19, 2011Applicant: Pharma Mar, S. A.Inventors: José Fernando Reyes Benítez, Gloria Crespo Sueiro, Rogelio Fernández Rodríguez, Andrés Francesch Solloso, María del Carmen Cuevas Marchante
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Publication number: 20110105409Abstract: Anticancer compounds of general formula I: wherein R1-R11 take permitted meanings for use in the treatment of cancer.Type: ApplicationFiled: July 16, 2009Publication date: May 5, 2011Applicant: PHARMA MAR, S.A.Inventors: Raquel Rodríguez Acebes, Rogelio Fernández Rodríguez, José Fernando Reyes Benítez, Ma Jesús Martín López, Isabel Marco Martínez, Isabel Digón Juárez, Maria del Carmen Cuevas Marchante, Andrés Francesch Solloso
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Publication number: 20100216817Abstract: Antitumoral compounds of the formula (I) wherein X is O, S, or NRa, obtained from a maze coral of the family Meandrinidae, genus Meandrina, species meandrites, or derivatives thereof are useful as antitumoral agents.Type: ApplicationFiled: May 3, 2006Publication date: August 26, 2010Applicant: Pharma Mar SAInventors: José Fernando Reyes Benitez, Maria del Carmen Cuevas Marchante, David Montalvo Lobo, Maria-Jesús Martin López, Maria Cristina Mateo Urbano, Andrés Francesch Solloso
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Publication number: 20100048596Abstract: Antitumoural compounds of general formula (I); wherein Ar is an heterocyclic group of formula (a) and R1, R2, R3, R4, R5, R6, R7, n and the dotted line take permitted meanings can be obtained from a tunicate of the family Polyclinidae, genus Aplidium, species cyaneum, and the invention further provides derivatives thereof.Type: ApplicationFiled: November 13, 2006Publication date: February 25, 2010Applicant: Pharma Mar, S.A.Inventors: Jose Fernando Reyes Benitez, Andrés Francesch Solloso, Carmen Cuevas Marchante, Marta Altuna Urquijo, Daniel Pla Queral, Mercedes Alvarez Domingo, Fernando Albericio Palomera
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Publication number: 20100048690Abstract: Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.Type: ApplicationFiled: June 15, 2007Publication date: February 25, 2010Applicant: PHARMA MAR, S.A.Inventors: Ma Jesus Martin Lopez, Laura Coello Molinero, Jose Fernando Reyes Benitez, Alberto Rodriguez Vicente, Maria Garranzo Garcia-Ibarrola, Carmen Murcia Perez, Andres Francesch Solloso, Francisco Sanchez Sancho, Maria del Carmen Cuevas Marchante, Rogelio Fernandez Rodriguez
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Publication number: 20090186938Abstract: Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.Type: ApplicationFiled: June 15, 2007Publication date: July 23, 2009Applicant: PHARMA MAR, S.A.Inventors: Ma Jesus Martin Lopez, Laura Coello Molinero, Jose Fernando Reyes Benitez, Alberto Rodriguez Vicente, Maria Garranzo Garcia-Ibarrola, Carmen Murcia Perez, Andres Francesch Solloso, Francisco Sanchez Sancho, Maria del Carmen Cuevas Marchante, Rogelio Fernandez Rodriguez
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Publication number: 20090124647Abstract: Antitumoural compounds of general formula (I); wherein Ar is an heterocyclic group of formula (a) and R1, R2, R3, R4, R5, R6, R7, n and the dotted line take permitted meanings can be obtained from a tunicate of the family Polyclinidae, genus Aplidium, species cyaneum, and the invention further provides derivatives thereof.Type: ApplicationFiled: November 13, 2006Publication date: May 14, 2009Applicant: PHARMA MAR, S.A.Inventors: Jose Fernando Reyes Benitez, Andres Francesch Solloso, Carmen Cuevas Marchante, Marta Altuna Urquijo, Daniel Pla Queral, Mercedes Alvarez Domingo, Fernando Albericio Palomera
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Patent number: 7524956Abstract: Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an acyloxymethylene group; R5 and R8 are independently chosen from —H, —OH or —OCOCH2OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring; R14a and R14b are both —H ozone is —H and the other is —OH, —OCH3 or —OCH2CH3, or R14a and R14b together form a keto group; and R15 and R18 are independently chosen from —H or —OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.Type: GrantFiled: July 9, 2007Date of Patent: April 28, 2009Assignee: Pharma Mar, S.A.Inventors: Carmen Cuevas, Marta Perez, Andres Francesch, Carolina Fernandez, Jose Luis Chicharro, Pilar Gallego, Maria Zarzuelo, Fernando de Calle, Ignacio Manzanares
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Patent number: 7521478Abstract: Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR?3, SOR?, SO2X, C(?O)R?, C(?O)OR?, C(?O)NR?, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aryl, heteroaryl or aralkyl; the group R? is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aminoalkyl, aryl, aralkyl and heterocyclic groups; and the group R? is selected from the group consisting of H, OH, OR?, OCOR?, SH, SR?, SOR?, SO2R?, NO2, NH2, NHR?, N(R?)2, NHCOR?, N(COR?)2, NHSO2R?, CN, halogen, C(?O)H, C(?O)R?, CO2H, CO2R?, CH2OR, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkylidene, substituted or unsubstituted alkynyl, substitType: GrantFiled: July 30, 2003Date of Patent: April 21, 2009Assignee: Pharma Mar, S.A.U.Inventors: Carlos del Pozo Losada, Andres Francesch, Carmen Cuevas Marchante, Marta Perez Alvarez
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Publication number: 20090030068Abstract: The invention relates to novel antitumor compounds of general formula as well as their corresponding pharmaceutically acceptable salts, derivatives, prodrugs and stereoisomers. These compounds can be obtained by isolating a sponge from family Theonellidae, genus Theonella and species swinhoei, and forming derivatives from the isolated compounds. These compounds have cytotoxic activity and can be used for the treatment of the cancer.Type: ApplicationFiled: December 14, 2006Publication date: January 29, 2009Applicant: PHARMA MAR, S.A.Inventors: Ma Jesus Martin Lopez, Jose Fernando Reyes Benitez, Rogelio Fernandez Rodriguez, Andres Francesch Solloso, Maria del Carmen Cuevas Marchante, Laura Coello Molinero
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Publication number: 20080269511Abstract: Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR?3, SOR?, SO2X, C(?O)R?, C(?O)OR?, C(?O)NR?, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aryl, heteroaryl or aralkyl; the group R? is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aminoalkyl, aryl, aralkyl and heterocyclic groups; and the group R? is selected from the group consisting of H, OH, OR?, OCOR?, SH, SR?, SOR?, SO2R?, NO2, NH2, NHR?, N(R?)2, NHCOR?, N(COR?)2, NHSO2R?, CN, halogen, C(?O)H, C(?O)R?, CO2H, CO2R?, CH2OR, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkylidene, substituted or unsubstituted alkynyl, substitType: ApplicationFiled: September 1, 2005Publication date: October 30, 2008Applicant: Pharma Mar S.A.U.Inventors: Carlos del Pozo Losada, Andres Francesch Solloso, Carmen Cuevas Marchante, Marta Perez Alvarez
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Patent number: 7420051Abstract: Processes are provided for preparing compounds with a fused ring structure of formula (XIV). Such products include ecteinascidins and have a spiroamine-1,4-bridge. The process involving forming a 1,4 bridge using a 1-labile, 10-hydroxy, 18-protected hydroxyl, di-6,8-en-5-one fused ring compound. After formation of the 1,4 brige, C-18 protection is removed before spiroamine introduction.Type: GrantFiled: October 11, 2005Date of Patent: September 2, 2008Assignee: Pharma Mar, S.A.Inventors: Andrés Francesch, Carolina Fernández, José Luis Chicharro, Pilar Gallego, Maria Zarzuelo, Ignacio Manzanares, Marta Perez, Carmen Cuevas, María Jes{dot over (u)}s Martin, Simon Munt
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Patent number: 7396837Abstract: New lamellarins are provided of the general formula III or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereofType: GrantFiled: August 13, 2003Date of Patent: July 8, 2008Assignee: Pharma Mar, S.A.U.Inventors: Christian Bailly, Andrés Francesch, Maria Cristina Mateo Urbano, José Antonio Jiménez Guerrero, Alfredo Pastor Del Castillo, Carmen Cuevas Marchante
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Publication number: 20080103320Abstract: Compounds of the general formula (I) or pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR?3, SOR?, SO2X, C(?O)R?, C(?O)OR?, C(?O)NR?, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aryl, heteroaryl or aralkyl; the group R? is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aminoalkyl, aryl, aralkyl and heterocyclic groups; and the group R? is selected from the group consisting of H, OH, OR?, OCOR?, SH, SR?, SOR?, SO2R?, NO2, NH2, NHR?, N(R?)2, NHCOR?, N(COR?)2, NHSO2R?, CN, halogen, C(=O)H, C(=O)R?, CO2H, CO2R?, CH2OR, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkylidene, substituted or unsubstituted alkynyl, substitutType: ApplicationFiled: September 1, 2005Publication date: May 1, 2008Applicant: Pharma Mar S.A.U.Inventors: Carlos del Pozo Losada, Andres Francesch Solloso, Carmen Cuevas Marchante, Marta Perez Alvarez
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Publication number: 20080045713Abstract: Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically; R1 is an amidomethylene group or an aryloxymethylene group; R5 and R8 are independently chosen from —H, —OH or —OCOCH2OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring; R14a and R14b are both —H ozone is —H and the other is —OH, —OCH3 or —OCH2CH3, or R14a and R14b together form a keto group; and R15 and R18 are independently chosen from —H or —OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.Type: ApplicationFiled: July 9, 2007Publication date: February 21, 2008Applicant: Pharma Mar, S.A.Inventors: Carmen Cuevas, Marta Perez, Andres Francesch, Carolina Fernandez, Jose Chicharro, Pilar Gallego, Maria Zarzuelo, Fernando Calle, Ignacio Manzanares
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Patent number: 7241892Abstract: Methods are provided for preparing a compound with a fused ring structure of formula (XIV) which comprises one or more reactions starting from a 21-cyano compound of formula (XVI) where typically: R1 is an amidomethylene group or an acyloxymethylene group; R5 and R8 are independently chosen from —H, —OH or —OCOCH2OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring; R14a and R14b are both —H ozone is —H and the other is —OH, —OCH3 or —OCH2CH3, or R14a and R14b together form a keto group; and R15 and R18 are independently chosen from —H or —OH, or R5 and R8 are both keto and the ring A is a p-benzoquinone ring. In modified starting materials, the 21-cyano group can be replaced by other groups introduced using nucleophilic reagents.Type: GrantFiled: May 15, 2000Date of Patent: July 10, 2007Assignee: Pharma Mar, S.A.Inventors: Carmen Cuevas, Marta Perez, Andres Francesch, Carolina Fernandez, Jose Luis Chicharro, Pilar Gallego, Maria Zarzuelo, Fernando de la Calle, Ignacio Manzanares
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Patent number: 7202361Abstract: This invention relates to compounds of the formula: wherein: the substituent groups defined by R1, R2 are each independently selected of H, C(?O)R?, C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, or aryl; each of the R? groups is independently selected from the group consisting of H; OH; NO2; NH2; SH; CN; halogen; ?O; C(?O)H; C(?O)CH3; CO2H; or C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, or aryl, each of which, independently, may be substituted with one or more substituents selected from the group consisting of halogen, cyano, hydroxy, nitro, azido; alkanoyl, carboxamido, alkyl, alkenyl, alkynyl, aryloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, aminoalkyl, carbocylic aryl having 6 or more carbons, and aralkyl; X2 is OX1 or N(X1)2 wherein each X1 is independently H, C(?O)R? where R? is as defined, C1–C18 alkyl, C2–C18 alkenyl, C2–C18 alkynyl, aryl, alkoxy, heterocyclyl, or two X1 groups together form a cyclic substituent on the nitrogen atom, or X1 is SO2CH3 when X2 is OX1, or N(X1)2 is NHCOalkType: GrantFiled: April 12, 2001Date of Patent: April 10, 2007Assignee: PharmaMarInventors: Maria Flores, Andrés Francesch, Pilar Gallego, José Luis Chicharro, Maria Zarzuelo, Carolina Fernández, Ignacio Manzanares
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Publication number: 20060173030Abstract: New lamellarins are provided of the general formula III wherein X is selected from the group consisting of N, O and S; wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from the group consisting of H, OH, OR?, SH, SR?, SO2R?, NHR?, N(R?)2, N?R?, NHCOR?, N(COR?)2, NHS02R?, N02, PO(R?2, P02R?, C(=0)H, C(=0)R?, C02H, C02R?, OPO(R?)2, OP02R?, OC(=0)H, OC(=0)R?, N?C(R?)2, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C1-C12 haloalkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; wherein each of the R? groups is independently selected from the group consisting of H, OH, N02, NH2, SH, CN, halogen, =0, C(=0)H, C(?O)CH3, C02H, C(=0)R?, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl, sType: ApplicationFiled: August 13, 2003Publication date: August 3, 2006Inventors: Christian Bailly, Andres Francesch, Maria Mateo Urbano, Jose Jimenez Guerrero, Alfredo Pastor Del Castillo, Carmen Cuevas Marchante
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Publication number: 20060111570Abstract: Processes are provided for preparing compounds with a fused ring structure of formula (XIV). Such products include ecteinascidins and have a spiroamine-1,4-bridge. The process involving forming a 1,4 bridge using a 1-labile, 10-hydroxy, 18-protected hydroxyl, di-6,8-en-5-one fused ring compound. After formation of the 1,4 brige, C-18 protection is removed before spiroamine introduction.Type: ApplicationFiled: October 11, 2005Publication date: May 25, 2006Inventors: Andres Francesch, Carolina Fernandez, Jose Chicharro, Pilar Gallego, Maria Zarzuelo, Ignacio Manzanares, Marta Perez, Carmen Cuevas, Maria Martin, Simon Munt